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This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, incl... See more...
Aliases for OSM Gene
External Ids for OSM Gene
- HGNC: 8506
- Entrez Gene: 5008
- Ensembl: ENSG00000099985
- OMIM: 165095
- UniProtKB: P13725
Previous GeneCards Identifiers for OSM Gene
- GC22M027354
- GC22M028983
- GC22M030658
- GC22M013620
Summaries for OSM Gene
-
This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
GeneCards Summary for OSM Gene
OSM (Oncostatin M) is a Protein Coding gene. Diseases associated with OSM include Plasmacytoma and Cerebral Meningioma. Among its related pathways are G-protein signaling Ras family GTPases in kinase cascades (scheme) and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and oncostatin-M receptor binding.
UniProtKB/Swiss-Prot Summary for OSM Gene
-
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).
Additional gene information for OSM Gene
- HGNC(8506)
- Entrez Gene(5008)
- Ensembl(ENSG00000099985)
- OMIM(165095)
- UniProtKB(P13725)
- Open Targets Platform(ENSG00000099985)
- Monarch Initiative
- Search for OSM at DataMed
- Search for OSM at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OSM Gene
Genomics for OSM Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for OSM Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around OSM on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OSM
- Top Transcription factor binding sites by QIAGEN in the OSM gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- c-Myc
- Max
- STAT1
Genomic Locations for OSM Gene
Genomic Locations for OSM Gene
- chr22:30,262,829-30,266,851
- (GRCh38/hg38)
- Size:
- 4,023 bases
- Orientation:
- Minus strand
- chr22:30,658,818-30,662,829
- (GRCh37/hg19)
- Size:
- 4,012 bases
- Orientation:
- Minus strand
Genomic View for OSM Gene
Genes around OSM on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.2 by HGNC
- 22q12.2 by Entrez Gene
- 22q12.2 by Ensembl
OSM Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for OSM Gene
Proteins for OSM Gene
-
Protein details for OSM Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13725-ONCM_HUMAN
- Recommended name:
- Oncostatin-M
- Protein Accession:
- P13725
- Q6FHP8
- Q9UCP6
Protein attributes for OSM Gene
- Size:
- 252 amino acids
- Molecular mass:
- 28484 Da
- Quaternary structure:
- No Data Available
Protein Expression for OSM Gene
Post-translational modifications for OSM Gene
- Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.
-
Glycosylation at Asn100 and Asn217
- NX_P13725 (NX_P13725-1)
- Modification sites at PhosphoSitePlus
Other Protein References for OSM Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents Oncostatin M Antibody
- Novus Biologicals Antibodies for OSM
-
Abcam antibodies for OSM
- Invitrogen Antibodies for OSM (AFLGC-OSM)
- antibodies-online: Show 126 available Oncostatin M Antibodies ranked by validation data
- Compare Top Oncostatin M Antibodies
-
Recommended
- 109 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 7 FACS Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 3 Neut Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 22 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 9 WB Antibodies (anti-rat)
- 1 IF/ICC Antibody (anti-rat)
- Sino Biological Antibodies for OSM
Protein Products
- G Biosciences Human Oncostatin M/OSM, Lyophilized
- RayBiotech Recombinant Human Oncostatin-M
- Search Origene for MassSpec and Protein Over-expression Lysates for OSM
- Origene Custom Protein Services for OSM
- Sino Biological Cell Lysates for OSM
- Sino Biological Recombinant Proteins for OSM
- ProSpec Recombinant Proteins for OSM
-
Abcam proteins for OSM
Assay Products
- G Biosciences Immunotag™ Human OSM (Oncostatin-M) ELISA and Immunotag™ Oncostatin-M ELISA Kit
- RayBiotech Human OSM ELISA
- Novus Biologicals ELISA Kits for OSM
- antibodies-online: Show 76 available Oncostatin M Elisa Kits ranked by validation data
- Compare Top Oncostatin M Elisa Kits
-
Quality Products:
- ABIN1116292
- ABIN625069
- ABIN414913
- ABIN365749
- ABIN1672746
- ABIN491815
- ABIN3032974
- ABIN1029426
- ABIN5521339
- ABIN2708349
- ABIN1116296
- ABIN415531
- ABIN367714
- ABIN2859275
- ABIN1029427
- ABIN5521340
- ABIN6720203
- ABIN5669865
- ABIN511980
- ABIN5592464
- ABIN1116295
- ABIN819774
- ABIN416340
- ABIN1571679
- ABIN5521341
- ABIN5670524
- ABIN511763
- ABIN5657505
- ABIN2537373
- ABIN4971722
- ABIN775344
- ABIN1564884
-
Abcam assays for OSM
No data available for DME Specific Peptides for OSM Gene
Domains & Families for OSM Gene
Gene Families for OSM Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for OSM Gene
- InterPro:
- Blocks:
-
- Oncostatin
- ProtoNet:
Suggested Antigen Peptide Sequences for OSM Gene
- GenScript: Design optimal peptide antigens:
-
- Oncostatin M (B5BUQ7_HUMAN)
- Oncostatin-M (ONCM_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P13725- Family:
-
- Belongs to the LIF/OSM family.
Function for OSM Gene
Molecular function for OSM Gene
- UniProtKB/Swiss-Prot Function:
- Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).
- GENATLAS Biochemistry:
- oncostatin M,interleukin-6,28.5kDa,interleukin 6 subfamily member,expressed in T cells and PMA treated monocytes
LifeMap Function Summary for OSM Gene
During embryonic development, OSM as signaling molecule is secreted from the following cells
- Liver
It affects the following cells:
- Liver
OSM as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Liver
Phenotypes From GWAS Catalog for OSM Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IEA,IDA | 8999038 |
| GO:0005147 | oncostatin-M receptor binding | IEA,IPI | 8999038 |
| GO:0005515 | protein binding | IPI | 16051226 |
| GO:0008083 | growth factor activity | IDA | 8999038 |
Phenotypes for OSM Gene
- MGI mutant phenotypes for OSM:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for OSM:
-
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Moderately decreased NFAT1-GFP nuclear translocation
- Decreased viability
- Negative genetic interaction between BLM-/- and BLM+/+
- Increased gamma-H2AX phosphorylation
- Decreased viability in pancreas lineage
- Decreased homologous recombination repair frequency
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Effect on mitosis
- Synthetic lethal with c-Myc after tamoxifen stimulation
Animal Model Products
-
Taconic Biosciences Mouse Models for OSM
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for OSM - Select products 50% OFF >
- * OSM CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for OSM
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OSM
-
Santa Cruz Biotechnology (SCBT) CRISPR for OSM
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OSM
- Browse OriGene Inhibitory RNA Products For OSM
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OSM
Clone Products
- Applied Biological Materials (abm): Clones for OSM - Select products 50% OFF >
- * OSM as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for OSM
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OSM
Cell Line Products
-
Horizon Cell Lines for OSM
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OSM Gene
Localization for OSM Gene
Subcellular locations from UniProtKB/Swiss-Prot for OSM Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005615 | extracellular space | TAS,IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for OSM Gene
Pathways & Interactions for OSM Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
|
IL-6 Pathway
.61
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
|
| 2 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
MAPK Signaling
.58
Molecular Mechanisms of Cancer
.51
|
| 3 | Akt Signaling |
Akt Signaling
.60
|
p38 Signaling
.60
|
| 4 | PAK Pathway |
Antioxidant Action of Vitamin-C
.56
|
PAK Pathway
.56
|
| 5 | Cytokine Signaling in Immune system | ||
Pathways by source for OSM Gene
2 BioSystems pathways for OSM Gene
6 Reactome pathways for OSM Gene
3 KEGG pathways for OSM Gene
4 GeneGo (Thomson Reuters) pathways for OSM Gene
- Development_Thrombopoetin signaling via JAK-STAT pathway
- Immune response IL-3 activation and signaling pathway
- Immune response Oncostatin M signaling via MAPK in human cells
- Immune response_Oncostatin M signaling via JAK-Stat in human cells
17 Qiagen pathways for OSM Gene
- Akt Signaling
- all-trans-Retinoic Acid Signaling in Brain
- Antioxidant Action of Vitamin-C
- Endothelin-1 Signaling Pathway
- ERK Signaling
Interacting Proteins for OSM Gene
Selected Interacting proteins:
P13725-ONCM_HUMAN
ENSP00000215781
for OSM Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for OSM
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002675 | positive regulation of acute inflammatory response | IC | 8999038 |
| GO:0006955 | immune response | IEA | -- |
| GO:0007275 | multicellular organism development | TAS | 1717982 |
| GO:0008284 | positive regulation of cell proliferation | IDA | 8999038 |
| GO:0008285 | negative regulation of cell proliferation | TAS | 1717982 |
Drugs & Compounds for OSM Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- G Biosciences Human Oncostatin M/OSM, Lyophilized
- RayBiotech Recombinant Human Oncostatin-M
Transcripts for OSM Gene
mRNA/cDNA for OSM Gene
- 2 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000215781 1865 nts (view in UCSC)
- ENST00000403389 1000 nts (view in UCSC)
- ENST00000403463 464 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for OSM - Select products 50% OFF >
- * OSM CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for OSM
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OSM
-
Santa Cruz Biotechnology (SCBT) CRISPR for OSM
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OSM
- Browse OriGene Inhibitory RNA Products For OSM
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OSM
Clone Products
- Applied Biological Materials (abm): Clones for OSM - Select products 50% OFF >
- * OSM as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for OSM
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OSM
Relevant External Links for OSM Gene
- GeneLoc Exon Structure for
- OSM
Expression for OSM Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Hematopoietic Stem Cells Liver Bud
- Mesenchymal Stem Cells
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
- Umbilical Cord (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for OSM Gene
This gene is overexpressed in Whole Blood (x37.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OSM Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OSM
SOURCE GeneReport for Unigene cluster for OSM Gene:
Hs.248156Evidence on tissue expression from TISSUES for OSM Gene
- Blood(4.5)
- Lung(4.4)
- Bone marrow(3.2)
- Nervous system(2.8)
- Liver(2.7)
- Lymph node(2.7)
- Skin(2.5)
- Intestine(2.5)
- Spleen(2.4)
- Heart(2.4)
- Muscle(2.3)
- Bone(2.3)
- Kidney(2.2)
- Pancreas(2)
- Adrenal gland(2)
Primer Products
-
OriGene qPCR primer pairs for OSM
-
OriGene qPCR primer pairs and template standards for OSM
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSM Gene
Orthologs for OSM Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | OSM 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | OSM 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | OSM 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Osm 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Osm 30 17 31 |
|
OneToOne |
- Species where no ortholog for OSM was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for OSM Gene
- ENSEMBL:
- Gene Tree for OSM (if available)
- TreeFam:
- Gene Tree for OSM (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for OSM: view image
Paralogs for OSM Gene
No data available for Paralogs for OSM Gene
Variants for OSM Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OSM Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs5763919 | - | p.Thr9Met |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1062388 | CNV | gain | 25217958 |
| nsv1110864 | OTHER | inversion | 24896259 |
| nsv588885 | CNV | loss | 21841781 |
| nsv829171 | CNV | loss | 20364138 |
| nsv834174 | CNV | gain+loss | 17160897 |
Residual Variation Intolerance Score:
76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.71;
32.53% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for OSM Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- OSM
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSM Gene
Disorders for OSM Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| plasmacytoma |
|
|
| cerebral meningioma |
|
|
| kaposi sarcoma |
|
|
| chronic eosinophilic leukemia |
|
|
| arthritis |
|
Search OSM in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for OSM
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for OSM Gene
Publications for OSM Gene
- Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. (PMID: 1717982) Rose TM … Bruce AG (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 23
- Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. (PMID: 8999038) Mosley B … Cosman D (The Journal of biological chemistry 1996) 3 4 23
- Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. (PMID: 1542793) Miles SA … Linsley PS (Science (New York, N.Y.) 1992) 3 4 23
- Gingival crevicular fluid levels of oncostatin M in periodontal conditions. (PMID: 20189410) Thorat Manojkumar S … Raju A (Cytokine 2010) 3 23
- S100A7 (psoriasin) is induced by the proinflammatory cytokines oncostatin-M and interleukin-6 in human breast cancer. (PMID: 20101226) West NR … Watson PH (Oncogene 2010) 3 23
ExternalLinks
Products for OSM Gene
- View all 21 R&D Systems OSM (Oncostatin M/OSM) Products
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- Custom Antibody ServicesOriGene Antibodies for OSM
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- OriGene qPCR primer pairs for OSM
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- High-throughput Antibody Production Service
- Protein Production Service
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- ProSpec Recombinant Proteins for OSM
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- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for OSM (AFLGC-OSM)
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- VectorBuilder Stable cell line generation for OSM
- antibodies-online: Show 126 available Oncostatin M Antibodies ranked by validation data
- Compare Top Oncostatin M Antibodies
- Recommended
- 109 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 7 FACS Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 3 Neut Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 22 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 9 WB Antibodies (anti-rat)
- 1 IF/ICC Antibody (anti-rat)
- antibodies-online: Show 76 available Oncostatin M Elisa Kits ranked by validation data
- Compare Top Oncostatin M Elisa Kits
- Quality Products:
- ABIN1116292
- ABIN625069
- ABIN414913
- ABIN365749
- ABIN1672746
- ABIN491815
- ABIN3032974
- ABIN1029426
- ABIN5521339
- ABIN2708349
- ABIN1116296
- ABIN415531
- ABIN367714
- ABIN2859275
- ABIN1029427
- ABIN5521340
- ABIN6720203
- ABIN5669865
- ABIN511980
- ABIN5592464
- ABIN1116295
- ABIN819774
- ABIN416340
- ABIN1571679
- ABIN5521341
- ABIN5670524
- ABIN511763
- ABIN5657505
- ABIN2537373
- ABIN4971722
- ABIN775344
- ABIN1564884
- antibodies-online: Show 74 available Oncostatin M Proteins ranked by validation data
- Compare Top Oncostatin M Proteins
- Search Santa Cruz Biotechnology (SCBT) for OSM siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for OSM
- Horizon Cell Lines for OSM
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OSM
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OSM
- Search GeneCopoeia for miRNA 3'UTR Target clone products for OSM
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OSM
Sources for OSM Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB