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This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. [provided by RefSeq, Jul 2008]
OSBPL11 (Oxysterol Binding Protein Like 11) is a Protein Coding gene. Diseases associated with OSBPL11 include Wernicke-Korsakoff Syndrome and Thiamine Deficiency Disease. Gene Ontology (GO) annotations related to this gene include lipid binding. An important paralog of this gene is OSBPL10.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 19615732 |
GO:0008289 | lipid binding | IEA | -- |
GO:0015248 | sterol transporter activity | IBA | 21873635 |
GO:0032934 | sterol binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005768 | endosome | IEA | -- |
GO:0005794 | Golgi apparatus | IEA,IDA | -- |
GO:0005829 | cytosol | IBA | 21873635 |
GO:0016020 | membrane | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006869 | lipid transport | IEA | -- |
GO:0010890 | positive regulation of sequestering of triglyceride | IMP | 23028956 |
GO:0015918 | sterol transport | IEA | -- |
GO:0045444 | fat cell differentiation | IMP | 23028956 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | OSBPL11 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | OSBPL11 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | OSBPL11 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Osbpl11 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Osbpl11 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | OSBPL11 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | OSBPL11 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | OSBPL11 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | osbpl11 30 |
|
||
Str.8471 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.13782 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | osbpl11 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG9205 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | OSH7 31 |
|
ManyToMany | |
OSH6 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1971 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs746035150 | A breast cancer sample |
p.Ser184Leu |
Disorder | Aliases | PubMed IDs |
---|---|---|
wernicke-korsakoff syndrome |
|
|
thiamine deficiency disease |
|
|