The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this ge... See more...

Aliases for ORC5 Gene

Aliases for ORC5 Gene

  • Origin Recognition Complex Subunit 5 2 3 4 5
  • Protein Phosphatase 1, Regulatory Subunit 117 2 3
  • PPP1R117 2 3
  • ORC5L 3 4
  • ORC5T 2 3
  • Origin Recognition Complex, Subunit 5 (Yeast Homolog)-Like 2
  • Origin Recognition Complex, Subunit 5 Homolog (Yeast) 2
  • Origin Recognition Complex, Subunit 5-Like (Yeast) 2
  • Origin Recognition Complex, Subunit 5 2
  • ORC5P 3
  • Orc5p 2
  • ORC5 5

External Ids for ORC5 Gene

Previous HGNC Symbols for ORC5 Gene

  • ORC5L

Previous GeneCards Identifiers for ORC5 Gene

  • GC07M103767

Summaries for ORC5 Gene

Entrez Gene Summary for ORC5 Gene

  • The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]

GeneCards Summary for ORC5 Gene

ORC5 (Origin Recognition Complex Subunit 5) is a Protein Coding gene. Diseases associated with ORC5 include Hyperinsulinemic Hypoglycemia, Familial, 1 and Hyperinsulinemic Hypoglycemia, Familial, 2. Among its related pathways are Cell Cycle, Mitotic and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include nucleotide binding and DNA replication origin binding.

UniProtKB/Swiss-Prot Summary for ORC5 Gene

  • Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.

Gene Wiki entry for ORC5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ORC5 Gene

Genomics for ORC5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ORC5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ORC5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ORC5

Genomic Locations for ORC5 Gene

Latest Assembly
chr7:104,126,341-104,208,047
(GRCh38/hg38)
Size:
81,707 bases
Orientation:
Minus strand

Previous Assembly
chr7:103,766,788-103,848,461
(GRCh37/hg19 by Entrez Gene)
Size:
81,674 bases
Orientation:
Minus strand

chr7:103,766,788-103,848,495
(GRCh37/hg19 by Ensembl)
Size:
81,708 bases
Orientation:
Minus strand

Genomic View for ORC5 Gene

Genes around ORC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORC5 Gene

Proteins for ORC5 Gene

  • Protein details for ORC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43913-ORC5_HUMAN
    Recommended name:
    Origin recognition complex subunit 5
    Protein Accession:
    O43913
    Secondary Accessions:
    • A4D0P8
    • O60590
    • O95268

    Protein attributes for ORC5 Gene

    Size:
    435 amino acids
    Molecular mass:
    50283 Da
    Quaternary structure:
    • Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.
    Miscellaneous:
    • [Isoform 2]: Does not interact with ORC2.

    Three dimensional structures from OCA and Proteopedia for ORC5 Gene

    Alternative splice isoforms for ORC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ORC5 Gene

Post-translational modifications for ORC5 Gene

  • Multi-mono-ubiquitinated by OBI1; ubiquitination is important for efficient DNA replication origin site activation. Ubiquitination levels are low in mitotic and early G1-phAse cells and are induced in late G1-/early S-phase, peaking in S-phase and decrease toward the end of the cell cycle.
  • Ubiquitination at Lys107 and Lys263
  • Modification sites at PhosphoSitePlus

Other Protein References for ORC5 Gene

No data available for DME Specific Peptides for ORC5 Gene

Domains & Families for ORC5 Gene

Gene Families for ORC5 Gene

Protein Domains for ORC5 Gene

Suggested Antigen Peptide Sequences for ORC5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ94165, Homo sapiens origin recognition complex, subunit 5-like (yeast) (ORC5L), mRNA (A4D0P7_HUMAN)
  • cDNA FLJ53851, highly similar to Origin recognition complex subunit 5 (B4DXT8_HUMAN)
  • Origin recognition complex subunit ORC5T (O95268_HUMAN)
  • Origin recognition complex subunit 5 (ORC5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43913

UniProtKB/Swiss-Prot:

ORC5_HUMAN :
  • Belongs to the ORC5 family.
Family:
  • Belongs to the ORC5 family.
genes like me logo Genes that share domains with ORC5: view

Function for ORC5 Gene

Molecular function for ORC5 Gene

UniProtKB/Swiss-Prot Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.

Phenotypes From GWAS Catalog for ORC5 Gene

Gene Ontology (GO) - Molecular Function for ORC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 9765232
GO:0003674 molecular_function ND --
GO:0003688 DNA replication origin binding TAS,IBA 21873635
GO:0005515 protein binding IPI 15232106
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ORC5: view
genes like me logo Genes that share phenotypes with ORC5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ORC5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ORC5 Gene

Localization for ORC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORC5 Gene

Nucleus. Chlorosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ORC5 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ORC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region HDA 19135898
GO:0000785 chromatin IDA 31160578
GO:0000808 origin recognition complex IEA,IDA 17716973
GO:0005634 nucleus IEA,NAS 9765232
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ORC5: view

Pathways & Interactions for ORC5 Gene

genes like me logo Genes that share pathways with ORC5: view

Pathways by source for ORC5 Gene

1 GeneGo (Thomson Reuters) pathway for ORC5 Gene
  • Cell cycle Start of DNA replication in early S phase
1 Qiagen pathway for ORC5 Gene
  • Cell Cycle Control of Chromosomal Replication

Gene Ontology (GO) - Biological Process for ORC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006260 DNA replication IEA,TAS --
GO:0006270 DNA replication initiation TAS,IBA 21873635
GO:0006275 regulation of DNA replication IDA 31160578
genes like me logo Genes that share ontologies with ORC5: view

No data available for SIGNOR curated interactions for ORC5 Gene

Drugs & Compounds for ORC5 Gene

No Compound Related Data Available

Transcripts for ORC5 Gene

mRNA/cDNA for ORC5 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ORC5

Alternative Splicing Database (ASD) splice patterns (SP) for ORC5 Gene

No ASD Table

Relevant External Links for ORC5 Gene

GeneLoc Exon Structure for
ORC5

Expression for ORC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ORC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ORC5 Gene

This gene is overexpressed in Bone (37.4) and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ORC5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ORC5

SOURCE GeneReport for Unigene cluster for ORC5 Gene:

Hs.432948

mRNA Expression by UniProt/SwissProt for ORC5 Gene:

O43913-ORC5_HUMAN
Tissue specificity: Abundant in spleen, ovary, prostate, testis, and colon mucosa.

Evidence on tissue expression from TISSUES for ORC5 Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with ORC5: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ORC5 Gene

Orthologs for ORC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ORC5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ORC5 29 30
  • 99.85 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ORC5L 30
  • 96 (a)
OneToOne
ORC5 29
  • 92.95 (n)
Dog
(Canis familiaris)
Mammalia ORC5 29 30
  • 94.18 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ORC5 30
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Orc5 29 16 30
  • 88.97 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ORC5 30
  • 88 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Orc5 29
  • 87.59 (n)
Chicken
(Gallus gallus)
Aves ORC5 29 30
  • 79.07 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ORC5 30
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia orc5 29
  • 71.89 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19639 29
Zebrafish
(Danio rerio)
Actinopterygii orc5 29 30
  • 64.37 (n)
OneToOne
wufb62d08 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3282 29
Fruit Fly
(Drosophila melanogaster)
Insecta Orc5 29 30
  • 47.05 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000978 29
  • 43.57 (n)
Worm
(Caenorhabditis elegans)
Secernentea orc-5 30
  • 23 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ORC5 30 32
  • 20 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons ORC5 29
  • 44.88 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0759500 29
  • 41.46 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 47 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes orc5 29
  • 43.97 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU05433 29
  • 40.13 (n)
Species where no ortholog for ORC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ORC5 Gene

ENSEMBL:
Gene Tree for ORC5 (if available)
TreeFam:
Gene Tree for ORC5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ORC5: view image
Alliance of Genome Resources:
Additional Orthologs for ORC5

Paralogs for ORC5 Gene

(1) SIMAP similar genes for ORC5 Gene using alignment to 3 proteins:

  • ORC5_HUMAN
  • B4DXT8_HUMAN
  • G3V0H0_HUMAN
genes like me logo Genes that share paralogs with ORC5: view

No data available for Paralogs for ORC5 Gene

Variants for ORC5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ORC5 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs1056677 -- p.Gly37Arg
rs2307402 -- p.Arg166Cys
rs2307413 -- p.Lys52Asn

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ORC5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ORC5 Gene

Variant ID Type Subtype PubMed ID
dgv1231e199 CNV deletion 23128226
dgv6544n100 CNV gain 25217958
esv2762692 CNV gain 21179565
esv28909 CNV loss 19812545
esv3304800 CNV mobile element insertion 20981092
esv3385126 CNV insertion 20981092
esv3429813 CNV insertion 20981092
esv3542206 CNV deletion 23714750
esv3614386 CNV gain 21293372
esv3614387 CNV loss 21293372
esv3891172 CNV gain 25118596
nsv507406 OTHER sequence alteration 20534489
nsv526062 CNV gain 19592680
nsv527105 CNV loss 19592680
nsv608065 CNV gain 21841781

Variation tolerance for ORC5 Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.55; 44.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ORC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ORC5
Leiden Open Variation Database (LOVD)
ORC5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORC5 Gene

Disorders for ORC5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ORC5 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search ORC5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ORC5

genes like me logo Genes that share disorders with ORC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ORC5 Gene

Publications for ORC5 Gene

  1. The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. (PMID: 9829972) Tugal T … Stillman B (The Journal of biological chemistry 1998) 2 3 4 22
  2. Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22. (PMID: 9417919) Ishiai M … Eki T (Genomics 1997) 2 3 4 22
  3. The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing. (PMID: 31160578) Coulombe P … Méchali M (Nature communications 2019) 3 4
  4. ATP-dependent assembly of the human origin recognition complex. (PMID: 17716973) Siddiqui K … Stillman B (The Journal of biological chemistry 2007) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ORC5 Gene

Sources for ORC5 Gene