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OSM Gene(Protein Coding)

Oncostatin M

GCID:
GC22M030262
GIFtS:
53
Genes Participants
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Aliases for OSM Gene

Aliases for OSM Gene

  • Oncostatin M 2 3 5
  • Oncostatin-M 3

External Ids for OSM Gene

Previous GeneCards Identifiers for OSM Gene

  • GC22M027354
  • GC22M028983
  • GC22M030658
  • GC22M013620

Summaries for OSM Gene

Entrez Gene Summary for OSM Gene

  • This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

GeneCards Summary for OSM Gene

OSM (Oncostatin M) is a Protein Coding gene. Diseases associated with OSM include Kaposi Sarcoma and Chronic Eosinophilic Leukemia. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include cytokine activity and oncostatin-M receptor binding.

UniProtKB/Swiss-Prot for OSM Gene

  • Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).

Gene Wiki entry for OSM Gene

Additional gene information for OSM Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSM Gene

Genomics for OSM Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for OSM Gene

Promoters and enhancers for OSM Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH22I030264 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.2 -155 4.3 PKNOX1 ATF1 GLIS2 ZNF143 ATF7 RUNX3 CREM SMARCA5 CEBPB ELF1 OSM THOC5 SEC14L4 ENSG00000279699
GH22I030190 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 31 +71.5 71548 9.1 PKNOX1 FOXA2 ZFP64 SIN3A FEZF1 ZNF2 IRF4 ZNF213 FOS SP3 OSM MTMR3 HORMAD2-AS1 ASCC2 SELENOM SF3A1 SLC35E4 MTFP1 DUSP18 CCDC157
GH22I030270 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 36 -4.1 -4149 1.3 CTCF ATF1 NRF1 CEBPB MAFG CTBP1 ZNF316 POLR2A CREB1 FOS OSM TBC1D10A ENSG00000248751 LIF-AS1 MTMR3 SLC35E4 DUSP18 SF3A1 CCDC157 ENSG00000279699
GH22I030263 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 37 +5.5 5546 0.4 PKNOX1 ZNF189 HLF CEBPB CEBPG SREBF1 NFIL3 SP1 ATF4 ZNF316 OSM MTMR3 SLC35E4 DUSP18 SF3A1 CCDC157 TBC1D10A LIF
GH22I030201 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21 +59.1 59071 12.4 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 FOS SP5 LOC105372988 OSM TUG1 HORMAD2-AS1 MTMR3 MORC2 RNF215 EWSR1 PES1 THOC5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OSM on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OSM gene promoter:

Genomic Locations for OSM Gene

Genomic Locations for OSM Gene
chr22:30,262,826-30,266,840
(GRCh38/hg38)
Size:
4,015 bases
Orientation:
Minus strand
chr22:30,658,818-30,662,829
(GRCh37/hg19)

Genomic View for OSM Gene

Genes around OSM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSM Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OSM Gene

Proteins for OSM Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for OSM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13725-ONCM_HUMAN
    Recommended name:
    Oncostatin-M
    Protein Accession:
    P13725
    Secondary Accessions:
    • Q6FHP8
    • Q9UCP6

    Protein attributes for OSM Gene

    Size:
    252 amino acids
    Molecular mass:
    28484 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for OSM Gene

neXtProt entry for OSM Gene

Protein Expression for OSM Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for OSM Gene

  • Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.
  • Glycosylation at isoforms=100 and Asn217
  • Modification sites at PhosphoSitePlus

Other Protein References for OSM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OSM Gene

Domains & Families for OSM Gene

Gene Families for OSM Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for OSM Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OSM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13725

UniProtKB/Swiss-Prot:

ONCM_HUMAN :
  • Belongs to the LIF/OSM family.
Family:
  • Belongs to the LIF/OSM family.
genes like me logo Genes that share domains with OSM: view

Function for OSM Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for OSM Gene

GENATLAS Biochemistry:
oncostatin M,interleukin-6,28.5kDa,interleukin 6 subfamily member,expressed in T cells and PMA treated monocytes
UniProtKB/Swiss-Prot Function:
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).

LifeMap Function Summary for OSM Gene

During embryonic development, OSM as signaling molecule is secreted from the following cells
It affects the following cells:

Phenotypes From GWAS Catalog for OSM Gene

Gene Ontology (GO) - Molecular Function for OSM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,IDA 8999038
GO:0005147 oncostatin-M receptor binding IPI,TAS 8999038
GO:0008083 growth factor activity IDA 8999038
genes like me logo Genes that share ontologies with OSM: view
genes like me logo Genes that share phenotypes with OSM: view

Animal Models for OSM Gene

MGI Knock Outs for OSM:
  • Osm tm1Ymo
  • Osm tm1b(KOMP)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for OSM

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OSM Gene

Localization for OSM Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSM Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSM gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytoskeleton 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for OSM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space IEA,TAS --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with OSM: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OSM Gene

Pathways & Interactions for OSM Gene

genes like me logo Genes that share pathways with OSM: view

SIGNOR curated interactions for OSM Gene

Activates:

Gene Ontology (GO) - Biological Process for OSM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002675 positive regulation of acute inflammatory response IC 8999038
GO:0006955 immune response IEA --
GO:0007275 multicellular organism development TAS 1717982
GO:0008283 cell proliferation TAS 1542793
GO:0008284 positive regulation of cell proliferation IDA 8999038
genes like me logo Genes that share ontologies with OSM: view

Drugs & Compounds for OSM Gene

Products:

  1. Drug

(25) Drugs for OSM Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(31) Additional Compounds for OSM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with OSM: view

Transcripts for OSM Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for OSM Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(34) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OSM Gene

Oncostatin M:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSM Gene

No ASD Table

Relevant External Links for OSM Gene

GeneLoc Exon Structure for
OSM
ECgene alternative splicing isoforms for
OSM

Expression for OSM Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OSM Gene

mRNA expression in normal human tissues for OSM Gene
mRNA expression by BioGPS for OSM GenemRNA expression by GTEx for OSM Gene

mRNA differential expression in normal tissues according to GTEx for OSM Gene

This gene is overexpressed in Whole Blood (x37.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OSM Gene



NURSA nuclear receptor signaling pathways regulating expression of OSM Gene:

OSM

SOURCE GeneReport for Unigene cluster for OSM Gene:

Hs.248156

Evidence on tissue expression from TISSUES for OSM Gene

  • Blood(4.4)
  • Lung(4.3)
  • Bone marrow(2.7)
  • Liver(2.3)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with OSM: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSM Gene

Orthologs for OSM Gene

This gene was present in the common ancestor of mammals.

Orthologs for OSM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia OSM 33 34
  • 99.6 (n)
dog
(Canis familiaris)
 Mammalia OSM 33 34
  • 77.07 (n)
cow
(Bos Taurus)
 Mammalia OSM 33 34
  • 69.34 (n)
rat
(Rattus norvegicus)
 Mammalia Osm 33
  • 66.19 (n)
mouse
(Mus musculus)
 Mammalia Osm 33 16 34
  • 64.75 (n)
Species where no ortholog for OSM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OSM Gene

ENSEMBL:
Gene Tree for OSM (if available)
TreeFam:
Gene Tree for OSM (if available)

Paralogs for OSM Gene

No data available for Paralogs for OSM Gene

Variants for OSM Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for OSM Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000106555 -- 30,266,522(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000277910 -- 30,264,559(-) A/G intron_variant
rs1000815266 -- 30,268,808(-) T/G upstream_transcript_variant
rs1001550599 -- 30,265,776(-) A/T 5_prime_UTR_variant, intron_variant
rs1001566032 -- 30,265,355(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OSM Gene

Variant ID Type Subtype PubMed ID
nsv1062388 CNV gain 25217958
nsv1110864 OTHER inversion 24896259
nsv588885 CNV loss 21841781
nsv829171 CNV loss 20364138
nsv834174 CNV gain+loss 17160897

Variation tolerance for OSM Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OSM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSM

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSM Gene

Disorders for OSM Gene

MalaCards: The human disease database

(3) MalaCards diseases for OSM Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kaposi sarcoma
  • kaposi sarcoma, susceptibility to
chronic eosinophilic leukemia
  • pdgfra-associated chronic eosinophilic leukemia
indolent myeloma
  • indolent multiple myeloma
- elite association - COSMIC cancer census association via MalaCards
Search OSM in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OSM

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OSM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OSM Gene

Publications for OSM Gene

  1. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. (PMID: 8999038) Mosley B … Cosman D (The Journal of biological chemistry 1996) 3 4 22 58
  2. Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. (PMID: 1542793) Miles SA … Linsley PS (Science (New York, N.Y.) 1992) 3 4 22 58
  3. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. (PMID: 1717982) Rose TM … Bruce AG (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. The inflammatory mediator oncostatin M induces angiopoietin 2 expression in endothelial cells in vitro and in vivo. (PMID: 20088942) Rychli K … Wojta J (Journal of thrombosis and haemostasis : JTH 2010) 3 22 58

Products for OSM Gene

Sources for OSM Gene

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