Aliases for OSCP1 Gene

Aliases for OSCP1 Gene

  • Organic Solute Carrier Partner 1 2 3 5
  • Oxidored-Nitro Domain-Containing Protein 1 3 4
  • Oxidored Nitro Domain Containing Protein 2 3
  • Organic Solute Transport Protein 1 3 4
  • Protein OSCP1 3 4
  • C1orf102 3 4
  • NOR1 3 4
  • Chromosome 1 Open Reading Frame 102 2
  • Organic Solute Carrier Protein 1 3
  • HOSCP1 4

External Ids for OSCP1 Gene

Previous HGNC Symbols for OSCP1 Gene

  • C1orf102

Previous GeneCards Identifiers for OSCP1 Gene

  • GC01M036658
  • GC01M036881
  • GC01M035001

Summaries for OSCP1 Gene

GeneCards Summary for OSCP1 Gene

OSCP1 (Organic Solute Carrier Partner 1) is a Protein Coding gene. Diseases associated with OSCP1 include Nasopharyngeal Carcinoma.

UniProtKB/Swiss-Prot Summary for OSCP1 Gene

Additional gene information for OSCP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OSCP1 Gene

Genomics for OSCP1 Gene

GeneHancer (GH) Regulatory Elements for OSCP1 Gene

Promoters and enhancers for OSCP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J036449 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 507.2 -0.2 -216 1.8 ZBTB40 EP300 CTCF SIN3A TCF12 POLR2G SP1 PHF8 ZFX ZNF639 OSCP1 lnc-SH3D21-1 SNORA63C LSM10 AGO3 lnc-SH3D21-4
GH01J036450 Enhancer 0.2 ENCODE 507.2 +1.2 1196 0.3 OSCP1 lnc-SH3D21-1 SNORA63C LSM10 HSALNG0002577
GH01J036383 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.4 +62.8 62776 8.6 EP300 ZBTB40 ZNF217 NRF1 MYC TCF12 POLR2G SP1 NCOR1 GTF2E2 STK40 lnc-LSM10-2 lnc-SH3D21-7 EVA1B THRAP3 CSF3R ENSG00000271554 SH3D21 AGO3 COL8A2
GH01J036481 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 18 -32.0 -32036 2.8 ZBTB25 ZNF740 ZSCAN9 KMT2B SIN3A NCOR1 SRSF1 CEBPB TARDBP KAT7 CSF3R lnc-MRPS15-2 OSCP1 SNORA63C lnc-MRPS15-1
GH01J036463 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 12.8 -14.1 -14086 3.1 EP300 ZBTB40 ZNF217 SIN3A TCF12 NRF1 MYC USF1 POLR2G SP1 MRPS15 lnc-SH3D21-9 AGO3 STK40 THRAP3 OSCP1 lnc-MRPS15-1 CSF3R
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OSCP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OSCP1

Genomic Locations for OSCP1 Gene

Genomic Locations for OSCP1 Gene
chr1:36,415,827-36,450,485
(GRCh38/hg38)
Size:
34,659 bases
Orientation:
Minus strand
chr1:36,881,428-36,916,086
(GRCh37/hg19)
Size:
34,659 bases
Orientation:
Minus strand

Genomic View for OSCP1 Gene

Genes around OSCP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSCP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSCP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSCP1 Gene

Proteins for OSCP1 Gene

  • Protein details for OSCP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVF1-OSCP1_HUMAN
    Recommended name:
    Protein OSCP1
    Protein Accession:
    Q8WVF1
    Secondary Accessions:
    • A6NHM5
    • A6NHS9
    • A6NIN9
    • Q4AEJ0
    • Q8N7G2
    • Q8TDF1

    Protein attributes for OSCP1 Gene

    Size:
    389 amino acids
    Molecular mass:
    44586 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • May be involved in the development and/or progression of nosopharyngeal carcinoma.
    SequenceCaution:
    • Sequence=AAL89738.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for OSCP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSCP1 Gene

Post-translational modifications for OSCP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OSCP1 Gene

Domains & Families for OSCP1 Gene

Gene Families for OSCP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for OSCP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OSCP1 Gene

GenScript: Design optimal peptide antigens:
  • Oxidored-nitro domain-containing protein 1 (OSCP1_HUMAN)
genes like me logo Genes that share domains with OSCP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for OSCP1 Gene

Function for OSCP1 Gene

Molecular function for OSCP1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in drug clearance in the placenta.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=35.0 uM for p-aminohippurate (PAH) {ECO:0000269 PubMed:16006562}; KM=62.3 uM for tetraethylammonium {ECO:0000269 PubMed:16006562}; Note=In Xenopus laevis oocytes, in a sodium-independent manner.;

Phenotypes From GWAS Catalog for OSCP1 Gene

Gene Ontology (GO) - Molecular Function for OSCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IMP 16006562
genes like me logo Genes that share ontologies with OSCP1: view
genes like me logo Genes that share phenotypes with OSCP1: view

Animal Models for OSCP1 Gene

MGI Knock Outs for OSCP1:
  • Oscp1 Oscp1<tm1b(EUCOMM)Hmgu>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OSCP1 Gene

Localization for OSCP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSCP1 Gene

Basal cell membrane. Note=Syncytiotrophoblast in placenta.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSCP1 gene
Compartment Confidence
plasma membrane 5
nucleus 3
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
cytoskeleton 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OSCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19727524
GO:0005886 plasma membrane IEA --
GO:0009925 basal plasma membrane IDA,IEA 16006562
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with OSCP1: view

Pathways & Interactions for OSCP1 Gene

PathCards logo

SuperPathways for OSCP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1990961 drug transmembrane export IMP 16006562
genes like me logo Genes that share ontologies with OSCP1: view

No data available for Pathways by source and SIGNOR curated interactions for OSCP1 Gene

Drugs & Compounds for OSCP1 Gene

(1) Additional Compounds for OSCP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Na(+)
  • Na+
  • SODIUM ion
7440-23-5
genes like me logo Genes that share compounds with OSCP1: view

Transcripts for OSCP1 Gene

mRNA/cDNA for OSCP1 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSCP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: -
SP7: -
SP8:
SP9:

Relevant External Links for OSCP1 Gene

GeneLoc Exon Structure for
OSCP1

Expression for OSCP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OSCP1 Gene

mRNA differential expression in normal tissues according to GTEx for OSCP1 Gene

This gene is overexpressed in Testis (x6.7).

Protein differential expression in normal tissues from HIPED for OSCP1 Gene

This gene is overexpressed in Testis (29.5), Liver, secretome (15.7), and Frontal cortex (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OSCP1 Gene



Protein tissue co-expression partners for OSCP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OSCP1

SOURCE GeneReport for Unigene cluster for OSCP1 Gene:

Hs.202207

mRNA Expression by UniProt/SwissProt for OSCP1 Gene:

Q8WVF1-OSCP1_HUMAN
Tissue specificity: Expressed predominantly in testis, also found in placenta and to a lesser extent in thymus and small intestine; abundantly expressed in tumor-derived cell lines (PubMed:16006562). Ubiquitously expressed (PubMed:12819961).

Evidence on tissue expression from TISSUES for OSCP1 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with OSCP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSCP1 Gene

Orthologs for OSCP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OSCP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSCP1 31
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSCP1 31 30
  • 89.15 (n)
OneToOne
cow
(Bos Taurus)
Mammalia OSCP1 31 30
  • 88.65 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oscp1 30
  • 86.63 (n)
mouse
(Mus musculus)
Mammalia Oscp1 17 31 30
  • 85.49 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OSCP1 31
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OSCP1 31
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves OSCP1 31 30
  • 76.52 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSCP1 31
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oscp1 30
  • 71.06 (n)
Str.15507 30
zebrafish
(Danio rerio)
Actinopterygii OSCP1 (2 of 2) 31
  • 73 (a)
OneToMany
LOC100334608 30
  • 70.36 (n)
oscp1a 31
  • 57 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011836 30
  • 48.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13178 31 30
  • 48.85 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R10F2.5 31 30
  • 50.53 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
OneToOne
Species where no ortholog for OSCP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSCP1 Gene

ENSEMBL:
Gene Tree for OSCP1 (if available)
TreeFam:
Gene Tree for OSCP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OSCP1: view image

Paralogs for OSCP1 Gene

No data available for Paralogs for OSCP1 Gene

Variants for OSCP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OSCP1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs11547025 - p.Pro31Arg
rs2359016 - p.Lys242Glu
rs34409118 - p.Thr141Ala

Additional dbSNP identifiers (rs#s) for OSCP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OSCP1 Gene

Variant ID Type Subtype PubMed ID
dgv28e212 CNV loss 25503493
esv2758931 CNV loss 17122850
esv3577808 CNV loss 25503493
nsv509202 CNV insertion 20534489

Variation tolerance for OSCP1 Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.95; 93.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OSCP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSCP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSCP1 Gene

Disorders for OSCP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OSCP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
nasopharyngeal carcinoma
  • npc
- elite association - COSMIC cancer census association via MalaCards
Search OSCP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OSCP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OSCP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OSCP1 Gene

Publications for OSCP1 Gene

  1. Cloning, expression, and mutation analysis of NOR1, a novel human gene down-regulated in HNE1 nasopharyngeal carcinoma cell line. (PMID: 12819961) Nie X … Li G (Journal of cancer research and clinical oncology 2003) 2 3 4 23 54
  2. Isolation and functional characterization of a novel organic solute carrier protein, hOSCP1. (PMID: 16006562) Kobayashi Y … Yamamoto T (The Journal of biological chemistry 2005) 2 3 4 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. Preparation of polyclonal antibody specific for NOR1 and detection of its expression pattern in human tissues and nasopharyngeal carcinoma. (PMID: 19727524) Xiang B … Li G (Acta biochimica et biophysica Sinica 2009) 3 23 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for OSCP1 Gene

Sources for OSCP1 Gene