Aliases for OXER1 Gene
External Ids for OXER1 Gene
Previous GeneCards Identifiers for OXER1 Gene
GeneCards Summary for OXER1 Gene
OXER1 (Oxoeicosanoid Receptor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding. An important paralog of this gene is HCAR2.
UniProtKB/Swiss-Prot Summary for OXER1 Gene
Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.
Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They are important in inflammatory signaling pathways.