Aliases for ORAI3 Gene

Aliases for ORAI3 Gene

  • ORAI Calcium Release-Activated Calcium Modulator 3 2 3 5
  • Transmembrane Protein 142C 2 3 4
  • Protein Orai-3 3 4
  • TMEM142C 3 4
  • MGC13024 2
  • ORAI3 5

External Ids for ORAI3 Gene

Previous HGNC Symbols for ORAI3 Gene

  • TMEM142C

Previous GeneCards Identifiers for ORAI3 Gene

  • GC16P030869
  • GC16P030870
  • GC16P030960
  • GC16P028524

Summaries for ORAI3 Gene

GeneCards Summary for ORAI3 Gene

ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3) is a Protein Coding gene. Diseases associated with ORAI3 include Estrogen-Receptor Negative Breast Cancer and Myopathy, Tubular Aggregate, 1. Among its related pathways are Calcium signaling pathway and B Cell Receptor Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include store-operated calcium channel activity. An important paralog of this gene is ORAI1.

UniProtKB/Swiss-Prot Summary for ORAI3 Gene

  • Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.

Tocris Summary for ORAI3 Gene

  • STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). STIM (stromal interaction molecule) proteins are ER Ca2+ sensors. Orai proteins are STIM binding partners that form the channel pore.

Additional gene information for ORAI3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ORAI3 Gene

Genomics for ORAI3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ORAI3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ORAI3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ORAI3

Top Transcription factor binding sites by QIAGEN in the ORAI3 gene promoter:
  • AREB6
  • Arnt
  • c-Rel
  • CREB
  • HTF
  • LCR-F1
  • MZF-1
  • NF-1
  • NF-1/L
  • NF-AT

Genomic Locations for ORAI3 Gene

Genomic Locations for ORAI3 Gene
chr16:30,949,068-30,956,461
(GRCh38/hg38)
Size:
7,394 bases
Orientation:
Plus strand
chr16:30,960,387-30,967,782
(GRCh37/hg19)
Size:
7,396 bases
Orientation:
Plus strand

Genomic View for ORAI3 Gene

Genes around ORAI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORAI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORAI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORAI3 Gene

Proteins for ORAI3 Gene

  • Protein details for ORAI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRQ5-ORAI3_HUMAN
    Recommended name:
    Protein orai-3
    Protein Accession:
    Q9BRQ5
    Secondary Accessions:
    • Q96BI8

    Protein attributes for ORAI3 Gene

    Size:
    295 amino acids
    Molecular mass:
    31499 Da
    Quaternary structure:
    • Interacts with CRACR2A/EFCAB4B.

neXtProt entry for ORAI3 Gene

Post-translational modifications for ORAI3 Gene

  • Glycosylation at Ser213, Ser214, Ser216, and Ser220
  • Modification sites at PhosphoSitePlus

Other Protein References for ORAI3 Gene

No data available for DME Specific Peptides for ORAI3 Gene

Domains & Families for ORAI3 Gene

Gene Families for ORAI3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for ORAI3 Gene

InterPro:
Blocks:
  • Protein of unknown function DUF1650
ProtoNet:

Suggested Antigen Peptide Sequences for ORAI3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60134, highly similar to Protein orai-3 (B4DPC5_HUMAN)
  • Transmembrane protein 142C (ORAI3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BRQ5

UniProtKB/Swiss-Prot:

ORAI3_HUMAN :
  • Belongs to the Orai family.
Family:
  • Belongs to the Orai family.
genes like me logo Genes that share domains with ORAI3: view

Function for ORAI3 Gene

Molecular function for ORAI3 Gene

UniProtKB/Swiss-Prot Function:
Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.

Phenotypes From GWAS Catalog for ORAI3 Gene

Gene Ontology (GO) - Molecular Function for ORAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19887627
GO:0015279 store-operated calcium channel activity IBA 21873635
genes like me logo Genes that share ontologies with ORAI3: view
genes like me logo Genes that share phenotypes with ORAI3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ORAI3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ORAI3 Gene

Localization for ORAI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORAI3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ORAI3 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 3
extracellular 2
peroxisome 2
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ORAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA,IBA 21873635
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ORAI3: view

Pathways & Interactions for ORAI3 Gene

genes like me logo Genes that share pathways with ORAI3: view

Pathways by source for ORAI3 Gene

1 Sino Biological pathway for ORAI3 Gene
1 KEGG pathway for ORAI3 Gene

Gene Ontology (GO) - Biological Process for ORAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002115 store-operated calcium entry IBA 21873635
GO:0070588 calcium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with ORAI3: view

No data available for SIGNOR curated interactions for ORAI3 Gene

Drugs & Compounds for ORAI3 Gene

(4) Drugs for ORAI3 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-APB Pharma Channel blocker, Pore Blocker, Antagonist, Gating inhibitor, Activator, Agonist, Potentiation IP3 receptor antagonist. Also TRP channel modulator 0
ML 9 hydrochloride Pharma Myosin light chain kinase inhibitor 0
SKF 96365 hydrochloride Pharma SOCE inhibitor, TRPC channel blocker; also inhibits store-operated Ca2+ entry 0
YM 58483 Pharma Inhibitor of SOCE in non-excitable cells 0

(1) Additional Compounds for ORAI3 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5J 4
827001-82-1

(5) Tocris Compounds for ORAI3 Gene

Compound Action Cas Number
2-APB IP3 receptor antagonist. Also TRP channel modulator 524-95-8
5J 4 CRAC channel blocker; anti-inflammatory 827001-82-1
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
SKF 96365 hydrochloride TRPC channel blocker; also inhibits store-operated Ca2+ entry 130495-35-1
YM 58483 Inhibitor of SOCE in non-excitable cells 223499-30-7
genes like me logo Genes that share compounds with ORAI3: view

Transcripts for ORAI3 Gene

mRNA/cDNA for ORAI3 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ORAI3

Alternative Splicing Database (ASD) splice patterns (SP) for ORAI3 Gene

No ASD Table

Relevant External Links for ORAI3 Gene

GeneLoc Exon Structure for
ORAI3

Expression for ORAI3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ORAI3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ORAI3

SOURCE GeneReport for Unigene cluster for ORAI3 Gene:

Hs.745104

mRNA Expression by UniProt/SwissProt for ORAI3 Gene:

Q9BRQ5-ORAI3_HUMAN
Tissue specificity: Expressed in both naive and effector T helper cells with higher levels in effector cells.

Evidence on tissue expression from TISSUES for ORAI3 Gene

  • Lung(4.4)
  • Blood(2.5)
  • Muscle(2.4)
  • Kidney(2.4)
  • Nervous system(2.3)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with ORAI3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ORAI3 Gene

Orthologs for ORAI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ORAI3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ORAI3 30 31
  • 98.98 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ORAI3 30 31
  • 90.9 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ORAI3 30 31
  • 89.97 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Orai3 30 17 31
  • 86.04 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Orai3 30
  • 85.81 (n)
Oppossum
(Monodelphis domestica)
Mammalia ORAI3 31
  • 79 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ORAI3 31
  • 74 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ORAI3 31
  • 61 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii orai1b 31
  • 68 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005071 30
  • 57.21 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta olf186-F 31
  • 23 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea orai-1 31
  • 28 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8521 31
  • 35 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.15111 30
Species where no ortholog for ORAI3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ORAI3 Gene

ENSEMBL:
Gene Tree for ORAI3 (if available)
TreeFam:
Gene Tree for ORAI3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ORAI3: view image

Paralogs for ORAI3 Gene

Paralogs for ORAI3 Gene

(2) SIMAP similar genes for ORAI3 Gene using alignment to 4 proteins:

  • ORAI3_HUMAN
  • H3BT51_HUMAN
  • H3BTK7_HUMAN
  • H3BTY7_HUMAN
genes like me logo Genes that share paralogs with ORAI3: view

Variants for ORAI3 Gene

Additional dbSNP identifiers (rs#s) for ORAI3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ORAI3 Gene

Variant ID Type Subtype PubMed ID
dgv35n68 CNV loss 17160897
nsv457483 CNV loss 19166990
nsv482192 CNV gain 20164927
nsv571820 CNV loss 21841781
nsv833189 CNV loss 17160897
nsv833193 CNV gain+loss 17160897
nsv953802 CNV deletion 24416366

Variation tolerance for ORAI3 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ORAI3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ORAI3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ORAI3 Gene

Disorders for ORAI3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ORAI3 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ORAI3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ORAI3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ORAI3 Gene

Publications for ORAI3 Gene

  1. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. (PMID: 16582901) Feske S … Rao A (Nature 2006) 2 3 4
  2. A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels. (PMID: 26956485) Saul S … Bogeski I (Science signaling 2016) 2 3
  3. Orai channel-mediated Ca2+ signals in vascular and airway smooth muscle. (PMID: 26718630) Spinelli AM … Trebak M (American journal of physiology. Cell physiology 2016) 2 3
  4. The neglected CRAC proteins: Orai2, Orai3, and STIM2. (PMID: 23890118) Hoth M … Niemeyer BA (Current topics in membranes 2013) 2 3
  5. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. (PMID: 20418871) Srikanth S … Gwack Y (Nature cell biology 2010) 3 4

Products for ORAI3 Gene

  • Signalway Proteins for ORAI3

Sources for ORAI3 Gene