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The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
OTUB1 (OTU Deubiquitinase, Ubiquitin Aldehyde Binding 1) is a Protein Coding gene. Diseases associated with OTUB1 include Autosomal Dominant Cerebellar Ataxia. Among its related pathways are Deubiquitination and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include hydrolase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is OTUB2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004843 | thiol-dependent ubiquitin-specific protease activity | IEA,IDA | 18954305 |
GO:0005515 | protein binding | IPI | 16364312 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008234 | cysteine-type peptidase activity | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Deubiquitination |
.74
|
|
2 | Metabolism of proteins | ||
3 | DNA Damage | ||
4 | Protein ubiquitination | ||
5 | Ovarian tumor domain proteases |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002250 | adaptive immune response | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0006281 | DNA repair | IEA | -- |
GO:0006508 | proteolysis | IEA | -- |
GO:0006974 | cellular response to DNA damage stimulus | IEA,IDA | 20725033 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||
SP7: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Mouse (Mus musculus) |
Mammalia | Otub1 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | OTUB1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | OTUB1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | OTUB1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | OTUB1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | RGD1565010 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | OTUB1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | OTUB1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | OTUB1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | otub1 30 |
|
||
Str.10055 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | otub1b 31 |
|
OneToMany | |
otub1a 31 |
|
OneToMany | |||
wufa19h07 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG4968 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | otub-1 31 |
|
OneToMany | |
Barley (Hordeum vulgare) |
Liliopsida | Hv.12030 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.10490 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU00595 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5787 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
autosomal dominant cerebellar ataxia |
|
|