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Aliases for OVOS2 Gene

Aliases for OVOS2 Gene

  • Ovostatin 2 3
  • AC024940.1 5

External Ids for OVOS2 Gene

Previous GeneCards Identifiers for OVOS2 Gene

  • GC12M031156
  • GC12M031157
  • GC12M031163
  • GC12M031265
  • GC12M031267

Summaries for OVOS2 Gene

GeneCards Summary for OVOS2 Gene

OVOS2 (Ovostatin 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is ENSG00000214776.

UniProtKB/Swiss-Prot for OVOS2 Gene

  • Is able to inhibit all four classes of proteinases by a unique trapping mechanism.

Additional gene information for OVOS2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVOS2 Gene

Genomics for OVOS2 Gene

GeneHancer (GH) Regulatory Elements for OVOS2 Gene

Promoters and enhancers for OVOS2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I031234 Enhancer 0.7 ENCODE 0.8 -2.4 -2384 1.7 CTCF ZBTB21 ZNF449 FEZF1 RAD21 ZNF335 POLR2A ZNF366 SCRT2 ZBTB20 DDX11 SINHCAF DDX11-AS1 OVOS2 ENSG00000270766
GH12I031228 Enhancer 0.6 ENCODE 0.8 +2.9 2916 1.4 TFAP4 NFIA RXRA TAF1 ZNF133 MAX ZNF48 RAD21 YY1 JUND DDX11 OVOS2 LOC101060058
GH12I031205 Enhancer 1 Ensembl ENCODE dbSUPER 0.3 +26.6 26557 1.7 USF1 TRIM22 USF2 KLF5 ATF2 RELA JUND IKZF1 ATF7 FOS DDX11 OVOS2 LOC101060058
GH12I031238 Enhancer 0.6 ENCODE 0.4 -6.5 -6470 0.2 CTCF ZNF654 TRIM22 ZNF2 RAD21 RFX5 ZNF121 ZNF143 SMC3 HNF4A SINHCAF DDX11 DDX11-AS1 ENSG00000270766 OVOS2
GH12I031226 Enhancer 0.4 ENCODE 0.4 +5.2 5167 1.6 POLR2A RCOR1 CHD2 DDX11 OVOS2 LOC101060058
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OVOS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OVOS2 gene promoter:

Genomic Locations for OVOS2 Gene

Genomic Locations for OVOS2 Gene
120,881 bases
Minus strand

Genomic View for OVOS2 Gene

Genes around OVOS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OVOS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OVOS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVOS2 Gene

Proteins for OVOS2 Gene

  • Protein details for OVOS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ovostatin homolog 2
    Protein Accession:

    Protein attributes for OVOS2 Gene

    1432 amino acids
    Molecular mass:
    161251 Da
    Quaternary structure:
    • Homotetramer.
    • Sequence=CAE51409.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OVOS2 Gene

Post-translational modifications for OVOS2 Gene

  • Glycosylation at Asn35, Asn59, isoforms=159, isoforms=375, and isoforms=858
  • Modification sites at PhosphoSitePlus

Other Protein References for OVOS2 Gene

No data available for DME Specific Peptides for OVOS2 Gene

Domains & Families for OVOS2 Gene

Gene Families for OVOS2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for OVOS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
genes like me logo Genes that share domains with OVOS2: view

Function for OVOS2 Gene

Molecular function for OVOS2 Gene

UniProtKB/Swiss-Prot Function:
Is able to inhibit all four classes of proteinases by a unique trapping mechanism.

Phenotypes From GWAS Catalog for OVOS2 Gene

Gene Ontology (GO) - Molecular Function for OVOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with OVOS2: view
genes like me logo Genes that share phenotypes with OVOS2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OVOS2 Gene

Localization for OVOS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OVOS2 Gene


Gene Ontology (GO) - Cellular Components for OVOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with OVOS2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OVOS2 Gene

Pathways & Interactions for OVOS2 Gene

SuperPathways for OVOS2 Gene

No Data Available

Interacting Proteins for OVOS2 Gene

Gene Ontology (GO) - Biological Process for OVOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with OVOS2: view

No data available for Pathways by source and SIGNOR curated interactions for OVOS2 Gene

Drugs & Compounds for OVOS2 Gene

No Compound Related Data Available

Transcripts for OVOS2 Gene

Unigene Clusters for OVOS2 Gene

Ovostatin 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OVOS2 Gene

No ASD Table

Relevant External Links for OVOS2 Gene

GeneLoc Exon Structure for

Expression for OVOS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OVOS2 Gene

mRNA expression in normal human tissues for OVOS2 Gene

Protein differential expression in normal tissues from HIPED for OVOS2 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OVOS2 Gene

Protein tissue co-expression partners for OVOS2 Gene

SOURCE GeneReport for Unigene cluster for OVOS2 Gene:

genes like me logo Genes that share expression patterns with OVOS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OVOS2 Gene

Orthologs for OVOS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OVOS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC611455 33
  • 83.21 (n)
(Bos Taurus)
Mammalia OVOS2 33
  • 81.51 (n)
(Mus musculus)
Mammalia BC048546 33
  • 72.32 (n)
A2ml1 16
(Rattus norvegicus)
Mammalia RGD1565709 33
  • 71.63 (n)
(Gallus gallus)
Aves OVST 33
  • 55.39 (n)
Species where no ortholog for OVOS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OVOS2 Gene

Gene Tree for OVOS2 (if available)
Gene Tree for OVOS2 (if available)

Paralogs for OVOS2 Gene

Paralogs for OVOS2 Gene

(10) SIMAP similar genes for OVOS2 Gene using alignment to 2 proteins: Pseudogenes for OVOS2 Gene

genes like me logo Genes that share paralogs with OVOS2: view

Variants for OVOS2 Gene

Sequence variations from dbSNP and Humsavar for OVOS2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000069237 -- 31,114,390(-) A/G downstream_transcript_variant
rs1000090755 -- 31,164,961(-) G/A/T intron_variant
rs1000122518 -- 31,177,073(-) C/T intron_variant
rs1000168646 -- 31,173,640(-) C/T intron_variant
rs1000318534 -- 31,123,773(-) G/C intron_variant

Additional Variant Information for OVOS2 Gene

Human Gene Mutation Database (HGMD)

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OVOS2 Gene

Disorders for OVOS2 Gene

Additional Disease Information for OVOS2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OVOS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OVOS2 Gene

Publications for OVOS2 Gene

  1. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PMID: 20808825) Chen X … Kong X (PloS one 2010) 3 44 58
  2. A genomic analysis of rat proteases and protease inhibitors. (PMID: 15060002) Puente XS … López-Otín C (Genome research 2004) 3 4 58
  3. Expression analysis of ovostatin 2 reveals its involvement in proliferation, invasion and angiogenesis of cutaneous malignant melanoma. (PMID: 24112097) Huang YX … Sun JF (The Journal of dermatology 2013) 3 58
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OVOS2 Gene

Sources for OVOS2 Gene

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