The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of... See more...

Aliases for ORC4 Gene

Aliases for ORC4 Gene

  • Origin Recognition Complex Subunit 4 2 3 4 5
  • ORC4L 3 4
  • Origin Recognition Complex, Subunit 4 Homolog (S. Cerevisiae) 2
  • Origin Recognition Complex, Subunit 4 (Yeast Homolog)-Like 2
  • Origin Recognition Complex, Subunit 4-Like (S. Cerevisiae) 2
  • Origin Recognition Complex, Subunit 4-Like (Yeast) 2
  • Origin Recognition Complex, Subunit 4 Homolog 3
  • Origin Recognition Complex, Subunit 4 2
  • HsORC4 2
  • ORC4P 3
  • Orc4p 2
  • ORC4 5

External Ids for ORC4 Gene

Previous HGNC Symbols for ORC4 Gene

  • ORC4L

Previous GeneCards Identifiers for ORC4 Gene

  • GC02M148691

Summaries for ORC4 Gene

Entrez Gene Summary for ORC4 Gene

  • The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for ORC4 Gene

ORC4 (Origin Recognition Complex Subunit 4) is a Protein Coding gene. Diseases associated with ORC4 include Meier-Gorlin Syndrome 2 and Meier-Gorlin Syndrome 1. Among its related pathways are Cell Cycle, Mitotic and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include nucleotide binding and DNA replication origin binding.

UniProtKB/Swiss-Prot Summary for ORC4 Gene

  • Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

Gene Wiki entry for ORC4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ORC4 Gene

Genomics for ORC4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ORC4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J148018 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 267.8 +0.5 503 6.2 SP1 MYC IKZF1 ZNF600 SSRP1 ZNF580 ZMYM3 POLR2A ZNF10 ZSCAN16 ORC4 MBD5 lnc-MBD5-1 lnc-MMADHC-10 ACVR2A
GH02J147843 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 16.9 +176.2 176203 5.2 BCLAF1 SP1 ZNF600 CEBPA BRCA1 POLR2A ZBTB10 YY1 MXD4 NONO ACVR2A lnc-ORC4-2 ORC4 HSALNG0019474 MBD5
GH02J147989 Enhancer 0.8 Ensembl ENCODE 21.6 +31.6 31603 2 ZNF654 REST ZNF592 TRIM22 HOMEZ CTCF RAD21 SMC3 SMARCA5 PRDM6 ORC4 MBD5 HSALNG0019483 LOC105373674 lnc-MMADHC-10 ACVR2A
GH02J147849 Enhancer 0.8 Ensembl 16.9 +170.9 170903 2.2 ZMYM3 CEBPA CHD4 HOMEZ THAP11 FOXA2 SMAD4 ZNF511 SAP130 ETV4 ORC4 ACVR2A HSALNG0019474 MBD5
GH02J148041 Enhancer 0.7 Ensembl 13.7 -20.8 -20797 1.2 BCLAF1 BCL11A ZNF592 TRIM22 IRF4 SMARCA5 BATF ELF1 IKZF1 BMI1 ENSG00000281469 HSALNG0019487 ORC4 MN297723 lnc-MBD5-1 MBD5 HSALNG0019486 LOC105373673 EPC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ORC4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ORC4

Genomic Locations for ORC4 Gene

Latest Assembly
chr2:147,930,396-148,021,604
(GRCh38/hg38)
Size:
91,209 bases
Orientation:
Minus strand

Previous Assembly
chr2:148,687,965-148,779,120
(GRCh37/hg19 by Entrez Gene)
Size:
91,156 bases
Orientation:
Minus strand

chr2:148,687,968-148,779,147
(GRCh37/hg19 by Ensembl)
Size:
91,180 bases
Orientation:
Minus strand

Genomic View for ORC4 Gene

Genes around ORC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORC4 Gene

Proteins for ORC4 Gene

  • Protein details for ORC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43929-ORC4_HUMAN
    Recommended name:
    Origin recognition complex subunit 4
    Protein Accession:
    O43929
    Secondary Accessions:
    • B7Z3D0
    • B7Z5F1
    • D3DP86
    • F5H069
    • Q96C42

    Protein attributes for ORC4 Gene

    Size:
    436 amino acids
    Molecular mass:
    50377 Da
    Quaternary structure:
    • Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (PubMed:12909626, PubMed:17716973). Interacts with DBF4 (By similarity). Interacts with POLQ (PubMed:24989122).

    Three dimensional structures from OCA and Proteopedia for ORC4 Gene

    Alternative splice isoforms for ORC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ORC4 Gene

Post-translational modifications for ORC4 Gene

  • Ubiquitination at Lys204, Lys243, and Lys417
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for ORC4

No data available for DME Specific Peptides for ORC4 Gene

Domains & Families for ORC4 Gene

Gene Families for ORC4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for ORC4 Gene

Suggested Antigen Peptide Sequences for ORC4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60571, highly similar to Origin recognition complex subunit 4 (B7Z3D0_HUMAN)
  • cDNA FLJ60856, highly similar to Origin recognition complex subunit 4 (B7Z632_HUMAN)
  • Origin recognition complex subunit 4 (ORC4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43929

UniProtKB/Swiss-Prot:

ORC4_HUMAN :
  • Belongs to the ORC4 family.
Family:
  • Belongs to the ORC4 family.
genes like me logo Genes that share domains with ORC4: view

Function for ORC4 Gene

Molecular function for ORC4 Gene

UniProtKB/Swiss-Prot Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

Phenotypes From GWAS Catalog for ORC4 Gene

Gene Ontology (GO) - Molecular Function for ORC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA,IDA 9353276
GO:0003677 DNA binding IEA --
GO:0003688 DNA replication origin binding IMP 9353276
GO:0005515 protein binding IPI 15232106
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ORC4: view
genes like me logo Genes that share phenotypes with ORC4: view

Human Phenotype Ontology for ORC4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for ORC4 Gene

miRTarBase miRNAs that target ORC4

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ORC4

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ORC4 Gene

Localization for ORC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORC4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ORC4 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
mitochondrion 3
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ORC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 colocalizes_with chromosome, telomeric region IDA 24270157
GO:0000808 origin recognition complex IEA,IDA 17716973
GO:0005634 nucleus IEA,IDA 9353276
GO:0005654 nucleoplasm IDA,TAS --
GO:0005664 nuclear origin of replication recognition complex IBA,IDA 20932478
genes like me logo Genes that share ontologies with ORC4: view

Pathways & Interactions for ORC4 Gene

genes like me logo Genes that share pathways with ORC4: view

Pathways by source for ORC4 Gene

1 GeneGo (Thomson Reuters) pathway for ORC4 Gene
  • Cell cycle Start of DNA replication in early S phase
1 Qiagen pathway for ORC4 Gene
  • Cell Cycle Control of Chromosomal Replication

Gene Ontology (GO) - Biological Process for ORC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006260 DNA replication IEA,TAS --
GO:0006270 DNA replication initiation IBA,IMP 9353276
genes like me logo Genes that share ontologies with ORC4: view

No data available for SIGNOR curated interactions for ORC4 Gene

Drugs & Compounds for ORC4 Gene

No Compound Related Data Available

Transcripts for ORC4 Gene

mRNA/cDNA for ORC4 Gene

8 REFSEQ mRNAs :
33 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ORC4

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for ORC4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - -
SP2:
SP3: -
SP4: -

Relevant External Links for ORC4 Gene

GeneLoc Exon Structure for
ORC4

Expression for ORC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ORC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ORC4 Gene

This gene is overexpressed in Testis (24.3) and Bone (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ORC4 Gene



Protein tissue co-expression partners for ORC4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ORC4

SOURCE GeneReport for Unigene cluster for ORC4 Gene:

Hs.558364

Evidence on tissue expression from TISSUES for ORC4 Gene

  • Nervous system(4.9)
  • Kidney(2.1)
  • Skin(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ORC4 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • inner ear
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • nose
  • outer ear
  • skull
  • tongue
  • tooth
  • vocal cord
Thorax:
  • breast
  • bronchus
  • chest wall
  • clavicle
  • esophagus
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • trachea
Abdomen:
  • stomach
Pelvis:
  • pelvis
  • penis
  • testicle
  • uterus
  • vagina
  • vulva
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • hair
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with ORC4: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ORC4 Gene

Orthologs for ORC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ORC4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ORC4 29 30
  • 99.85 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ORC4 29 30
  • 92.66 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ORC4 29 30
  • 91.44 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Orc4 29 16 30
  • 88.53 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Orc4 29
  • 87.25 (n)
Oppossum
(Monodelphis domestica)
Mammalia ORC4 30
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ORC4 30
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ORC4 29 30
  • 72.71 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ORC4 30
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia orc4 29
  • 68.9 (n)
Str.7089 29
African clawed frog
(Xenopus laevis)
Amphibia Orc4 29
Zebrafish
(Danio rerio)
Actinopterygii orc4 29 30
  • 62.56 (n)
OneToOne
Dr.20190 29
Fruit Fly
(Drosophila melanogaster)
Insecta Orc4 29 30
  • 48.5 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007063 29
  • 46.93 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ORC4 30 32
  • 22 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons ORC4 29
  • 46.2 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0683400 29
  • 44.97 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1951 30
  • 50 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes orc4 29
  • 47.47 (n)
Species where no ortholog for ORC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ORC4 Gene

ENSEMBL:
Gene Tree for ORC4 (if available)
TreeFam:
Gene Tree for ORC4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ORC4: view image
Alliance of Genome Resources:
Additional Orthologs for ORC4

Paralogs for ORC4 Gene

(1) SIMAP similar genes for ORC4 Gene using alignment to 3 proteins:

  • ORC4_HUMAN
  • C9J2X8_HUMAN
  • C9JGH7_HUMAN
genes like me logo Genes that share paralogs with ORC4: view

No data available for Paralogs for ORC4 Gene

Variants for ORC4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ORC4 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
1006987 Uncertain Significance: not provided 147,938,298(-) C/T
NM_181741.4(ORC4):c.1054G>A (p.Glu352Lys)
MISSENSE
1007497 Uncertain Significance: not provided 147,972,764(-) C/A
NM_181741.4(ORC4):c.200G>T (p.Gly67Val)
MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON
1017707 Uncertain Significance: not provided 147,973,481(-) T/C
NM_181741.4(ORC4):c.101A>G (p.His34Arg)
MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON
1018893 Uncertain Significance: not provided 147,939,196(-) T/C
NM_181741.4(ORC4):c.902A>G (p.Asp301Gly)
MISSENSE
1026709 Uncertain Significance: not provided 147,958,352(-) TA/T
NM_181741.4(ORC4):c.332del (p.Leu111fs)
FRAMESHIFT

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ORC4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ORC4 Gene

Variant ID Type Subtype PubMed ID
esv3446864 CNV insertion 20981092
esv3592832 CNV loss 21293372
nsv1015003 CNV gain 25217958
nsv1138857 CNV deletion 24896259

Variation tolerance for ORC4 Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.48; 91.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ORC4 Gene

Human Gene Mutation Database (HGMD)
ORC4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ORC4
Leiden Open Variation Database (LOVD)
ORC4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORC4 Gene

Disorders for ORC4 Gene

MalaCards: The human disease database

(10) MalaCards diseases for ORC4 Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search ORC4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ORC4_HUMAN
  • Meier-Gorlin syndrome 2 (MGORS2) [MIM:613800]: A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. {ECO:0000269 PubMed:21358631, ECO:0000269 PubMed:21358632}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for ORC4

genes like me logo Genes that share disorders with ORC4: view

No data available for Genatlas for ORC4 Gene

Publications for ORC4 Gene

  1. Mutations in the pre-replication complex cause Meier-Gorlin syndrome. (PMID: 21358632) Bicknell LS … Jackson AP (Nature genetics 2011) 3 4 72
  2. Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome. (PMID: 21358631) Guernsey DL … Samuels ME (Nature genetics 2011) 3 4 72
  3. Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22-->q23 by in situ hybridization and somatic cell hybrid analysis. (PMID: 9691185) Eki T … Hanaoka F (Cytogenetics and cell genetics 1998) 2 3 22
  4. Identification of HsORC4, a member of the human origin of replication recognition complex. (PMID: 9353276) Quintana DG … Dutta A (The Journal of biological chemistry 1997) 2 3 4
  5. Novel ORC4L gene mutation in B-cell lymphoproliferative disorders. (PMID: 20010161) Radojkovic M … Radojkovic D (The American journal of the medical sciences 2009) 3 22

Products for ORC4 Gene

Sources for ORC4 Gene