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ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3) is a Protein Coding gene. Diseases associated with ORAI3 include Estrogen-Receptor Negative Breast Cancer and Myopathy, Tubular Aggregate, 1. Among its related pathways are Calcium signaling pathway and B Cell Receptor Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include store-operated calcium channel activity. An important paralog of this gene is ORAI1.
STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). STIM (stromal interaction molecule) proteins are ER Ca2+ sensors. Orai proteins are STIM binding partners that form the channel pore.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 19887627 |
GO:0015279 | store-operated calcium channel activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA,IBA | 21873635 |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Calcium signaling pathway | ||
2 | B Cell Receptor Signaling Pathway (sino) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002115 | store-operated calcium entry | IBA | 21873635 |
GO:0070588 | calcium ion transmembrane transport | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
2-APB | Pharma | Channel blocker, Pore Blocker, Antagonist, Gating inhibitor, Activator, Agonist, Potentiation | IP3 receptor antagonist. Also TRP channel modulator | 0 | ||
ML 9 hydrochloride | Pharma | Myosin light chain kinase inhibitor | 0 | |||
SKF 96365 hydrochloride | Pharma | SOCE inhibitor, TRPC channel blocker; also inhibits store-operated Ca2+ entry | 0 | |||
YM 58483 | Pharma | Inhibitor of SOCE in non-excitable cells | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
5J 4 |
|
827001-82-1 |
|
|
Compound | Action | Cas Number |
---|---|---|
2-APB | IP3 receptor antagonist. Also TRP channel modulator | 524-95-8 |
5J 4 | CRAC channel blocker; anti-inflammatory | 827001-82-1 |
ML 9 hydrochloride | Myosin light chain kinase inhibitor | 105637-50-1 |
SKF 96365 hydrochloride | TRPC channel blocker; also inhibits store-operated Ca2+ entry | 130495-35-1 |
YM 58483 | Inhibitor of SOCE in non-excitable cells | 223499-30-7 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ORAI3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ORAI3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ORAI3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Orai3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Orai3 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | ORAI3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ORAI3 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ORAI3 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | orai1b 31 |
|
ManyToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005071 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | olf186-F 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | orai-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8521 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.15111 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
estrogen-receptor negative breast cancer |
|
|
myopathy, tubular aggregate, 1 |
|
|
stormorken syndrome |
|
|
combined t cell and b cell immunodeficiency |
|
|