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Aliases for OTUD6A Gene

Aliases for OTUD6A Gene

  • OTU Deubiquitinase 6A 2 3 5
  • DUBA2 3 4
  • OTU Domain-Containing Protein 6A 3
  • OTU Domain Containing 6A 2
  • HIN-6 Protease 3
  • EC 4
  • HSHIN6 3
  • DUBA-2 4

External Ids for OTUD6A Gene

Previous GeneCards Identifiers for OTUD6A Gene

  • GC0XP069066
  • GC0XP069199
  • GC0XP069282
  • GC0XP063103

Summaries for OTUD6A Gene

Entrez Gene Summary for OTUD6A Gene

  • Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA2 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]

GeneCards Summary for OTUD6A Gene

OTUD6A (OTU Deubiquitinase 6A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is OTUD6B.

UniProtKB/Swiss-Prot for OTUD6A Gene

  • Deubiquitinating enzyme that hydrolyzes Lys-27-, Lys-29- and Lys-33-linked polyubiquitin chains. Also able to hydrolyze Lys-11-linked ubiquitin chains.

Additional gene information for OTUD6A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTUD6A Gene

Genomics for OTUD6A Gene

GeneHancer (GH) Regulatory Elements for OTUD6A Gene

Promoters and enhancers for OTUD6A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI070062 Promoter 0.5 EPDnew 550.8 -0.1 -53 0.1 OTUD6A AWAT2
GH0XI070087 Enhancer 0.4 Ensembl 13.8 +25.6 25610 0.6 NFIB FEZF1 OTUD6A PIR51137
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OTUD6A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OTUD6A gene promoter:

Genomic Locations for OTUD6A Gene

Genomic Locations for OTUD6A Gene
1,689 bases
Plus strand

Genomic View for OTUD6A Gene

Genes around OTUD6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTUD6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTUD6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD6A Gene

Proteins for OTUD6A Gene

  • Protein details for OTUD6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    OTU domain-containing protein 6A
    Protein Accession:
    Secondary Accessions:
    • B2RPB7

    Protein attributes for OTUD6A Gene

    288 amino acids
    Molecular mass:
    33300 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OTUD6A Gene

Post-translational modifications for OTUD6A Gene

No Post-translational modifications

Other Protein References for OTUD6A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OTUD6A Gene

Domains & Families for OTUD6A Gene

Gene Families for OTUD6A Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for OTUD6A Gene


Suggested Antigen Peptide Sequences for OTUD6A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OTUD6A: view

No data available for UniProtKB/Swiss-Prot for OTUD6A Gene

Function for OTUD6A Gene

Molecular function for OTUD6A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that hydrolyzes Lys-27-, Lys-29- and Lys-33-linked polyubiquitin chains. Also able to hydrolyze Lys-11-linked ubiquitin chains.

Enzyme Numbers (IUBMB) for OTUD6A Gene

Gene Ontology (GO) - Molecular Function for OTUD6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 23827681
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with OTUD6A: view
genes like me logo Genes that share phenotypes with OTUD6A: view

Animal Models for OTUD6A Gene

MGI Knock Outs for OTUD6A:

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OTUD6A Gene

Localization for OTUD6A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OTUD6A gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for OTUD6A Gene

Pathways & Interactions for OTUD6A Gene

SuperPathways for OTUD6A Gene

No Data Available

Gene Ontology (GO) - Biological Process for OTUD6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0035523 protein K29-linked deubiquitination IDA 23827681
GO:0035871 protein K11-linked deubiquitination IDA 23827681
GO:1990167 protein K27-linked deubiquitination IDA 23827681
GO:1990168 protein K33-linked deubiquitination IDA 23827681
genes like me logo Genes that share ontologies with OTUD6A: view

No data available for Pathways by source and SIGNOR curated interactions for OTUD6A Gene

Drugs & Compounds for OTUD6A Gene

No Compound Related Data Available

Transcripts for OTUD6A Gene

mRNA/cDNA for OTUD6A Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OTUD6A Gene

OTU domain containing 6A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD6A Gene

No ASD Table

Relevant External Links for OTUD6A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OTUD6A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OTUD6A Gene

mRNA differential expression in normal tissues according to GTEx for OTUD6A Gene

This gene is overexpressed in Testis (x52.5).

Protein differential expression in normal tissues from HIPED for OTUD6A Gene

This gene is overexpressed in Testis (55.0) and Bone (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OTUD6A Gene

Protein tissue co-expression partners for OTUD6A Gene

NURSA nuclear receptor signaling pathways regulating expression of OTUD6A Gene:


SOURCE GeneReport for Unigene cluster for OTUD6A Gene:

genes like me logo Genes that share expression patterns with OTUD6A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OTUD6A Gene

Orthologs for OTUD6A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OTUD6A Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia OTUD6A 33 34
  • 80.73 (n)
(Bos Taurus)
Mammalia OTUD6A 33 34
  • 78.05 (n)
(Mus musculus)
Mammalia Otud6a 33 16 34
  • 71.08 (n)
(Rattus norvegicus)
Mammalia Otud6a 33
  • 70.62 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 49 (a)
(Gallus gallus)
Aves OTUD6B 34
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 43 (a)
(Danio rerio)
Actinopterygii otud6b 34
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7857 34
  • 32 (a)
(Caenorhabditis elegans)
Secernentea otub-3 34
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OTU2 34
  • 24 (a)
(Triticum aestivum)
Liliopsida Ta.11946 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
-- 34
  • 36 (a)
-- 34
  • 26 (a)
Species where no ortholog for OTUD6A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for OTUD6A Gene

Gene Tree for OTUD6A (if available)
Gene Tree for OTUD6A (if available)

Paralogs for OTUD6A Gene

Paralogs for OTUD6A Gene

(1) SIMAP similar genes for OTUD6A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OTUD6A: view

Variants for OTUD6A Gene

Sequence variations from dbSNP and Humsavar for OTUD6A Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000406206 -- 70,062,067(+) C/T upstream_transcript_variant
rs1003448566 -- 70,062,065(+) A/G upstream_transcript_variant
rs1004202132 -- 70,062,838(+) A/AA coding_sequence_variant, frameshift
rs1004379444 -- 70,063,501(+) T/C 3_prime_UTR_variant
rs1006433795 -- 70,062,150(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OTUD6A Gene

Variant ID Type Subtype PubMed ID
nsv6949 CNV insertion 18451855
esv1584074 OTHER inversion 17803354

Variation tolerance for OTUD6A Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OTUD6A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTUD6A Gene

Disorders for OTUD6A Gene

Additional Disease Information for OTUD6A

No disorders were found for OTUD6A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTUD6A Gene

Publications for OTUD6A Gene

  1. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PMID: 23827681) Mevissen TE … Komander D (Cell 2013) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  5. Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. (PMID: 23105109) Hayes SD … Urbé S (The Journal of biological chemistry 2012) 3 58

Products for OTUD6A Gene

Sources for OTUD6A Gene

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