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Aliases for OVOS2 Gene
Aliases for OVOS2 Gene
External Ids for OVOS2 Gene
- NCBI Entrez Gene: 144203
- Ensembl: ENSG00000177359
- UniProtKB/Swiss-Prot: Q6IE36
Previous GeneCards Identifiers for OVOS2 Gene
- GC12M031156
- GC12M031157
- GC12M031163
- GC12M031265
- GC12M031267
Summaries for OVOS2 Gene
GeneCards Summary for OVOS2 Gene
OVOS2 (Alpha-2-Macroglobulin Like 1 Pseudogene) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity.
UniProtKB/Swiss-Prot Summary for OVOS2 Gene
-
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OVOS2 Gene
Genomics for OVOS2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for OVOS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around OVOS2 on the GeneHancer Hub at the UCSC Golden Path
- Top Transcription factor binding sites by QIAGEN in the OVOS2 gene promoter:
-
- Brachyury
- CREB
- HNF-1
- HNF-1A
- Lhx3a
- LHX3b
- Pbx1a
- POU3F1
- RSRFC4
- TBP
Genomic Locations for OVOS2 Gene
Latest Assembly
- chr12:31,111,652-31,201,235
- (GRCh38/hg38)
- Size:
- 89,584 bases
- Orientation:
- Minus strand
Previous Assembly
- chr12:31,264,586-31,354,169
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 89,584 bases
- Orientation:
- Minus strand
- chr12:31,264,586-31,359,088
- (GRCh37/hg19 by Ensembl)
- Size:
- 94,503 bases
- Orientation:
- Minus strand
Genomic View for OVOS2 Gene
Genes around OVOS2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p11.21 by Entrez Gene
- 12p11.21 by Ensembl
OVOS2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for OVOS2 Gene
Proteins for OVOS2 Gene
-
Protein details for OVOS2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6IE36-OVOS2_HUMAN
- Recommended name:
- Ovostatin homolog 2
- Protein Accession:
- Q6IE36
Protein attributes for OVOS2 Gene
- Size:
- 1432 amino acids
- Molecular mass:
- 161251 Da
- Quaternary structure:
-
- Homotetramer.
- SequenceCaution:
-
- Sequence=CAE51409.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for OVOS2 Gene
Post-translational modifications for OVOS2 Gene
Antibodies for research
- Invitrogen Antibodies for OVOS2 (AFLGC-OVOS2)
- antibodies-online: Show 8 available OVOS2 Antibodies ranked by validation data
-
Biorbyt antibodies for OVOS2
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for OVOS2
- Origene Custom Protein Services for OVOS2
Assay products for research
No data available for DME Specific Peptides for OVOS2 Gene
Domains & Families for OVOS2 Gene
Protein Domains for OVOS2 Gene
Suggested Antigen Peptide Sequences for OVOS2 Gene
- GenScript: Design optimal peptide antigens:
-
- Ovostatin homolog 2 (OVOS2_HUMAN)
- OVOS2 protein (Q86X61_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6IE36UniProtKB/Swiss-Prot:
OVOS2_HUMAN :- Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
- Family:
-
- Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
No data available for Gene Families for OVOS2 Gene
Function for OVOS2 Gene
Molecular function for OVOS2 Gene
- UniProtKB/Swiss-Prot Function:
- Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.
Phenotypes From GWAS Catalog for OVOS2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity | IEA | -- |
Phenotypes for OVOS2 Gene
- MGI mutant phenotypes for OVOS2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for OVOS2:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for OVOS2 - Starting at $85 >
- * OVOS2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Browse CRISPR knockouts for OVOS2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OVOS2
miRNA for OVOS2 Gene
- miRTarBase miRNAs that target OVOS2
-
- hsa-miR-1304-5p (MIRT628790)
- hsa-miR-6765-5p (MIRT628791)
- hsa-miR-6087 (MIRT628792)
- hsa-miR-3197 (MIRT628793)
- hsa-miR-4772-3p (MIRT628794)
- hsa-miR-3925-3p (MIRT628795)
- hsa-miR-199b-5p (MIRT628796)
- hsa-miR-199a-5p (MIRT628797)
- hsa-miR-1825 (MIRT628798)
- hsa-miR-1306-5p (MIRT628799)
- hsa-miR-1304-3p (MIRT631833)
- hsa-miR-6890-3p (MIRT631834)
- hsa-miR-6787-3p (MIRT648350)
- hsa-miR-6736-3p (MIRT648351)
- hsa-miR-216a-5p (MIRT648352)
- hsa-miR-891a-3p (MIRT680266)
- hsa-miR-5693 (MIRT680267)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OVOS2
- Browse OriGene Inhibitory RNA Products For OVOS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OVOS2
Clone products for research
- Applied Biological Materials (abm): Clones for OVOS2 - Starting at $45 >
- * OVOS2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for OVOS2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OVOS2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OVOS2 Gene
Localization for OVOS2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for OVOS2 Gene
- Secreted.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IEA | -- |
No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OVOS2 Gene
Pathways & Interactions for OVOS2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010951 | negative regulation of endopeptidase activity | IEA | -- |
No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for OVOS2 Gene
Transcripts for OVOS2 Gene
mRNA/cDNA for OVOS2 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000391394 1215 nts (view in UCSC)
- ENST00000542490 1264 nts (view in UCSC)
- ENST00000542925 520 nts (view in UCSC)
- ENST00000641844 5833 nts (view in UCSC)
- ENST00000642199 1145 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for OVOS2 - Starting at $85 >
- * OVOS2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Browse CRISPR knockouts for OVOS2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OVOS2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OVOS2
- Browse OriGene Inhibitory RNA Products For OVOS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OVOS2
Clone products for research
- Applied Biological Materials (abm): Clones for OVOS2 - Starting at $45 >
- * OVOS2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for OVOS2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OVOS2
Relevant External Links for OVOS2 Gene
- GeneLoc Exon Structure for
- OVOS2
Expression for OVOS2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OVOS2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OVOS2
SOURCE GeneReport for Unigene cluster for OVOS2 Gene:
Hs.524331Primer products for research
-
OriGene qPCR primer pairs for OVOS2
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OVOS2 Gene
Orthologs for OVOS2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | LOC611455 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | OVOS2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | BC048546 30 |
|
||
| A2ml1 17 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | RGD1565709 30 |
|
||
| Chicken (Gallus gallus) |
Aves | OVST 30 |
|
- Species where no ortholog for OVOS2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Paralogs for OVOS2 Gene
(10) SIMAP similar genes for OVOS2 Gene using alignment to 2 proteins:
- OVOS2_HUMAN
- Q86X61_HUMAN
Pseudogenes.org Pseudogenes for OVOS2 Gene
No data available for Paralogs for OVOS2 Gene
Variants for OVOS2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OVOS2 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11051266 | - |
p.Ser789Leu |
|||
| rs12309295 | - |
p.Leu587Val |
|||
| rs17418189 | - |
p.Val1328Ala |
|||
| rs7971718 | - |
p.Thr211Met |
Gene Damage Index Score:
1.45;
28.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for OVOS2 Gene
- Human Gene Mutation Database (HGMD)
- OVOS2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance and Structural Variations from Database of Genomic Variants (DGV) for OVOS2 Gene
Disorders for OVOS2 Gene
No disorders were found for OVOS2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OVOS2 Gene
Publications for OVOS2 Gene
- Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PMID: 20808825) Chen X … Kong X (PloS one 2010) 3 41
- A genomic analysis of rat proteases and protease inhibitors. (PMID: 15060002) Puente XS … López-Otín C (Genome research 2004) 3 4
- Expression analysis of ovostatin 2 reveals its involvement in proliferation, invasion and angiogenesis of cutaneous malignant melanoma. (PMID: 24112097) Huang YX … Sun JF (The Journal of dermatology 2013) 3
- The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
No data available for Mastermind for OVOS2 Gene
Products for OVOS2 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for OVOS2
- Origene Custom Protein Services for OVOS2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OVOS2
- Browse OriGene Inhibitory RNA Products For OVOS2
- OriGene qPCR primer pairs for OVOS2
- Browse CRISPR knockouts for OVOS2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For OVOS2
- Sino Biological Human cDNA Clone for OVOS2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Invitrogen Antibodies for OVOS2 (AFLGC-OVOS2)
- antibodies-online: Show 8 available OVOS2 Antibodies ranked by validation data
- antibodies-online: Search results for available OVOS2 related products ranked by validation data
- antibodies-online: Search results for available OVOS2 related products ranked by validation data
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OVOS2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OVOS2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for OVOS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OVOS2
- Biorbyt antibodies for OVOS2
Sources for OVOS2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB