This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation ... See more...

Aliases for OTUD5 Gene

Aliases for OTUD5 Gene

  • OTU Deubiquitinase 5 2 3 5
  • DUBA 2 3 4
  • OTU Domain-Containing Protein 5 3 4
  • Deubiquitinating Enzyme A 3 4
  • OTU Domain Containing 5 2 3
  • Deubiquinating Enzyme A 3
  • DKFZp761A052 2
  • EC 3.4.19.12 4
  • OTUD5 5

External Ids for OTUD5 Gene

Previous GeneCards Identifiers for OTUD5 Gene

  • GC0XM048536
  • GC0XM048665
  • GC0XM048779
  • GC0XM046435

Summaries for OTUD5 Gene

Entrez Gene Summary for OTUD5 Gene

  • This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]

GeneCards Summary for OTUD5 Gene

OTUD5 (OTU Deubiquitinase 5) is a Protein Coding gene. Among its related pathways are Gastric Cancer Network 2 and Ovarian tumor domain proteases. Gene Ontology (GO) annotations related to this gene include thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is OTUD1.

UniProtKB/Swiss-Prot Summary for OTUD5 Gene

  • Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro).

Additional gene information for OTUD5 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OTUD5 Gene

Genomics for OTUD5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OTUD5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OTUD5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OTUD5

Top Transcription factor binding sites by QIAGEN in the OTUD5 gene promoter:
  • c-Ets-1
  • Nkx2-5
  • Pax-4a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for OTUD5 Gene

Genomic Locations for OTUD5 Gene
chrX:48,922,024-48,960,783
(GRCh38/hg38)
Size:
38,760 bases
Orientation:
Minus strand
chrX:48,779,301-48,815,648
(GRCh37/hg19)
Size:
36,348 bases
Orientation:
Minus strand

Genomic View for OTUD5 Gene

Genes around OTUD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTUD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTUD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTUD5 Gene

Proteins for OTUD5 Gene

  • Protein details for OTUD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G74-OTUD5_HUMAN
    Recommended name:
    OTU domain-containing protein 5
    Protein Accession:
    Q96G74
    Secondary Accessions:
    • B4DGG7
    • G5E9D7
    • Q4KMN9
    • Q8N6T5
    • Q9H650
    • Q9H9U0
    • Q9NT65

    Protein attributes for OTUD5 Gene

    Size:
    571 amino acids
    Molecular mass:
    60626 Da
    Quaternary structure:
    • Interacts with TRAF3.
    SequenceCaution:
    • Sequence=BAB14131.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB15416.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: Dubious isoform produced through aberrant splice sites.
    • [Isoform 3]: Dubious isoform produced through aberrant splice sites.

    Three dimensional structures from OCA and Proteopedia for OTUD5 Gene

    Alternative splice isoforms for OTUD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OTUD5 Gene

Post-translational modifications for OTUD5 Gene

  • Phosphorylation at Ser-177 is required for deubiquitinating activity.
  • Ubiquitination at Lys253, Lys343, Lys356, Lys370, Lys205, Lys219, and Lys429
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OTUD5 Gene

Domains & Families for OTUD5 Gene

Gene Families for OTUD5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for OTUD5 Gene

InterPro:
Blocks:
  • OTU-like cysteine protease
ProtoNet:

Suggested Antigen Peptide Sequences for OTUD5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58178, highly similar to Rattus norvegicus OTU domain containing 5 (Otud5), mRNA (B4DGG7_HUMAN)
  • Deubiquitinating enzyme A (OTUD5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96G74

UniProtKB/Swiss-Prot:

OTUD5_HUMAN :
  • Belongs to the peptidase C85 family.
Family:
  • Belongs to the peptidase C85 family.
genes like me logo Genes that share domains with OTUD5: view

Function for OTUD5 Gene

Molecular function for OTUD5 Gene

UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000269|PubMed:22245969};.
UniProtKB/Swiss-Prot Induction:
Up-regulated by bacterial lipopolysaccharide (LPS) in bone marrow-derived macrophages.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethyl-maleimide (NEM).

Enzyme Numbers (IUBMB) for OTUD5 Gene

Gene Ontology (GO) - Molecular Function for OTUD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IEA,IDA 22245969
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with OTUD5: view
genes like me logo Genes that share phenotypes with OTUD5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OTUD5

Clone Products

  • Addgene plasmids for OTUD5

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OTUD5 Gene

Localization for OTUD5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OTUD5 gene
Compartment Confidence
cytosol 5
plasma membrane 3
nucleus 2
endosome 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OTUD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with OTUD5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OTUD5 Gene

Pathways & Interactions for OTUD5 Gene

genes like me logo Genes that share pathways with OTUD5: view

Pathways by source for OTUD5 Gene

Gene Ontology (GO) - Biological Process for OTUD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0016579 protein deubiquitination IEA,TAS --
GO:0032480 negative regulation of type I interferon production TAS --
GO:0032496 response to lipopolysaccharide IDA 22245969
GO:0070536 protein K63-linked deubiquitination IDA 22245969
genes like me logo Genes that share ontologies with OTUD5: view

No data available for SIGNOR curated interactions for OTUD5 Gene

Drugs & Compounds for OTUD5 Gene

No Compound Related Data Available

Transcripts for OTUD5 Gene

mRNA/cDNA for OTUD5 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OTUD5

Clone Products

  • Addgene plasmids for OTUD5

Alternative Splicing Database (ASD) splice patterns (SP) for OTUD5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for OTUD5 Gene

GeneLoc Exon Structure for
OTUD5

Expression for OTUD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OTUD5 Gene

Protein differential expression in normal tissues from HIPED for OTUD5 Gene

This gene is overexpressed in Retina (43.2) and Fetal Liver (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OTUD5 Gene



Protein tissue co-expression partners for OTUD5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OTUD5

SOURCE GeneReport for Unigene cluster for OTUD5 Gene:

Hs.496098

mRNA Expression by UniProt/SwissProt for OTUD5 Gene:

Q96G74-OTUD5_HUMAN
Tissue specificity: Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for OTUD5 Gene

  • Nervous system(4.7)
  • Kidney(4.5)
  • Intestine(4.5)
  • Skin(4.4)
  • Liver(4.4)
  • Spleen(2.4)
  • Lymph node(2.4)
  • Lung(2.3)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with OTUD5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OTUD5 Gene

Orthologs for OTUD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OTUD5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OTUD5 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Otud5 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OTUD5 30 31
  • 93.05 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OTUD5 30 31
  • 92.59 (n)
OneToOne
Chicken
(Gallus gallus)
Aves OTUD5 31
  • 78 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia OTUD5 31
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53520 30
Zebrafish
(Danio rerio)
Actinopterygii otud5a 31
  • 73 (a)
OneToMany
otud5b 31
  • 68 (a)
OneToMany
sibz30i22.1 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG6091 31
  • 25 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea otub-4 31
  • 36 (a)
OneToOne
Corn
(Zea mays)
Liliopsida Zm.4444 30
Species where no ortholog for OTUD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for OTUD5 Gene

ENSEMBL:
Gene Tree for OTUD5 (if available)
TreeFam:
Gene Tree for OTUD5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OTUD5: view image

Paralogs for OTUD5 Gene

Paralogs for OTUD5 Gene

genes like me logo Genes that share paralogs with OTUD5: view

Variants for OTUD5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OTUD5 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
774751 Benign: not provided 48,925,907(-) G/C SYNONYMOUS_VARIANT
871498 Uncertain Significance: not provided 48,957,512(-) G/T MISSENSE_VARIANT,INTRON_VARIANT
rs1295653938 Uncertain Significance: Ependymoma 48,923,188(-) G/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for OTUD5 Gene

Structural Variations from Database of Genomic Variants (DGV) for OTUD5 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV gain+loss 17666407
esv3344450 CNV insertion 20981092
nsv1119633 CNV deletion 24896259
nsv528292 CNV gain 19592680
nsv6894 CNV insertion 18451855

Variation tolerance for OTUD5 Gene

Residual Variation Intolerance Score: 24.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OTUD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OTUD5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTUD5 Gene

Disorders for OTUD5 Gene

No disorders were found for OTUD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTUD5 Gene

Publications for OTUD5 Gene

  1. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PMID: 23827681) Mevissen TE … Komander D (Cell 2013) 3 4
  2. OTUD5 regulates p53 stability by deubiquitinating p53. (PMID: 24143256) Luo J … Zhou X (PloS one 2013) 2 3
  3. Phosphorylation-dependent activity of the deubiquitinase DUBA. (PMID: 22245969) Huang OW … Cochran AG (Nature structural & molecular biology 2012) 3 4
  4. DUBA: a deubiquitinase that regulates type I interferon production. (PMID: 17991829) Kayagaki N … Dixit VM (Science (New York, N.Y.) 2007) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for OTUD5 Gene

Sources for OTUD5 Gene