Aliases for ORC5 Gene
External Ids for ORC5 Gene
Previous HGNC Symbols for ORC5 Gene
Previous GeneCards Identifiers for ORC5 Gene
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]
GeneCards Summary for ORC5 Gene
ORC5 (Origin Recognition Complex Subunit 5) is a Protein Coding gene. Diseases associated with ORC5 include Hyperinsulinemic Hypoglycemia, Familial, 1 and Hyperinsulinemic Hypoglycemia, Familial, 2. Among its related pathways are Cell Cycle, Mitotic and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include nucleotide binding and DNA replication origin binding.
UniProtKB/Swiss-Prot Summary for ORC5 Gene
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.