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Aliases for OTOP3 Gene
External Ids for OTOP3 Gene
- HGNC: 19658
- Entrez Gene: 347741
- Ensembl: ENSG00000182938
- OMIM: 607828
- UniProtKB: Q7RTS5
Previous GeneCards Identifiers for OTOP3 Gene
- GC17P073396
- GC17P073529
- GC17P070443
- GC17P072931
- GC17P068342
Summaries for OTOP3 Gene
GeneCards Summary for OTOP3 Gene
OTOP3 (Otopetrin 3) is a Protein Coding gene. An important paralog of this gene is OTOP2.
UniProtKB/Swiss-Prot Summary for OTOP3 Gene
-
Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes.
Additional gene information for OTOP3 Gene
- HGNC(19658)
- Entrez Gene(347741)
- Ensembl(ENSG00000182938)
- OMIM(607828)
- UniProtKB(Q7RTS5)
- Open Targets Platform(ENSG00000182938)
- Search for OTOP3 at DataMed
- Search for OTOP3 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OTOP3 Gene
Genomics for OTOP3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for OTOP3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around OTOP3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OTOP3
- Top Transcription factor binding sites by QIAGEN in the OTOP3 gene promoter:
-
- C/EBPalpha
- CHOP-10
- CREB
- deltaCREB
- FOXO1
- FOXO1a
- Hlf
- Nkx5-1
- Pax-4a
- ZID
Genomic Locations for OTOP3 Gene
Genomic Locations for OTOP3 Gene
- chr17:74,935,802-74,949,993
- (GRCh38/hg38)
- Size:
- 14,192 bases
- Orientation:
- Plus strand
- chr17:72,931,814-72,946,087
- (GRCh37/hg19)
- Size:
- 14,274 bases
- Orientation:
- Plus strand
Genomic View for OTOP3 Gene
Genes around OTOP3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
OTOP3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for OTOP3 Gene
Proteins for OTOP3 Gene
-
Protein details for OTOP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7RTS5-OTOP3_HUMAN
- Recommended name:
- Proton channel OTOP3
- Protein Accession:
- Q7RTS5
Protein attributes for OTOP3 Gene
- Size:
- 596 amino acids
- Molecular mass:
- 66296 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for OTOP3 Gene
Other Protein References for OTOP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for OTOP3
- Invitrogen Antibodies for OTOP3 (AFLGC-OTOP3)
- antibodies-online: Show 10 available OTOP3 Antibodies ranked by validation data
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for OTOP3
- Origene Custom Protein Services for OTOP3
No data available for DME Specific Peptides for OTOP3 Gene
Domains & Families for OTOP3 Gene
Gene Families for OTOP3 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for OTOP3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for OTOP3 Gene
- GenScript: Design optimal peptide antigens:
-
- Otopetrin-3 (OTOP3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q7RTS5- Family:
-
- Belongs to the otopetrin family.
Function for OTOP3 Gene
Molecular function for OTOP3 Gene
- UniProtKB/Swiss-Prot Function:
- Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes.
Phenotypes From GWAS Catalog for OTOP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0015252 | proton channel activity | ISS | -- |
Phenotypes for OTOP3 Gene
- MGI mutant phenotypes for OTOP3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for OTOP3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for OTOP3 - Select products 50% OFF >
- * OTOP3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for OTOP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OTOP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for OTOP3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OTOP3
- Browse OriGene Inhibitory RNA Products For OTOP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OTOP3
Clone Products
- Applied Biological Materials (abm): Clones for OTOP3 - Select products 50% OFF >
- * OTOP3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for OTOP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OTOP3
Cell Line Products
-
Horizon Cell Lines for OTOP3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OTOP3 Gene
Localization for OTOP3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for OTOP3 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| peroxisome | 1 |
| nucleus | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for OTOP3 Gene
Pathways & Interactions for OTOP3 Gene
Interacting Proteins for OTOP3 Gene
Selected Interacting proteins:
Q7RTS5-OTOP3_HUMAN
ENSP00000328090
for OTOP3 Gene via
UniProtKB
STRING
GPS-Prot Interaction Network for OTOP3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1902600 | proton transmembrane transport | ISS | -- |
No data available for Pathways by source and SIGNOR curated interactions for OTOP3 Gene
Transcripts for OTOP3 Gene
mRNA/cDNA for OTOP3 Gene
- 2 REFSEQ mRNAs :
- 3 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000328801 2337 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for OTOP3 - Select products 50% OFF >
- * OTOP3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for OTOP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OTOP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for OTOP3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OTOP3
- Browse OriGene Inhibitory RNA Products For OTOP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OTOP3
Clone Products
- Applied Biological Materials (abm): Clones for OTOP3 - Select products 50% OFF >
- * OTOP3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for OTOP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OTOP3
Relevant External Links for OTOP3 Gene
- GeneLoc Exon Structure for
- OTOP3
Expression for OTOP3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for OTOP3 Gene
This gene is overexpressed in Esophagus - Mucosa (x36.7) and Skin - Sun Exposed (Lower leg) (x4.5).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OTOP3
SOURCE GeneReport for Unigene cluster for OTOP3 Gene:
Hs.454407Primer Products
-
OriGene qPCR primer pairs for OTOP3
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OTOP3 Gene
Orthologs for OTOP3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | OTOP3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | OTOP3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | OTOP3 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Otop3 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Otop3 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | OTOP3 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | OTOP3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | OTOP3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | OTOP3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101731580 30 |
|
- Species where no ortholog for OTOP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for OTOP3 Gene
- ENSEMBL:
- Gene Tree for OTOP3 (if available)
- TreeFam:
- Gene Tree for OTOP3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for OTOP3: view image
Paralogs for OTOP3 Gene
Variants for OTOP3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OTOP3 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1542752 | - | p.Ser199Pro | |||
| rs35131040 | - | p.Leu477Val | |||
| rs7210616 | - | p.Arg64Gln | |||
| rs9890664 | - | p.Arg146Gln |
Residual Variation Intolerance Score:
97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.35;
63.25% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for OTOP3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- OTOP3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OTOP3 Gene
Disorders for OTOP3 Gene
Additional Disease Information for OTOP3
No disorders were found for OTOP3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OTOP3 Gene
Publications for OTOP3 Gene
- Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1. (PMID: 12651873) Hurle B … Ornitz DM (Human molecular genetics 2003) 2 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M … Kato S (Investigative ophthalmology & visual science 2011) 3
- A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 4
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4
ExternalLinks
Products for OTOP3 Gene
- Custom Antibody ServicesOriGene Antibodies for OTOP3
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for OTOP3
- Origene Custom Protein Services for OTOP3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OTOP3
- Browse OriGene Inhibitory RNA Products For OTOP3
- OriGene qPCR primer pairs for OTOP3
- OriGene CRISPR knockouts for OTOP3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For OTOP3
- Sino Biological Human cDNA Clone for OTOP3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Invitrogen Antibodies for OTOP3 (AFLGC-OTOP3)
- VectorBuilder Custom and pre-made DNA vectors for OTOP3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for OTOP3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for OTOP3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for OTOP3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for OTOP3
- antibodies-online: Show 10 available OTOP3 Antibodies ranked by validation data
- antibodies-online: Search results for available OTOP3 related products ranked by validation data
- antibodies-online: Search results for available OTOP3 related products ranked by validation data
- Horizon Cell Lines for OTOP3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OTOP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OTOP3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for OTOP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OTOP3
Sources for OTOP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB