Aliases for ORMDL3 Gene
Aliases for ORMDL3 Gene
External Ids for ORMDL3 Gene
- HGNC: 16038
- Entrez Gene: 94103
- Ensembl: ENSG00000172057
- OMIM: 610075
- UniProtKB: Q8N138
Previous GeneCards Identifiers for ORMDL3 Gene
- GC17P037421
- GC17U900023
- GC17M037987
- GC17M038452
- GC17M035330
- GC17M038077
- GC17M033871
Summaries for ORMDL3 Gene
GeneCards Summary for ORMDL3 Gene
ORMDL3 (ORMDL Sphingolipid Biosynthesis Regulator 3) is a Protein Coding gene. Diseases associated with ORMDL3 include Retinitis Pigmentosa 26 and Asthma. Among its related pathways are Metabolism and Innate Immune System. An important paralog of this gene is ORMDL1.
UniProtKB/Swiss-Prot for ORMDL3 Gene
-
Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.
Additional gene information for ORMDL3 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORMDL3 Gene
Genomics for ORMDL3 Gene
GeneHancer (GH) Regulatory Elements for ORMDL3 Gene
Promoters and enhancers for ORMDL3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ORMDL3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ORMDL3 gene promoter:
-
- AP-4
- c-Ets-1
- HOXA5
- COUP-TF
- C/EBPbeta
- COUP
- COUP-TF1
- HNF-4alpha1
- HNF-4alpha2
- LCR-F1
Regulatory Element Products
Genomic Locations for ORMDL3 Gene
Genomic Locations for ORMDL3 Gene
- chr17:39,921,041-39,927,631
- (GRCh38/hg38)
- Size:
- 6,591 bases
- Orientation:
- Minus strand
- chr17:38,077,294-38,083,884
- (GRCh37/hg19)
- Size:
- 6,591 bases
- Orientation:
- Minus strand
Genomic View for ORMDL3 Gene
Genes around ORMDL3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.1 by Entrez Gene
- 17q21.1 by HGNC
- 17q21.1 by Ensembl
ORMDL3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ORMDL3 Gene
Proteins for ORMDL3 Gene
-
Protein details for ORMDL3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N138-ORML3_HUMAN
- Recommended name:
- ORM1-like protein 3
- Protein Accession:
- Q8N138
- B3KS83
- Q6UY83
Protein attributes for ORMDL3 Gene
- Size:
- 153 amino acids
- Molecular mass:
- 17495 Da
- Quaternary structure:
-
- Interacts with SPTLC1.
- Miscellaneous:
-
- SNPs on 17q21 locus that are associated with childhood asthma also show a consistent and strong association with transcript levels of ORMDL3, indicating that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma.
Protein Expression for ORMDL3 Gene
Post-translational modifications for ORMDL3 Gene
Other Protein References for ORMDL3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ORMDL3
- Novus Biologicals Antibodies for ORMDL3
-
Abcam antibodies for ORMDL3
- Invitrogen Antibodies for ORMDL3
- Search GeneTex for Antibodies for ORMDL3
-
Boster Bio Antibodies for ORMDL3
Protein Products
-
OriGene Purified Proteins for ORMDL3
- Search Origene for MassSpec and Protein Over-expression Lysates for ORMDL3
- Origene Custom Protein Services for ORMDL3
- antibodies-online: Search results for 4 available ORMDL3 Proteins ranked by validation data
- Compare Top ORMDL3 Proteins
-
Quality Products:
- Search GeneTex for Proteins for ORMDL3
-
Abcam proteins for ORMDL3
Assay Products
- antibodies-online: Search results for 1 available ORMDL3 Elisa Kits ranked by validation data
- Compare Top ORMDL3 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ORMDL3 Gene
Domains & Families for ORMDL3 Gene
Gene Families for ORMDL3 Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for ORMDL3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N138- Family:
-
- Belongs to the ORM family.
Function for ORMDL3 Gene
Molecular function for ORMDL3 Gene
- UniProtKB/Swiss-Prot Function:
- Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.
Phenotypes From GWAS Catalog for ORMDL3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 20182505 |
Phenotypes for ORMDL3 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for ORMDL3
- Cyagen custom Knockout/knockin (KOKI) mouse models for ORMDL3
-
CRISPR Products
-
OriGene CRISPR knockouts for ORMDL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ORMDL3
- genomics-online: gRNA clones - Search results for 112 available ORMDL3 gene related products
- Overview of 112 available ORMDL3 gene related products
- Applied Biological Materials CRISPR for ORMDL3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ORMDL3
- GenScript: Design CRISPR guide RNA sequences for ORMDL3
miRNA for ORMDL3 Gene
- miRTarBase miRNAs that target ORMDL3
-
- hsa-mir-20a-5p (MIRT050551)
- hsa-mir-6771-3p (MIRT145735)
- hsa-mir-106b-5p (MIRT440063)
- hsa-mir-1229-3p (MIRT530712)
- hsa-mir-155-3p (MIRT530713)
- hsa-mir-197-3p (MIRT530714)
- hsa-mir-4713-3p (MIRT530715)
- hsa-mir-6862-3p (MIRT530716)
- hsa-mir-6784-3p (MIRT530717)
- hsa-mir-6511b-3p (MIRT530718)
- hsa-mir-6511a-3p (MIRT530719)
- hsa-mir-4700-3p (MIRT530720)
- hsa-mir-140-3p (MIRT530721)
- hsa-mir-4665-5p (MIRT555901)
- hsa-mir-1275 (MIRT555902)
- hsa-mir-5010-5p (MIRT555903)
- hsa-mir-4525 (MIRT555904)
- hsa-mir-7111-5p (MIRT555905)
- hsa-mir-6870-5p (MIRT555906)
- hsa-mir-5698 (MIRT555907)
- hsa-mir-4723-5p (MIRT555908)
- hsa-mir-625-5p (MIRT555909)
- hsa-mir-6780b-5p (MIRT555910)
- hsa-mir-4725-3p (MIRT555911)
- hsa-mir-4271 (MIRT555912)
- hsa-mir-637 (MIRT555913)
- hsa-mir-5695 (MIRT555914)
- hsa-mir-4715-5p (MIRT555915)
- hsa-mir-3691-3p (MIRT555916)
- hsa-mir-508-5p (MIRT555917)
- hsa-mir-3145-5p (MIRT555918)
- hsa-mir-4653-3p (MIRT655603)
- hsa-mir-6778-3p (MIRT655604)
- hsa-mir-4424 (MIRT655605)
- hsa-mir-4667-3p (MIRT655606)
- hsa-mir-1470 (MIRT655607)
- hsa-mir-519d-3p (MIRT727044)
- hsa-mir-93-5p (MIRT727045)
- hsa-mir-17-5p (MIRT727046)
- hsa-mir-20b-5p (MIRT727047)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ORMDL3
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- genomics-online: shRNA clones - Search results for 112 available ORMDL3 gene related products
- Overview of 112 available ORMDL3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ORMDL3
- VectorBuilder custom plasmid, inducible vectors for ORMDL3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ORMDL3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ORMDL3
- Applied Biological Materials Clones for ORMDL3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ORMDL3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ORMDL3 Gene
Localization for ORMDL3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ORMDL3 Gene
- Endoplasmic reticulum membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 5 |
| mitochondrion | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
- Endoplasmic reticulum (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IDA | 12093374 |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for ORMDL3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Metabolism |
.37
|
|
| 3 | Sphingolipid metabolism | ||
Pathways by source for ORMDL3 Gene
7 Reactome pathways for ORMDL3 Gene
Interacting Proteins for ORMDL3 Gene
Selected Interacting proteins:
Q8N138-ORML3_HUMAN
ENSP00000304858
for ORMDL3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ORMDL3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006672 | ceramide metabolic process | IEA,IMP | 20182505 |
| GO:0043312 | neutrophil degranulation | TAS | -- |
| GO:0090156 | cellular sphingolipid homeostasis | IEA,IBA | -- |
| GO:1900060 | negative regulation of ceramide biosynthetic process | IMP | 25691431 |
No data available for SIGNOR curated interactions for ORMDL3 Gene
Transcripts for ORMDL3 Gene
mRNA/cDNA for ORMDL3 Gene
- (5) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (324) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000304046 2111 bps (uc002htj.3)
- ENST00000579695 2106 bps (uc002htk.3)
- ENST00000579287 349 bps (uc060eup.1)
- ENST00000581284 561 bps (uc060euq.1)
- ENST00000394169 2230 bps (uc060eur.1)
Unigene Clusters for ORMDL3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ORMDL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ORMDL3
- genomics-online: gRNA clones - Search results for 112 available ORMDL3 gene related products
- Overview of 112 available ORMDL3 gene related products
- Applied Biological Materials CRISPR for ORMDL3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ORMDL3
- GenScript: Design CRISPR guide RNA sequences for ORMDL3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ORMDL3
- Browse OriGene Inhibitory RNA Products For ORMDL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ORMDL3
- genomics-online: shRNA clones - Search results for 112 available ORMDL3 gene related products
- Overview of 112 available ORMDL3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ORMDL3
- VectorBuilder custom plasmid, inducible vectors for ORMDL3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ORMDL3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ORMDL3
- Applied Biological Materials Clones for ORMDL3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||
| SP7: | - | - |
Expression for ORMDL3 Gene
mRNA differential expression in normal tissues according to GTEx for ORMDL3 Gene
This gene is overexpressed in Liver (x5.0).
This gene is overexpressed in Bone (10.8) and Plasma (9.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ORMDL3 Gene
NURSA nuclear receptor signaling pathways regulating expression of ORMDL3 Gene:
ORMDL3SOURCE GeneReport for Unigene cluster for ORMDL3 Gene:
Hs.514151mRNA Expression by UniProt/SwissProt for ORMDL3 Gene:
Q8N138-ORML3_HUMAN
Tissue specificity:
Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus.
Evidence on tissue expression from TISSUES for ORMDL3 Gene
- Nervous system(4.5)
- Intestine(4.4)
- Lung(2.7)
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for ORMDL3
-
OriGene qPCR primer pairs for ORMDL3
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ORMDL3 Gene
Orthologs for ORMDL3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ORMDL3 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ORMDL3 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ORMDL3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ORMDL3 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ormdl3 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ORMDL3 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ormdl3 16 34 33 |
|
||
| chicken (Gallus gallus) |
Aves | ORMDL3 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ORMDL3 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | ormdl3 34 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010566 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | ORMDL 34 33 |
|
OneToMany | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ACL189C 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ORM2 34 33 |
|
ManyToMany | |
| ORM1 36 34 |
|
||||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B05621g 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU11109 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPBC119.09c 33 |
|
- Species where no ortholog for ORMDL3 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ORMDL3 Gene
- ENSEMBL:
- Gene Tree for ORMDL3 (if available)
- TreeFam:
- Gene Tree for ORMDL3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ORMDL3: view image
Paralogs for ORMDL3 Gene
Variants for ORMDL3 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000912627 | -- | 39,925,210(-) | G/A | 5_prime_UTR_variant, intron_variant | |
| rs1001178786 | -- | 39,926,998(-) | G/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1001261341 | -- | 39,925,538(-) | C/G | intron_variant | |
| rs1001268330 | -- | 39,920,923(-) | C/T | downstream_transcript_variant | |
| rs1001630188 | -- | 39,926,700(-) | C/T | 5_prime_UTR_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3573064 | CNV | gain | 25503493 |
| nsv1146669 | OTHER | inversion | 26484159 |
Residual Variation Intolerance Score:
37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.17;
3.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ORMDL3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORMDL3 Gene
Disorders for ORMDL3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinitis pigmentosa 26 |
|
|
| asthma |
|
|
| bronchial disease |
|
|
Search ORMDL3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ORML3_HUMAN- Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269 PubMed:18395550, ECO:0000269 PubMed:18760456, ECO:0000269 PubMed:19133921}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Additional Disease Information for ORMDL3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for ORMDL3 Gene
Publications for ORMDL3 Gene
- Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma. (PMID: 19133921) Wu H … London SJ (Allergy 2009) 3 4 22 44 58
- A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications. (PMID: 18395550) Tavendale R … Palmer CN (The Journal of allergy and clinical immunology 2008) 3 4 44 58
- ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry. (PMID: 18760456) Sleiman PM … Hakonarson H (The Journal of allergy and clinical immunology 2008) 3 4 44 58
- Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. (PMID: 17611496) Moffatt MF … Cookson WO (Nature 2007) 3 4 44 58
- Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis. (PMID: 23066021) Siow DL … Wattenberg BW (The Journal of biological chemistry 2012) 2 3 58
Products for ORMDL3 Gene
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- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ORMDL3
- Cyagen custom Knockout/knockin (KOKI) mouse models for ORMDL3
- VectorBuilder custom plasmid, inducible vectors for ORMDL3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ORMDL3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 24 available ORMDL3 Antibodies ranked by validation data
- Compare Top ORMDL3 Antibodies
- antibodies-online: Search results for 1 available ORMDL3 Elisa Kits ranked by validation data
- Compare Top ORMDL3 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 4 available ORMDL3 Proteins ranked by validation data
- Compare Top ORMDL3 Proteins
- Quality Products:
- Search GeneTex for Antibodies for ORMDL3
- Search GeneTex for Proteins for ORMDL3
- Horizon Cell Lines for ORMDL3
- genomics-online: cdna clones - Search results for 112 available ORMDL3 gene related products
- Overview of 112 available ORMDL3 gene related products
- orf clones - Search results for 112 available ORMDL3 gene related products
- Overview of 112 available ORMDL3 gene related products
- genomics-online: gRNA clones - Search results for 112 available ORMDL3 gene related products
- Overview of 112 available ORMDL3 gene related products
- genomics-online: primer clones - Search results for 112 available ORMDL3 gene related products
- Overview of 112 available ORMDL3 gene related products
- genomics-online: shRNA clones - Search results for 112 available ORMDL3 gene related products
- Overview of 112 available ORMDL3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ORMDL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ORMDL3
- GeneCopoeia miRNA 3'UTR Target clone products for ORMDL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ORMDL3
- Boster Bio Antibodies for ORMDL3
- Browse Boster Bio ELISA Kits
Sources for ORMDL3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt