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Aliases for OST4 Gene

Aliases for OST4 Gene

  • Oligosaccharyltransferase Complex Subunit 4, Non-Catalytic 2 3 5
  • Oligosaccharyltransferase Complex Subunit 4 (Non-Catalytic) 2
  • Oligosaccharyltransferase 4 Homolog (S. Cerevisiae) 2

External Ids for OST4 Gene

Previous GeneCards Identifiers for OST4 Gene

  • GC02M027294
  • GC02M027035

Summaries for OST4 Gene

GeneCards Summary for OST4 Gene

OST4 (Oligosaccharyltransferase Complex Subunit 4, Non-Catalytic) is a Protein Coding gene.

UniProtKB/Swiss-Prot for OST4 Gene

  • Acts as component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for efficient N-glycosylation. Specifically involved in maintaining stability of STT3A-containing OST complexes.

Additional gene information for OST4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OST4 Gene

Genomics for OST4 Gene

GeneHancer (GH) Regulatory Elements for OST4 Gene

Promoters and enhancers for OST4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I027069 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 560.8 -4.7 -4721 14.9 CLOCK MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 MCM3 EMILIN1 OST4 CAD GTF3C2 SNX17 NRBP1 LOC105374363 GPN1 KHK TMEM214
GH02I027662 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.7 -591.9 -591873 2.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SUPT7L SLC4A1AP IFT172 GTF3C2 CAD ZNF512 GPN1 NRBP1 EIF2B4 SNX17
GH02I026763 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.1 +307.0 306954 2.9 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 POLR2B ZNF207 SP3 SLC35F6 CENPA CAD LOC105374363 EIF2B4 ATRAID GTF3C2 TMEM214 KHK GPN1
GH02I026784 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 +285.7 285665 2.3 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A CENPA ASXL2 EIF2B4 NRBP1 GPN1 GTF3C2 PPM1G ATRAID CAD GTF3C2-AS1
GH02I026410 Enhancer 1.5 FANTOM5 Ensembl ENCODE 10 +659.9 659856 2.5 HDGF SMAD1 ARNT YY1 POLR2B ZNF766 REST ZNF592 MEF2D SMARCA4 ATRAID HADHA OST4 RAB10 SELENOI DRC1 ADGRF3 CENPA OTOF
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OST4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OST4 Gene

Genomic Locations for OST4 Gene
chr2:27,070,472-27,071,773
(GRCh38/hg38)
Size:
1,302 bases
Orientation:
Minus strand
chr2:27,293,340-27,294,641
(GRCh37/hg19)

Genomic View for OST4 Gene

Genes around OST4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OST4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OST4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OST4 Gene

Proteins for OST4 Gene

  • Protein details for OST4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C6T2-OST4_HUMAN
    Recommended name:
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
    Protein Accession:
    P0C6T2

    Protein attributes for OST4 Gene

    Size:
    37 amino acids
    Molecular mass:
    4193 Da
    Quaternary structure:
    • Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.

    Three dimensional structures from OCA and Proteopedia for OST4 Gene

neXtProt entry for OST4 Gene

Post-translational modifications for OST4 Gene

No Post-translational modifications

Other Protein References for OST4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OST4 Gene

Domains & Families for OST4 Gene

Gene Families for OST4 Gene

Protein Domains for OST4 Gene

Suggested Antigen Peptide Sequences for OST4 Gene

Graphical View of Domain Structure for InterPro Entry

P0C6T2

UniProtKB/Swiss-Prot:

OST4_HUMAN :
  • Belongs to the OST4 family.
Family:
  • Belongs to the OST4 family.
genes like me logo Genes that share domains with OST4: view

Function for OST4 Gene

Molecular function for OST4 Gene

UniProtKB/Swiss-Prot Function:
Acts as component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for efficient N-glycosylation. Specifically involved in maintaining stability of STT3A-containing OST complexes.

Phenotypes From GWAS Catalog for OST4 Gene

Phenotypes for OST4 Gene

genes like me logo Genes that share phenotypes with OST4: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OST4 Gene

Localization for OST4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OST4 Gene

Endoplasmic reticulum. Endoplasmic reticulum membrane; Single-pass type III membrane protein. Note=The single transmembrane helix has a kink in the middle of the transmembrane span.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OST4 gene
Compartment Confidence
endoplasmic reticulum 5

Gene Ontology (GO) - Cellular Components for OST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0008250 oligosaccharyltransferase complex IDA 23606741
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OST4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OST4 Gene

Pathways & Interactions for OST4 Gene

No Data Available

UniProtKB/Swiss-Prot P0C6T2-OST4_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for OST4 Gene

Gene Ontology (GO) - Biological Process for OST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0018279 protein N-linked glycosylation via asparagine IMP 23606741
genes like me logo Genes that share ontologies with OST4: view

No data available for Pathways by source and SIGNOR curated interactions for OST4 Gene

Drugs & Compounds for OST4 Gene

No Compound Related Data Available

Transcripts for OST4 Gene

mRNA/cDNA for OST4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OST4 Gene

Oligosaccharyltransferase 4 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OST4 Gene

No ASD Table

Relevant External Links for OST4 Gene

GeneLoc Exon Structure for
OST4
ECgene alternative splicing isoforms for
OST4

Expression for OST4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OST4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OST4 Gene:

OST4

SOURCE GeneReport for Unigene cluster for OST4 Gene:

Hs.502948
genes like me logo Genes that share expression patterns with OST4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OST4 Gene

Orthologs for OST4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OST4 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Ost4 34
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ost4 34
  • 95 (a)
OneToOne
Species where no ortholog for OST4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OST4 Gene

ENSEMBL:
Gene Tree for OST4 (if available)
TreeFam:
Gene Tree for OST4 (if available)

Paralogs for OST4 Gene

No data available for Paralogs for OST4 Gene

Variants for OST4 Gene

Sequence variations from dbSNP and Humsavar for OST4 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000267952 -- 27,072,428(-) G/C upstream_transcript_variant
rs1000791296 -- 27,070,469(-) A/G downstream_transcript_variant
rs1000822366 -- 27,070,677(-) G/C 3_prime_UTR_variant
rs1001155224 -- 27,070,943(-) A/C intron_variant
rs1001257327 -- 27,071,817(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OST4 Gene

Variant ID Type Subtype PubMed ID
nsv833603 CNV loss 17160897
nsv817673 CNV gain 17921354
nsv455974 CNV loss 19166990
dgv6744n54 CNV loss 21841781

Additional Variant Information for OST4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OST4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for OST4 Gene

Disorders for OST4 Gene

Additional Disease Information for OST4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OST4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OST4 Gene

Publications for OST4 Gene

  1. OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation. (PMID: 23606741) Dumax-Vorzet A … High S (Journal of cell science 2013) 2 3 4 58
  2. Solution structure of a human minimembrane protein Ost4, a subunit of the oligosaccharyltransferase complex. (PMID: 21609714) Gayen S … Kang C (Biochemical and biophysical research communications 2011) 3 4 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. An evolving view of the eukaryotic oligosaccharyltransferase. (PMID: 16317064) Kelleher DJ … Gilmore R (Glycobiology 2006) 2 3 58
  5. A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. (PMID: 26272612) Dai FF … Wheeler MB (The Journal of biological chemistry 2015) 3 58

Products for OST4 Gene

Sources for OST4 Gene

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