Aliases for OSTN Gene

Aliases for OSTN Gene

  • Osteocrin 2 3 4 5
  • MUSCLIN 3
  • Musclin 4
  • OSTN 5

External Ids for OSTN Gene

Previous GeneCards Identifiers for OSTN Gene

  • GC03U900494
  • GC03P192251
  • GC03P192413
  • GC03P190917
  • GC03P188329

Summaries for OSTN Gene

GeneCards Summary for OSTN Gene

OSTN (Osteocrin) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and hormone activity.

UniProtKB/Swiss-Prot Summary for OSTN Gene

  • Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782). Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782). Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OSTN Gene

Genomics for OSTN Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OSTN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J191199 Promoter 0.6 EPDnew 600.7 0.0 -19 0.1 PRDM1 ZBTB17 ZNF366 OSTN piR-40348-033 GMNC
GH03J191375 Enhancer 1.1 Ensembl ENCODE dbSUPER 9.7 +178.7 178660 4.2 PRDM10 ZNF629 IKZF2 ZNF600 KLF9 ZXDB NFE2 FOS ZNF316 OSR2 CCDC50 UTS2B OSTN lnc-PYDC2-7 lnc-PYDC2-5 PYDC2
GH03J191141 Enhancer 0.9 Ensembl ENCODE 10.1 -58.0 -57973 4.7 IKZF2 EED ARID3A DPF2 JUND CEBPB RUNX3 GATAD2B CBFB JUN OSTN CCDC50 RF00017-4212 LOC107986171 GMNC
GH03J191252 Enhancer 0.9 Ensembl ENCODE 9.9 +54.8 54759 3.2 TCF12 IKZF2 ZNF600 EED DPF2 RUNX3 GATAD2B ZNF316 MAFK MAFG UTS2B CCDC50 OSTN OSTN-AS1 piR-34822-241
GH03J191364 Enhancer 0.8 Ensembl dbSUPER 10 +167.9 167852 5.8 HMBOX1 ZNF316 MAFG MAFK RCOR1 ATF4 DPF2 JUN NFE2 NANOG CCDC50 UTS2B OSTN lnc-PYDC2-7 PYDC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OSTN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OSTN

Top Transcription factor binding sites by QIAGEN in the OSTN gene promoter:
  • AhR
  • aMEF-2
  • ATF-2
  • Evi-1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • MEF-2
  • MEF-2A

Genomic Locations for OSTN Gene

Genomic Locations for OSTN Gene
chr3:191,199,241-191,265,615
(GRCh38/hg38)
Size:
66,375 bases
Orientation:
Plus strand
chr3:190,917,030-190,983,404
(GRCh37/hg19)
Size:
66,375 bases
Orientation:
Plus strand

Genomic View for OSTN Gene

Genes around OSTN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSTN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSTN Gene

Proteins for OSTN Gene

  • Protein details for OSTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61366-OSTN_HUMAN
    Recommended name:
    Osteocrin
    Protein Accession:
    P61366
    Secondary Accessions:
    • A1A4U3

    Protein attributes for OSTN Gene

    Size:
    133 amino acids
    Molecular mass:
    14722 Da
    Quaternary structure:
    • Interacts with NPR3.

neXtProt entry for OSTN Gene

Post-translational modifications for OSTN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSTN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OSTN Gene

Domains & Families for OSTN Gene

Gene Families for OSTN Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for OSTN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OSTN Gene

GenScript: Design optimal peptide antigens:
  • Musclin (OSTN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61366

UniProtKB/Swiss-Prot:

OSTN_HUMAN :
  • Belongs to the Osteocrin family.
Family:
  • Belongs to the Osteocrin family.
genes like me logo Genes that share domains with OSTN: view

Function for OSTN Gene

Molecular function for OSTN Gene

UniProtKB/Swiss-Prot Function:
Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782). Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782). Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).
UniProtKB/Swiss-Prot Induction:
Expression is induced in the developing cerebral cortex in response to neuronal activity in neurons: expression is driven by the presence of a enhancer sequence only present in primates that binds the MEF2 transcription factors (PubMed:27830782).

Phenotypes From GWAS Catalog for OSTN Gene

Gene Ontology (GO) - Molecular Function for OSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA --
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with OSTN: view
genes like me logo Genes that share phenotypes with OSTN: view

Animal Models for OSTN Gene

MGI Knock Outs for OSTN:
  • Ostn Ostn<tm1.1Geno>

Animal Model Products

  • Taconic Biosciences Mouse Models for OSTN

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OSTN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OSTN Gene

Localization for OSTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSTN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSTN gene
Compartment Confidence
extracellular 4
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for OSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with OSTN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OSTN Gene

Pathways & Interactions for OSTN Gene

PathCards logo

SuperPathways for OSTN Gene

No Data Available

Interacting Proteins for OSTN Gene

Selected Interacting proteins: P61366-OSTN_HUMAN for OSTN Gene via IID

Symbol External ID(s) Details
FOXO1

Gene Ontology (GO) - Biological Process for OSTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003416 endochondral bone growth IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007275 multicellular organism development IEA --
GO:0009755 hormone-mediated signaling pathway IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with OSTN: view

No data available for Pathways by source and SIGNOR curated interactions for OSTN Gene

Drugs & Compounds for OSTN Gene

No Compound Related Data Available

Transcripts for OSTN Gene

mRNA/cDNA for OSTN Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OSTN

Alternative Splicing Database (ASD) splice patterns (SP) for OSTN Gene

No ASD Table

Relevant External Links for OSTN Gene

GeneLoc Exon Structure for
OSTN

Expression for OSTN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OSTN Gene

mRNA differential expression in normal tissues according to GTEx for OSTN Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x11.1) and Brain - Frontal Cortex (BA9) (x6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OSTN Gene



Protein tissue co-expression partners for OSTN Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OSTN

SOURCE GeneReport for Unigene cluster for OSTN Gene:

Hs.526794

mRNA Expression by UniProt/SwissProt for OSTN Gene:

P61366-OSTN_HUMAN
Tissue specificity: Enriched in neocortical regions of the developing cerebral cortex (PubMed:27830782). Not expressed in other compartments of the neocortical wall or in brain regions such as the hippocampus, striatum, mediodorsal nucleus of the thalamus and cerebellum (PubMed:27830782). Also expressed in bone (PubMed:14523025). In developing neonatal rib bone, present at high level in osteoblasts on bone-forming surfaces, in newly incorporated osteocytes and in some late hypertrophic chondrocytes (at protein level) (PubMed:15923362). In adult bone, localizes specifically to osteoblasts and young osteocytes at bone-forming sites (at protein level) (PubMed:15923362).

Evidence on tissue expression from TISSUES for OSTN Gene

  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with OSTN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSTN Gene

Orthologs for OSTN Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSTN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OSTN 30 31
  • 99.5 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OSTN 30 31
  • 90.4 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia OSTN 30 31
  • 89.39 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ostn 30
  • 81.57 (n)
Mouse
(Mus musculus)
Mammalia Ostn 30 17 31
  • 81.03 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 69 (a)
OneToMany
-- 31
  • 60 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia OSTN 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves OSTN 30 31
  • 61.65 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ostn 30
  • 64.9 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100333936 30
  • 55.74 (n)
ostn 31
  • 46 (a)
OneToOne
Species where no ortholog for OSTN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for OSTN Gene

ENSEMBL:
Gene Tree for OSTN (if available)
TreeFam:
Gene Tree for OSTN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OSTN: view image

Paralogs for OSTN Gene

No data available for Paralogs for OSTN Gene

Variants for OSTN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OSTN Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
775208 Benign: not provided 191,218,788(+) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for OSTN Gene

Structural Variations from Database of Genomic Variants (DGV) for OSTN Gene

Variant ID Type Subtype PubMed ID
esv2661473 CNV deletion 23128226
esv2759209 CNV gain+loss 17122850
esv3599089 CNV loss 21293372
esv3599090 CNV gain 21293372
esv3599091 CNV loss 21293372
esv3599092 CNV gain 21293372
esv3599094 CNV loss 21293372
nsv1012488 CNV loss 25217958
nsv428428 CNV gain 18775914
nsv997716 CNV loss 25217958

Variation tolerance for OSTN Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OSTN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSTN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSTN Gene

Disorders for OSTN Gene

Additional Disease Information for OSTN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for OSTN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSTN Gene

Publications for OSTN Gene

  1. Characterization of osteocrin expression in human bone. (PMID: 15923362) Bord S … Compston JE (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005) 3 4 23
  2. Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype. (PMID: 14523025) Thomas G … Lanctôt C (The Journal of biological chemistry 2003) 2 3 4
  3. Evolution of Osteocrin as an activity-regulated factor in the primate brain. (PMID: 27830782) Ataman B … Greenberg ME (Nature 2016) 3 4
  4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 41
  5. Musclin, a novel skeletal muscle-derived secretory factor. (PMID: 15044443) Nishizawa H … Shimomura I (The Journal of biological chemistry 2004) 3 4

Products for OSTN Gene

  • Signalway ELISA kits for OSTN
  • Signalway Proteins for OSTN

Sources for OSTN Gene