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Aliases for ORAI2 Gene

Aliases for ORAI2 Gene

  • ORAI Calcium Release-Activated Calcium Modulator 2 2 3 5
  • Transmembrane Protein 142B 2 3 4
  • CAP-Binding Protein Complex Interacting Protein 2 2 3
  • TMEM142B 3 4
  • C7orf19 3 4
  • CBCIP2 3 4
  • CAP-Binding Protein Complex-Interacting Protein 2 4
  • Chromosome 7 Open Reading Frame 19 2
  • Putative Protein ORAI2-2 3
  • Protein Orai-2 3
  • H_NH0514P08.8 3
  • MEM142B 3

External Ids for ORAI2 Gene

Previous HGNC Symbols for ORAI2 Gene

  • C7orf19
  • TMEM142B

Previous GeneCards Identifiers for ORAI2 Gene

  • GC07P101862
  • GC07P102074
  • GC07P096656

Summaries for ORAI2 Gene

GeneCards Summary for ORAI2 Gene

ORAI2 (ORAI Calcium Release-Activated Calcium Modulator 2) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Platelet homeostasis. Gene Ontology (GO) annotations related to this gene include store-operated calcium channel activity. An important paralog of this gene is ORAI3.

UniProtKB/Swiss-Prot for ORAI2 Gene

  • Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.

Tocris Summary for ORAI2 Gene

  • STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). STIM (stromal interaction molecule) proteins are ER Ca2+ sensors. Orai proteins are STIM binding partners that form the channel pore.

Gene Wiki entry for ORAI2 Gene

Additional gene information for ORAI2 Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORAI2 Gene

Genomics for ORAI2 Gene

GeneHancer (GH) Regulatory Elements for ORAI2 Gene

Promoters and enhancers for ORAI2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I102423 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 589.9 -3.7 -3721 12.2 HDGF PKNOX1 ATF1 SMAD1 SIN3A DMAP1 GLI4 IRF4 ZNF48 ZNF121 ORAI2 GC07M102430 PRKRIP1 ENSG00000239486 ENSG00000272949 ALKBH4 NAPEPLD POLR2J RASA4DP PIR39315
GH07I102395 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 28.3 -36.8 -36805 2.5 CLOCK FOXA2 SMAD1 ARID4B SIN3A IRF4 YY1 POLR2B E2F8 ZNF143 PRKRIP1 ORAI2 ENSG00000213385 CRYZP1 ENSG00000272949 PMPCB POLR2J DNAJC2 POLR2J2 MIR548O
GH07I102419 Enhancer 1.3 Ensembl ENCODE dbSUPER 31.9 -12.5 -12456 2.8 PKNOX1 ARNT TCF12 ZNF766 GATA2 ATF7 CAVIN1 NCOA1 ZNF592 MBD2 LOC105375433 ORAI2 ENSG00000272949 ALKBH4 LRWD1 DNAJC2 RASA4B CRYZP1 MIR548O LOC100630923
GH07I102363 Promoter/Enhancer 1.5 Ensembl ENCODE 26.6 -68.9 -68928 2 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 PRKRIP1 ENSG00000239969 LOC100630923 LOC100289561 ORAI2 ALKBH4 ENSG00000239486 GC07P102225
GH07I102414 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 29.6 -16.1 -16133 4.4 HDGF NFIB BACH1 EBF1 BATF ZNF316 GATA3 POLR2A IKZF2 RUNX3 ORAI2 ALKBH4 LRWD1 POLR2J ENSG00000272949 PRKRIP1 LOC105375433 MIR548O LOC100630923
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ORAI2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ORAI2 gene promoter:

Genomic Locations for ORAI2 Gene

Genomic Locations for ORAI2 Gene
chr7:102,433,106-102,456,821
(GRCh38/hg38)
Size:
23,716 bases
Orientation:
Plus strand
chr7:102,073,553-102,097,268
(GRCh37/hg19)

Genomic View for ORAI2 Gene

Genes around ORAI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORAI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORAI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORAI2 Gene

Proteins for ORAI2 Gene

  • Protein details for ORAI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SN7-ORAI2_HUMAN
    Recommended name:
    Protein orai-2
    Protein Accession:
    Q96SN7
    Secondary Accessions:
    • Q6IA68
    • Q8WY94
    • Q9H9Y3

    Protein attributes for ORAI2 Gene

    Size:
    254 amino acids
    Molecular mass:
    28570 Da
    Quaternary structure:
    • Interacts with CRACR2A/EFCAB4B.
    SequenceCaution:
    • Sequence=AAG23755.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAP22352.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAG33568.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for ORAI2 Gene

Post-translational modifications for ORAI2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ORAI2 Gene

Domains & Families for ORAI2 Gene

Gene Families for ORAI2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ORAI2 Gene

Suggested Antigen Peptide Sequences for ORAI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96SN7

UniProtKB/Swiss-Prot:

ORAI2_HUMAN :
  • Belongs to the Orai family.
Family:
  • Belongs to the Orai family.
genes like me logo Genes that share domains with ORAI2: view

Function for ORAI2 Gene

Molecular function for ORAI2 Gene

UniProtKB/Swiss-Prot Function:
Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.

Phenotypes From GWAS Catalog for ORAI2 Gene

Gene Ontology (GO) - Molecular Function for ORAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20418871
GO:0015279 store-operated calcium channel activity IBA --
genes like me logo Genes that share ontologies with ORAI2: view
genes like me logo Genes that share phenotypes with ORAI2: view

Animal Models for ORAI2 Gene

MGI Knock Outs for ORAI2:

Animal Model Products

miRNA for ORAI2 Gene

miRTarBase miRNAs that target ORAI2

Clone Products

  • Addgene plasmids for ORAI2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ORAI2 Gene

Localization for ORAI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORAI2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ORAI2 gene
Compartment Confidence
plasma membrane 4
nucleus 2
endoplasmic reticulum 2
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ORAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IBA --
GO:0016021 integral component of membrane IEA --
GO:0030426 growth cone IEA --
genes like me logo Genes that share ontologies with ORAI2: view

Pathways & Interactions for ORAI2 Gene

genes like me logo Genes that share pathways with ORAI2: view

Gene Ontology (GO) - Biological Process for ORAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002115 store-operated calcium entry IBA --
GO:0070588 calcium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with ORAI2: view

No data available for SIGNOR curated interactions for ORAI2 Gene

Drugs & Compounds for ORAI2 Gene

(1) Drugs for ORAI2 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
SKF 96365 hydrochloride Pharma SOCE inhibitor, TRPC channel blocker; also inhibits store-operated Ca2+ entry 0

(5) Tocris Compounds for ORAI2 Gene

Compound Action Cas Number
2-APB IP3 receptor antagonist. Also TRP channel modulator 524-95-8
5J 4 CRAC channel blocker; anti-inflammatory 827001-82-1
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
SKF 96365 hydrochloride TRPC channel blocker; also inhibits store-operated Ca2+ entry 130495-35-1
YM 58483 Inhibitor of SOCE in non-excitable cells 223499-30-7
genes like me logo Genes that share compounds with ORAI2: view

Transcripts for ORAI2 Gene

Unigene Clusters for ORAI2 Gene

ORAI calcium release-activated calcium modulator 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for ORAI2

Alternative Splicing Database (ASD) splice patterns (SP) for ORAI2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3:

Relevant External Links for ORAI2 Gene

GeneLoc Exon Structure for
ORAI2
ECgene alternative splicing isoforms for
ORAI2

Expression for ORAI2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ORAI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ORAI2 Gene

This gene is overexpressed in Whole Blood (x10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ORAI2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ORAI2 Gene:

ORAI2

SOURCE GeneReport for Unigene cluster for ORAI2 Gene:

Hs.363308

Evidence on tissue expression from TISSUES for ORAI2 Gene

  • Nervous system(4.7)
  • Kidney(2)
genes like me logo Genes that share expression patterns with ORAI2: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ORAI2 Gene

Orthologs for ORAI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ORAI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ORAI2 33 34
  • 99.08 (n)
cow
(Bos Taurus)
Mammalia ORAI2 33 34
  • 92.91 (n)
oppossum
(Monodelphis domestica)
Mammalia ORAI2 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ORAI2 33 34
  • 91.34 (n)
mouse
(Mus musculus)
Mammalia Orai2 33 16 34
  • 89.73 (n)
rat
(Rattus norvegicus)
Mammalia Orai2 33
  • 89.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ORAI2 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves ORAI2 33 34
  • 82.68 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia orai1 33
  • 71.26 (n)
zebrafish
(Danio rerio)
Actinopterygii orai2 33 34
  • 78.74 (n)
Dr.14076 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8808 33
fruit fly
(Drosophila melanogaster)
Insecta olf186-F 34
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea orai-1 34
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8521 34
  • 36 (a)
OneToMany
Species where no ortholog for ORAI2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ORAI2 Gene

ENSEMBL:
Gene Tree for ORAI2 (if available)
TreeFam:
Gene Tree for ORAI2 (if available)

Paralogs for ORAI2 Gene

Paralogs for ORAI2 Gene

(2) SIMAP similar genes for ORAI2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ORAI2: view

Variants for ORAI2 Gene

Sequence variations from dbSNP and Humsavar for ORAI2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000151807 -- 102,443,380(+) G/A intron_variant
rs1000233651 -- 102,454,668(+) C/G 3_prime_UTR_variant
rs1000248964 -- 102,431,995(+) G/T upstream_transcript_variant
rs1000357573 -- 102,438,399(+) T/G intron_variant
rs1000447728 -- 102,433,208(+) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ORAI2 Gene

Variant ID Type Subtype PubMed ID
nsv831083 CNV loss 17160897
nsv824248 CNV gain 20364138
nsv8192 CNV gain 18304495
nsv607999 CNV loss 21841781
nsv607998 CNV gain+loss 21841781
nsv5879 CNV deletion 18451855
nsv464665 CNV loss 19166990
nsv464664 CNV gain 19166990
nsv428182 CNV gain 18775914
esv3614353 CNV loss 21293372
esv3614352 CNV loss 21293372
esv3442204 CNV duplication 20981092
esv3303091 CNV tandem duplication 20981092
esv3302638 CNV tandem duplication 20981092
esv2672060 CNV deletion 23128226
esv2656867 CNV deletion 23128226
dgv6538n100 CNV gain 25217958

Variation tolerance for ORAI2 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 19.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ORAI2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ORAI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORAI2 Gene

Disorders for ORAI2 Gene

Additional Disease Information for ORAI2

No disorders were found for ORAI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ORAI2 Gene

Publications for ORAI2 Gene

  1. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. (PMID: 16582901) Feske S … Rao A (Nature 2006) 2 3 4 58
  2. The neglected CRAC proteins: Orai2, Orai3, and STIM2. (PMID: 23890118) Hoth M … Niemeyer BA (Current topics in membranes 2013) 2 3 58
  3. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. (PMID: 20418871) Srikanth S … Gwack Y (Nature cell biology 2010) 3 4 58
  4. Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels. (PMID: 17452328) DeHaven WI … Putney JW (The Journal of biological chemistry 2007) 3 4 58
  5. Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. (PMID: 16807233) Mercer JC … Putney JW (The Journal of biological chemistry 2006) 3 4 58

Products for ORAI2 Gene

  • Addgene plasmids for ORAI2

Sources for ORAI2 Gene

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