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Aliases for OSTF1 Gene

Aliases for OSTF1 Gene

  • Osteoclast Stimulating Factor 1 2 3 5
  • Osteoclast-Stimulating Factor 1 3
  • BA235O14.1 3
  • SH3P2 3
  • OSF 3

External Ids for OSTF1 Gene

Previous GeneCards Identifiers for OSTF1 Gene

  • GC09P068747
  • GC09P069560
  • GC09P071273
  • GC09P073160
  • GC09P074933
  • GC09P076893
  • GC09P077703
  • GC09P047530

Summaries for OSTF1 Gene

Entrez Gene Summary for OSTF1 Gene

  • Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).[supplied by OMIM, Mar 2008]

GeneCards Summary for OSTF1 Gene

OSTF1 (Osteoclast Stimulating Factor 1) is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include SH3 domain binding. An important paralog of this gene is ANKRD27.

UniProtKB/Swiss-Prot for OSTF1 Gene

  • Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.

Gene Wiki entry for OSTF1 Gene

Additional gene information for OSTF1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSTF1 Gene

Genomics for OSTF1 Gene

GeneHancer (GH) Regulatory Elements for OSTF1 Gene

Promoters and enhancers for OSTF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I075084 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.9 -935 5.1 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF766 ZNF207 NMRK1 OSTF1 CARNMT1
GH09I074951 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 17.2 -135.6 -135639 3.3 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 E2F8 ZNF143 C9orf40 C9orf41-AS1 NMRK1 OSTF1 CARNMT1 TRPM6 RNU6-445P LOC100133316
GH09I075141 Enhancer 0.6 ENCODE dbSUPER 20.9 +53.9 53857 0.9 POLR2A GABPA NMRK1 OSTF1 LOC105376090
GH09I075000 Enhancer 0.9 ENCODE 11.2 -87.0 -87029 2.1 FOXA2 MLX ARID4B DMAP1 ETS1 YY1 SLC30A9 ZNF143 RUNX3 RXRA CARNMT1 OSTF1 NMRK1 C9orf40 GC09P074993 ENSG00000229587
GH09I075167 Enhancer 0.9 Ensembl ENCODE 10.9 +81.1 81128 4.3 ATF1 JUN ETV1 TEAD4 FOSL1 ZNF766 ZNF316 POLR3A VEZF1 NFE2 OSTF1 NMRK1 RNU6-1228P ENSG00000200041 LOC105376090
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OSTF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OSTF1 gene promoter:

Genomic Locations for OSTF1 Gene

Genomic Locations for OSTF1 Gene
chr9:75,088,482-75,148,137
(GRCh38/hg38)
Size:
59,656 bases
Orientation:
Plus strand
chr9:77,703,398-77,762,181
(GRCh37/hg19)

Genomic View for OSTF1 Gene

Genes around OSTF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSTF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSTF1 Gene

Proteins for OSTF1 Gene

  • Protein details for OSTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92882-OSTF1_HUMAN
    Recommended name:
    Osteoclast-stimulating factor 1
    Protein Accession:
    Q92882
    Secondary Accessions:
    • Q5W126
    • Q96IJ4

    Protein attributes for OSTF1 Gene

    Size:
    214 amino acids
    Molecular mass:
    23787 Da
    Quaternary structure:
    • Interacts with SRC and SMN1. Interacts with FASLG.

    Three dimensional structures from OCA and Proteopedia for OSTF1 Gene

neXtProt entry for OSTF1 Gene

Post-translational modifications for OSTF1 Gene

  • Ubiquitination at Lys82 and Lys162
  • Modification sites at PhosphoSitePlus

Other Protein References for OSTF1 Gene

No data available for DME Specific Peptides for OSTF1 Gene

Domains & Families for OSTF1 Gene

Gene Families for OSTF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for OSTF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92882

UniProtKB/Swiss-Prot:

OSTF1_HUMAN :
  • The SH3 domain mediates interaction with SMN1.
Domain:
  • The SH3 domain mediates interaction with SMN1.
genes like me logo Genes that share domains with OSTF1: view

Function for OSTF1 Gene

Molecular function for OSTF1 Gene

GENATLAS Biochemistry:
osteoclast stimulating factor 1,indirectly enhancing osteoclast formation and osteoclastic bone resorption through the cellular signal transduction cascade, possibly through its interactions with c-Src or other Src-related proteins
UniProtKB/Swiss-Prot Function:
Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.

Phenotypes From GWAS Catalog for OSTF1 Gene

Gene Ontology (GO) - Molecular Function for OSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17500595
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with OSTF1: view
genes like me logo Genes that share phenotypes with OSTF1: view

Animal Models for OSTF1 Gene

MGI Knock Outs for OSTF1:

Animal Model Products

CRISPR Products

miRNA for OSTF1 Gene

miRTarBase miRNAs that target OSTF1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OSTF1 Gene

Localization for OSTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSTF1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSTF1 gene
Compartment Confidence
extracellular 5
cytosol 4
mitochondrion 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for OSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA,TAS --
GO:0005622 intracellular TAS 10092216
GO:0005737 cytoplasm IEA --
GO:0034774 secretory granule lumen TAS --
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with OSTF1: view

Pathways & Interactions for OSTF1 Gene

genes like me logo Genes that share pathways with OSTF1: view

Pathways by source for OSTF1 Gene

3 Reactome pathways for OSTF1 Gene

Gene Ontology (GO) - Biological Process for OSTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification TAS 10092216
GO:0007165 signal transduction TAS 10092216
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with OSTF1: view

No data available for SIGNOR curated interactions for OSTF1 Gene

Drugs & Compounds for OSTF1 Gene

No Compound Related Data Available

Transcripts for OSTF1 Gene

mRNA/cDNA for OSTF1 Gene

Unigene Clusters for OSTF1 Gene

Osteoclast stimulating factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSTF1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: -
SP2:
SP3: - -

Relevant External Links for OSTF1 Gene

GeneLoc Exon Structure for
OSTF1
ECgene alternative splicing isoforms for
OSTF1

Expression for OSTF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OSTF1 Gene

mRNA differential expression in normal tissues according to GTEx for OSTF1 Gene

This gene is overexpressed in Whole Blood (x11.0).

Protein differential expression in normal tissues from HIPED for OSTF1 Gene

This gene is overexpressed in Spleen (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OSTF1 Gene



Protein tissue co-expression partners for OSTF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OSTF1 Gene:

OSTF1

SOURCE GeneReport for Unigene cluster for OSTF1 Gene:

Hs.494192

mRNA Expression by UniProt/SwissProt for OSTF1 Gene:

Q92882-OSTF1_HUMAN
Tissue specificity: Ubiquitously expressed. Present in osteoclasts (at protein level).

Evidence on tissue expression from TISSUES for OSTF1 Gene

  • Blood(4.3)
  • Bone marrow(4.3)
  • Kidney(4.3)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with OSTF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSTF1 Gene

Orthologs for OSTF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSTF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSTF1 33 34
  • 99.69 (n)
oppossum
(Monodelphis domestica)
Mammalia OSTF1 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSTF1 33 34
  • 93.61 (n)
dog
(Canis familiaris)
Mammalia OSTF1 33 34
  • 92.54 (n)
mouse
(Mus musculus)
Mammalia Ostf1 33 16 34
  • 88.16 (n)
rat
(Rattus norvegicus)
Mammalia Ostf1 33
  • 88.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OSTF1 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves OSTF1 33 34
  • 81.76 (n)
lizard
(Anolis carolinensis)
Reptilia OSTF1 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ostf1 33
  • 76.64 (n)
Str.7364 33
African clawed frog
(Xenopus laevis)
Amphibia sh3d3-prov 33
zebrafish
(Danio rerio)
Actinopterygii LOC100537888 33
  • 73.21 (n)
ostf1 34 34 34
  • 72 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.445 33
worm
(Caenorhabditis elegans)
Secernentea CELE_Y106G6H.14 33
  • 53.47 (n)
Y106G6H.14 35 34
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1316 34
  • 53 (a)
OneToOne
Species where no ortholog for OSTF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSTF1 Gene

ENSEMBL:
Gene Tree for OSTF1 (if available)
TreeFam:
Gene Tree for OSTF1 (if available)

Paralogs for OSTF1 Gene

Paralogs for OSTF1 Gene

(4) SIMAP similar genes for OSTF1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OSTF1 Gene

genes like me logo Genes that share paralogs with OSTF1: view

Variants for OSTF1 Gene

Sequence variations from dbSNP and Humsavar for OSTF1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000011585 -- 75,089,091(+) G/A intron_variant
rs1000013149 -- 75,088,532(+) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000022544 -- 75,115,873(+) G/A intron_variant
rs1000093404 -- 75,122,075(+) T/C intron_variant
rs1000145780 -- 75,106,562(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OSTF1 Gene

Variant ID Type Subtype PubMed ID
esv3573267 CNV loss 25503493

Variation tolerance for OSTF1 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OSTF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSTF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSTF1 Gene

Disorders for OSTF1 Gene

Additional Disease Information for OSTF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OSTF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSTF1 Gene

Publications for OSTF1 Gene

  1. Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption. (PMID: 10092216) Reddy S … Roodman GD (Journal of cellular physiology 1998) 2 3 4 58
  2. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 44 58
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 44 58
  4. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PMID: 19807924) Voss M … Janssen O (BMC immunology 2009) 3 4 58
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58

Products for OSTF1 Gene

Sources for OSTF1 Gene

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