Aliases for ORC4 Gene
External Ids for ORC4 Gene
Previous HGNC Symbols for ORC4 Gene
Previous GeneCards Identifiers for ORC4 Gene
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010]
GeneCards Summary for ORC4 Gene
ORC4 (Origin Recognition Complex Subunit 4) is a Protein Coding gene. Diseases associated with ORC4 include Meier-Gorlin Syndrome 2 and Meier-Gorlin Syndrome 1. Among its related pathways are Cell Cycle, Mitotic and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include nucleotide binding and DNA replication origin binding.
UniProtKB/Swiss-Prot Summary for ORC4 Gene
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.