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Aliases for OVCH2 Gene

Aliases for OVCH2 Gene

  • Ovochymase 2 (Gene/Pseudogene) 2 3 5
  • OVTN 3 4
  • Oviductin Protease 3
  • Ovochymase 2 2
  • Ovochymase-2 3
  • EC 3.4.21.- 4
  • Oviductin 4

External Ids for OVCH2 Gene

Previous GeneCards Identifiers for OVCH2 Gene

  • GC11M007371

Summaries for OVCH2 Gene

GeneCards Summary for OVCH2 Gene

OVCH2 (Ovochymase 2 (Gene/Pseudogene)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS36.

Additional gene information for OVCH2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVCH2 Gene

Genomics for OVCH2 Gene

GeneHancer (GH) Regulatory Elements for OVCH2 Gene

Promoters and enhancers for OVCH2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I007706 Promoter 0.5 EPDnew 550.8 0.0 -4 0.1 OVCH2 LOC105376533 OR10AB1P ENSG00000271758
GH11I007571 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.8 +130.5 130519 9.3 PKNOX1 FOXA2 MLX ARID4B FEZF1 DMAP1 BRCA1 ZNF48 ETS1 YY1 OLFML1 OVCH2 PPFIBP2 NLRP10 LOC105376535 GC11M007541
GH11I007665 Enhancer 1 ENCODE dbSUPER 10.7 +40.4 40396 0.7 HDGF PKNOX1 RB1 ARID4B SIN3A ZNF2 IRF4 RAD21 ZNF143 KLF7 CYB5R2 LOC105376533 OVCH2 GC11P007617 PPFIBP2
GH11I007676 Enhancer 0.9 ENCODE dbSUPER 11.3 +29.1 29124 1.7 PKNOX1 MZF1 FEZF1 ZIC2 ZNF335 ZFHX2 CTBP1 ZNF398 ZNF518A ZNF843 CYB5R2 EIF3F LOC100506258 LOC105376533 OVCH2 OLFML1 OR10AB1P ENSG00000275612
GH11I007904 Enhancer 0.8 Ensembl ENCODE 10.2 -200.1 -200131 4.4 CTCF CEBPB KLF4 POLR2A SCRT2 GLIS1 ZBTB33 TCF7L2 LOC283299 PIR62490 NLRP10 OR10A6 OR10A3 OVCH2 CASC23 TUB EIF3F
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OVCH2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OVCH2 gene promoter:

Genomic Locations for OVCH2 Gene

Genomic Locations for OVCH2 Gene
27,763 bases
Minus strand

Genomic View for OVCH2 Gene

Genes around OVCH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OVCH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OVCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVCH2 Gene

Proteins for OVCH2 Gene

  • Protein details for OVCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for OVCH2 Gene

    564 amino acids
    Molecular mass:
    62642 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OVCH2 Gene

Post-translational modifications for OVCH2 Gene

  • Glycosylation at isoforms=104, isoforms=415, Asn451, and Asn530
  • Modification sites at PhosphoSitePlus

Other Protein References for OVCH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OVCH2 Gene

Domains & Families for OVCH2 Gene

Gene Families for OVCH2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for OVCH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with OVCH2: view

Function for OVCH2 Gene

Enzyme Numbers (IUBMB) for OVCH2 Gene

Phenotypes From GWAS Catalog for OVCH2 Gene

Gene Ontology (GO) - Molecular Function for OVCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OVCH2: view
genes like me logo Genes that share phenotypes with OVCH2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OVCH2

miRNA for OVCH2 Gene

miRTarBase miRNAs that target OVCH2

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OVCH2 Gene

Localization for OVCH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OVCH2 Gene


Gene Ontology (GO) - Cellular Components for OVCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OVCH2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OVCH2 Gene

Pathways & Interactions for OVCH2 Gene

SuperPathways for OVCH2 Gene

No Data Available

Interacting Proteins for OVCH2 Gene

Gene Ontology (GO) - Biological Process for OVCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with OVCH2: view

No data available for Pathways by source and SIGNOR curated interactions for OVCH2 Gene

Drugs & Compounds for OVCH2 Gene

No Compound Related Data Available

Transcripts for OVCH2 Gene

mRNA/cDNA for OVCH2 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OVCH2 Gene

Ovochymase 2 (gene/pseudogene):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OVCH2 Gene

No ASD Table

Relevant External Links for OVCH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OVCH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OVCH2 Gene

mRNA differential expression in normal tissues according to GTEx for OVCH2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x11.9), Skin - Sun Exposed (Lower leg) (x8.7), Breast - Mammary Tissue (x5.2), Bladder (x4.6), and Prostate (x4.1).

Protein differential expression in normal tissues from HIPED for OVCH2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (62.8) and Platelet (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OVCH2 Gene

Protein tissue co-expression partners for OVCH2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OVCH2 Gene:


SOURCE GeneReport for Unigene cluster for OVCH2 Gene:

genes like me logo Genes that share expression patterns with OVCH2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OVCH2 Gene

Orthologs for OVCH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OVCH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OVCH2 33 34
  • 99 (n)
(Canis familiaris)
Mammalia OVCH2 33 34
  • 84.31 (n)
(Bos Taurus)
Mammalia OVCH2 33 34
  • 84.16 (n)
(Rattus norvegicus)
Mammalia Ovch2 33
  • 83.6 (n)
(Mus musculus)
Mammalia Ovch2 33 16 34
  • 82.5 (n)
(Monodelphis domestica)
Mammalia OVCH2 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia OVCH2 34
  • 56 (a)
(Gallus gallus)
Aves OVCH2 33 34
  • 65.13 (n)
(Anolis carolinensis)
Reptilia OVCH2 34
  • 35 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398108 33
(Danio rerio)
Actinopterygii LOC101884131 33
  • 48.49 (n)
ovch2 34
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11836 34
  • 32 (a)
CG18735 34
  • 28 (a)
CG3355 34
  • 28 (a)
CG6865 34
  • 28 (a)
CG4914 34
  • 27 (a)
CG4386 34
  • 25 (a)
CG11843 34
  • 23 (a)
CG4613 34
  • 23 (a)
CG9294 34
  • 23 (a)
CG4927 34
  • 22 (a)
CG11841 34
  • 21 (a)
CG3700 34
  • 21 (a)
CG9372 34
  • 21 (a)
spirit 34
  • 21 (a)
CG14642 34
  • 20 (a)
CG11842 34
  • 19 (a)
CG1299 34
  • 18 (a)
CG14892 34
  • 18 (a)
CG8172 34
  • 18 (a)
psh 34
  • 18 (a)
snk 34
  • 18 (a)
CG11670 34
  • 17 (a)
CG11668 34
  • 16 (a)
CG32260 34
  • 16 (a)
CG31728 34
  • 13 (a)
CG7432 34
  • 13 (a)
Sb 34
  • 13 (a)
CG6361 34
  • 12 (a)
CG34350 34
  • 10 (a)
CG8213 34
  • 5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3856 34
  • 18 (a)
Species where no ortholog for OVCH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OVCH2 Gene

Gene Tree for OVCH2 (if available)
Gene Tree for OVCH2 (if available)

Paralogs for OVCH2 Gene

Variants for OVCH2 Gene

Sequence variations from dbSNP and Humsavar for OVCH2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000078500 -- 7,707,281(-) A/C upstream_transcript_variant
rs1000227343 -- 7,708,690(-) G/A upstream_transcript_variant
rs1000230259 -- 7,681,910(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000455862 -- 7,702,571(-) T/C intron_variant
rs1000482087 -- 7,678,961(-) A/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OVCH2 Gene

Variant ID Type Subtype PubMed ID
dgv184e214 CNV gain 21293372
esv2518653 CNV deletion 19546169
esv3891925 CNV gain 25118596
esv3891927 CNV loss 25118596
nsv1035575 CNV gain 25217958
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855
nsv951305 CNV duplication 24416366

Additional Variant Information for OVCH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for OVCH2 Gene

Disorders for OVCH2 Gene

Additional Disease Information for OVCH2

No disorders were found for OVCH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OVCH2 Gene

Publications for OVCH2 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3 4 58
  2. NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. (PMID: 19557197) Heard-Costa NL … North KE (PLoS genetics 2009) 3 44 58
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 58

Products for OVCH2 Gene

Sources for OVCH2 Gene

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