This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontro... See more...

Aliases for OSGIN1 Gene

Aliases for OSGIN1 Gene

  • Oxidative Stress Induced Growth Inhibitor 1 2 3 5
  • Bone Marrow Stromal Cell-Derived Growth Inhibitor 2 3 4
  • OKL38 2 3 4
  • BDGI 2 3 4
  • Oxidative Stress-Induced Growth Inhibitor 1 3 4
  • Pregnancy-Induced Growth Inhibitor OKL38 3 4
  • Ovary, Kidney And Liver Protein 38 3 4
  • BMSC-Derived Growth Inhibitor 3 4
  • Pregnancy Induced Growth Inhibitor 2
  • EC 2.7.1.130 51
  • EC 2.4.2.7 51
  • EC 1.6.5 51
  • HuOKL38 4
  • OSGIN1 5

External Ids for OSGIN1 Gene

Previous GeneCards Identifiers for OSGIN1 Gene

  • GC16P082541
  • GC16P083982
  • GC16P069733

Summaries for OSGIN1 Gene

Entrez Gene Summary for OSGIN1 Gene

  • This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]

GeneCards Summary for OSGIN1 Gene

OSGIN1 (Oxidative Stress Induced Growth Inhibitor 1) is a Protein Coding gene. Diseases associated with OSGIN1 include Cervical Polyp. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and growth factor activity. An important paralog of this gene is OSGIN2.

UniProtKB/Swiss-Prot Summary for OSGIN1 Gene

  • Regulates the differentiation and proliferation through the regulation of cell death.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OSGIN1 Gene

Genomics for OSGIN1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OSGIN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OSGIN1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OSGIN1

Top Transcription factor binding sites by QIAGEN in the OSGIN1 gene promoter:
  • CREB
  • ER-alpha
  • FOXO3
  • FOXO3a
  • FOXO3b
  • HOXA3

Genomic Locations for OSGIN1 Gene

Latest Assembly
chr16:83,931,311-83,966,332
(GRCh38/hg38)
Size:
35,022 bases
Orientation:
Plus strand

Previous Assembly
chr16:83,986,845-83,999,937
(GRCh37/hg19 by Entrez Gene)
Size:
13,093 bases
Orientation:
Plus strand

chr16:83,981,887-83,999,937
(GRCh37/hg19 by Ensembl)
Size:
18,051 bases
Orientation:
Plus strand

Genomic View for OSGIN1 Gene

Genes around OSGIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSGIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSGIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSGIN1 Gene

Proteins for OSGIN1 Gene

  • Protein details for OSGIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX0-OSGI1_HUMAN
    Recommended name:
    Oxidative stress-induced growth inhibitor 1
    Protein Accession:
    Q9UJX0
    Secondary Accessions:
    • Q52M33
    • Q86UQ1
    • Q96S88
    • Q9BZ70

    Protein attributes for OSGIN1 Gene

    Size:
    477 amino acids
    Molecular mass:
    51992 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF06662.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAF06662.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAK01722.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAP14662.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
    Miscellaneous:
    • Loss of OSGIN1 protein disturbs the balance between cell growth, differentiation, and cell death in normal tissue, resulting in uncontrolled growth and formation of tumors.

neXtProt entry for OSGIN1 Gene

Selected DME Specific Peptides for OSGIN1 Gene

Q9UJX0:
  • SYLLSGY
  • AFRRAVD
  • PVIIVGN

Post-translational modifications for OSGIN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OSGIN1 Gene

Domains & Families for OSGIN1 Gene

Gene Families for OSGIN1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OSGIN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OSGIN1 Gene

GenScript: Design optimal peptide antigens:
  • Pregnancy-induced growth inhibitor OKL38 (OSGI1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UJX0

UniProtKB/Swiss-Prot:

OSGI1_HUMAN :
  • Belongs to the OKL38 family.
Family:
  • Belongs to the OKL38 family.
genes like me logo Genes that share domains with OSGIN1: view

Function for OSGIN1 Gene

Molecular function for OSGIN1 Gene

UniProtKB/Swiss-Prot Function:
Regulates the differentiation and proliferation through the regulation of cell death.
UniProtKB/Swiss-Prot Induction:
By pregnancy.

Enzyme Numbers (IUBMB) for OSGIN1 Gene

Phenotypes From GWAS Catalog for OSGIN1 Gene

Gene Ontology (GO) - Molecular Function for OSGIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008083 growth factor activity IBA,IDA 11459809
genes like me logo Genes that share ontologies with OSGIN1: view
genes like me logo Genes that share phenotypes with OSGIN1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OSGIN1

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OSGIN1 Gene

Localization for OSGIN1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSGIN1 gene
Compartment Confidence
plasma membrane 3
nucleus 3
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OSGIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with OSGIN1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OSGIN1 Gene

Pathways & Interactions for OSGIN1 Gene

PathCards logo

SuperPathways for OSGIN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSGIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0030308 negative regulation of cell growth IEA,IDA 11459809
GO:0030334 regulation of cell migration IMP 15569677
genes like me logo Genes that share ontologies with OSGIN1: view

No data available for Pathways by source and SIGNOR curated interactions for OSGIN1 Gene

Drugs & Compounds for OSGIN1 Gene

No Compound Related Data Available

Transcripts for OSGIN1 Gene

mRNA/cDNA for OSGIN1 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OSGIN1

Alternative Splicing Database (ASD) splice patterns (SP) for OSGIN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - - -
SP3: - -
SP4:
SP5:

Relevant External Links for OSGIN1 Gene

GeneLoc Exon Structure for
OSGIN1

Expression for OSGIN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OSGIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSGIN1 Gene

This gene is overexpressed in Liver (x14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OSGIN1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OSGIN1

SOURCE GeneReport for Unigene cluster for OSGIN1 Gene:

Hs.128055

mRNA Expression by UniProt/SwissProt for OSGIN1 Gene:

Q9UJX0-OSGI1_HUMAN
Tissue specificity: Ubiquitous. Highest expression in the ovary, testis, kidney, skeletal muscle and liver (PubMed:11459809, PubMed:14570898, PubMed:15569677). Weakly expressed in spleen, heart, kidney, and pancreas (PubMed:15569677). Highly expressed in tumor cells (at protein level) (PubMed:15569677).

Evidence on tissue expression from TISSUES for OSGIN1 Gene

  • Liver(4.5)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with OSGIN1: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSGIN1 Gene

Orthologs for OSGIN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSGIN1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OSGIN1 30 31
  • 99.09 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OSGIN1 30 31
  • 87.14 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia OSGIN1 30 31
  • 87 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Osgin1 30 17 31
  • 82.32 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Osgin1 30
  • 82.32 (n)
Oppossum
(Monodelphis domestica)
Mammalia OSGIN1 31
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia OSGIN1 31
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves OSGIN1 30 31
  • 61.36 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia OSGIN1 31
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia osgin1 30
  • 59.26 (n)
Zebrafish
(Danio rerio)
Actinopterygii osgn1 30 31
  • 59.28 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011390 30
  • 55.56 (n)
Worm
(Caenorhabditis elegans)
Secernentea F30B5.4 31
  • 25 (a)
OneToMany
Species where no ortholog for OSGIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for OSGIN1 Gene

ENSEMBL:
Gene Tree for OSGIN1 (if available)
TreeFam:
Gene Tree for OSGIN1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OSGIN1: view image

Paralogs for OSGIN1 Gene

Paralogs for OSGIN1 Gene

(1) SIMAP similar genes for OSGIN1 Gene using alignment to 4 proteins:

  • OSGI1_HUMAN
  • H3BT09_HUMAN
  • H3BTF9_HUMAN
  • J3KRK7_HUMAN
genes like me logo Genes that share paralogs with OSGIN1: view

Variants for OSGIN1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OSGIN1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs111436159 Benign: not provided 83,965,113(+) G/A
NM_182981.3(OSGIN1):c.540G>A (p.Arg180=)
SYNONYMOUS
rs148139055 Benign: not provided 83,957,708(+) A/C
NM_182981.3(OSGIN1):c.37A>C (p.Ser13Arg)
MISSENSE
rs76469730 Benign: not provided 83,965,089(+) C/T
NM_182981.3(OSGIN1):c.516C>T (p.Ala172=)
SYNONYMOUS
rs35145453 - p.Glu356Asp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OSGIN1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OSGIN1 Gene

Variant ID Type Subtype PubMed ID
dgv3056n100 CNV loss 25217958
dgv5259n54 CNV loss 21841781
esv3639403 CNV loss 21293372
nsv1065790 CNV loss 25217958
nsv471106 CNV gain 18288195
nsv517566 CNV gain+loss 19592680
nsv528396 CNV loss 19592680
nsv573409 CNV loss 21841781

Variation tolerance for OSGIN1 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OSGIN1 Gene

Human Gene Mutation Database (HGMD)
OSGIN1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSGIN1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSGIN1 Gene

Disorders for OSGIN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OSGIN1 Gene - From: COP

Disorder Aliases PubMed IDs
cervical polyp
  • cervix adenomatous polyp
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OSGIN1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with OSGIN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OSGIN1 Gene

Publications for OSGIN1 Gene

  1. Genomic structure of human OKL38 gene and its differential expression in kidney carcinogenesis. (PMID: 14570898) Ong CK … Huynh H (The Journal of biological chemistry 2004) 2 3 4
  2. Cloning and characterization of a novel pregnancy-induced growth inhibitor in mammary gland. (PMID: 11459809) Huynh H … Chan TW (Endocrinology 2001) 2 3 4
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 41
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 41
  5. OKL38 is an oxidative stress response gene stimulated by oxidized phospholipids. (PMID: 17192422) Li R … Berliner JA (Journal of lipid research 2007) 3 23

Products for OSGIN1 Gene

Sources for OSGIN1 Gene