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This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]
OTUB2 (OTU Deubiquitinase, Ubiquitin Aldehyde Binding 2) is a Protein Coding gene. Among its related pathways are Deubiquitination and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include hydrolase activity and omega peptidase activity. An important paralog of this gene is OTUB1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004843 | thiol-dependent ubiquitin-specific protease activity | IBA,IMP | 15258613 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008234 | cysteine-type peptidase activity | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism of proteins | ||
2 | Protein ubiquitination | ||
3 | Deubiquitination |
.74
|
|
4 | Ovarian tumor domain proteases |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IEA | -- |
GO:0016579 | protein deubiquitination | IMP | 15258613 |
GO:0018215 | protein phosphopantetheinylation | IEA | -- |
GO:0035871 | protein K11-linked deubiquitination | IBA,IDA | 23827681 |
GO:0070536 | protein K63-linked deubiquitination | IBA,IDA | 18954305 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | OTUB2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | OTUB2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Otub2 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | OTUB2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Otub2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | OTUB2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | OTUB2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | otub2 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG4968 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | otub-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5787 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv34067 | CNV | loss | 18971310 |
esv3581391 | CNV | loss | 25503493 |
esv3635373 | CNV | gain | 21293372 |
nsv565620 | CNV | loss | 21841781 |
nsv952233 | CNV | deletion | 24416366 |
No disorders were found for OTUB2 Gene.