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ORAI3 Gene(Protein Coding)

ORAI Calcium Release-Activated Calcium Modulator 3

GCID:
GC16P030949
GIFtS:
41
Genes Participants
UDN Logo

Aliases for ORAI3 Gene

Aliases for ORAI3 Gene

  • ORAI Calcium Release-Activated Calcium Modulator 3 2 3 5
  • Transmembrane Protein 142C 2 3 4
  • TMEM142C 3 4
  • Protein Orai-3 3

External Ids for ORAI3 Gene

Previous HGNC Symbols for ORAI3 Gene

  • TMEM142C

Previous GeneCards Identifiers for ORAI3 Gene

  • GC16P030869
  • GC16P030870
  • GC16P030960
  • GC16P028524

Summaries for ORAI3 Gene

GeneCards Summary for ORAI3 Gene

ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3) is a Protein Coding gene. Among its related pathways are Calcium signaling pathway. Gene Ontology (GO) annotations related to this gene include store-operated calcium channel activity. An important paralog of this gene is ORAI2.

UniProtKB/Swiss-Prot for ORAI3 Gene

  • Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import.

Tocris Summary for ORAI3 Gene

  • STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). STIM (stromal interaction molecule) proteins are ER Ca2+ sensors. Orai proteins are STIM binding partners that form the channel pore.

Additional gene information for ORAI3 Gene

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORAI3 Gene

Genomics for ORAI3 Gene

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  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for ORAI3 Gene

Promoters and enhancers for ORAI3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH16I030946 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 0.0 -19 4.6 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 NFYC SETD1A ENSG00000261487 PIR42450 ORAI3 RNF40 ZNF646 HSD3B7 INO80E FBRS ZNF689
GH16I030052 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 26.9 -894.9 -894861 3.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ALDOA FAM57B SETD1A SRCAP NPIPB12 INO80E SMG1P5 SMG1P2 ZNF764 ZNF747
GH16I031178 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 26.4 +231.8 231768 4.7 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 FUS SRCAP SETD1A SMG1P5 ZNF764 ENSG00000260267 PRR14 RNF40 ENSG00000260304 FBRS
GH16I031125 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.8 +182.1 182072 10.7 HDGF CLOCK ARNT NEUROD1 SIN3A ZNF766 ZNF207 ZNF548 MCM3 SP3 ENSG00000261385 PRSS8 SRCAP SETD1A ENSG00000260267 SMG1P5 ZNF764 ENSG00000260304 KAT8 BCL7C
GH16I030956 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.1 +8.8 8825 3.4 CLOCK FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 SP3 SETD1A ENSG00000275263 FUS SRCAP INO80E ENSG00000260267 SMG1P5 ZNF764 BCL7C ENSG00000260304
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ORAI3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ORAI3 gene promoter:

Genomic Locations for ORAI3 Gene

Genomic Locations for ORAI3 Gene
chr16:30,949,066-30,956,461
(GRCh38/hg38)
Size:
7,396 bases
Orientation:
Plus strand
chr16:30,960,387-30,967,782
(GRCh37/hg19)

Genomic View for ORAI3 Gene

Genes around ORAI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORAI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORAI3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ORAI3 Gene

Proteins for ORAI3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ORAI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRQ5-ORAI3_HUMAN
    Recommended name:
    Protein orai-3
    Protein Accession:
    Q9BRQ5
    Secondary Accessions:
    • Q96BI8

    Protein attributes for ORAI3 Gene

    Size:
    295 amino acids
    Molecular mass:
    31499 Da
    Quaternary structure:
    • Interacts with CRACR2A/EFCAB4B.

neXtProt entry for ORAI3 Gene

Post-translational modifications for ORAI3 Gene

  • Glycosylation at isoforms=213, isoforms=214, Ser216, and isoforms=220
  • Modification sites at PhosphoSitePlus

Other Protein References for ORAI3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ORAI3 Gene

Domains & Families for ORAI3 Gene

Gene Families for ORAI3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for ORAI3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ORAI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRQ5

UniProtKB/Swiss-Prot:

ORAI3_HUMAN :
  • Belongs to the Orai family.
Family:
  • Belongs to the Orai family.
genes like me logo Genes that share domains with ORAI3: view

Function for ORAI3 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ORAI3 Gene

UniProtKB/Swiss-Prot Function:
Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import.

Phenotypes From GWAS Catalog for ORAI3 Gene

Gene Ontology (GO) - Molecular Function for ORAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19887627
GO:0015279 store-operated calcium channel activity IBA --
genes like me logo Genes that share ontologies with ORAI3: view
genes like me logo Genes that share phenotypes with ORAI3: view

Animal Model Products

miRNA for ORAI3 Gene

miRTarBase miRNAs that target ORAI3

Clone Products

  • Addgene plasmids for ORAI3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ORAI3 Gene

Localization for ORAI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORAI3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ORAI3 gene
Compartment Confidence
plasma membrane 4
cytosol 3
peroxisome 2
nucleus 2
endoplasmic reticulum 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ORAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ORAI3: view

Pathways & Interactions for ORAI3 Gene

SuperPathways for ORAI3 Gene

PathCards logo More details on SuperPathways for ORAI3
SuperPathway Contained pathways
1 Calcium signaling pathway
Calcium signaling pathway
-
genes like me logo Genes that share pathways with ORAI3: view

Pathways by source for ORAI3 Gene

1 KEGG pathway for ORAI3 Gene

Gene Ontology (GO) - Biological Process for ORAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002115 store-operated calcium entry IBA --
GO:0070588 calcium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with ORAI3: view

No data available for SIGNOR curated interactions for ORAI3 Gene

Drugs & Compounds for ORAI3 Gene

Products:

  1. Drug

(1) Drugs for ORAI3 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
SKF 96365 hydrochloride Pharma SOCE inhibitor, TRPC channel blocker; also inhibits store-operated Ca2+ entry 0

(5) Tocris Compounds for ORAI3 Gene

Compound Action Cas Number
2-APB IP3 receptor antagonist. Also TRP channel modulator 524-95-8
5J 4 CRAC channel blocker; anti-inflammatory 827001-82-1
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
SKF 96365 hydrochloride TRPC channel blocker; also inhibits store-operated Ca2+ entry 130495-35-1
YM 58483 Inhibitor of SOCE in non-excitable cells 223499-30-7
genes like me logo Genes that share compounds with ORAI3: view

Transcripts for ORAI3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ORAI3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(186) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ORAI3 Gene

ORAI calcium release-activated calcium modulator 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for ORAI3

Alternative Splicing Database (ASD) splice patterns (SP) for ORAI3 Gene

No ASD Table

Relevant External Links for ORAI3 Gene

GeneLoc Exon Structure for
ORAI3
ECgene alternative splicing isoforms for
ORAI3

Expression for ORAI3 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ORAI3 Gene

mRNA expression in normal human tissues for ORAI3 Gene
mRNA expression by BioGPS for ORAI3 GenemRNA expression by GTEx for ORAI3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ORAI3 Gene:

ORAI3

SOURCE GeneReport for Unigene cluster for ORAI3 Gene:

Hs.745104

Evidence on tissue expression from TISSUES for ORAI3 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ORAI3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ORAI3 Gene

Orthologs for ORAI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ORAI3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ORAI3 33 34
  • 98.98 (n)
dog
(Canis familiaris)
 Mammalia ORAI3 33 34
  • 90.9 (n)
cow
(Bos Taurus)
 Mammalia ORAI3 33 34
  • 89.97 (n)
mouse
(Mus musculus)
 Mammalia Orai3 33 16 34
  • 86.04 (n)
rat
(Rattus norvegicus)
 Mammalia Orai3 33
  • 85.81 (n)
oppossum
(Monodelphis domestica)
 Mammalia ORAI3 34
  • 79 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ORAI3 34
  • 74 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ORAI3 34
  • 61 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii orai1b 34
  • 68 (a)
 ManyToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP005071 33
  • 57.21 (n)
fruit fly
(Drosophila melanogaster)
 Insecta olf186-F 34
  • 23 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea orai-1 34
  • 28 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.8521 34
  • 35 (a)
 OneToMany
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.15111 33
Species where no ortholog for ORAI3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ORAI3 Gene

ENSEMBL:
Gene Tree for ORAI3 (if available)
TreeFam:
Gene Tree for ORAI3 (if available)

Paralogs for ORAI3 Gene

Paralogs for ORAI3 Gene

(2) SIMAP similar genes for ORAI3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ORAI3: view

Variants for ORAI3 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for ORAI3 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000252352 -- 30,955,321(+) C/T downstream_transcript_variant
rs1001689636 -- 30,949,687(+) G/C intron_variant
rs1002436049 -- 30,951,783(+) C/T intron_variant
rs1002841141 -- 30,952,009(+) C/G intron_variant
rs1003043860 -- 30,949,560(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ORAI3 Gene

Variant ID Type Subtype PubMed ID
dgv35n68 CNV loss 17160897
nsv457483 CNV loss 19166990
nsv482192 CNV gain 20164927
nsv571820 CNV loss 21841781
nsv833189 CNV loss 17160897
nsv833193 CNV gain+loss 17160897
nsv953802 CNV deletion 24416366

Variation tolerance for ORAI3 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ORAI3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ORAI3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORAI3 Gene

Disorders for ORAI3 Gene

Additional Disease Information for ORAI3

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ORAI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ORAI3 Gene

Publications for ORAI3 Gene

  1. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. (PMID: 16582901) Feske S … Rao A (Nature 2006) 2 3 4 58
  2. Orai channel-mediated Ca2+ signals in vascular and airway smooth muscle. (PMID: 26718630) Spinelli AM … Trebak M (American journal of physiology. Cell physiology 2016) 2 3 58
  3. A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels. (PMID: 26956485) Saul S … Bogeski I (Science signaling 2016) 2 3 58
  4. The neglected CRAC proteins: Orai2, Orai3, and STIM2. (PMID: 23890118) Hoth M … Niemeyer BA (Current topics in membranes 2013) 2 3 58
  5. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. (PMID: 20418871) Srikanth S … Gwack Y (Nature cell biology 2010) 3 4 58

Products for ORAI3 Gene

  • Addgene plasmids for ORAI3

Sources for ORAI3 Gene

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