Aliases for OXER1 Gene

Aliases for OXER1 Gene

  • Oxoeicosanoid Receptor 1 2 3 4 5
  • GPR170 2 3 4
  • TG1019 2 3 4
  • 5-Oxo-ETE Acid G-Protein-Coupled Receptor 1 2 3
  • 5-Oxo-ETE G-Protein Coupled Receptor 3 4
  • G-Protein Coupled Receptor TG1019 3 4
  • G-Protein Coupled Receptor R527 3 4
  • G-Protein Coupled Receptor 170 3 4
  • OXE Receptor 2 3
  • GPCR 2 3
  • Oxoeicosanoid (OXE) Receptor 1 3
  • OXER1 5

External Ids for OXER1 Gene

Previous GeneCards Identifiers for OXER1 Gene

  • GC02M042930
  • GC02M042901
  • GC02M042843
  • GC02M042989
  • GC02M042723

Summaries for OXER1 Gene

GeneCards Summary for OXER1 Gene

OXER1 (Oxoeicosanoid Receptor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding. An important paralog of this gene is HCAR2.

UniProtKB/Swiss-Prot Summary for OXER1 Gene

  • Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.

Tocris Summary for OXER1 Gene

  • Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They are important in inflammatory signaling pathways.

Gene Wiki entry for OXER1 Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OXER1 Gene

Genomics for OXER1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OXER1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J042763 Promoter/Enhancer 0.8 Ensembl ENCODE 257.3 0.0 -20 0.2 ZIC2 RBM22 SPI1 MYC OXER1 HSALNG0014489 HAAO MTA3
GH02J042765 Promoter 0.3 Ensembl 258.8 -1.2 -1240 0.6 OXER1 HSALNG0014489 HAAO MTA3
GH02J042762 Promoter 0.3 Ensembl 257.2 +1.8 1760 0.2 OXER1 piR-44133-013 MTA3
GH02J043167 Enhancer 1.7 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 23.6 -410.6 -410588 14.4 BCLAF1 SP1 NCOR1 MYC ZNF600 IKZF1 SSRP1 JUND ZNF592 ZMYM3 RNU6-1048P THADA OXER1 RNU6-242P ZFP36L2 HSALNG0014526-003 HSALNG0014527-001 HSALNG0014526-002 HSALNG0014527-002 lnc-ZFP36L2-1
GH02J042808 Promoter/Enhancer 1.8 ENCODE CraniofacialAtlas dbSUPER 18 -46.2 -46159 3.4 BCLAF1 ZNF207 MYC ZNF600 SSRP1 ZNF580 ZNF592 ZMYM3 POLR2A CEBPA LOC107985875 TRI-TAT2-1 lnc-HAAO-1 lnc-MTA3-6 THADA EML4 OXER1 HAAO lnc-MTA3-5 LOC107985876
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OXER1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OXER1

Top Transcription factor binding sites by QIAGEN in the OXER1 gene promoter:
  • c-Myb
  • ER-alpha
  • FOXL1
  • Nkx2-5
  • p53
  • PPAR-gamma1
  • PPAR-gamma2
  • SEF-1 (1)
  • Sp1
  • XBP-1

Genomic Locations for OXER1 Gene

Latest Assembly
chr2:42,762,481-42,764,261
(GRCh38/hg38)
Size:
1,781 bases
Orientation:
Minus strand

Previous Assembly
chr2:42,989,639-42,991,401
(GRCh37/hg19 by Entrez Gene)
Size:
1,763 bases
Orientation:
Minus strand

chr2:42,989,642-42,991,401
(GRCh37/hg19 by Ensembl)
Size:
1,760 bases
Orientation:
Minus strand

Genomic View for OXER1 Gene

Genes around OXER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OXER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OXER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXER1 Gene

Proteins for OXER1 Gene

  • Protein details for OXER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDS5-OXER1_HUMAN
    Recommended name:
    Oxoeicosanoid receptor 1
    Protein Accession:
    Q8TDS5
    Secondary Accessions:
    • Q86WP7
    • Q8NGW4

    Protein attributes for OXER1 Gene

    Size:
    423 amino acids
    Molecular mass:
    45811 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO17739.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05878.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OXER1 Gene

Post-translational modifications for OXER1 Gene

  • Glycosylation at Asn44
  • Modification sites at PhosphoSitePlus

Other Protein References for OXER1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OXER1 Gene

Domains & Families for OXER1 Gene

Gene Families for OXER1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OXER1 Gene

Suggested Antigen Peptide Sequences for OXER1 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor TG1019 (OXER1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TDS5

UniProtKB/Swiss-Prot:

OXER1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OXER1: view

Function for OXER1 Gene

Molecular function for OXER1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.

Phenotypes From GWAS Catalog for OXER1 Gene

Gene Ontology (GO) - Molecular Function for OXER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IMP 12065583
GO:0005515 protein binding IPI 32296183
GO:0050646 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding IDA 12065583
GO:0050647 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding IDA 12065583
GO:0050648 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding IDA 12065583
genes like me logo Genes that share ontologies with OXER1: view
genes like me logo Genes that share phenotypes with OXER1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OXER1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OXER1 Gene

Localization for OXER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXER1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OXER1 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for OXER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OXER1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OXER1 Gene

Pathways & Interactions for OXER1 Gene

genes like me logo Genes that share pathways with OXER1: view

Gene Ontology (GO) - Biological Process for OXER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA 12065583
genes like me logo Genes that share ontologies with OXER1: view

No data available for SIGNOR curated interactions for OXER1 Gene

Drugs & Compounds for OXER1 Gene

(21) Drugs for OXER1 Gene - From: DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
arachidonic acid Experimental Pharma 41
Cinalukast Experimental Pharma Potent, selective CysLT1 (LTD4) antagonist; orally active 0
Leukotriene B4 Investigational Pharma BLT1/BLT2 receptor agonist and potent chemotactic factor 0
[<sup>3</sup>H]5-oxo-ETE Pharma Agonist 0
5-(6-chloro-2-hexyl-1H-indol-1-yl)-5-oxo-valeric acid Pharma Antagonist 0

(4) Additional Compounds for OXER1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for OXER1 Gene

Compound Action Cas Number
Cinalukast Potent, selective CysLT1 (LTD4) antagonist; orally active 128312-51-6
FPL 55712 Leukotriene receptor antagonist 40785-97-5
Leukotriene B4 BLT1/BLT2 receptor agonist and potent chemotactic factor 71160-24-2
LY 255283 Selective, competitive BLT2 receptor antagonist 117690-79-6
SR 2640 hydrochloride Potent, selective LTD4 /LTE4 receptor antagonist 146662-42-2
genes like me logo Genes that share compounds with OXER1: view

Transcripts for OXER1 Gene

mRNA/cDNA for OXER1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OXER1

Alternative Splicing Database (ASD) splice patterns (SP) for OXER1 Gene

No ASD Table

Relevant External Links for OXER1 Gene

GeneLoc Exon Structure for
OXER1

Expression for OXER1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OXER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OXER1 Gene

This gene is overexpressed in Whole Blood (x10.2) and Liver (x9.5).

Protein differential expression in normal tissues from HIPED for OXER1 Gene

This gene is overexpressed in Heart (58.2) and Rectum (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OXER1 Gene



Protein tissue co-expression partners for OXER1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OXER1

SOURCE GeneReport for Unigene cluster for OXER1 Gene:

Hs.168439

mRNA Expression by UniProt/SwissProt for OXER1 Gene:

Q8TDS5-OXER1_HUMAN
Tissue specificity: Expressed in various tissues except brain. Expression is more intense in liver, kidney, peripheral leukocyte, lung, and spleen than in other tissues. Highly expressed in eosinophils, neutrophils, and lung macrophages.

Evidence on tissue expression from TISSUES for OXER1 Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with OXER1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OXER1 Gene

Orthologs for OXER1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OXER1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OXER1 29 30
  • 99.45 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia OXER1 29 30
  • 82.4 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OXER1 29 30
  • 81.62 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OXER1 30
  • 56 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii hcar1-3 30
  • 38 (a)
OneToMany
hcar1-4 30
  • 31 (a)
OneToMany
Species where no ortholog for OXER1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for OXER1 Gene

ENSEMBL:
Gene Tree for OXER1 (if available)
TreeFam:
Gene Tree for OXER1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OXER1: view image
Alliance of Genome Resources:
Additional Orthologs for OXER1

Paralogs for OXER1 Gene

(4) SIMAP similar genes for OXER1 Gene using alignment to 2 proteins:

  • OXER1_HUMAN
  • L8E891_HUMAN
genes like me logo Genes that share paralogs with OXER1: view

Variants for OXER1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OXER1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs540127113 Likely Benign: not provided 42,763,180(-) T/G
NM_148962.4(OXER1):c.1000A>C (p.Thr334Pro)
MISSENSE
rs76606481 Benign: not provided 42,763,077(-) G/A
NM_148962.4(OXER1):c.1103C>T (p.Ala368Val)
MISSENSE
rs77519354 Benign: not provided 42,763,238(-) A/G
NM_148962.4(OXER1):c.942T>C (p.Phe314=)
SYNONYMOUS
rs17029947 -- p.Met316Leu
rs2278586 -- p.Leu407Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OXER1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OXER1 Gene

Variant ID Type Subtype PubMed ID
nsv457152 CNV loss 19166990
nsv519877 CNV loss 19592680
nsv581644 CNV loss 21841781
nsv817795 CNV gain 17921354

Variation tolerance for OXER1 Gene

Residual Variation Intolerance Score: 98.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.08; 75.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OXER1 Gene

Human Gene Mutation Database (HGMD)
OXER1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OXER1
Leiden Open Variation Database (LOVD)
OXER1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OXER1 Gene

Disorders for OXER1 Gene

Additional Disease Information for OXER1

No disorders were found for OXER1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OXER1 Gene

Publications for OXER1 Gene

  1. Identification of a novel human eicosanoid receptor coupled to G(i/o). (PMID: 12065583) Hosoi T … Ohnuki T (The Journal of biological chemistry 2002) 2 3 4 22
  2. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PMID: 18821565) Lasky-Su J … Faraone SV (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 40
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor. (PMID: 15001665) Brink C … Yokomizo T (Pharmacological reviews 2004) 2 3

Products for OXER1 Gene

Sources for OXER1 Gene