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Aliases for ORAOV1 Gene

Aliases for ORAOV1 Gene

  • Oral Cancer Overexpressed 1 2 3 5
  • Tumor-Amplified And Overexpressed Sequence 1 3 4
  • Oral Cancer Overexpressed Protein 1-A 2 3
  • TAOS1 3 4
  • Oral Cancer-Overexpressed Protein 1 3

External Ids for ORAOV1 Gene

Previous GeneCards Identifiers for ORAOV1 Gene

  • GC11M071975
  • GC11M071166
  • GC11M069727
  • GC11M069253
  • GC11M069189
  • GC11M069468
  • GC11M065772

Summaries for ORAOV1 Gene

GeneCards Summary for ORAOV1 Gene

ORAOV1 (Oral Cancer Overexpressed 1) is a Protein Coding gene. Diseases associated with ORAOV1 include Oral Cancer.

Additional gene information for ORAOV1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORAOV1 Gene

Genomics for ORAOV1 Gene

GeneHancer (GH) Regulatory Elements for ORAOV1 Gene

Promoters and enhancers for ORAOV1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I069673 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 565.6 +0.7 691 3.1 FOXA2 PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 ORAOV1 CCND1 GC11M069658
GH11I069292 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 53.1 +376.8 376809 11.6 HDGF PKNOX1 CLOCK SMAD1 ARID4B NEUROD1 SIN3A YBX1 FEZF1 ZBTB7B LOC105369370 MYEOV ORAOV1 TPCN2 PPP6R3 ENSG00000260808 FADD IGHMBP2 LRP5 ANO1
GH11I068902 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 42.2 +771.1 771090 2.7 ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 ZC3H11A ZFP41 ZNF610 IGHMBP2 MRPL21 ORAOV1 KMT5B MRGPRF-AS1 MRGPRF LOC105369364 PPP6R3 ENSG00000260808 ENSG00000261625
GH11I069635 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.8 +33.0 32950 13.5 PKNOX1 CLOCK ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF143 CCND1 ORAOV1 ANO1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ORAOV1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ORAOV1 gene promoter:

Genomic Locations for ORAOV1 Gene

Genomic Locations for ORAOV1 Gene
22,341 bases
Minus strand

Genomic View for ORAOV1 Gene

Genes around ORAOV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORAOV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORAOV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORAOV1 Gene

Proteins for ORAOV1 Gene

  • Protein details for ORAOV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oral cancer-overexpressed protein 1
    Protein Accession:
    Secondary Accessions:
    • B2R4R2
    • Q8NFK0

    Protein attributes for ORAOV1 Gene

    137 amino acids
    Molecular mass:
    15354 Da
    Quaternary structure:
    No Data Available
    • Amplified and overexpressed in oral cancer cells.

neXtProt entry for ORAOV1 Gene

Post-translational modifications for ORAOV1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ORAOV1 Gene

Domains & Families for ORAOV1 Gene

Gene Families for ORAOV1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ORAOV1 Gene


Suggested Antigen Peptide Sequences for ORAOV1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ORAOV1 family.
  • Belongs to the ORAOV1 family.
genes like me logo Genes that share domains with ORAOV1: view

Function for ORAOV1 Gene

Phenotypes From GWAS Catalog for ORAOV1 Gene

Gene Ontology (GO) - Molecular Function for ORAOV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with ORAOV1: view
genes like me logo Genes that share phenotypes with ORAOV1: view

Animal Model Products

miRNA for ORAOV1 Gene

miRTarBase miRNAs that target ORAOV1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ORAOV1 Gene

Localization for ORAOV1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ORAOV1 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 2
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ORAOV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0030896 checkpoint clamp complex IBA --
GO:0035861 site of double-strand break IBA --
genes like me logo Genes that share ontologies with ORAOV1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ORAOV1 Gene

Pathways & Interactions for ORAOV1 Gene

SuperPathways for ORAOV1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ORAOV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IBA --
GO:0006289 nucleotide-excision repair IBA --
GO:0008150 biological_process ND --
GO:0031573 intra-S DNA damage checkpoint IBA --
GO:0033314 mitotic DNA replication checkpoint IBA --
genes like me logo Genes that share ontologies with ORAOV1: view

No data available for Pathways by source and SIGNOR curated interactions for ORAOV1 Gene

Drugs & Compounds for ORAOV1 Gene

No Compound Related Data Available

Transcripts for ORAOV1 Gene

Unigene Clusters for ORAOV1 Gene

Oral cancer overexpressed 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ORAOV1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8
SP1: - - - - - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - - -
SP10: - - - - - - - - -
SP11: - -
SP12: - -

Relevant External Links for ORAOV1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ORAOV1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ORAOV1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ORAOV1 Gene

This gene is overexpressed in Pancreatic juice (57.7) and Testis (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ORAOV1 Gene

Protein tissue co-expression partners for ORAOV1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ORAOV1 Gene:


SOURCE GeneReport for Unigene cluster for ORAOV1 Gene:


mRNA Expression by UniProt/SwissProt for ORAOV1 Gene:

Tissue specificity: Widely expressed. Highly expressed in placenta, kidney and skeletal muscle.

Evidence on tissue expression from TISSUES for ORAOV1 Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with ORAOV1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ORAOV1 Gene

Orthologs for ORAOV1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ORAOV1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ORAOV1 33 34
  • 99.51 (n)
(Canis familiaris)
Mammalia ORAOV1 33 34
  • 86.62 (n)
(Bos Taurus)
Mammalia ORAOV1 33 34
  • 85.64 (n)
(Mus musculus)
Mammalia Oraov1 33 16 34
  • 77.13 (n)
(Rattus norvegicus)
Mammalia Oraov1 33
  • 76.31 (n)
(Monodelphis domestica)
Mammalia ORAOV1 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia ORAOV1 34
  • 69 (a)
(Gallus gallus)
Aves ORAOV1 33 34
  • 69.38 (n)
(Anolis carolinensis)
Reptilia ORAOV1 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia oraov1 33
  • 63.26 (n)
(Danio rerio)
Actinopterygii oraov1 34 33
  • 64.44 (n)
Species where no ortholog for ORAOV1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ORAOV1 Gene

Gene Tree for ORAOV1 (if available)
Gene Tree for ORAOV1 (if available)

Paralogs for ORAOV1 Gene Pseudogenes for ORAOV1 Gene

genes like me logo Genes that share paralogs with ORAOV1: view

No data available for Paralogs for ORAOV1 Gene

Variants for ORAOV1 Gene

Sequence variations from dbSNP and Humsavar for ORAOV1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000343924 -- 69,674,364(-) G/A intron_variant
rs1000375301 -- 69,674,632(-) G/A intron_variant
rs1000493325 -- 69,668,129(-) C/T intron_variant
rs1000858545 -- 69,669,745(-) G/A intron_variant
rs1000941105 -- 69,664,964(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ORAOV1 Gene

Variant ID Type Subtype PubMed ID
dgv16n68 CNV loss 17160897
esv3626752 CNV loss 21293372
nsv825973 CNV gain 20364138
nsv825974 CNV gain 20364138

Variation tolerance for ORAOV1 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ORAOV1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORAOV1 Gene

Disorders for ORAOV1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ORAOV1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
oral cancer
  • malignant neoplasm of mouth
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ORAOV1

genes like me logo Genes that share disorders with ORAOV1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ORAOV1 Gene

Publications for ORAOV1 Gene

  1. High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells. (PMID: 12172009) Huang X … Godfrey TE (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) Kärblane K … Sarmiento C (PloS one 2015) 3 58
  4. ORAOV1 overexpression in esophageal squamous cell carcinoma and esophageal dysplasia: a possible biomarker of progression and poor prognosis in esophageal carcinoma. (PMID: 25732110) Li M … Li F (Human pathology 2015) 3 58
  5. Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production. (PMID: 24930674) Togashi Y … Nishio K (Oncotarget 2014) 3 58

Products for ORAOV1 Gene

Sources for ORAOV1 Gene

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