Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OSER1 Gene

Aliases for OSER1 Gene

  • Oxidative Stress Responsive Serine Rich 1 2 3 5
  • Peroxide-Inducible Transcript 1 Protein 3 4
  • Oxidative Stress-Responsive Protein 1 3 4
  • Oxidative Stress-Responsive 1 2 3
  • C20orf111 3 4
  • Oxidative Stress-Responsive Serine-Rich Protein 1 3
  • Oxidative Stress Responsive Serine-Rich 1 2
  • Chromosome 20 Open Reading Frame 111 2
  • Peroxide-Inducible Transcript 1 2
  • DJ1183I21.1 3
  • HSPC207 3
  • Perit1 3
  • Osr1 3

External Ids for OSER1 Gene

Previous HGNC Symbols for OSER1 Gene

  • C20orf111

Previous GeneCards Identifiers for OSER1 Gene

  • GC20M042824

Summaries for OSER1 Gene

GeneCards Summary for OSER1 Gene

OSER1 (Oxidative Stress Responsive Serine Rich 1) is a Protein Coding gene.

Additional gene information for OSER1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSER1 Gene

Genomics for OSER1 Gene

GeneHancer (GH) Regulatory Elements for OSER1 Gene

Promoters and enhancers for OSER1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J044206 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 670.3 +1.0 1017 6.1 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 OSER1 OSER1-DT SRSF6 IFT52 RPL27AP LINC01728 ENSG00000237555 FITM2 L3MBTL1 KCNK15
GH20J044173 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 30.8 +29.1 29120 15.7 HDGF PKNOX1 MLX YBX1 DMAP1 ZNF48 TCF12 ZNF121 ZNF207 MCM5 JPH2 SRSF6 OSER1 L3MBTL1 FITM2 IFT52 SGK2 OSER1-DT GC20P044130
GH20J043656 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 26.3 +553.2 553227 2.8 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 MYBL2 GC20P043655 IFT52 OSER1 SRSF6 SGK2 L3MBTL1 GC20M043632
GH20J044745 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 20.8 -536.1 -536065 2.7 PKNOX1 ARNT SIN3A ZNF2 BRCA1 ZNF48 ZNF143 ZFP91 RUNX3 REST KCNK15 ENSG00000276223 KCNK15-AS1 OSER1 PIGT GC20P044749
GH20J044392 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.8 -183.9 -183857 4.9 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 PAF1 SP5 NFYC GC20P044393 HNF4A-AS1 OSER1 HNF4A LINC01430 LINC01620 OSER1-DT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OSER1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OSER1 Gene

Genomic Locations for OSER1 Gene
chr20:44,195,939-44,210,906
(GRCh38/hg38)
Size:
14,968 bases
Orientation:
Minus strand
chr20:42,824,579-42,839,546
(GRCh37/hg19)
Size:
14,968 bases
Orientation:
Minus strand

Genomic View for OSER1 Gene

Genes around OSER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSER1 Gene

Proteins for OSER1 Gene

  • Protein details for OSER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX31-OSER1_HUMAN
    Recommended name:
    Oxidative stress-responsive serine-rich protein 1
    Protein Accession:
    Q9NX31
    Secondary Accessions:
    • B2RCK4
    • O95912
    • Q9NZ84
    • Q9P0R8

    Protein attributes for OSER1 Gene

    Size:
    292 amino acids
    Molecular mass:
    31779 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF36127.1; Type=Frameshift; Positions=201, 195; Evidence={ECO:0000305}; Sequence=AAF67625.1; Type=Frameshift; Positions=201, 287; Evidence={ECO:0000305}; Sequence=BAA91191.1; Type=Frameshift; Positions=183; Evidence={ECO:0000305};

neXtProt entry for OSER1 Gene

Post-translational modifications for OSER1 Gene

  • Ubiquitination at isoforms=190 and Lys59
  • Modification sites at PhosphoSitePlus

Other Protein References for OSER1 Gene

No data available for DME Specific Peptides for OSER1 Gene

Domains & Families for OSER1 Gene

Gene Families for OSER1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OSER1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OSER1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for OSER1 Gene

Function for OSER1 Gene

Phenotypes From GWAS Catalog for OSER1 Gene

genes like me logo Genes that share phenotypes with OSER1: view

Animal Model Products

CRISPR Products

miRNA for OSER1 Gene

miRTarBase miRNAs that target OSER1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OSER1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OSER1 Gene

Localization for OSER1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSER1 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Nucleoli (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OSER1 Gene

Pathways & Interactions for OSER1 Gene

SuperPathways for OSER1 Gene

No Data Available

Interacting Proteins for OSER1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000255174%0d%0a9606.ENSP00000317619%0d%0a9606.ENSP00000363993%0d%0a
Selected Interacting proteins: Q9NX31-OSER1_HUMAN ENSP00000255174 for OSER1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for OSER1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OSER1 Gene

Drugs & Compounds for OSER1 Gene

No Compound Related Data Available

Transcripts for OSER1 Gene

mRNA/cDNA for OSER1 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OSER1

Alternative Splicing Database (ASD) splice patterns (SP) for OSER1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e
SP1: - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - - - -
SP7:

Relevant External Links for OSER1 Gene

GeneLoc Exon Structure for
OSER1
ECgene alternative splicing isoforms for
OSER1

Expression for OSER1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OSER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OSER1 Gene

This gene is overexpressed in Whole Blood (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OSER1 Gene



NURSA nuclear receptor signaling pathways regulating expression of OSER1 Gene:

OSER1

Evidence on tissue expression from TISSUES for OSER1 Gene

  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with OSER1: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSER1 Gene

Orthologs for OSER1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSER1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSER1 34
  • 100 (a)
OneToOne
C20H20orf111 33
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia C24H20orf111 33
  • 94.29 (n)
OSER1 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSER1 34 33
  • 91.64 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Oser1 16 34 33
  • 87.86 (n)
rat
(Rattus norvegicus)
Mammalia Oser1 33
  • 87.4 (n)
oppossum
(Monodelphis domestica)
Mammalia OSER1 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSER1 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves C20H20ORF111 34 33
  • 69.63 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSER1 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oser1 33
  • 62.51 (n)
MGC76290 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8276 33
zebrafish
(Danio rerio)
Actinopterygii oser1 34 33
  • 54.8 (n)
OneToOne
-- 33
Species where no ortholog for OSER1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSER1 Gene

ENSEMBL:
Gene Tree for OSER1 (if available)
TreeFam:
Gene Tree for OSER1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OSER1: view image

Paralogs for OSER1 Gene

No data available for Paralogs for OSER1 Gene

Variants for OSER1 Gene

Sequence variations from dbSNP and Humsavar for OSER1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000152439 -- 44,214,647(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000369003 -- 44,209,140(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000503330 -- 44,215,698(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000611942 -- 44,210,251(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000681052 -- 44,210,380(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OSER1 Gene

Variant ID Type Subtype PubMed ID
nsv1057847 CNV loss 25217958
nsv507908 OTHER sequence alteration 20534489

Variation tolerance for OSER1 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.40; 92.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OSER1 Gene

Human Gene Mutation Database (HGMD)
OSER1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSER1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSER1 Gene

Disorders for OSER1 Gene

Additional Disease Information for OSER1

No disorders were found for OSER1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSER1 Gene

Publications for OSER1 Gene

  1. TargetLink, a new method for identifying the endogenous target set of a specific microRNA in intact living cells. (PMID: 27982722) Xu Y … Li WH (RNA biology 2017) 2 3 58
  2. Cardiac myocyte gene expression profiling during H2O2-induced apoptosis. (PMID: 17148688) Clerk A … Sugden PH (Physiological genomics 2007) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58

Products for OSER1 Gene

Sources for OSER1 Gene

Content
Loading form....