The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this g... See more...

Aliases for ORC3 Gene

Aliases for ORC3 Gene

  • Origin Recognition Complex Subunit 3 2 3 4 5
  • LATHEO 2 3 4
  • Origin Recognition Complex Subunit Latheo 3 4
  • ORC3L 3 4
  • Origin Recognition Complex, Subunit 3 (Yeast Homolog)-Like 2
  • Origin Recognition Complex, Subunit 3 Honolog (Yeast) 2
  • Origin Recognition Complex, Subunit 3-Like (Yeast) 2
  • Origin Recognition Complex, Subunit 3 Honolog 3
  • Origin Recognition Complex, Subunit 3 2
  • Homolog Of Latheo, Drosophila 3
  • IMAGE50150 2
  • ORC3 5
  • LAT 3

External Ids for ORC3 Gene

Previous HGNC Symbols for ORC3 Gene

  • ORC3L

Previous GeneCards Identifiers for ORC3 Gene

  • GC06P088299

Summaries for ORC3 Gene

Entrez Gene Summary for ORC3 Gene

  • The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ORC3 Gene

ORC3 (Origin Recognition Complex Subunit 3) is a Protein Coding gene. Diseases associated with ORC3 include Meier-Gorlin Syndrome 1 and Isolated Growth Hormone Deficiency, Type Ia. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include DNA replication origin binding.

UniProtKB/Swiss-Prot Summary for ORC3 Gene

  • Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

Gene Wiki entry for ORC3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ORC3 Gene

Genomics for ORC3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ORC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ORC3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ORC3

Genomic Locations for ORC3 Gene

Genomic Locations for ORC3 Gene
chr6:87,590,067-87,677,824
(GRCh38/hg38)
Size:
87,758 bases
Orientation:
Plus strand
chr6:88,299,785-88,377,172
(GRCh37/hg19)
Size:
77,388 bases
Orientation:
Plus strand

Genomic View for ORC3 Gene

Genes around ORC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORC3 Gene

Proteins for ORC3 Gene

  • Protein details for ORC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBD5-ORC3_HUMAN
    Recommended name:
    Origin recognition complex subunit 3
    Protein Accession:
    Q9UBD5
    Secondary Accessions:
    • A2A2T5
    • B4E025
    • Q13565
    • Q53GY6
    • Q5T159
    • Q6IUY7
    • Q86TN5
    • Q9UG44
    • Q9UNT6

    Protein attributes for ORC3 Gene

    Size:
    711 amino acids
    Molecular mass:
    82254 Da
    Quaternary structure:
    • Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.

    Three dimensional structures from OCA and Proteopedia for ORC3 Gene

    Alternative splice isoforms for ORC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ORC3 Gene

Post-translational modifications for ORC3 Gene

  • Multi-mono-ubiquitinated by OBI1; ubiquitination is important for efficient DNA replication origin site activation. Ubiquitination levels are low in mitotic and early G1-phAse cells and are induced in late G1-/early S-phase, peaking in S-phase and decrease toward the end of the cell cycle.
  • Ubiquitination at Lys428 and Lys523
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ORC3 Gene

Domains & Families for ORC3 Gene

Gene Families for ORC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ORC3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ORC3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59790, highly similar to Origin recognition complex subunit 3 (B4DZ51_HUMAN)
  • cDNA, FLJ78810, highly similar to Origin recognition complex subunit 3 (B4E025_HUMAN)
  • Origin recognition complex subunit Latheo (ORC3_HUMAN)
  • ORC3L protein (Q6IBJ0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UBD5

UniProtKB/Swiss-Prot:

ORC3_HUMAN :
  • Belongs to the ORC3 family.
Family:
  • Belongs to the ORC3 family.
genes like me logo Genes that share domains with ORC3: view

Function for ORC3 Gene

Molecular function for ORC3 Gene

UniProtKB/Swiss-Prot Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

Phenotypes From GWAS Catalog for ORC3 Gene

Gene Ontology (GO) - Molecular Function for ORC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003688 DNA replication origin binding TAS,IBA 21873635
GO:0005515 protein binding IPI 15232106
genes like me logo Genes that share ontologies with ORC3: view
genes like me logo Genes that share phenotypes with ORC3: view

Animal Models for ORC3 Gene

MGI Knock Outs for ORC3:
  • Orc3 Orc3<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for ORC3 Gene

miRTarBase miRNAs that target ORC3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ORC3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ORC3 Gene

Localization for ORC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORC3 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ORC3 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ORC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region HDA 19135898
GO:0000785 chromatin IDA 31160578
GO:0000808 origin recognition complex IDA 17716973
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ORC3: view

Pathways & Interactions for ORC3 Gene

genes like me logo Genes that share pathways with ORC3: view

Pathways by source for ORC3 Gene

1 GeneGo (Thomson Reuters) pathway for ORC3 Gene
  • Cell cycle Start of DNA replication in early S phase
1 Qiagen pathway for ORC3 Gene
  • Cell Cycle Control of Chromosomal Replication

Gene Ontology (GO) - Biological Process for ORC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication IBA 21873635
GO:0006270 DNA replication initiation IBA 21873635
GO:0006275 regulation of DNA replication IDA 31160578
genes like me logo Genes that share ontologies with ORC3: view

No data available for SIGNOR curated interactions for ORC3 Gene

Drugs & Compounds for ORC3 Gene

No Compound Related Data Available

Transcripts for ORC3 Gene

mRNA/cDNA for ORC3 Gene

3 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ORC3

Alternative Splicing Database (ASD) splice patterns (SP) for ORC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - - - -
SP2: -
SP3: - -
SP4:
SP5:

ExUns: 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ORC3 Gene

GeneLoc Exon Structure for
ORC3

Expression for ORC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ORC3 Gene

Protein differential expression in normal tissues from HIPED for ORC3 Gene

This gene is overexpressed in Breast (27.7), Testis (6.8), and Lymph node (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ORC3 Gene



Protein tissue co-expression partners for ORC3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ORC3

SOURCE GeneReport for Unigene cluster for ORC3 Gene:

Hs.410228

Evidence on tissue expression from TISSUES for ORC3 Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Kidney(2.3)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with ORC3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ORC3 Gene

Orthologs for ORC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ORC3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ORC3 30 31
  • 99.72 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ORC3 30 31
  • 90.85 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ORC3 30 31
  • 89.12 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Orc3 30
  • 84.41 (n)
Mouse
(Mus musculus)
Mammalia Orc3 30 17 31
  • 84.06 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ORC3 31
  • 77 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ORC3 31
  • 75 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ORC3 30 31
  • 69.6 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ORC3 31
  • 66 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia orc3 30
  • 68.46 (n)
Str.19920 30
African clawed frog
(Xenopus laevis)
Amphibia MGC53625 30
Zebrafish
(Danio rerio)
Actinopterygii orc3 30 31
  • 58.69 (n)
OneToOne
Dr.2362 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.410 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010406 30
  • 46.64 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta lat 30 31
  • 46 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons ORC3 30
  • 43.4 (n)
Rice
(Oryza sativa)
Liliopsida Os10g0402200 30
  • 44.37 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU02683 30
  • 38.06 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToOne
Species where no ortholog for ORC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ORC3 Gene

ENSEMBL:
Gene Tree for ORC3 (if available)
TreeFam:
Gene Tree for ORC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ORC3: view image

Paralogs for ORC3 Gene

(1) SIMAP similar genes for ORC3 Gene using alignment to 3 proteins:

  • ORC3_HUMAN
  • B4DZ51_HUMAN
  • U3KQL3_HUMAN

Pseudogenes.org Pseudogenes for ORC3 Gene

genes like me logo Genes that share paralogs with ORC3: view

No data available for Paralogs for ORC3 Gene

Variants for ORC3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ORC3 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
785176 Benign: not provided 87,675,861(+) G/A SYNONYMOUS_VARIANT
rs2307365 - p.Gln94Lys
rs2307370 - p.Arg588Cys
rs2307371 - p.Gln126Arg
rs2307372 - p.Thr389Pro

Additional dbSNP identifiers (rs#s) for ORC3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ORC3 Gene

Variant ID Type Subtype PubMed ID
dgv6085n100 CNV gain 25217958
esv2732392 CNV deletion 23290073
esv2759454 CNV loss 17122850
esv3540112 CNV deletion 23714750
nsv1117652 CNV deletion 24896259
nsv1137123 CNV deletion 24896259

Variation tolerance for ORC3 Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.00; 80.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ORC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ORC3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORC3 Gene

Disorders for ORC3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ORC3 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search ORC3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ORC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ORC3 Gene

Publications for ORC3 Gene

  1. latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant. (PMID: 10402192) Pinto S … Dutta A (Neuron 1999) 2 3 4
  2. The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing. (PMID: 31160578) Coulombe P … Méchali M (Nature communications 2019) 3 4
  3. The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia. (PMID: 18628273) DeRosse P … Malhotra AK (Schizophrenia bulletin 2008) 3 23
  4. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PMID: 17525332) Matsuoka S … Elledge SJ (Science (New York, N.Y.) 2007) 3 4
  5. ATP-dependent assembly of the human origin recognition complex. (PMID: 17716973) Siddiqui K … Stillman B (The Journal of biological chemistry 2007) 3 4

Products for ORC3 Gene

Sources for ORC3 Gene