Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OVCA2 Gene

Aliases for OVCA2 Gene

  • OVCA2, Serine Hydrolase Domain Containing 2 3 5
  • Candidate Tumor Suppressor In Ovarian Cancer 2 2
  • Ovarian Cancer-Associated Gene 2 Protein 4
  • Ovarian Tumor Suppressor Candidate 2 2
  • EC 3.1.2.- 4

External Ids for OVCA2 Gene

Previous GeneCards Identifiers for OVCA2 Gene

  • GC17U990304
  • GC17P002273
  • GC17P001884
  • GC17P002151
  • GC17P001892
  • GC17P001945

Summaries for OVCA2 Gene

GeneCards Summary for OVCA2 Gene

OVCA2 (OVCA2, Serine Hydrolase Domain Containing) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity.

Additional gene information for OVCA2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVCA2 Gene

Genomics for OVCA2 Gene

GeneHancer (GH) Regulatory Elements for OVCA2 Gene

Promoters and enhancers for OVCA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I002040 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.0 1033 4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ENSG00000262533 ENSG00000263050 OVCA2 DPH1 PRPF8 MNT WDR81 RN7SL608P SMYD4 MYO1C
GH17I002170 Enhancer 2.5 VISTA UCNEbase FANTOM5 Ensembl ENCODE dbSUPER 11.3 +135.6 135563 13.4 PKNOX1 FOXA2 ARID4B FEZF1 ZNF48 ETS1 YY1 ZNF121 ZNF213 KLF7 GC17P002179 SRR ENSG00000236838 HIC1 ENSG00000236457 LOC101927839 OVCA2 SNORD91A SNORD91B SMG6
GH17I002080 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +45.6 45627 13.2 PKNOX1 CLOCK ATF1 FOXA2 SMAD1 SIN3A FEZF1 IRF4 ZNF766 GATA2 SRR HIC1 OVCA2 LOC101927839 ENSG00000236457 ENSG00000236838 SMG6 DPH1 SLC43A2 SCARF1
GH17I002261 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 +223.2 223154 7.3 PKNOX1 SMAD1 FEZF1 ZNF2 ZNF207 ATF7 FOS RUNX3 ZNF214 ZNF491 SMG6 GC17P002267 SRR HNRNPA1P16 ENSG00000263050 METTL16 LOC105371592 DPH1 ENSG00000263345 TSR1
GH17I002235 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.7 +196.7 196737 7.3 PKNOX1 ZSCAN4 BATF KLF5 IRF4 RAD21 ZNF143 ATF7 FOS BCLAF1 SMG6 SRR HIC1 ENSG00000236457 ENSG00000236838 OVCA2 DPH1 TSR1 SGSM2 SMG6-IT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OVCA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OVCA2 gene promoter:

Genomic Locations for OVCA2 Gene

Genomic Locations for OVCA2 Gene
chr17:2,041,936-2,043,431
(GRCh38/hg38)
Size:
1,496 bases
Orientation:
Plus strand
chr17:1,945,277-1,946,725
(GRCh37/hg19)

Genomic View for OVCA2 Gene

Genes around OVCA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OVCA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OVCA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVCA2 Gene

Proteins for OVCA2 Gene

  • Protein details for OVCA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ82-OVCA2_HUMAN
    Recommended name:
    Esterase OVCA2
    Protein Accession:
    Q8WZ82
    Secondary Accessions:
    • Q86XN3
    • Q8IW87
    • Q9UCX9

    Protein attributes for OVCA2 Gene

    Size:
    227 amino acids
    Molecular mass:
    24418 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OVCA2 Gene

Post-translational modifications for OVCA2 Gene

  • Proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocytic leukemia cell line HL-60.

Other Protein References for OVCA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OVCA2 Gene

Domains & Families for OVCA2 Gene

Gene Families for OVCA2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OVCA2 Gene

Suggested Antigen Peptide Sequences for OVCA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WZ82

UniProtKB/Swiss-Prot:

OVCA2_HUMAN :
  • Belongs to the LovG family.
Family:
  • Belongs to the LovG family.
genes like me logo Genes that share domains with OVCA2: view

Function for OVCA2 Gene

Molecular function for OVCA2 Gene

GENATLAS Biochemistry:
ovarian cancer 2 gene (see TSG17D),with homology to C elegans clone,CEC14B1,unlikely to be the same as OVCA1

Enzyme Numbers (IUBMB) for OVCA2 Gene

Phenotypes From GWAS Catalog for OVCA2 Gene

Gene Ontology (GO) - Molecular Function for OVCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity NAS 11979432
genes like me logo Genes that share ontologies with OVCA2: view
genes like me logo Genes that share phenotypes with OVCA2: view

Animal Model Products

miRNA for OVCA2 Gene

miRTarBase miRNAs that target OVCA2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OVCA2 Gene

Localization for OVCA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OVCA2 gene
Compartment Confidence
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OVCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA,IEA 16368187
genes like me logo Genes that share ontologies with OVCA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OVCA2 Gene

Pathways & Interactions for OVCA2 Gene

SuperPathways for OVCA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OVCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032526 response to retinoic acid IDA 11979432
genes like me logo Genes that share ontologies with OVCA2: view

No data available for Pathways by source and SIGNOR curated interactions for OVCA2 Gene

Drugs & Compounds for OVCA2 Gene

No Compound Related Data Available

Transcripts for OVCA2 Gene

mRNA/cDNA for OVCA2 Gene

(1) REFSEQ mRNAs :
(384) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OVCA2 Gene

No ASD Table

Relevant External Links for OVCA2 Gene

GeneLoc Exon Structure for
OVCA2
ECgene alternative splicing isoforms for
OVCA2

Expression for OVCA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OVCA2 Gene

Protein differential expression in normal tissues from HIPED for OVCA2 Gene

This gene is overexpressed in Liver (9.9) and Peripheral blood mononuclear cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OVCA2 Gene



Protein tissue co-expression partners for OVCA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OVCA2 Gene:

OVCA2

mRNA Expression by UniProt/SwissProt for OVCA2 Gene:

Q8WZ82-OVCA2_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for OVCA2 Gene

  • Intestine(4)
  • Liver(4)
  • Skin(4)
genes like me logo Genes that share expression patterns with OVCA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OVCA2 Gene

Orthologs for OVCA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OVCA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPH1 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OVCA2 33 34
  • 84.73 (n)
dog
(Canis familiaris)
Mammalia OVCA2 33
  • 84.73 (n)
DPH1 34
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ovca2 33 16 34
  • 84 (n)
rat
(Rattus norvegicus)
Mammalia Ovca2 33
  • 82.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OVCA2 34
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OVCA2 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves OVCA2 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ovca2 33
  • 56.01 (n)
zebrafish
(Danio rerio)
Actinopterygii ovca2 33 34
  • 49.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5412 35 33 34
  • 48.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta U483_ANOGA 33
  • 47.85 (n)
worm
(Caenorhabditis elegans)
Secernentea C25G4.2 35 33 34
  • 46.09 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FSH1 34
  • 21 (a)
OneToOne
Species where no ortholog for OVCA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OVCA2 Gene

ENSEMBL:
Gene Tree for OVCA2 (if available)
TreeFam:
Gene Tree for OVCA2 (if available)

Paralogs for OVCA2 Gene

No data available for Paralogs for OVCA2 Gene

Variants for OVCA2 Gene

Sequence variations from dbSNP and Humsavar for OVCA2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000112259 -- 2,042,402(+) C/T intron_variant
rs1000148954 -- 2,043,466(+) T/G downstream_transcript_variant
rs1000201625 -- 2,043,215(+) C/G 3_prime_UTR_variant
rs1000484055 -- 2,042,483(+) A/C intron_variant
rs1001146133 -- 2,041,581(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OVCA2 Gene

Variant ID Type Subtype PubMed ID
nsv827857 CNV gain 20364138
nsv574216 CNV gain 21841781
esv33335 CNV loss 17666407

Variation tolerance for OVCA2 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OVCA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OVCA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OVCA2 Gene

Disorders for OVCA2 Gene

Additional Disease Information for OVCA2

No disorders were found for OVCA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OVCA2 Gene

Publications for OVCA2 Gene

  1. OVCA2 is downregulated and degraded during retinoid-induced apoptosis. (PMID: 11979432) Prowse AH … Godwin AK (International journal of cancer 2002) 2 3 4 22 58
  2. Identification of two candidate tumor suppressor genes on chromosome 17p13.3. (PMID: 8616839) Schultz DC … Godwin AK (Cancer research 1996) 2 3 4 58
  3. Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY. (PMID: 16368187) Azizi AA … Lubec G (Cancer letters 2006) 2 3 58
  4. Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast. (PMID: 14645503) Baxter SM … Fetrow JS (Molecular & cellular proteomics : MCP 2004) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for OVCA2 Gene

Sources for OVCA2 Gene

Content
Loading form....