Aliases for ORAI2 Gene
External Ids for ORAI2 Gene
Previous HGNC Symbols for ORAI2 Gene
Previous GeneCards Identifiers for ORAI2 Gene
GeneCards Summary for ORAI2 Gene
ORAI2 (ORAI Calcium Release-Activated Calcium Modulator 2) is a Protein Coding gene. Diseases associated with ORAI2 include T Cell And Nk Cell Immunodeficiency and Immunodeficiency 10. Among its related pathways are Cardiac conduction and B Cell Receptor Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include store-operated calcium channel activity. An important paralog of this gene is ORAI1.
UniProtKB/Swiss-Prot Summary for ORAI2 Gene
Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.
STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). STIM (stromal interaction molecule) proteins are ER Ca2+ sensors. Orai proteins are STIM binding partners that form the channel pore.