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This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
OSM (Oncostatin M) is a Protein Coding gene. Diseases associated with OSM include Plasmacytoma and Cerebral Meningioma. Among its related pathways are G-protein signaling Ras family GTPases in kinase cascades (scheme) and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and oncostatin-M receptor binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005125 | cytokine activity | IEA,IDA | 8999038 |
GO:0005147 | oncostatin-M receptor binding | IEA,IPI | 8999038 |
GO:0005515 | protein binding | IPI | 16051226 |
GO:0008083 | growth factor activity | IDA | 8999038 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA,TAS | -- |
GO:0005615 | extracellular space | TAS,IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
|
IL-6 Pathway
.61
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
|
2 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
MAPK Signaling
.58
Molecular Mechanisms of Cancer
.51
|
3 | Akt Signaling |
Akt Signaling
.60
|
p38 Signaling
.60
|
4 | PAK Pathway |
Antioxidant Action of Vitamin-C
.56
|
PAK Pathway
.56
|
5 | Cytokine Signaling in Immune system |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002675 | positive regulation of acute inflammatory response | IC | 8999038 |
GO:0006955 | immune response | IEA | -- |
GO:0007275 | multicellular organism development | TAS | 1717982 |
GO:0008284 | positive regulation of cell proliferation | IDA | 8999038 |
GO:0008285 | negative regulation of cell proliferation | TAS | 1717982 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
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Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | OSM 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | OSM 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | OSM 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Osm 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Osm 30 17 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs5763919 | - | p.Thr9Met |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1062388 | CNV | gain | 25217958 |
nsv1110864 | OTHER | inversion | 24896259 |
nsv588885 | CNV | loss | 21841781 |
nsv829171 | CNV | loss | 20364138 |
nsv834174 | CNV | gain+loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
plasmacytoma |
|
|
cerebral meningioma |
|
|
kaposi sarcoma |
|
|
chronic eosinophilic leukemia |
|
|
arthritis |
|