Aliases for OVOS2 Gene

Aliases for OVOS2 Gene

  • Alpha-2-Macroglobulin Like 1 Pseudogene 3
  • Ovostatin Homolog 2 3 4
  • Ovostatin 2 5
  • AC024940.1 5

External Ids for OVOS2 Gene

Previous GeneCards Identifiers for OVOS2 Gene

  • GC12M031156
  • GC12M031157
  • GC12M031163
  • GC12M031265
  • GC12M031267

Summaries for OVOS2 Gene

GeneCards Summary for OVOS2 Gene

OVOS2 (Alpha-2-Macroglobulin Like 1 Pseudogene) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot Summary for OVOS2 Gene

  • Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.

Additional gene information for OVOS2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OVOS2 Gene

Genomics for OVOS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OVOS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J031200 Enhancer 0.3 dbSUPER 256 -0.2 -164 2.7 ATF4 DACH1 OVOS2 DDX11 lnc-SINHCAF-4 SINHCAF
GH12J031117 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 12.6 +82.2 82234 4.8 ZBTB10 CTCF ZEB1 ZIC2 REST ZNF740 VEZF1 TRIM22 KLF7 ZNF341 lnc-DDX11-1 lnc-SINHCAF-6 piR-35894-001 DDX11 SINHCAF IPO8 FLJ13224 DDX11-AS1 OVOS2 HSALNG0090177
GH12J031726 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 4.7 -529.9 -529863 9.1 ZSCAN16 TBP ZBTB10 MXD4 SP1 FEZF1 CEBPA ZNF217 SIX5 NR2C1 AMN1 ENSG00000276900 lnc-AMN1-1 piR-61945-095 ENSG00000257511 DDX11 DDX11-AS1 ENSG00000252204 BICD1 AK4P3
GH12J031234 Enhancer 1 Ensembl ENCODE CraniofacialAtlas 9.7 -33.9 -33899 2.1 ZSCAN16 FEZF1 CTCF ZNF341 ZNF843 PRDM6 SCRT1 RAD21 ZBTB21 ZNF366 HSALNG0090185 DDX11 SINHCAF OVOS2 DDX11-AS1 lnc-DDX11-3
GH12J031228 Enhancer 0.8 Ensembl ENCODE 10.9 -28.4 -28366 1.6 SMAD4 RXRA JUND HNF4A ZNF48 RAD21 ZNF133 TFAP4 SP1 NFIA DDX11 OVOS2 HSALNG0090183 HSALNG0090185 SINHCAF
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OVOS2 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the OVOS2 gene promoter:
  • Brachyury
  • CREB
  • HNF-1
  • HNF-1A
  • Lhx3a
  • LHX3b
  • Pbx1a
  • POU3F1
  • RSRFC4
  • TBP

Genomic Locations for OVOS2 Gene

Latest Assembly
chr12:31,111,652-31,201,235
(GRCh38/hg38)
Size:
89,584 bases
Orientation:
Minus strand

Previous Assembly
chr12:31,264,586-31,354,169
(GRCh37/hg19 by Entrez Gene)
Size:
89,584 bases
Orientation:
Minus strand

chr12:31,264,586-31,359,088
(GRCh37/hg19 by Ensembl)
Size:
94,503 bases
Orientation:
Minus strand

Genomic View for OVOS2 Gene

Genes around OVOS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OVOS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OVOS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVOS2 Gene

Proteins for OVOS2 Gene

  • Protein details for OVOS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IE36-OVOS2_HUMAN
    Recommended name:
    Ovostatin homolog 2
    Protein Accession:
    Q6IE36

    Protein attributes for OVOS2 Gene

    Size:
    1432 amino acids
    Molecular mass:
    161251 Da
    Quaternary structure:
    • Homotetramer.
    SequenceCaution:
    • Sequence=CAE51409.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OVOS2 Gene

Post-translational modifications for OVOS2 Gene

  • Glycosylation at Asn35, Asn59, Asn159, Asn375, and Asn858
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OVOS2 Gene

Domains & Families for OVOS2 Gene

Suggested Antigen Peptide Sequences for OVOS2 Gene

GenScript: Design optimal peptide antigens:
  • Ovostatin homolog 2 (OVOS2_HUMAN)
  • OVOS2 protein (Q86X61_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6IE36

UniProtKB/Swiss-Prot:

OVOS2_HUMAN :
  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
Family:
  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
genes like me logo Genes that share domains with OVOS2: view

No data available for Gene Families for OVOS2 Gene

Function for OVOS2 Gene

Molecular function for OVOS2 Gene

UniProtKB/Swiss-Prot Function:
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.

Phenotypes From GWAS Catalog for OVOS2 Gene

Gene Ontology (GO) - Molecular Function for OVOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with OVOS2: view
genes like me logo Genes that share phenotypes with OVOS2: view

Animal Models for research

CRISPR products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OVOS2 Gene

Localization for OVOS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OVOS2 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for OVOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with OVOS2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OVOS2 Gene

Pathways & Interactions for OVOS2 Gene

PathCards logo

SuperPathways for OVOS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OVOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with OVOS2: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for OVOS2 Gene

Drugs & Compounds for OVOS2 Gene

No Compound Related Data Available

Transcripts for OVOS2 Gene

mRNA/cDNA for OVOS2 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR products for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OVOS2

Alternative Splicing Database (ASD) splice patterns (SP) for OVOS2 Gene

No ASD Table

Relevant External Links for OVOS2 Gene

GeneLoc Exon Structure for
OVOS2

Expression for OVOS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OVOS2 Gene

mRNA expression in normal human tissues for OVOS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)
  • Eye (Sensory Organs)

Protein differential expression in normal tissues from HIPED for OVOS2 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OVOS2 Gene



Protein tissue co-expression partners for OVOS2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OVOS2

SOURCE GeneReport for Unigene cluster for OVOS2 Gene:

Hs.524331
genes like me logo Genes that share expression patterns with OVOS2: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OVOS2 Gene

Orthologs for OVOS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OVOS2 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia LOC611455 30
  • 83.21 (n)
Cow
(Bos Taurus)
Mammalia OVOS2 30
  • 81.51 (n)
Mouse
(Mus musculus)
Mammalia BC048546 30
  • 72.32 (n)
A2ml1 17
Rat
(Rattus norvegicus)
Mammalia RGD1565709 30
  • 71.63 (n)
Chicken
(Gallus gallus)
Aves OVST 30
  • 55.39 (n)
Species where no ortholog for OVOS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OVOS2 Gene

ENSEMBL:
Gene Tree for OVOS2 (if available)
TreeFam:
Gene Tree for OVOS2 (if available)

Paralogs for OVOS2 Gene

(10) SIMAP similar genes for OVOS2 Gene using alignment to 2 proteins:

  • OVOS2_HUMAN
  • Q86X61_HUMAN

Pseudogenes.org Pseudogenes for OVOS2 Gene

genes like me logo Genes that share paralogs with OVOS2: view

No data available for Paralogs for OVOS2 Gene

Variants for OVOS2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OVOS2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs11051266 - p.Ser789Leu
rs12309295 - p.Leu587Val
rs17418189 - p.Val1328Ala
rs7971718 - p.Thr211Met

Variation tolerance for OVOS2 Gene

Gene Damage Index Score: 1.45; 28.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OVOS2 Gene

Human Gene Mutation Database (HGMD)
OVOS2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance and Structural Variations from Database of Genomic Variants (DGV) for OVOS2 Gene

Disorders for OVOS2 Gene

Additional Disease Information for OVOS2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)

No disorders were found for OVOS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OVOS2 Gene

Publications for OVOS2 Gene

  1. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PMID: 20808825) Chen X … Kong X (PloS one 2010) 3 41
  2. A genomic analysis of rat proteases and protease inhibitors. (PMID: 15060002) Puente XS … López-Otín C (Genome research 2004) 3 4
  3. Expression analysis of ovostatin 2 reveals its involvement in proliferation, invasion and angiogenesis of cutaneous malignant melanoma. (PMID: 24112097) Huang YX … Sun JF (The Journal of dermatology 2013) 3
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

No data available for Mastermind for OVOS2 Gene

Products for OVOS2 Gene

Sources for OVOS2 Gene