Aliases for OVOL3 Gene

Aliases for OVOL3 Gene

  • Ovo Like Zinc Finger 3 2 3 5
  • Putative Transcription Factor Ovo-Like Protein 3 3 4
  • HOVO3 2 3
  • Ovo-Like 3 (Drosophila) 2
  • OVO Homolog-Like 3 3
  • Ovo-Like 3 3
  • OVOL3 5

External Ids for OVOL3 Gene

Previous GeneCards Identifiers for OVOL3 Gene

  • GC19P037241
  • GC19P037050
  • GC19P041278
  • GC19U900376
  • GC19P036603
  • GC19P037069
  • GC19P037238
  • GC19P037309
  • GC19P037741
  • GC19P036118
  • GC19P036327
  • GC19P036432
  • GC19P036594
  • GC19P036760
  • GC19P036906

Summaries for OVOL3 Gene

GeneCards Summary for OVOL3 Gene

OVOL3 (Ovo Like Zinc Finger 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is OVOL2.

UniProtKB/Swiss-Prot Summary for OVOL3 Gene

Additional gene information for OVOL3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OVOL3 Gene

Genomics for OVOL3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OVOL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J036110 Enhancer 0.8 Ensembl ENCODE 600.7 +0.4 445 2 PRDM10 KDM1A ZIC2 RBFOX2 BCOR POLR2A ZFP69B SIN3A GLIS1 SMARCA4 OVOL3 WDR62 TBCB
GH19J036035 Enhancer 1.1 Ensembl ENCODE 11.2 -74.7 -74650 2.6 ARHGAP35 LEF1 IKZF1 MTA2 ZSCAN4 PKNOX1 MTA1 ZNF24 BRD9 DPF2 WDR62 KMT2B ZNF345 RBM42 THAP8 PROSER3 ZNF850 OVOL3 POLR2I TBCB
GH19J036041 Enhancer 0.9 Ensembl ENCODE 11.2 -69.3 -69251 2.2 CEBPG CREB1 ATF7 TEAD4 TARDBP ZIC2 ZNF747 ZNF311 CEBPA SCRT2 ZNF345 ZNF567 ZNF850 TBCB THAP8 WDR62 OVOL3 POLR2I ZNF829 TMEM147-AS1
GH19J036159 Enhancer 0.6 ENCODE dbSUPER 12.1 +49.7 49696 1.9 NFE2 POLR2A ZNF362 piR-32559-203 piR-36770-045 CAPNS1 OVOL3 POLR2I TBCB SDHAF1 ZNF565 RF00017-2949 COX7A1
GH19J036157 Enhancer 0.4 FANTOM5 12.1 +46.4 46427 0.2 ZNF600 ZBTB17 piR-36770-045 piR-37567-079 piR-37656-108 POLR2I TBCB OVOL3 SDHAF1 ZNF565 COX7A1 ZNF146
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OVOL3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OVOL3

Genomic Locations for OVOL3 Gene

Genomic Locations for OVOL3 Gene
chr19:36,111,151-36,113,711
(GRCh38/hg38)
Size:
2,561 bases
Orientation:
Plus strand
chr19:36,602,104-36,604,613
(GRCh37/hg19)
Size:
2,510 bases
Orientation:
Plus strand

Genomic View for OVOL3 Gene

Genes around OVOL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OVOL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OVOL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVOL3 Gene

Proteins for OVOL3 Gene

  • Protein details for OVOL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00110-OVOL3_HUMAN
    Recommended name:
    Putative transcription factor ovo-like protein 3
    Protein Accession:
    O00110

    Protein attributes for OVOL3 Gene

    Size:
    214 amino acids
    Molecular mass:
    23826 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB51180.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OVOL3 Gene

Post-translational modifications for OVOL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OVOL3 Gene

No data available for DME Specific Peptides for OVOL3 Gene

Domains & Families for OVOL3 Gene

Gene Families for OVOL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for OVOL3 Gene

Graphical View of Domain Structure for InterPro Entry

O00110

UniProtKB/Swiss-Prot:

OVOL3_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with OVOL3: view

No data available for Suggested Antigen Peptide Sequences for OVOL3 Gene

Function for OVOL3 Gene

Molecular function for OVOL3 Gene

UniProtKB/Swiss-Prot Function:
May act as a transcription regulator.

Gene Ontology (GO) - Molecular Function for OVOL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IBA 21873635
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with OVOL3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OVOL3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OVOL3 Gene

Localization for OVOL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OVOL3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OVOL3 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for OVOL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with OVOL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OVOL3 Gene

Pathways & Interactions for OVOL3 Gene

PathCards logo

SuperPathways for OVOL3 Gene

No Data Available

Interacting Proteins for OVOL3 Gene

Gene Ontology (GO) - Biological Process for OVOL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0009913 epidermal cell differentiation IBA 21873635
GO:0045892 negative regulation of transcription, DNA-templated IBA 21873635
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with OVOL3: view

No data available for Pathways by source and SIGNOR curated interactions for OVOL3 Gene

Drugs & Compounds for OVOL3 Gene

No Compound Related Data Available

Transcripts for OVOL3 Gene

mRNA/cDNA for OVOL3 Gene

2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OVOL3

Alternative Splicing Database (ASD) splice patterns (SP) for OVOL3 Gene

No ASD Table

Relevant External Links for OVOL3 Gene

GeneLoc Exon Structure for
OVOL3

Expression for OVOL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OVOL3 Gene

mRNA differential expression in normal tissues according to GTEx for OVOL3 Gene

This gene is overexpressed in Testis (x19.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OVOL3

SOURCE GeneReport for Unigene cluster for OVOL3 Gene:

Hs.143920
genes like me logo Genes that share expression patterns with OVOL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OVOL3 Gene

Orthologs for OVOL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for OVOL3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OVOL3 30 31
  • 99.84 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OVOL3 30 31
  • 84.66 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia OVOL3 30 31
  • 84.19 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ovol3 30 17
  • 83.78 (n)
Rat
(Rattus norvegicus)
Mammalia LOC100912425 30
  • 82.8 (n)
Oppossum
(Monodelphis domestica)
Mammalia OVOL3 31
  • 57 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101730693 30
  • 57.83 (n)
Zebrafish
(Danio rerio)
Actinopterygii OVOL3 31
  • 45 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta ovo 31
  • 7 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea lin-48 31
  • 27 (a)
OneToMany
Species where no ortholog for OVOL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for OVOL3 Gene

ENSEMBL:
Gene Tree for OVOL3 (if available)
TreeFam:
Gene Tree for OVOL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OVOL3: view image

Paralogs for OVOL3 Gene

genes like me logo Genes that share paralogs with OVOL3: view

Variants for OVOL3 Gene

Additional dbSNP identifiers (rs#s) for OVOL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for OVOL3 Gene

Variant ID Type Subtype PubMed ID
nsv833815 CNV loss 17160897

Variation tolerance for OVOL3 Gene

Gene Damage Index Score: 3.60; 56.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OVOL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OVOL3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OVOL3 Gene

Disorders for OVOL3 Gene

Additional Disease Information for OVOL3

No disorders were found for OVOL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OVOL3 Gene

Publications for OVOL3 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  2. Molecular phylogeny of OVOL genes illustrates a conserved C2H2 zinc finger domain coupled by hypervariable unstructured regions. (PMID: 22737237) Kumar A … Grapputo A (PloS one 2012) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Ovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice. (PMID: 12213202) Li B … Dai X (Genomics 2002) 3

Products for OVOL3 Gene

Sources for OVOL3 Gene