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ORMDL3 (ORMDL Sphingolipid Biosynthesis Regulator 3) is a Protein Coding gene. Diseases associated with ORMDL3 include Asthma and Inflammatory Bowel Disease 22. Among its related pathways are Sphingolipid metabolism and Innate Immune System. An important paralog of this gene is ORMDL1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 20182505 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005783 | endoplasmic reticulum | IDA | 12093374 |
GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Metabolism |
.40
|
|
3 | Sphingolipid metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006672 | ceramide metabolic process | IEA,IMP | 20182505 |
GO:0043312 | neutrophil degranulation | TAS | -- |
GO:0090156 | cellular sphingolipid homeostasis | IEA,IBA | 21873635 |
GO:1900060 | negative regulation of ceramide biosynthetic process | IMP | 25691431 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f | ^ | 9 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||
SP7: | - | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ORMDL3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ORMDL3 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ORMDL3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ORMDL3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ormdl3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ORMDL3 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ormdl3 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ORMDL3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ORMDL3 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | ormdl3 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010566 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | ORMDL 30 31 |
|
OneToMany | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ACL189C 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ORM2 30 31 |
|
ManyToMany | |
ORM1 31 33 |
|
ManyToMany | |||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B05621g 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU11109 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPBC119.09c 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3573064 | CNV | gain | 25503493 |
nsv1146669 | OTHER | inversion | 26484159 |
Disorder | Aliases | PubMed IDs |
---|---|---|
asthma |
|
|
inflammatory bowel disease 22 |
|
|
ileocolitis |
|
|
retinitis pigmentosa 26 |
|
|
bronchial disease |
|
|