Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated ath... See more...

Aliases for OSCAR Gene

Aliases for OSCAR Gene

  • Osteoclast Associated Ig-Like Receptor 2 3 5
  • Osteoclast Associated, Immunoglobulin-Like Receptor 2 3
  • Osteoclast-Associated Immunoglobulin-Like Receptor 3 4
  • Polymeric Immunoglobulin Receptor 3 3 4
  • Poly-Ig Receptor 3 3 4
  • PIgR-3 3 4
  • Osteoclast Associated Receptor OSCAR-S1 3
  • Osteoclast Associated Receptor OSCAR-S2 3
  • Osteoclast-Associated Receptor 4
  • HOSCAR 4
  • PIGR3 3
  • OSCAR 5
  • PIgR3 4

External Ids for OSCAR Gene

Previous GeneCards Identifiers for OSCAR Gene

  • GC19M055243
  • GC19M055022
  • GC19M059273
  • GC19M059289
  • GC19M054597
  • GC19M050913

Summaries for OSCAR Gene

Entrez Gene Summary for OSCAR Gene

  • Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for OSCAR Gene

OSCAR (Osteoclast Associated Ig-Like Receptor) is a Protein Coding gene. Diseases associated with OSCAR include Mucinous Tubular And Spindle Renal Cell Carcinoma and Decubitus Ulcer. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is IGSF1.

UniProtKB/Swiss-Prot Summary for OSCAR Gene

  • Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.

Gene Wiki entry for OSCAR Gene

Additional gene information for OSCAR Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OSCAR Gene

Genomics for OSCAR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OSCAR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J054102 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 614.1 -0.4 -409 3.4 CREB1 PRDM10 SIX5 IKZF1 KDM1A ZNF692 POLR2A RCOR2 ZHX2 ZNF143 OSCAR NDUFA3 TMC4 CNOT3 HSALNG0127466 PRPF31
GH19J054095 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 607.1 +4.4 4391 5.8 RNF2 HNRNPL TFE3 ZNF512 CTCF ZNF692 LARP7 MTA2 PRDM1 PKNOX1 OSCAR CNOT3 NDUFA3 LENG8-AS1 ZNF525 LENG8 PRPF31 ENSG00000235681 ZNF761 ZNF160
GH19J054114 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.7 -12.5 -12509 4 BRCA1 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 SIX5 LEF1 IKZF1 PRPF31 TFPT lnc-OSCAR-1 piR-58943 CNOT3 LENG8-AS1 LENG8 ZNF765 ZNF845 ZNF525
GH19J054199 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.1 -102.9 -102897 12.4 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 REST TFE3 RPS9 PRPF31 LENG8-AS1 LENG8 CNOT3 ZNF525 ENSG00000235681 ZNF845 ZNF761 ZNF765
GH19J054018 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 11.7 +81.6 81575 6.8 CREB1 CTCF REST ZNF512 LEF1 IKZF1 JUND ETV6 RFX1 PKNOX1 LILRB3 VSTM1 LILRA5 OSCAR MYADM LILRB2 NLRP12 LAIR1 CACNG8 LILRA6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OSCAR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OSCAR

Top Transcription factor binding sites by QIAGEN in the OSCAR gene promoter:
  • AML1a
  • AP-1
  • COMP1
  • NF-1
  • NF-1/L
  • Pax-2
  • Pax-2a
  • PPAR-gamma1
  • PPAR-gamma2
  • YY1

Genomic Locations for OSCAR Gene

Genomic Locations for OSCAR Gene
chr19:54,094,668-54,102,692
(GRCh38/hg38)
Size:
8,025 bases
Orientation:
Minus strand
chr19:54,597,933-54,606,000
(GRCh37/hg19)
Size:
8,068 bases
Orientation:
Minus strand

Genomic View for OSCAR Gene

Genes around OSCAR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSCAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSCAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSCAR Gene

Proteins for OSCAR Gene

  • Protein details for OSCAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYS5-OSCAR_HUMAN
    Recommended name:
    Osteoclast-associated immunoglobulin-like receptor
    Protein Accession:
    Q8IYS5
    Secondary Accessions:
    • B7WNS2
    • Q5GRG5
    • Q8N763
    • Q8NHL4
    • Q8WXQ0
    • Q8WXQ1
    • Q8WXQ2

    Protein attributes for OSCAR Gene

    Size:
    282 amino acids
    Molecular mass:
    30481 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for OSCAR Gene

    Alternative splice isoforms for OSCAR Gene

neXtProt entry for OSCAR Gene

Post-translational modifications for OSCAR Gene

  • Glycosylation at Asn48 and Asn145

No data available for DME Specific Peptides for OSCAR Gene

Domains & Families for OSCAR Gene

Gene Families for OSCAR Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for OSCAR Gene

Suggested Antigen Peptide Sequences for OSCAR Gene

GenScript: Design optimal peptide antigens:
  • Polymeric immunoglobulin receptor 3 (OSCAR_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IYS5

UniProtKB/Swiss-Prot:

OSCAR_HUMAN :
  • Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family.
Family:
  • Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family.
genes like me logo Genes that share domains with OSCAR: view

Function for OSCAR Gene

Molecular function for OSCAR Gene

UniProtKB/Swiss-Prot Function:
Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.

Phenotypes From GWAS Catalog for OSCAR Gene

Gene Ontology (GO) - Molecular Function for OSCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038064 collagen receptor activity IEA,IMP 21841309
genes like me logo Genes that share ontologies with OSCAR: view
genes like me logo Genes that share phenotypes with OSCAR: view

Animal Models for OSCAR Gene

MGI Knock Outs for OSCAR:

Animal Model Products

  • Taconic Biosciences Mouse Models for OSCAR

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OSCAR

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OSCAR Gene

Localization for OSCAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSCAR Gene

[Isoform 1]: Secreted.
[Isoform 2]: Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSCAR gene
Compartment Confidence
plasma membrane 4
extracellular 4
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OSCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OSCAR: view

Pathways & Interactions for OSCAR Gene

genes like me logo Genes that share pathways with OSCAR: view

Gene Ontology (GO) - Biological Process for OSCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030316 osteoclast differentiation IEA,IMP 21841309
GO:0032623 interleukin-2 production IEA --
GO:0038065 collagen-activated signaling pathway IEA --
GO:0038094 Fc-gamma receptor signaling pathway IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with OSCAR: view

No data available for SIGNOR curated interactions for OSCAR Gene

Drugs & Compounds for OSCAR Gene

(1) Drugs for OSCAR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with OSCAR: view

Transcripts for OSCAR Gene

mRNA/cDNA for OSCAR Gene

7 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OSCAR

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSCAR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - - -
SP2: - - -
SP3: -
SP4: - - - -
SP5: -
SP6: - -

Relevant External Links for OSCAR Gene

GeneLoc Exon Structure for
OSCAR

Expression for OSCAR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OSCAR Gene

mRNA differential expression in normal tissues according to GTEx for OSCAR Gene

This gene is overexpressed in Whole Blood (x35.1).

Protein differential expression in normal tissues from HIPED for OSCAR Gene

This gene is overexpressed in Urine (54.4), Serum (7.4), and Monocytes (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OSCAR Gene



Protein tissue co-expression partners for OSCAR Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OSCAR

SOURCE GeneReport for Unigene cluster for OSCAR Gene:

Hs.347655

Evidence on tissue expression from TISSUES for OSCAR Gene

  • Bone(2.5)
  • Blood(2.5)
  • Bone marrow(2.4)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with OSCAR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSCAR Gene

Orthologs for OSCAR Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSCAR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OSCAR 30 31
  • 99.13 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OSCAR 30 31
  • 84.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia OSCAR 30 31
  • 83.2 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Oscar 30 17 31
  • 75.2 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Oscar 30
  • 73.2 (n)
Oppossum
(Monodelphis domestica)
Mammalia OSCAR 31
  • 51 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia OSCAR 31
  • 45 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 11 (a)
OneToMany
Species where no ortholog for OSCAR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OSCAR Gene

ENSEMBL:
Gene Tree for OSCAR (if available)
TreeFam:
Gene Tree for OSCAR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OSCAR: view image

Paralogs for OSCAR Gene

(1) SIMAP similar genes for OSCAR Gene using alignment to 2 proteins:

  • OSCAR_HUMAN
  • A8MWV3_HUMAN
genes like me logo Genes that share paralogs with OSCAR: view

Variants for OSCAR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OSCAR Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1657535 - p.Ile97Ser
rs8106130 - p.Ser229Tyr

Additional dbSNP identifiers (rs#s) for OSCAR Gene

Structural Variations from Database of Genomic Variants (DGV) for OSCAR Gene

Variant ID Type Subtype PubMed ID
dgv3653n100 CNV gain 25217958
esv1149991 CNV insertion 17803354
esv2718812 CNV deletion 23290073
esv3556615 CNV deletion 23714750
esv3893246 CNV gain 25118596
nsv1056177 CNV gain 25217958
nsv182 CNV deletion 15895083
nsv2542 CNV deletion 18451855
nsv470157 CNV loss 18288195
nsv510773 CNV deletion 20534489
nsv833877 CNV loss 17160897
nsv953613 CNV deletion 24416366

Variation tolerance for OSCAR Gene

Gene Damage Index Score: 3.79; 58.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OSCAR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSCAR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSCAR Gene

Disorders for OSCAR Gene

MalaCards: The human disease database

(7) MalaCards diseases for OSCAR Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
mucinous tubular and spindle renal cell carcinoma
  • mucinous tubular and spindle cell renal carcinoma
decubitus ulcer
  • bedsore
chronic ulcer of skin
  • chronic wounds
malignant biphasic mesothelioma
  • mesothelioma, biphasic, malignant
inflammatory liposarcoma
- elite association - COSMIC cancer census association via MalaCards
Search OSCAR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OSCAR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with OSCAR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OSCAR Gene

Publications for OSCAR Gene

  1. A novel member of the leukocyte receptor complex regulates osteoclast differentiation. (PMID: 11805147) Kim N … Choi Y (The Journal of experimental medicine 2002) 2 3 4 23
  2. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 41
  3. Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis. (PMID: 18821671) Herman S … Schett G (Arthritis and rheumatism 2008) 3 23
  4. Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. (PMID: 16109714) Kim K … Kim N (The Journal of biological chemistry 2005) 3 23
  5. Association of the OSCAR promoter polymorphism with BMD in postmenopausal women. (PMID: 16007331) Kim GS … Shin HD (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005) 3 23

Products for OSCAR Gene

  • Signalway ELISA kits for OSCAR

Sources for OSCAR Gene