Aliases for OTUD7B Gene
External Ids for OTUD7B Gene
Previous HGNC Symbols for OTUD7B Gene
Previous GeneCards Identifiers for OTUD7B Gene
GeneCards Summary for OTUD7B Gene
OTUD7B (OTU Deubiquitinase 7B) is a Protein Coding gene. Diseases associated with OTUD7B include Autoinflammation, Panniculitis, And Dermatosis Syndrome. Among its related pathways are Metabolism of proteins and TNF signaling (REACTOME). Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity and obsolete ubiquitin thiolesterase activity. An important paralog of this gene is OTUD7A.
UniProtKB/Swiss-Prot Summary for OTUD7B Gene
Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin.