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Aliases for ORAI1 Gene

Aliases for ORAI1 Gene

  • ORAI Calcium Release-Activated Calcium Modulator 1 2 3 5
  • Transmembrane Protein 142A 2 3 4
  • Calcium Release-Activated Calcium Modulator 1 2 3
  • Protein Orai-1 3 4
  • TMEM142A 3 4
  • CRACM1 3 4
  • Calcium Release-Activated Calcium Channel Protein 1 3
  • ORAT1 3
  • IMD9 3
  • TAM2 3

External Ids for ORAI1 Gene

Previous HGNC Symbols for ORAI1 Gene

  • TMEM142A

Previous GeneCards Identifiers for ORAI1 Gene

  • GC12P120550
  • GC12P122064
  • GC12P119077
  • GC12P121665
  • GC12P121668
  • GC12P121672
  • GC12P121679
  • GC12P121683
  • GC12P121997
  • GC12P122020

Summaries for ORAI1 Gene

Entrez Gene Summary for ORAI1 Gene

  • The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]

GeneCards Summary for ORAI1 Gene

ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1) is a Protein Coding gene. Diseases associated with ORAI1 include Immunodeficiency 9 and Myopathy, Tubular Aggregate, 2. Among its related pathways are Cardiac conduction and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include identical protein binding and store-operated calcium channel activity. An important paralog of this gene is ORAI2.

UniProtKB/Swiss-Prot for ORAI1 Gene

  • Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901).

Tocris Summary for ORAI1 Gene

  • STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). STIM (stromal interaction molecule) proteins are ER Ca2+ sensors. Orai proteins are STIM binding partners that form the channel pore.

Gene Wiki entry for ORAI1 Gene

Additional gene information for ORAI1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORAI1 Gene

Genomics for ORAI1 Gene

GeneHancer (GH) Regulatory Elements for ORAI1 Gene

Promoters and enhancers for ORAI1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I121625 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 554.6 +2.0 2035 5.8 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZNF302 ZNF207 ZNF143 KLF13 ORAI1 SETD1B RSRC2 ZCCHC8 UNC119B MORN3 TMEM120B LOC105370034
GH12I121624 Enhancer 1.1 ENCODE dbSUPER 550.8 -1.8 -1776 1.1 PKNOX1 ATF1 RB1 NFRKB ARID4B DMAP1 RAD21 ZNF335 EGR1 ZNF143 GC12P122169 ORAI1 MORN3
GH12I121589 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -35.2 -35242 3.9 HDGF ATF1 PKNOX1 ZBTB7B IRF4 ZNF121 ZNF766 ZNF143 ATF7 FOS KNTC1 KDM2B ZCCHC8 RSRC2 ORAI1 MORN3 LINC01089 SETD1B UNC119B RNF34
GH12I121783 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.9 +169.4 169442 24.5 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ENSG00000272849 SETD1B RHOF ZCCHC8 RSRC2 PSMD9 ANAPC5 KNTC1 LINC01089 HPD
GH12I121398 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 5.2 -226.2 -226224 3.3 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ANAPC5 RNF34 SETD1B ENSG00000272849 KDM2B PSMD9 ENSG00000258435 LINC01089 MLXIP RPL31P52
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ORAI1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ORAI1 gene promoter:

Genomic Locations for ORAI1 Gene

Genomic Locations for ORAI1 Gene
chr12:121,626,550-121,642,677
(GRCh38/hg38)
Size:
16,128 bases
Orientation:
Plus strand
chr12:122,064,455-122,080,583
(GRCh37/hg19)

Genomic View for ORAI1 Gene

Genes around ORAI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORAI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORAI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORAI1 Gene

Proteins for ORAI1 Gene

  • Protein details for ORAI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96D31-CRCM1_HUMAN
    Recommended name:
    Calcium release-activated calcium channel protein 1
    Protein Accession:
    Q96D31
    Secondary Accessions:
    • Q3MHV3
    • Q6DHX2
    • Q96BP7
    • Q96K71

    Protein attributes for ORAI1 Gene

    Size:
    301 amino acids
    Molecular mass:
    32668 Da
    Quaternary structure:
    • Interacts with STIM1 and STIM2; this regulates channel activity (PubMed:17905723, PubMed:19249086, PubMed:24351972, PubMed:28219928, PubMed:27185316). Interacts with CALM; this may displace STIM1 and STIM2 and might thereby modulate channel activity (PubMed:23109337). Interacts with CRACR2A/EFCAB4B; the interaction is direct and takes place in absence of Ca(2+) (PubMed:20418871). Forms a complex with CRACR2A/EFCAB4B and STIM1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Interacts with ASPH (isoform 8) (PubMed:22586105). Interacts with SLC35G1 (PubMed:22084111). Interacts with UBQLN1 (PubMed:23307288).
    Miscellaneous:
    • According to a report, ORAI1 has been shown to colocalize with UBQLN1 in the autophagosome as a target for autophagic degradation; ORAI1 is however not an autophagosomal protein.
    • In Greek mythology, the Orai are the keepers of the gates of heaven: Eunomia (order or harmony), Dike (justice) and Eirene (peace).
    SequenceCaution:
    • Sequence=AAH13386.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI04634.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55068.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ORAI1 Gene

    Alternative splice isoforms for ORAI1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ORAI1 Gene

Post-translational modifications for ORAI1 Gene

Other Protein References for ORAI1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ORAI1 Gene

Domains & Families for ORAI1 Gene

Gene Families for ORAI1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for ORAI1 Gene

Suggested Antigen Peptide Sequences for ORAI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96D31

UniProtKB/Swiss-Prot:

CRCM1_HUMAN :
  • Belongs to the Orai family.
Family:
  • Belongs to the Orai family.
genes like me logo Genes that share domains with ORAI1: view

Function for ORAI1 Gene

Molecular function for ORAI1 Gene

UniProtKB/Swiss-Prot Function:
Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901).

Phenotypes From GWAS Catalog for ORAI1 Gene

Gene Ontology (GO) - Molecular Function for ORAI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17360584
GO:0005516 calmodulin binding IEA --
GO:0015279 store-operated calcium channel activity IDA 16645049
GO:0042802 identical protein binding IPI 18757751
genes like me logo Genes that share ontologies with ORAI1: view
genes like me logo Genes that share phenotypes with ORAI1: view

Human Phenotype Ontology for ORAI1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ORAI1 Gene

MGI Knock Outs for ORAI1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ORAI1

Clone Products

  • Addgene plasmids for ORAI1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ORAI1 Gene

Localization for ORAI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORAI1 Gene

Cell membrane; Multi-pass membrane protein. Note=Isoform beta is more mobile in the plasma membrane (PubMed:23307288). Colocalizes with STIM1 at the cell membrane (PubMed:27185316). {ECO:0000269 PubMed:23307288, ECO:0000269 PubMed:27185316}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ORAI1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
cytosol 3
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ORAI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 27185316
GO:0005887 integral component of plasma membrane IDA 16645049
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with ORAI1: view

Pathways & Interactions for ORAI1 Gene

genes like me logo Genes that share pathways with ORAI1: view

SIGNOR curated interactions for ORAI1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ORAI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002115 store-operated calcium entry IDA 28219928
GO:0002250 adaptive immune response IEA --
GO:0051924 regulation of calcium ion transport IMP 16921383
GO:0051928 positive regulation of calcium ion transport IDA 16645049
GO:0061180 mammary gland epithelium development IEA --
genes like me logo Genes that share ontologies with ORAI1: view

Drugs & Compounds for ORAI1 Gene

(1) Drugs for ORAI1 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
SKF 96365 hydrochloride Pharma SOCE inhibitor, TRPC channel blocker; also inhibits store-operated Ca2+ entry 0

(5) Tocris Compounds for ORAI1 Gene

Compound Action Cas Number
2-APB IP3 receptor antagonist. Also TRP channel modulator 524-95-8
5J 4 CRAC channel blocker; anti-inflammatory 827001-82-1
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
SKF 96365 hydrochloride TRPC channel blocker; also inhibits store-operated Ca2+ entry 130495-35-1
YM 58483 Inhibitor of SOCE in non-excitable cells 223499-30-7
genes like me logo Genes that share compounds with ORAI1: view

Transcripts for ORAI1 Gene

mRNA/cDNA for ORAI1 Gene

Unigene Clusters for ORAI1 Gene

ORAI calcium release-activated calcium modulator 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for ORAI1

Alternative Splicing Database (ASD) splice patterns (SP) for ORAI1 Gene

No ASD Table

Relevant External Links for ORAI1 Gene

GeneLoc Exon Structure for
ORAI1
ECgene alternative splicing isoforms for
ORAI1

Expression for ORAI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ORAI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ORAI1 Gene

This gene is overexpressed in Whole Blood (x7.2) and Skin - Sun Exposed (Lower leg) (x4.2).

Protein differential expression in normal tissues from HIPED for ORAI1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.9), Breast (19.1), and CD8 Tcells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ORAI1 Gene



Protein tissue co-expression partners for ORAI1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ORAI1 Gene:

ORAI1

SOURCE GeneReport for Unigene cluster for ORAI1 Gene:

Hs.55148

Evidence on tissue expression from TISSUES for ORAI1 Gene

  • Liver(4.4)
  • Bone marrow(4.3)
  • Muscle(3.6)
  • Blood(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ORAI1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • ear
  • eye
  • head
  • jaw
  • larynx
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
  • tooth
Thorax:
  • heart
  • lung
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • nail
  • shin
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • sweat gland
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with ORAI1: view

No data available for mRNA Expression by UniProt/SwissProt for ORAI1 Gene

Orthologs for ORAI1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ORAI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ORAI1 33
  • 98.34 (n)
cow
(Bos Taurus)
Mammalia ORAI1 33
  • 93.4 (n)
dog
(Canis familiaris)
Mammalia ORAI1 33
  • 91.56 (n)
mouse
(Mus musculus)
Mammalia Orai1 33 16
  • 88.27 (n)
rat
(Rattus norvegicus)
Mammalia Orai1 33
  • 88.01 (n)
chicken
(Gallus gallus)
Aves ORAI1 33
  • 77.43 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia orai2 33
  • 75.53 (n)
Str.15128 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23967 33
zebrafish
(Danio rerio)
Actinopterygii LOC566671 33
  • 74.19 (n)
Dr.25945 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8801 33
Species where no ortholog for ORAI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ORAI1 Gene

ENSEMBL:
Gene Tree for ORAI1 (if available)
TreeFam:
Gene Tree for ORAI1 (if available)

Paralogs for ORAI1 Gene

Paralogs for ORAI1 Gene

(2) SIMAP similar genes for ORAI1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ORAI1: view

Variants for ORAI1 Gene

Sequence variations from dbSNP and Humsavar for ORAI1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs118203993 pathogenic, Immune dysfunction with T-cell inactivation due to calcium entry defect 1, Immunodeficiency 9 (IMD9) [MIM:612782] 121,627,018(+) C/T coding_sequence_variant, missense_variant
rs3741596 benign, not specified, Immune dysfunction with T-cell inactivation due to calcium entry defect 1, Myopathy, tubular aggregate, 2 121,641,389(+) A/G coding_sequence_variant, missense_variant
rs3741597 benign, not specified, Immune dysfunction with T-cell inactivation due to calcium entry defect 1, Myopathy, tubular aggregate, 2 121,641,442(+) T/C coding_sequence_variant, synonymous_variant
rs3825174 benign, not specified, Immune dysfunction with T-cell inactivation due to calcium entry defect 1, Myopathy, tubular aggregate, 2 121,641,523(+) T/C coding_sequence_variant, synonymous_variant
rs587777528 pathogenic, Myopathy, tubular aggregate, 2, Myopathy, tubular aggregate, 2 (TAM2) [MIM:615883] 121,641,471(+) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for ORAI1 Gene

Variant ID Type Subtype PubMed ID
esv3630950 CNV loss 21293372
esv3630951 CNV gain 21293372
nsv1053272 CNV gain 25217958
nsv1131048 CNV deletion 24896259
nsv560458 CNV loss 21841781

Variation tolerance for ORAI1 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ORAI1 Gene

Human Gene Mutation Database (HGMD)
ORAI1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ORAI1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORAI1 Gene

Disorders for ORAI1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for ORAI1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ORAI1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CRCM1_HUMAN
  • Immunodeficiency 9 (IMD9) [MIM:612782]: An immune disorder characterized by recurrent infections, impaired activation and proliferative response of T-cells, decreased T-cell production of cytokines, and normal lymphocytes counts and serum immunoglobulin levels. In surviving patients ectodermal dysplasia with anhidrosis and non-progressive myopathy may be observed. {ECO:0000269 PubMed:16147976, ECO:0000269 PubMed:16582901}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Myopathy, tubular aggregate, 2 (TAM2) [MIM:615883]: A rare congenital myopathy characterized by regular arrays of membrane tubules on muscle biopsies without additional histopathological hallmarks. Tubular aggregates in muscle are structures of variable appearance consisting of an outer tubule containing either one or more microtubule-like structures or amorphous material. TAM2 patients have myopathy and pupillary abnormalities. {ECO:0000269 PubMed:24591628, ECO:0000269 PubMed:28058752}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ORAI1

genes like me logo Genes that share disorders with ORAI1: view

No data available for Genatlas for ORAI1 Gene

Publications for ORAI1 Gene

  1. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. (PMID: 16582901) Feske S … Rao A (Nature 2006) 2 3 4 58
  2. ORAI1 Mutations with Distinct Channel Gating Defects in Tubular Aggregate Myopathy. (PMID: 28058752) Böhm J … Laporte J (Human mutation 2017) 3 4 58
  3. Mitochondria control store-operated Ca2+ entry through Na+ and redox signals. (PMID: 28219928) Ben-Kasus Nissim T … Sekler I (The EMBO journal 2017) 3 4 58
  4. Calsequestrin-1 Regulates Store-Operated Ca2+ Entry by Inhibiting STIM1 Aggregation. (PMID: 27185316) Zhang L … Luo D (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016) 3 4 58
  5. Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis. (PMID: 24591628) Nesin V … Tsiokas L (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 4 58

Products for ORAI1 Gene

  • Addgene plasmids for ORAI1

Sources for ORAI1 Gene

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