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This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
OVGP1 (Oviductal Glycoprotein 1) is a Protein Coding gene. Diseases associated with OVGP1 include Anterior Scleritis and Chronic Salpingitis. Among its related pathways are Fertilization. Gene Ontology (GO) annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and chitinase activity. An important paralog of this gene is CHIA.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004568 | chitinase activity | IBA | 21873635 |
GO:0008061 | chitin binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0030133 | transport vesicle | IEA | -- |
GO:0031410 | cytoplasmic vesicle | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Fertilization |
1.00
1.00
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005975 | carbohydrate metabolic process | IEA | -- |
GO:0006032 | chitin catabolic process | IBA | 21873635 |
GO:0007338 | single fertilization | IEA | -- |
GO:0007339 | binding of sperm to zona pellucida | TAS | -- |
GO:0007565 | female pregnancy | TAS | 9341614 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | OVGP1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
LOC100138271 30 |
|
||||
OVGP1 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | OVGP1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ovgp1 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | OVGP1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | OVGP1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | OVGP1 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | OVGP1 (3 of 4) 31 |
|
OneToMany | |
chia.3 31 |
|
OneToMany | |||
chia.4 31 |
|
OneToMany | |||
chia.6 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG9357 32 |
|
|
|
CG10531 32 |
|
|
|||
Cht2 32 |
|
|
|||
Cht3 32 |
|
|
|||
CG3044 32 |
|
|
|||
Cht7 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | cht-1 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CTS2 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8046 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
716048 | Benign: not provided | 111,414,903(-) | G/C | MISSENSE_VARIANT | |
726804 | Benign: not provided | 111,422,994(-) | G/A | SYNONYMOUS_VARIANT | |
746882 | Likely Benign: not provided | 111,415,257(-) | G/A | MISSENSE_VARIANT | |
767686 | Benign: not provided | 111,414,879(-) | CTCACAGACTGATGAC | INFRAME_DELETION | |
767687 | Benign: not provided | 111,414,925(-) | GGGTCAGGGTCTTTTC | INFRAME_DELETION |
Disorder | Aliases | PubMed IDs |
---|---|---|
anterior scleritis |
|
|
chronic salpingitis |
|
|
taylor's syndrome |
|
|
endosalpingiosis |
|
|
acute salpingitis |
|
|