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Aliases for OSGIN1 Gene

Aliases for OSGIN1 Gene

  • Oxidative Stress Induced Growth Inhibitor 1 2 3 5
  • Bone Marrow Stromal Cell-Derived Growth Inhibitor 2 3
  • Pregnancy-Induced Growth Inhibitor OKL38 3 4
  • Ovary, Kidney And Liver Protein 38 3 4
  • OKL38 3 4
  • Oxidative Stress-Induced Growth Inhibitor 1 3
  • Pregnancy Induced Growth Inhibitor 2
  • EC 56
  • EC 56
  • EC 1.6.5 56
  • HuOKL38 4
  • BDGI 3

External Ids for OSGIN1 Gene

Previous GeneCards Identifiers for OSGIN1 Gene

  • GC16P082541
  • GC16P069733

Summaries for OSGIN1 Gene

Entrez Gene Summary for OSGIN1 Gene

  • This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]

GeneCards Summary for OSGIN1 Gene

OSGIN1 (Oxidative Stress Induced Growth Inhibitor 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and growth factor activity. An important paralog of this gene is OSGIN2.

UniProtKB/Swiss-Prot for OSGIN1 Gene

  • Regulates the differentiation and proliferation of normal cells through the regulation of cell death.

Additional gene information for OSGIN1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSGIN1 Gene

Genomics for OSGIN1 Gene

GeneHancer (GH) Regulatory Elements for OSGIN1 Gene

Promoters and enhancers for OSGIN1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I083952 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 563.6 +5.7 5734 3.2 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A OSGIN1 TAF1C KLHL36 ENSG00000261243 RNA5SP432 SLC38A8 MLYCD DNAAF1 HSDL1 NECAB2
GH16I083949 Enhancer 0.8 ENCODE 556 +0.8 829 0.2 ELF3 FOXA2 MLX ARID4B DMAP1 RAD21 THRB ZNF48 RARA CREM OSGIN1 NECAB2 LOC105371371 ENSG00000260300
GH16I083947 Enhancer 0.7 ENCODE 550.8 -0.3 -300 0.3 SOX13 MXI1 SAP130 ARID4B MAX DMAP1 RARA TEAD3 HNF4G NR2F6 OSGIN1 LOC105371371 ENSG00000260300
GH16I083926 Enhancer 1.4 FANTOM5 Ensembl ENCODE 13.1 -20.7 -20712 2.6 PKNOX1 CLOCK ARID4B SIN3A ZNF2 ZNF48 ETS1 SLC30A9 ARID2 ZNF143 OSGIN1 MLYCD TAF1C DNAAF1 HSDL1 LOC105371372 PIR36240 ENSG00000260300
GH16I083825 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11 -121.9 -121897 0.8 RB1 ZFP64 SIN3A ZNF48 RAD21 ARID2 EGR1 ZNF143 DEK ZNF654 MLYCD OSGIN1 HSDL1 LOC105371370
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OSGIN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OSGIN1 gene promoter:

Genomic Locations for OSGIN1 Gene

Genomic Locations for OSGIN1 Gene
18,051 bases
Plus strand

Genomic View for OSGIN1 Gene

Genes around OSGIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSGIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSGIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSGIN1 Gene

Proteins for OSGIN1 Gene

  • Protein details for OSGIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oxidative stress-induced growth inhibitor 1
    Protein Accession:
    Secondary Accessions:
    • Q52M33
    • Q86UQ1
    • Q96S88
    • Q9BZ70

    Protein attributes for OSGIN1 Gene

    560 amino acids
    Molecular mass:
    60849 Da
    Quaternary structure:
    No Data Available
    • Loss of OSGIN1 protein disturbs the balance between cell growth, differentiation, and cell death in normal tissue, resulting in uncontrolled growth and formation of tumors.
    • Sequence=AAF06662.1; Type=Frameshift; Positions=493, 523, 534, 554; Evidence={ECO:0000305}; Sequence=AAK01722.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for OSGIN1 Gene


neXtProt entry for OSGIN1 Gene

Selected DME Specific Peptides for OSGIN1 Gene


Post-translational modifications for OSGIN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSGIN1 Gene

Domains & Families for OSGIN1 Gene

Gene Families for OSGIN1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OSGIN1 Gene

Suggested Antigen Peptide Sequences for OSGIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the OKL38 family.
  • Belongs to the OKL38 family.
genes like me logo Genes that share domains with OSGIN1: view

Function for OSGIN1 Gene

Molecular function for OSGIN1 Gene

UniProtKB/Swiss-Prot Function:
Regulates the differentiation and proliferation of normal cells through the regulation of cell death.
UniProtKB/Swiss-Prot Induction:
By pregnancy.

Enzyme Numbers (IUBMB) for OSGIN1 Gene

Phenotypes From GWAS Catalog for OSGIN1 Gene

Gene Ontology (GO) - Molecular Function for OSGIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008083 growth factor activity IDA 11459809
genes like me logo Genes that share ontologies with OSGIN1: view
genes like me logo Genes that share phenotypes with OSGIN1: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OSGIN1 Gene

Localization for OSGIN1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSGIN1 gene
Compartment Confidence
plasma membrane 3
peroxisome 2
nucleus 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OSGIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with OSGIN1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OSGIN1 Gene

Pathways & Interactions for OSGIN1 Gene

SuperPathways for OSGIN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSGIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0010469 regulation of receptor activity IEA --
GO:0030154 cell differentiation IEA --
GO:0030308 negative regulation of cell growth IDA,IEA 11459809
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with OSGIN1: view

No data available for Pathways by source and SIGNOR curated interactions for OSGIN1 Gene

Drugs & Compounds for OSGIN1 Gene

No Compound Related Data Available

Transcripts for OSGIN1 Gene

Unigene Clusters for OSGIN1 Gene

Oxidative stress induced growth inhibitor 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSGIN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - - -
SP3: - -

Relevant External Links for OSGIN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OSGIN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OSGIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSGIN1 Gene

This gene is overexpressed in Liver (x14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OSGIN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OSGIN1 Gene:


SOURCE GeneReport for Unigene cluster for OSGIN1 Gene:


mRNA Expression by UniProt/SwissProt for OSGIN1 Gene:

Tissue specificity: Ubiquitous. Highest expression in the ovary, testis, kidney, and liver.

Evidence on tissue expression from TISSUES for OSGIN1 Gene

  • Liver(4.4)
  • Blood(4)
genes like me logo Genes that share expression patterns with OSGIN1: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSGIN1 Gene

Orthologs for OSGIN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSGIN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OSGIN1 33 34
  • 99.09 (n)
(Bos Taurus)
Mammalia OSGIN1 33 34
  • 87.14 (n)
(Canis familiaris)
Mammalia OSGIN1 33 34
  • 87 (n)
(Mus musculus)
Mammalia Osgin1 33 16 34
  • 82.32 (n)
(Rattus norvegicus)
Mammalia Osgin1 33
  • 82.32 (n)
(Monodelphis domestica)
Mammalia OSGIN1 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia OSGIN1 34
  • 68 (a)
(Gallus gallus)
Aves OSGIN1 33 34
  • 61.36 (n)
(Anolis carolinensis)
Reptilia OSGIN1 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia osgin1 33
  • 59.26 (n)
(Danio rerio)
Actinopterygii osgn1 33 34
  • 59.28 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011390 33
  • 55.56 (n)
(Caenorhabditis elegans)
Secernentea F30B5.4 34
  • 25 (a)
Species where no ortholog for OSGIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSGIN1 Gene

Gene Tree for OSGIN1 (if available)
Gene Tree for OSGIN1 (if available)

Paralogs for OSGIN1 Gene

Paralogs for OSGIN1 Gene

(1) SIMAP similar genes for OSGIN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with OSGIN1: view

Variants for OSGIN1 Gene

Sequence variations from dbSNP and Humsavar for OSGIN1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000315414 -- 83,957,269(+) G/A intron_variant
rs1000450064 -- 83,957,889(+) TTATT/TTATTATT intron_variant
rs1000775709 -- 83,960,315(+) G/A intron_variant
rs1000919316 -- 83,956,384(+) A/G/T intron_variant
rs1001003857 -- 83,954,168(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OSGIN1 Gene

Variant ID Type Subtype PubMed ID
dgv3056n100 CNV loss 25217958
dgv5259n54 CNV loss 21841781
esv3639403 CNV loss 21293372
nsv1065790 CNV loss 25217958
nsv471106 CNV gain 18288195
nsv517566 CNV gain+loss 19592680
nsv528396 CNV loss 19592680
nsv573409 CNV loss 21841781

Variation tolerance for OSGIN1 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OSGIN1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSGIN1 Gene

Disorders for OSGIN1 Gene

Additional Disease Information for OSGIN1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OSGIN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSGIN1 Gene

Publications for OSGIN1 Gene

  1. Genomic structure of human OKL38 gene and its differential expression in kidney carcinogenesis. (PMID: 14570898) Ong CK … Huynh H (The Journal of biological chemistry 2004) 2 3 4 58
  2. Cloning and characterization of a novel pregnancy-induced growth inhibitor in mammary gland. (PMID: 11459809) Huynh H … Chan TW (Endocrinology 2001) 2 3 4 58
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 44 58
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 44 58
  5. OKL38 is an oxidative stress response gene stimulated by oxidized phospholipids. (PMID: 17192422) Li R … Berliner JA (Journal of lipid research 2007) 3 22 58

Products for OSGIN1 Gene

Sources for OSGIN1 Gene

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