Aliases for OS9 Gene
External Ids for OS9 Gene
Previous GeneCards Identifiers for OS9 Gene
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for OS9 Gene
OS9 (OS9 Endoplasmic Reticulum Lectin) is a Protein Coding gene. Diseases associated with OS9 include Overhydrated Hereditary Stomatocytosis and Bone Cancer. Among its related pathways are Signaling by GPCR and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is ERLEC1.
UniProtKB/Swiss-Prot Summary for OS9 Gene
Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.