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Aliases for OTUD7B Gene

Aliases for OTUD7B Gene

  • OTU Deubiquitinase 7B 2 3 5
  • Cellular Zinc Finger Anti-NF-Kappa-B Protein 3 4
  • Zinc Finger A20 Domain-Containing Protein 1 3 4
  • Zinc Finger, A20 Domain Containing 1 2 3
  • Zinc Finger Protein Cezanne 3 4
  • OTU Domain Containing 7B 2 3
  • CEZANNE 3 4
  • ZA20D1 3 4
  • Cellular Zinc Finger Anti-NF-KappaB Cezanne 3
  • OTU Domain-Containing Protein 7B 3
  • EC 3.4.19.12 4

External Ids for OTUD7B Gene

Previous HGNC Symbols for OTUD7B Gene

  • ZA20D1

Previous GeneCards Identifiers for OTUD7B Gene

  • GC01M148178
  • GC01M149912
  • GC01M121292

Summaries for OTUD7B Gene

GeneCards Summary for OTUD7B Gene

OTUD7B (OTU Deubiquitinase 7B) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity and obsolete ubiquitin thiolesterase activity. An important paralog of this gene is OTUD7A.

UniProtKB/Swiss-Prot for OTUD7B Gene

  • Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates Lys-48-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward Lys-11, Lys-48 and Lys-63-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with Lys-11-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin.

Gene Wiki entry for OTUD7B Gene

Additional gene information for OTUD7B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUD7B Gene

Genomics for OTUD7B Gene

GeneHancer (GH) Regulatory Elements for OTUD7B Gene

Promoters and enhancers for OTUD7B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I150008 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 553.1 +0.6 564 2.9 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF416 ZNF143 ZNF548 SP3 OTUD7B PRPF3 SETDB1 MTMR11 ARNT ADAMTSL4 SV2A UBE2D3P3 RPRD2 CTSK
GH01I149999 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.4 +11.7 11720 0.1 OTUD7B MTMR11 HIST2H2AB HIST2H2AC HIST2H2BE BOLA1 PLEKHO1 PIR49087
GH01I149985 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.3 +24.0 24008 2.1 MEIS2 PKNOX1 ZNF133 HIC1 ZNF664 ZNF366 POLR2A PRDM10 ZNF600 KLF8 OTUD7B MTMR11 SF3B4 SV2A BOLA1 HIST2H2AC HIST2H2BE PIR49087
GH01I150006 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 8.7 +3.5 3452 1.7 JUN FOSL1 ZFHX2 EGR1 TRIM24 FOS EGR2 SMARCE1 L3MBTL2 DPF2 MTMR11 SF3B4 OTUD7B SV2A CA14 PIR49087
GH01I150061 Enhancer 0.8 Ensembl ENCODE 11.2 -51.1 -51061 0.9 MEIS2 PKNOX1 CEBPB CEBPG TSHZ1 ARHGAP35 ZNF316 JUND FOS MAFK HIST2H2AC OTUD7B MTMR11 PLEKHO1 HIST2H2AA3 HIST2H2BD SF3B4 HIST2H3C HIST2H2BE BOLA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OTUD7B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OTUD7B gene promoter:

Genomic Locations for OTUD7B Gene

Genomic Locations for OTUD7B Gene
chr1:149,937,812-150,010,772
(GRCh38/hg38)
Size:
72,961 bases
Orientation:
Minus strand
chr1:149,909,705-149,982,686
(GRCh37/hg19)

Genomic View for OTUD7B Gene

Genes around OTUD7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTUD7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTUD7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD7B Gene

Proteins for OTUD7B Gene

  • Protein details for OTUD7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6GQQ9-OTU7B_HUMAN
    Recommended name:
    OTU domain-containing protein 7B
    Protein Accession:
    Q6GQQ9
    Secondary Accessions:
    • B7Z643
    • D3DUZ8
    • Q5SZ60
    • Q8WWA7
    • Q9NQ53
    • Q9UFF4

    Protein attributes for OTUD7B Gene

    Size:
    843 amino acids
    Molecular mass:
    92526 Da
    Quaternary structure:
    • Interacts with ZAP70 in activated T cells, but not in resting T cells (PubMed:26903241). Interacts with TRAF3 (By similarity). Interacts with TRAF6 (PubMed:11463333). Interacts with PARK7, leading to inhibit deubiquitinase activity (PubMed:21097510). Interacts with EGFR, ITCH and NEDD4 (PubMed:22179831).
    SequenceCaution:
    • Sequence=CAB97494.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OTUD7B Gene

    Alternative splice isoforms for OTUD7B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OTUD7B Gene

Post-translational modifications for OTUD7B Gene

No data available for DME Specific Peptides for OTUD7B Gene

Domains & Families for OTUD7B Gene

Gene Families for OTUD7B Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for OTUD7B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OTUD7B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6GQQ9

UniProtKB/Swiss-Prot:

OTU7B_HUMAN :
  • The protein undergoes a significant conformation change upon binding to ubiquitinated substrates. The loop that precedes the active site is in an autoinhibitory conformation in the apoprotein. Ubiquitin binding leads to a conformation change; the loop is stabilized in a catalytically competent conformation with the result that the active site Cys can form the reaction state intermediate.
  • Belongs to the peptidase C64 family.
Domain:
  • The protein undergoes a significant conformation change upon binding to ubiquitinated substrates. The loop that precedes the active site is in an autoinhibitory conformation in the apoprotein. Ubiquitin binding leads to a conformation change; the loop is stabilized in a catalytically competent conformation with the result that the active site Cys can form the reaction state intermediate.
Family:
  • Belongs to the peptidase C64 family.
genes like me logo Genes that share domains with OTUD7B: view

Function for OTUD7B Gene

Molecular function for OTUD7B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot EnzymeRegulation:
Deubiquitinase activity is inhibited following interaction with PARK7.
UniProtKB/Swiss-Prot Function:
Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates Lys-48-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward Lys-11, Lys-48 and Lys-63-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with Lys-11-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin.
UniProtKB/Swiss-Prot Induction:
By TNF-alpha.

Enzyme Numbers (IUBMB) for OTUD7B Gene

Phenotypes From GWAS Catalog for OTUD7B Gene

Gene Ontology (GO) - Molecular Function for OTUD7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004843 thiol-dependent ubiquitin-specific protease activity IEA,IDA 23827681
GO:0005515 protein binding IPI 11463333
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity ISS --
genes like me logo Genes that share ontologies with OTUD7B: view
genes like me logo Genes that share phenotypes with OTUD7B: view

Animal Models for OTUD7B Gene

MGI Knock Outs for OTUD7B:

Animal Model Products

miRNA for OTUD7B Gene

miRTarBase miRNAs that target OTUD7B

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OTUD7B Gene

Localization for OTUD7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for OTUD7B Gene

Cytoplasm. Nucleus. Note=Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent manner. {ECO:0000269 PubMed:21888622}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OTUD7B gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OTUD7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11463333
GO:0005737 cytoplasm IDA 11463333
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with OTUD7B: view

Pathways & Interactions for OTUD7B Gene

genes like me logo Genes that share pathways with OTUD7B: view

Pathways by source for OTUD7B Gene

1 Cell Signaling Technology pathway for OTUD7B Gene
1 BioSystems pathway for OTUD7B Gene

Gene Ontology (GO) - Biological Process for OTUD7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 21097510
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002385 mucosal immune response IEA,ISS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with OTUD7B: view

No data available for SIGNOR curated interactions for OTUD7B Gene

Drugs & Compounds for OTUD7B Gene

No Compound Related Data Available

Transcripts for OTUD7B Gene

Unigene Clusters for OTUD7B Gene

OTU domain containing 7B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD7B Gene

No ASD Table

Relevant External Links for OTUD7B Gene

GeneLoc Exon Structure for
OTUD7B
ECgene alternative splicing isoforms for
OTUD7B

Expression for OTUD7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OTUD7B Gene

Protein differential expression in normal tissues from HIPED for OTUD7B Gene

This gene is overexpressed in Heart (53.5) and Urine (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OTUD7B Gene



NURSA nuclear receptor signaling pathways regulating expression of OTUD7B Gene:

OTUD7B

SOURCE GeneReport for Unigene cluster for OTUD7B Gene:

Hs.98322

mRNA Expression by UniProt/SwissProt for OTUD7B Gene:

Q6GQQ9-OTU7B_HUMAN
Tissue specificity: Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the mature cells.

Evidence on tissue expression from TISSUES for OTUD7B Gene

  • Nervous system(4.3)
  • Eye(4.2)
  • Liver(4.2)
  • Blood(4)
genes like me logo Genes that share expression patterns with OTUD7B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OTUD7B Gene

Orthologs for OTUD7B Gene

This gene was present in the common ancestor of animals.

Orthologs for OTUD7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OTUD7B 33
  • 98.33 (n)
cow
(Bos Taurus)
Mammalia OTUD7B 33
  • 92.57 (n)
dog
(Canis familiaris)
Mammalia OTUD7B 33
  • 91.93 (n)
rat
(Rattus norvegicus)
Mammalia Otud7b 33
  • 89.92 (n)
mouse
(Mus musculus)
Mammalia Otud7b 33 16
  • 89.79 (n)
chicken
(Gallus gallus)
Aves OTUD7B 33
  • 70.93 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia otud7b 33
  • 68.66 (n)
zebrafish
(Danio rerio)
Actinopterygii otud7b 33
  • 66.3 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010345 33
  • 50.22 (n)
Species where no ortholog for OTUD7B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OTUD7B Gene

ENSEMBL:
Gene Tree for OTUD7B (if available)
TreeFam:
Gene Tree for OTUD7B (if available)

Paralogs for OTUD7B Gene

Paralogs for OTUD7B Gene

(2) SIMAP similar genes for OTUD7B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OTUD7B: view

Variants for OTUD7B Gene

Sequence variations from dbSNP and Humsavar for OTUD7B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000089305 -- 150,001,569(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000167033 -- 149,994,737(-) A/C/G genic_upstream_transcript_variant, intron_variant
rs1000198627 -- 149,994,326(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000220341 -- 149,942,544(-) T/C 3_prime_UTR_variant
rs1000339281 -- 149,979,180(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OTUD7B Gene

Variant ID Type Subtype PubMed ID
nsv8358 CNV gain 18304495
nsv831537 CNV loss 17160897
nsv472725 CNV novel sequence insertion 20440878
esv3587497 CNV loss 21293372
esv2678478 CNV deletion 23128226

Variation tolerance for OTUD7B Gene

Residual Variation Intolerance Score: 5.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OTUD7B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OTUD7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTUD7B Gene

Disorders for OTUD7B Gene

Additional Disease Information for OTUD7B

No disorders were found for OTUD7B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTUD7B Gene

Publications for OTUD7B Gene

  1. Isolation and characterization of two novel A20-like proteins. (PMID: 11463333) Evans PC … Kilshaw PJ (The Biochemical journal 2001) 2 3 4 22 58
  2. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PMID: 23827681) Mevissen TE … Komander D (Cell 2013) 2 3 4 58
  3. Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne. (PMID: 27732584) Mevissen TET … Komander D (Nature 2016) 3 4 58
  4. Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression. (PMID: 22179831) Pareja F … Yarden Y (Oncogene 2012) 3 4 58
  5. A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family. (PMID: 21888622) García-Santisteban I … Rodríguez JA (The Biochemical journal 2012) 3 4 58

Products for OTUD7B Gene

Sources for OTUD7B Gene

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