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Aliases for OTP Gene

Aliases for OTP Gene

  • Orthopedia Homeobox 2 3 5
  • Orthopedia Homolog (Drosophila) 2
  • Homeobox Protein Orthopedia 3
  • Orthopedia Homolog 3

External Ids for OTP Gene

Previous GeneCards Identifiers for OTP Gene

  • GC05M075730
  • GC05M077158
  • GC05M076963
  • GC05M077008
  • GC05M076960
  • GC05M072131
  • GC05M076924

Summaries for OTP Gene

Entrez Gene Summary for OTP Gene

  • This gene encodes a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription factors that play key roles in the specification of cell fates. This protein may function during brain development. [provided by RefSeq, Jul 2008]

GeneCards Summary for OTP Gene

OTP (Orthopedia Homeobox) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is SHOX2.

UniProtKB/Swiss-Prot for OTP Gene

  • Probably involved in the differentiation of hypothalamic neuroendocrine cells.

Additional gene information for OTP Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OTP Gene

Genomics for OTP Gene

GeneHancer (GH) Regulatory Elements for OTP Gene

Promoters and enhancers for OTP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J077639 Enhancer 0.9 VISTA UCNEbase 650.7 -0.2 -233 1 POLR2A SUZ12 CTBP2 EZH2 OTP GC05M077675
GH05J077774 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.1 -135.8 -135848 3.2 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 TBCA LOC105379045 PIR43480 OTP
GH05J077681 Enhancer 0.5 FANTOM5 17.6 -41.6 -41613 0.2 ZNF766 MNT ZBTB33 CHAMP1 OTP TBCA GC05M077675 GC05P077690
GH05J077959 Enhancer 0.6 dbSUPER 10.6 -320.8 -320788 1.6 GFI1B FEZF1 PRDM6 IKZF1 ZNF24 HNF4A PRDM4 PRDM1 WT1 RUNX3 TBCA OTP ENSG00000253572 TRQ-TTG7-1
GH05J077777 Enhancer 0.6 ENCODE 10.1 -138.0 -138004 0.2 SAP130 SP1 JUND ATF3 SCRT2 HNF4A PRDM10 ZBTB33 FOS FOSL2 LOC105379045 TBCA OTP ACTBP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OTP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OTP gene promoter:
  • NRSF form 1
  • NRSF form 2
  • E2F-4
  • E2F-3a
  • E2F-2
  • E2F-1
  • E2F

Genomic Locations for OTP Gene

Genomic Locations for OTP Gene
chr5:77,628,712-77,639,688
(GRCh38/hg38)
Size:
10,977 bases
Orientation:
Minus strand
chr5:76,924,537-76,935,513
(GRCh37/hg19)
Size:
10,977 bases
Orientation:
Minus strand

Genomic View for OTP Gene

Genes around OTP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OTP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OTP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OTP Gene

Proteins for OTP Gene

  • Protein details for OTP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5XKR4-OTP_HUMAN
    Recommended name:
    Homeobox protein orthopedia
    Protein Accession:
    Q5XKR4

    Protein attributes for OTP Gene

    Size:
    325 amino acids
    Molecular mass:
    34159 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OTP Gene

Post-translational modifications for OTP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OTP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OTP Gene

Domains & Families for OTP Gene

Gene Families for OTP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for OTP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5XKR4

UniProtKB/Swiss-Prot:

OTP_HUMAN :
  • Belongs to the paired homeobox family. Bicoid subfamily.
Family:
  • Belongs to the paired homeobox family. Bicoid subfamily.
genes like me logo Genes that share domains with OTP: view

Function for OTP Gene

Molecular function for OTP Gene

UniProtKB/Swiss-Prot Function:
Probably involved in the differentiation of hypothalamic neuroendocrine cells.
GENATLAS Biochemistry:
orthopedia homolog gene,homeo domain gene,expressed in hypothalamus,amygdalia and brain

Phenotypes From GWAS Catalog for OTP Gene

Gene Ontology (GO) - Molecular Function for OTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM 19274049
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with OTP: view
genes like me logo Genes that share phenotypes with OTP: view

Animal Models for OTP Gene

MGI Knock Outs for OTP:
  • Otp Otp<tm1Asim>
  • Otp Otp<tm1Tlu>

Animal Model Products

CRISPR Products

miRNA for OTP Gene

miRTarBase miRNAs that target OTP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OTP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OTP Gene

Localization for OTP Gene

Subcellular locations from UniProtKB/Swiss-Prot for OTP Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OTP gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for OTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with OTP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OTP Gene

Pathways & Interactions for OTP Gene

No Data Available

Gene Ontology (GO) - Biological Process for OTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002052 positive regulation of neuroblast proliferation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with OTP: view

No data available for Pathways by source and SIGNOR curated interactions for OTP Gene

Drugs & Compounds for OTP Gene

No Compound Related Data Available

Transcripts for OTP Gene

mRNA/cDNA for OTP Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OTP Gene

Orthopedia homeobox:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OTP

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OTP Gene

No ASD Table

Relevant External Links for OTP Gene

GeneLoc Exon Structure for
OTP
ECgene alternative splicing isoforms for
OTP

Expression for OTP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OTP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OTP Gene

This gene is overexpressed in Brain - Hypothalamus (x48.7).

Protein differential expression in normal tissues from HIPED for OTP Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OTP Gene



Protein tissue co-expression partners for OTP Gene

NURSA nuclear receptor signaling pathways regulating expression of OTP Gene:

OTP

SOURCE GeneReport for Unigene cluster for OTP Gene:

Hs.202247

Evidence on tissue expression from TISSUES for OTP Gene

  • Eye(4.1)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with OTP: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OTP Gene

Orthologs for OTP Gene

This gene was present in the common ancestor of animals.

Orthologs for OTP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OTP 34 33
  • 99.49 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OTP 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OTP 34 33
  • 95.28 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OTP 34 33
  • 94.15 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Otp 16 34 33
  • 94.05 (n)
rat
(Rattus norvegicus)
Mammalia Otp 33
  • 94.05 (n)
chicken
(Gallus gallus)
Aves OTP 34 33
  • 88.62 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OTP 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia otp 33
  • 80.49 (n)
zebrafish
(Danio rerio)
Actinopterygii otpb 34
  • 81 (a)
OneToMany
otpa 34 33
  • 76.45 (n)
OneToMany
otp 33
fruit fly
(Drosophila melanogaster)
Insecta otp 34 35
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 16 (a)
OneToOne
Species where no ortholog for OTP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OTP Gene

ENSEMBL:
Gene Tree for OTP (if available)
TreeFam:
Gene Tree for OTP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OTP: view image

Paralogs for OTP Gene

Paralogs for OTP Gene

(3) SIMAP similar genes for OTP Gene using alignment to 1 proteins:

  • OTP_HUMAN
genes like me logo Genes that share paralogs with OTP: view

Variants for OTP Gene

Sequence variations from dbSNP and Humsavar for OTP Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000572659 -- 77,628,648(-) T/C downstream_transcript_variant
rs1000922471 -- 77,628,254(-) G/C/T downstream_transcript_variant
rs1000997008 -- 77,633,915(-) A/G intron_variant
rs1001049638 -- 77,639,707(-) C/A upstream_transcript_variant
rs1001050227 -- 77,629,319(-) C/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for OTP Gene

Variant ID Type Subtype PubMed ID
esv3387490 CNV insertion 20981092

Variation tolerance for OTP Gene

Gene Damage Index Score: 1.37; 27.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OTP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OTP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTP Gene

Disorders for OTP Gene

No disorders were found for OTP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTP Gene

Publications for OTP Gene

  1. Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP). (PMID: 10458915) Lin X … Leckman JF (Genomics 1999) 2 3 4 58
  2. Diagnostic Utility of Orthopedia Homeobox (OTP) in Pulmonary Carcinoid Tumors. (PMID: 26927888) Nonaka D … Mansoor W (The American journal of surgical pathology 2016) 3 58
  3. CD44 and OTP are strong prognostic markers for pulmonary carcinoids. (PMID: 23444222) Swarts DR … Speel EJ (Clinical cancer research : an official journal of the American Association for Cancer Research 2013) 3 58
  4. Genome-wide identification of OTP gene as a novel methylation marker of breast cancer. (PMID: 22366991) Kim MS … Lee JH (Oncology reports 2012) 3 58
  5. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3 58

Products for OTP Gene

Sources for OTP Gene

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