Aliases for OSBPL11 Gene
Aliases for OSBPL11 Gene
External Ids for OSBPL11 Gene
- HGNC: 16397
- Entrez Gene: 114885
- Ensembl: ENSG00000144909
- OMIM: 606739
- UniProtKB: Q9BXB4
Previous GeneCards Identifiers for OSBPL11 Gene
- GC03M122014
- GC03M125278
- GC03M126529
- GC03M126568
- GC03M126730
- GC03M122623
Summaries for OSBPL11 Gene
-
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. [provided by RefSeq, Jul 2008]
GeneCards Summary for OSBPL11 Gene
OSBPL11 (Oxysterol Binding Protein Like 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include lipid binding. An important paralog of this gene is OSBPL10.
UniProtKB/Swiss-Prot for OSBPL11 Gene
-
Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193).
Additional gene information for OSBPL11 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSBPL11 Gene
Genomics for OSBPL11 Gene
GeneHancer (GH) Regulatory Elements for OSBPL11 Gene
Promoters and enhancers for OSBPL11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around OSBPL11 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the OSBPL11 gene promoter:
-
- IRF-7A
- Brachyury
- NCX
- RFX1
- ITF-2
- Tal-1beta
- E2F
- E2F-1
- GCNF
- GCNF-1
Regulatory Element Products
Genomic Locations for OSBPL11 Gene
Genomic Locations for OSBPL11 Gene
- chr3:125,528,858-125,595,537
- (GRCh38/hg38)
- Size:
- 66,680 bases
- Orientation:
- Minus strand
- chr3:125,247,702-125,314,381
- (GRCh37/hg19)
- Size:
- 66,680 bases
- Orientation:
- Minus strand
Genomic View for OSBPL11 Gene
Genes around OSBPL11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q21.2 by Entrez Gene
- 3q21.2 by HGNC
- 3q21.2 by Ensembl
OSBPL11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for OSBPL11 Gene
Proteins for OSBPL11 Gene
-
Protein details for OSBPL11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BXB4-OSB11_HUMAN
- Recommended name:
- Oxysterol-binding protein-related protein 11
- Protein Accession:
- Q9BXB4
- A8K9I7
Protein attributes for OSBPL11 Gene
- Size:
- 747 amino acids
- Molecular mass:
- 83643 Da
- Quaternary structure:
-
- Heterodimer with OSBPL9.
Protein Expression for OSBPL11 Gene
Post-translational modifications for OSBPL11 Gene
Other Protein References for OSBPL11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for OSBPL11
- Invitrogen Antibodies for OSBPL11 (AFLGC-OSBPL11)
- GeneTex OSBPL11 Antibody for OSBPL11
Protein Products
-
OriGene Purified Proteins for OSBPL11
- Search Origene for MassSpec and Protein Over-expression Lysates for OSBPL11
- Origene Custom Protein Services for OSBPL11
- antibodies-online: Search results for 5 available OSBPL11 Proteins ranked by validation data
- Compare Top OSBPL11 Proteins
-
Quality Products:
- Search GeneTex for Proteins for OSBPL11
-
Abcam proteins for OSBPL11
Assay Products
No data available for DME Specific Peptides for OSBPL11 Gene
Domains & Families for OSBPL11 Gene
Gene Families for OSBPL11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for OSBPL11 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for OSBPL11 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BXB4UniProtKB/Swiss-Prot:
OSB11_HUMAN :- The PH domain binds phosphoinositides.
- Belongs to the OSBP family.
- Domain:
-
- The PH domain binds phosphoinositides.
- Family:
-
- Belongs to the OSBP family.
Function for OSBPL11 Gene
Molecular function for OSBPL11 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008289 | lipid binding | IEA | -- |
Phenotypes for OSBPL11 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
-
OriGene CRISPR knockouts for OSBPL11
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- Applied Biological Materials CRISPR for OSBPL11
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for OSBPL11
- GenScript: Design CRISPR guide RNA sequences for OSBPL11
miRNA for OSBPL11 Gene
- miRTarBase miRNAs that target OSBPL11
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OSBPL11
- Browse OriGene Inhibitory RNA Products For OSBPL11
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- genomics-online: shRNA clones - Search results for available OSBPL11 gene related products
Clone Products
- Sino Biological Human cDNA Clone for OSBPL11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OSBPL11
- genomics-online: cdna clones - Search results for available OSBPL11 gene related products
- orf clones - Search results for available OSBPL11 gene related products
- Applied Biological Materials Clones for OSBPL11
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for OSBPL11
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OSBPL11 Gene
Localization for OSBPL11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for OSBPL11 Gene
- Late endosome membrane. Golgi apparatus, trans-Golgi network membrane. Note=Localizes at the Golgi-late endosome interface.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| golgi apparatus | 5 |
| endosome | 4 |
| cytosol | 3 |
- Golgi apparatus (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA,IDA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0031902 | late endosome membrane | IEA | -- |
Pathways & Interactions for OSBPL11 Gene
No Data Available
Interacting Proteins for OSBPL11 Gene
GPS-Prot Interaction Network for OSBPL11
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006869 | lipid transport | IEA | -- |
| GO:0010890 | positive regulation of sequestering of triglyceride | IMP | 23028956 |
| GO:0045444 | fat cell differentiation | IMP | 23028956 |
No data available for Pathways by source and SIGNOR curated interactions for OSBPL11 Gene
Transcripts for OSBPL11 Gene
mRNA/cDNA for OSBPL11 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (163) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000296220 4191 bps (uc003eic.4)
Unigene Clusters for OSBPL11 Gene
CRISPR Products
-
OriGene CRISPR knockouts for OSBPL11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OSBPL11
- genomics-online: gRNA clones - Search results for available OSBPL11 gene related products
- Applied Biological Materials CRISPR for OSBPL11
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for OSBPL11
- GenScript: Design CRISPR guide RNA sequences for OSBPL11
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OSBPL11
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OSBPL11
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Clone Products
- Sino Biological Human cDNA Clone for OSBPL11
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- genomics-online: cdna clones - Search results for available OSBPL11 gene related products
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- Applied Biological Materials Clones for OSBPL11
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for OSBPL11 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Adult Dopaminergic Neurons Substantia Nigra pars Compacta
-
Neurons
- Adult Dopaminergic Neurons Substantia Nigra pars Compacta
mRNA differential expression in normal tissues according to GTEx for OSBPL11 Gene
This gene is overexpressed in Muscle - Skeletal (x8.5).
This gene is overexpressed in Monocytes (25.8), Peripheral blood mononuclear cells (9.6), and Ovary (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OSBPL11 Gene
NURSA nuclear receptor signaling pathways regulating expression of OSBPL11 Gene:
OSBPL11SOURCE GeneReport for Unigene cluster for OSBPL11 Gene:
Hs.477440mRNA Expression by UniProt/SwissProt for OSBPL11 Gene:
Q9BXB4-OSB11_HUMAN
Tissue specificity:
Present at highest levels in ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Strong expression (at protein level) in epithelial cells of kidney tubules, testicular tubules, caecum, and skin (PubMed:20599956). Present at low levels in subcutaneous and visceral adipose tissue (at protein level)(PubMed:23028956).
Evidence on tissue expression from TISSUES for OSBPL11 Gene
- Liver(4.3)
- Skin(4.2)
Primer Products
-
OriGene qPCR primer pairs for OSBPL11
-
OriGene qPCR primer pairs and template standards for OSBPL11
- genomics-online: primer clones - Search results for available OSBPL11 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OSBPL11 Gene
Orthologs for OSBPL11 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | OSBPL11 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | OSBPL11 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | OSBPL11 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Osbpl11 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Osbpl11 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | OSBPL11 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | OSBPL11 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | OSBPL11 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | osbpl11 33 |
|
||
| Str.8471 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.13782 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | osbpl11 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG9205 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | OSH7 34 |
|
ManyToMany | |
| OSH6 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1971 34 |
|
OneToMany |
- Species where no ortholog for OSBPL11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for OSBPL11 Gene
- ENSEMBL:
- Gene Tree for OSBPL11 (if available)
- TreeFam:
- Gene Tree for OSBPL11 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for OSBPL11: view image
Paralogs for OSBPL11 Gene
Variants for OSBPL11 Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs746035150 | A breast cancer sample | 125,576,304(-) | G/A | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000132680 | -- | 125,584,971(-) | G/C/T | intron_variant | |
| rs1000157621 | -- | 125,544,740(-) | G/C | intron_variant | |
| rs1000169369 | -- | 125,541,182(-) | G/C | intron_variant | |
| rs1000182866 | -- | 125,566,476(-) | C/T | intron_variant |
Residual Variation Intolerance Score:
10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.88;
18.33% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for OSBPL11 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- OSBPL11
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSBPL11 Gene
Disorders for OSBPL11 Gene
Additional Disease Information for OSBPL11
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for OSBPL11 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OSBPL11 Gene
Publications for OSBPL11 Gene
- Association of OSBPL11 gene polymorphisms with cardiovascular disease risk factors in obesity. (PMID: 19325544) Bouchard L … Vohl MC (Obesity (Silver Spring, Md.) 2009) 3 22 44 58
- OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype. (PMID: 23028956) Zhou Y … Olkkonen VM (PloS one 2012) 3 4 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface. (PMID: 20599956) Zhou Y … Olkkonen VM (Experimental cell research 2010) 3 4 58
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
Products for OSBPL11 Gene
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- Quality Products:
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Sources for OSBPL11 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
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- (165) LOVD
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- (168) Boster Bio
- (169) Biorbyt