Aliases for OSMR Gene
External Ids for OSMR Gene
Previous GeneCards Identifiers for OSMR Gene
This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
GeneCards Summary for OSMR Gene
OSMR (Oncostatin M Receptor) is a Protein Coding gene. Diseases associated with OSMR include Amyloidosis, Primary Localized Cutaneous, 1 and Primary Cutaneous Amyloidosis. Among its related pathways are Immune response_Oncostatin M signaling via JAK-Stat in human cells and Innate Immune System. Gene Ontology (GO) annotations related to this gene include growth factor binding and oncostatin-M receptor activity. An important paralog of this gene is LIFR.
UniProtKB/Swiss-Prot Summary for OSMR Gene
Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.