Aliases for OSM Gene
External Ids for OSM Gene
- HGNC: 8506
- Entrez Gene: 5008
- Ensembl: ENSG00000099985
- OMIM: 165095
- UniProtKB: P13725
Previous GeneCards Identifiers for OSM Gene
- GC22M027354
- GC22M028983
- GC22M030658
- GC22M013620
Summaries for OSM Gene
-
This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
GeneCards Summary for OSM Gene
OSM (Oncostatin M) is a Protein Coding gene. Diseases associated with OSM include Kaposi Sarcoma and Indolent Myeloma. Among its related pathways are Akt Signaling and Adipogenesis. Gene Ontology (GO) annotations related to this gene include cytokine activity and oncostatin-M receptor binding.
UniProtKB/Swiss-Prot for OSM Gene
-
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).
Additional gene information for OSM Gene
- Monarch Initiative
- Search for OSM at DataMed
- Search for OSM at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSM Gene
Genomics for OSM Gene
GeneHancer (GH) Regulatory Elements for OSM Gene
Promoters and enhancers for OSM Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around OSM on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the OSM gene promoter:
-
- AP-1
- c-Jun
- ATF-2
- STAT1
- Max
- c-Myc
Regulatory Element Products
Genomic Locations for OSM Gene
Genomic Locations for OSM Gene
- chr22:30,262,826-30,266,840
- (GRCh38/hg38)
- Size:
- 4,015 bases
- Orientation:
- Minus strand
- chr22:30,658,818-30,662,829
- (GRCh37/hg19)
- Size:
- 4,012 bases
- Orientation:
- Minus strand
Genomic View for OSM Gene
Genes around OSM on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.2 by Entrez Gene
- 22q12.2 by HGNC
- 22q12.2 by Ensembl
OSM Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for OSM Gene
Proteins for OSM Gene
-
Protein details for OSM Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13725-ONCM_HUMAN
- Recommended name:
- Oncostatin-M
- Protein Accession:
- P13725
- Q6FHP8
- Q9UCP6
Protein attributes for OSM Gene
- Size:
- 252 amino acids
- Molecular mass:
- 28484 Da
- Quaternary structure:
- No Data Available
Protein Expression for OSM Gene
Post-translational modifications for OSM Gene
- Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.
- Glycosylation at isoforms=217 and isoforms=100
- Modification sites at PhosphoSitePlus
Other Protein References for OSM Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for OSM (Oncostatin M/OSM)
- Novus Biologicals Antibodies for OSM
-
Abcam antibodies for OSM
- Invitrogen Antibodies for OSM (AFLGC-OSM)
- antibodies-online: Search results for 208 available Oncostatin M Antibodies ranked by validation data
- Compare Top Oncostatin M Antibodies
-
Recommended
- 120 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 16 FACS Antibodies (anti-human)
- 3 Neut Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 30 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 Neut Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 4 WB Antibodies (anti-rat)
- GeneTex OSM Antibody for OSM
- Sino Biological Antibodies for OSM
Protein Products
- R&D Systems Proteins and Enzymes for OSM (Oncostatin M/OSM)
- Search Origene for MassSpec and Protein Over-expression Lysates for OSM
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- ProSpec Recombinant Proteins for OSM
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-
Abcam proteins for OSM
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for OSM
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for OSM (Oncostatin M/OSM)
- Novus Biologicals ELISA Kits for OSM
-
Abcam assays for OSM
No data available for DME Specific Peptides for OSM Gene
Domains & Families for OSM Gene
Gene Families for OSM Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for OSM Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for OSM Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P13725- Family:
-
- Belongs to the LIF/OSM family.
Function for OSM Gene
Molecular function for OSM Gene
- UniProtKB/Swiss-Prot Function:
- Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).
- GENATLAS Biochemistry:
- oncostatin M,interleukin-6,28.5kDa,interleukin 6 subfamily member,expressed in T cells and PMA treated monocytes
LifeMap Function Summary for OSM Gene
During embryonic development, OSM as signaling molecule is secreted from the following cells
- Liver
It affects the following cells:
- Liver
OSM as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Liver
Phenotypes From GWAS Catalog for OSM Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IEA,IDA | 8999038 |
| GO:0005147 | oncostatin-M receptor binding | TAS,IPI | 8999038 |
| GO:0008083 | growth factor activity | IDA | 8999038 |
Phenotypes for OSM Gene
- MGI mutant phenotypes for OSM:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for OSM:
-
- Dynamic nuclei (hole, folded or small irregular)
- Moderately decreased NFAT1-GFP nuclear translocation
- Negative genetic interaction between BLM-/- and BLM+/+
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased gamma-H2AX phosphorylation
- Decreased homologous recombination repair frequency
Animal Model Products
-
Taconic Biosciences Mouse Models for OSM
- Cyagen custom Knockout/knockin (KOKI) mouse models for OSM
-
CRISPR Products
-
OriGene CRISPR knockouts for OSM
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OSM
- genomics-online: gRNA clones - Search results for 113 available Oncostatin M gene related products
- Overview of 113 available Oncostatin M gene related products
- Applied Biological Materials CRISPR for OSM
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for OSM
- GenScript: Design CRISPR guide RNA sequences for OSM
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OSM
- Browse OriGene Inhibitory RNA Products For OSM
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OSM
- genomics-online: shRNA clones - Search results for 113 available Oncostatin M gene related products
- Overview of 113 available Oncostatin M gene related products
Clone Products
- Sino Biological Human cDNA Clone for OSM
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OSM
- genomics-online: cdna clones - Search results for 113 available Oncostatin M gene related products
- Overview of 113 available Oncostatin M gene related products
- orf clones - Search results for 113 available Oncostatin M gene related products
- Overview of 113 available Oncostatin M gene related products
- Applied Biological Materials Clones for OSM
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for OSM
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OSM Gene
Localization for OSM Gene
Subcellular locations from UniProtKB/Swiss-Prot for OSM Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 2 |
| nucleus | 2 |
| cytoskeleton | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS,IEA | -- |
| GO:0005615 | extracellular space | IEA,TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for OSM Gene
Pathways & Interactions for OSM Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
.47
|
|
| 2 | ERK Signaling |
.61
|
.58
|
| 3 | Akt Signaling |
.60
|
.60
|
| 4 | PAK Pathway |
.56
|
|
| 5 | Cytokine Signaling in Immune system | ||
Pathways by source for OSM Gene
2 BioSystems pathways for OSM Gene
6 Reactome pathways for OSM Gene
3 KEGG pathways for OSM Gene
4 GeneGo (Thomson Reuters) pathways for OSM Gene
17 Qiagen pathways for OSM Gene
Interacting Proteins for OSM Gene
GPS-Prot Interaction Network for OSM
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002675 | positive regulation of acute inflammatory response | IC | 8999038 |
| GO:0006955 | immune response | IEA | -- |
| GO:0007275 | multicellular organism development | TAS | 1717982 |
| GO:0008283 | cell proliferation | TAS | 1542793 |
| GO:0008284 | positive regulation of cell proliferation | IDA | 8999038 |
Transcripts for OSM Gene
mRNA/cDNA for OSM Gene
- (2) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (34) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000215781 1854 bps (uc003ahb.4)
- ENST00000403389 1000 bps (uc062dan.1)
- ENST00000403463 464 bps (uc062dao.1)
CRISPR Products
-
OriGene CRISPR knockouts for OSM
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OSM
- genomics-online: gRNA clones - Search results for 113 available Oncostatin M gene related products
- Overview of 113 available Oncostatin M gene related products
- Applied Biological Materials CRISPR for OSM
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for OSM
- GenScript: Design CRISPR guide RNA sequences for OSM
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OSM
- Browse OriGene Inhibitory RNA Products For OSM
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OSM
- genomics-online: shRNA clones - Search results for 113 available Oncostatin M gene related products
- Overview of 113 available Oncostatin M gene related products
Clone Products
- Sino Biological Human cDNA Clone for OSM
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OSM
- genomics-online: cdna clones - Search results for 113 available Oncostatin M gene related products
- Overview of 113 available Oncostatin M gene related products
- orf clones - Search results for 113 available Oncostatin M gene related products
- Overview of 113 available Oncostatin M gene related products
- Applied Biological Materials Clones for OSM
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for OSM Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Hematopoietic Stem Cells Liver Bud
- Mesenchymal Stem Cells
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
- Umbilical Cord (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for OSM Gene
This gene is overexpressed in Whole Blood (x37.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OSM Gene
NURSA nuclear receptor signaling pathways regulating expression of OSM Gene:
OSMSOURCE GeneReport for Unigene cluster for OSM Gene:
Hs.248156Evidence on tissue expression from TISSUES for OSM Gene
- Blood(4.4)
- Lung(4.3)
- Bone marrow(2.7)
- Liver(2.3)
- Nervous system(2.2)
Primer Products
-
OriGene qPCR primer pairs for OSM
-
OriGene qPCR primer pairs and template standards for OSM
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSM Gene
Orthologs for OSM Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | OSM 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | OSM 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | OSM 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Osm 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Osm 16 34 33 |
|
- Species where no ortholog for OSM was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for OSM Gene
- ENSEMBL:
- Gene Tree for OSM (if available)
- TreeFam:
- Gene Tree for OSM (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for OSM: view image
Paralogs for OSM Gene
No data available for Paralogs for OSM Gene
Variants for OSM Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000106555 | -- | 30,266,522(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000277910 | -- | 30,264,559(-) | A/G | intron_variant | |
| rs1000815266 | -- | 30,268,808(-) | T/G | upstream_transcript_variant | |
| rs1001550599 | -- | 30,265,776(-) | A/T | 5_prime_UTR_variant, intron_variant | |
| rs1001566032 | -- | 30,265,355(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1062388 | CNV | gain | 25217958 |
| nsv1110864 | OTHER | inversion | 24896259 |
| nsv588885 | CNV | loss | 21841781 |
| nsv829171 | CNV | loss | 20364138 |
| nsv834174 | CNV | gain+loss | 17160897 |
Residual Variation Intolerance Score:
76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.71;
32.53% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for OSM Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- OSM
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSM Gene
Disorders for OSM Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| kaposi sarcoma |
|
|
| indolent myeloma |
|
|
| chronic eosinophilic leukemia |
|
|
Search OSM in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for OSM
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for OSM Gene
Publications for OSM Gene
- Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. (PMID: 8999038) Mosley B … Cosman D (The Journal of biological chemistry 1996) 3 4 22 58
- Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. (PMID: 1542793) Miles SA … Linsley PS (Science (New York, N.Y.) 1992) 3 4 22 58
- Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. (PMID: 1717982) Rose TM … Bruce AG (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Gingival crevicular fluid levels of oncostatin M in periodontal conditions. (PMID: 20189410) Thorat Manojkumar S … Raju A (Cytokine 2010) 3 22 58
Products for OSM Gene
- R&D Systems Antibodies for OSM (Oncostatin M/OSM)
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- antibodies-online: Search results for 208 available Oncostatin M Antibodies ranked by validation data
- Compare Top Oncostatin M Antibodies
- Recommended
- 120 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 16 FACS Antibodies (anti-human)
- 3 Neut Antibodies (anti-human)
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- 30 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 Neut Antibody (anti-mouse)
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- 4 WB Antibodies (anti-rat)
- antibodies-online: Search results for 63 available Oncostatin M Elisa Kits ranked by validation data
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- antibodies-online: Search results for 75 available Oncostatin M Proteins ranked by validation data
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- GeneTex OSM Antibody for OSM
- GeneTex Proteins for OSM
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- Santa Cruz Biotechnology (SCBT) CRISPR for OSM
- Horizon Cell Lines for OSM
- genomics-online: cdna clones - Search results for 113 available Oncostatin M gene related products
- Overview of 113 available Oncostatin M gene related products
- orf clones - Search results for 113 available Oncostatin M gene related products
- Overview of 113 available Oncostatin M gene related products
- genomics-online: gRNA clones - Search results for 113 available Oncostatin M gene related products
- Overview of 113 available Oncostatin M gene related products
- genomics-online: primer clones - Search results for 113 available Oncostatin M gene related products
- Overview of 113 available Oncostatin M gene related products
- genomics-online: shRNA clones - Search results for 113 available Oncostatin M gene related products
- Overview of 113 available Oncostatin M gene related products
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Sources for OSM Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
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