Aliases for ORC3 Gene
External Ids for ORC3 Gene
Previous HGNC Symbols for ORC3 Gene
Previous GeneCards Identifiers for ORC3 Gene
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ORC3 Gene
ORC3 (Origin Recognition Complex Subunit 3) is a Protein Coding gene. Diseases associated with ORC3 include Meier-Gorlin Syndrome 1 and Isolated Growth Hormone Deficiency, Type Ia. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include DNA replication origin binding.
UniProtKB/Swiss-Prot Summary for ORC3 Gene
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.