Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OSBPL7 Gene

Aliases for OSBPL7 Gene

  • Oxysterol Binding Protein Like 7 2 3 5
  • Oxysterol-Binding Protein-Related Protein 7 3 4
  • OSBP-Related Protein 7 3 4
  • ORP-7 3 4
  • ORP7 3 4
  • Oxysterol Binding Protein-Like 7 2
  • AC003665.1 5

External Ids for OSBPL7 Gene

Previous GeneCards Identifiers for OSBPL7 Gene

  • GC17M045590
  • GC17M048365
  • GC17M046226
  • GC17M046359
  • GC17M043239
  • GC17M045884
  • GC17M041255

Summaries for OSBPL7 Gene

Entrez Gene Summary for OSBPL7 Gene

  • This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for OSBPL7 Gene

OSBPL7 (Oxysterol Binding Protein Like 7) is a Protein Coding gene. Among its related pathways are Synthesis of bile acids and bile salts and Metabolism. Gene Ontology (GO) annotations related to this gene include cholesterol binding. An important paralog of this gene is OSBPL6.

Additional gene information for OSBPL7 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL7 Gene

Genomics for OSBPL7 Gene

GeneHancer (GH) Regulatory Elements for OSBPL7 Gene

Promoters and enhancers for OSBPL7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OSBPL7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OSBPL7 gene promoter:
  • Arnt
  • GATA-2
  • HOXA5
  • LyF-1
  • NF-E2
  • NF-E2 p45
  • NF-kappaB
  • NF-kappaB1
  • Pax-5
  • STAT5A

Genomic Locations for OSBPL7 Gene

Genomic Locations for OSBPL7 Gene
chr17:47,807,367-47,821,834
(GRCh38/hg38)
Size:
14,468 bases
Orientation:
Minus strand
chr17:45,884,733-45,899,200
(GRCh37/hg19)
Size:
14,468 bases
Orientation:
Minus strand

Genomic View for OSBPL7 Gene

Genes around OSBPL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OSBPL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OSBPL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSBPL7 Gene

Proteins for OSBPL7 Gene

  • Protein details for OSBPL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZF2-OSBL7_HUMAN
    Recommended name:
    Oxysterol-binding protein-related protein 7
    Protein Accession:
    Q9BZF2
    Secondary Accessions:
    • D3DTT6
    • Q6PIV6

    Protein attributes for OSBPL7 Gene

    Size:
    842 amino acids
    Molecular mass:
    95432 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OSBPL7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OSBPL7 Gene

Post-translational modifications for OSBPL7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OSBPL7 Gene

Domains & Families for OSBPL7 Gene

Gene Families for OSBPL7 Gene

Suggested Antigen Peptide Sequences for OSBPL7 Gene

GenScript: Design optimal peptide antigens:
  • Oxysterol-binding protein-related protein 7 (OSBL7_HUMAN)
  • cDNA FLJ76993, highly similar to Homo sapiens oxysterol binding protein-like 7, mRNA (Q6PIV6_HUMAN)
  • Oxysterol-binding protein (Q8WXP9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BZF2

UniProtKB/Swiss-Prot:

OSBL7_HUMAN :
  • Belongs to the OSBP family.
Family:
  • Belongs to the OSBP family.
genes like me logo Genes that share domains with OSBPL7: view

Function for OSBPL7 Gene

Phenotypes From GWAS Catalog for OSBPL7 Gene

Gene Ontology (GO) - Molecular Function for OSBPL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21669198
GO:0008289 lipid binding IBA 21873635
GO:0015248 sterol transporter activity IBA 21873635
GO:0015485 cholesterol binding IDA 17428193
GO:0032934 sterol binding IBA 21873635
genes like me logo Genes that share ontologies with OSBPL7: view
genes like me logo Genes that share phenotypes with OSBPL7: view

Animal Model Products

CRISPR Products

miRNA for OSBPL7 Gene

miRTarBase miRNAs that target OSBPL7

Clone Products

  • Applied Biological Materials (abm): Clones for OSBPL7 - Now 50% OFF >
  • * OSBPL7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OSBPL7 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OSBPL7 Gene

Localization for OSBPL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSBPL7 Gene

Cytoplasm, cytosol. Endoplasmic reticulum membrane. Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OSBPL7 gene
Compartment Confidence
cytosol 5
plasma membrane 4
endoplasmic reticulum 4
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OSBPL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005776 autophagosome IDA 21669198
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with OSBPL7: view

Pathways & Interactions for OSBPL7 Gene

genes like me logo Genes that share pathways with OSBPL7: view

Gene Ontology (GO) - Biological Process for OSBPL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006699 bile acid biosynthetic process TAS --
GO:0006869 lipid transport IEA --
GO:0010506 regulation of autophagy NAS 21669198
GO:0015918 sterol transport IEA --
GO:0071397 cellular response to cholesterol IMP 21669198
genes like me logo Genes that share ontologies with OSBPL7: view

No data available for SIGNOR curated interactions for OSBPL7 Gene

Drugs & Compounds for OSBPL7 Gene

No Compound Related Data Available

Transcripts for OSBPL7 Gene

mRNA/cDNA for OSBPL7 Gene

Unigene Clusters for OSBPL7 Gene

Oxysterol binding protein-like 7:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for OSBPL7 - Now 50% OFF >
  • * OSBPL7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OSBPL7 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for OSBPL7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - -
SP2: - - - - - - - - -
SP3:
SP4: - -
SP5:
SP6:
SP7: - - - - - - - - - - - - - - - - - -
SP8:
SP9:

ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b · 23c
SP1:
SP2: - - - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for OSBPL7 Gene

GeneLoc Exon Structure for
OSBPL7
ECgene alternative splicing isoforms for
OSBPL7

Expression for OSBPL7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OSBPL7 Gene

Protein differential expression in normal tissues from HIPED for OSBPL7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.0), CD8 Tcells (17.6), Frontal cortex (7.1), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OSBPL7 Gene



Protein tissue co-expression partners for OSBPL7 Gene

NURSA nuclear receptor signaling pathways regulating expression of OSBPL7 Gene:

OSBPL7

SOURCE GeneReport for Unigene cluster for OSBPL7 Gene:

Hs.463320

mRNA Expression by UniProt/SwissProt for OSBPL7 Gene:

Q9BZF2-OSBL7_HUMAN
Tissue specificity: Expressed in epithelium of small and large intestines (at protein level). Expressed in stomach, duodenum, jejunum, ascending colon, spleen, thymus, lymph node, trachea and leukocytes.

Evidence on tissue expression from TISSUES for OSBPL7 Gene

  • Nervous system(4.2)
  • Blood(4.1)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with OSBPL7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OSBPL7 Gene

Orthologs for OSBPL7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OSBPL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSBPL7 35 34
  • 97.94 (n)
OneToOne
cow
(Bos Taurus)
Mammalia OSBPL7 35 34
  • 90.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OSBPL7 35 34
  • 90.1 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSBPL7 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osbpl7 34
  • 87.67 (n)
mouse
(Mus musculus)
Mammalia Osbpl7 17 35 34
  • 87.57 (n)
oppossum
(Monodelphis domestica)
Mammalia OSBPL7 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves OSBPL7 35 34
  • 69.71 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OSBPL7 35
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii osbpl7 35
  • 42 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3351 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6737 35
  • 35 (a)
OneToMany
Species where no ortholog for OSBPL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OSBPL7 Gene

ENSEMBL:
Gene Tree for OSBPL7 (if available)
TreeFam:
Gene Tree for OSBPL7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OSBPL7: view image

Paralogs for OSBPL7 Gene

(4) SIMAP similar genes for OSBPL7 Gene using alignment to 5 proteins:

  • OSBL7_HUMAN
  • J3QLK7_HUMAN
  • J3QSC2_HUMAN
  • Q6PIV6_HUMAN
  • Q8WXP9_HUMAN
genes like me logo Genes that share paralogs with OSBPL7: view

Variants for OSBPL7 Gene

Sequence variations from dbSNP and Humsavar for OSBPL7 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000044925 -- 47,811,436(-) C/T intron_variant
rs1000112481 -- 47,807,342(-) T/C downstream_transcript_variant
rs1000902711 -- 47,816,957(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000915323 -- 47,823,033(-) C/T upstream_transcript_variant
rs1001662639 -- 47,821,899(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OSBPL7 Gene

Variant ID Type Subtype PubMed ID
esv23195 CNV loss 19812545
nsv517880 CNV loss 19592680
nsv518892 CNV loss 19592680

Variation tolerance for OSBPL7 Gene

Residual Variation Intolerance Score: 16.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OSBPL7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OSBPL7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSBPL7 Gene

Disorders for OSBPL7 Gene

Additional Disease Information for OSBPL7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OSBPL7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSBPL7 Gene

Publications for OSBPL7 Gene

  1. Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7. (PMID: 14593528) Lehto M … Olkkonen VM (Cell and tissue research 2004) 2 3 4 23 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A family of 12 human genes containing oxysterol-binding domains. (PMID: 11735225) Jaworski CJ … Rodriguez IR (Genomics 2001) 2 3 58

Products for OSBPL7 Gene

Sources for OSBPL7 Gene

Content
Loading form....