Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR9Q2 Gene

Aliases for OR9Q2 Gene

  • Olfactory Receptor Family 9 Subfamily Q Member 2 2 3 5
  • Olfactory Receptor 9Q2 3 4
  • OR9Q2P 3 4
  • Olfactory Receptor, Family 9, Subfamily Q, Member 2 Pseudogene 3
  • Olfactory Receptor, Family 9, Subfamily Q, Member 2 2

External Ids for OR9Q2 Gene

Previous HGNC Symbols for OR9Q2 Gene

  • OR9Q2P

Previous GeneCards Identifiers for OR9Q2 Gene

  • GC11P057735
  • GC11P057714
  • GC11P057957

Summaries for OR9Q2 Gene

Entrez Gene Summary for OR9Q2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR9Q2 Gene

OR9Q2 (Olfactory Receptor Family 9 Subfamily Q Member 2) is a Protein Coding gene. Among its related pathways are Olfactory transduction and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR9Q1.

UniProtKB/Swiss-Prot Summary for OR9Q2 Gene

Additional gene information for OR9Q2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR9Q2 Gene

Genomics for OR9Q2 Gene

GeneHancer (GH) Regulatory Elements for OR9Q2 Gene

Promoters and enhancers for OR9Q2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J057740 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 14.6 -447.2 -447185 2.7 ZNF785 SIN3A ZNF24 SP1 ZBTB40 SIX5 RBPJ SMARCE1 POLR2A CTBP1 ENSG00000254732 SELENOH piR-42309-001 piR-47609-001 piR-48815 ZFP91 PRG2 ZDHHC5 RPS4XP13 OR5AZ1P
GH11J057496 Promoter/Enhancer 2.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.6 -689.1 -689141 6.7 FOXA1 LCORL RBPJ NR2F1 NR2F6 CREB1 MIXL1 NFYC HLF L3MBTL2 TIMM10 RPS4XP13 OR5AZ1P OR9Q2 OR5B1P OR5B15P BTBD18 RTN4RL2 RN7SKP259 MIR130A
GH11J058164 Enhancer 0.8 ENCODE 16.4 -23.8 -23751 2 MLX RBPJ NR2F6 ATF1 CREB1 MIXL1 RERE ELF3 TFE3 CEBPG HSALNG0084335 OR9Q2 OR1S2 OR10W1 RNU6-899P OR9Q1 MED19 TIMM10 OR5BL1P
GH11J058133 Enhancer 0.5 Ensembl ENCODE 10.6 -55.2 -55195 0.3 SCRT2 SCRT1 OR9Q2 piR-38352-081 OR9I2P OR9Q1
GH11J058134 Enhancer 0.4 Ensembl 10.6 -55.6 -55569 0.2 MNT SCRT2 SCRT1 OR9Q2 PRG2 piR-38352-081 OR9I2P OR9Q1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR9Q2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR9Q2 gene promoter:
  • AP-1
  • AP-4
  • ATF-2
  • ATF6
  • Ik-1
  • IRF-1
  • Pax-4a
  • Sox5
  • YY1

Genomic Locations for OR9Q2 Gene

Genomic Locations for OR9Q2 Gene
chr11:58,189,070-58,194,053
(GRCh38/hg38)
Size:
4,984 bases
Orientation:
Plus strand
chr11:57,957,906-57,958,990
(GRCh37/hg19)
Size:
1,085 bases
Orientation:
Plus strand

Genomic View for OR9Q2 Gene

Genes around OR9Q2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR9Q2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR9Q2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR9Q2 Gene

Proteins for OR9Q2 Gene

  • Protein details for OR9Q2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGE9-OR9Q2_HUMAN
    Recommended name:
    Olfactory receptor 9Q2
    Protein Accession:
    Q8NGE9
    Secondary Accessions:
    • B9EIK5

    Protein attributes for OR9Q2 Gene

    Size:
    314 amino acids
    Molecular mass:
    35363 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR9Q2 Gene

Post-translational modifications for OR9Q2 Gene

  • Glycosylation at Asn5

Other Protein References for OR9Q2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR9Q2 Gene

Domains & Families for OR9Q2 Gene

Gene Families for OR9Q2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR9Q2 Gene

Suggested Antigen Peptide Sequences for OR9Q2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 9, subfamily Q, member 2 (B9EIK5_HUMAN)
  • Olfactory receptor 9Q2 (OR9Q2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGE9

UniProtKB/Swiss-Prot:

OR9Q2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR9Q2: view

Function for OR9Q2 Gene

Molecular function for OR9Q2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR9Q2 Gene

Gene Ontology (GO) - Molecular Function for OR9Q2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR9Q2: view

Phenotypes for OR9Q2 Gene

genes like me logo Genes that share phenotypes with OR9Q2: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR9Q2 Gene

Localization for OR9Q2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR9Q2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR9Q2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR9Q2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR9Q2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR9Q2 Gene

Pathways & Interactions for OR9Q2 Gene

genes like me logo Genes that share pathways with OR9Q2: view

Pathways by source for OR9Q2 Gene

Interacting Proteins for OR9Q2 Gene

Gene Ontology (GO) - Biological Process for OR9Q2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR9Q2: view

No data available for SIGNOR curated interactions for OR9Q2 Gene

Drugs & Compounds for OR9Q2 Gene

No Compound Related Data Available

Transcripts for OR9Q2 Gene

mRNA/cDNA for OR9Q2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR9Q2 Gene

No ASD Table

Relevant External Links for OR9Q2 Gene

GeneLoc Exon Structure for
OR9Q2
ECgene alternative splicing isoforms for
OR9Q2

Expression for OR9Q2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR9Q2 Gene

mRNA differential expression in normal tissues according to GTEx for OR9Q2 Gene

This gene is overexpressed in Testis (x45.1) and Fallopian Tube (x7.8).

NURSA nuclear receptor signaling pathways regulating expression of OR9Q2 Gene:

OR9Q2

SOURCE GeneReport for Unigene cluster for OR9Q2 Gene:

Hs.553643
genes like me logo Genes that share expression patterns with OR9Q2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR9Q2 Gene

Orthologs for OR9Q2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR9Q2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466596 32
  • 99.26 (n)
OR9Q2 33
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or9q2 49 Olfr1497 17 33 32
  • 82.48 (n)
rat
(Rattus norvegicus)
Mammalia Olr377 32
  • 81.62 (n)
cow
(Bos Taurus)
Mammalia OR9Q2 33 32
  • 79.45 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 60 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 33
  • 58 (a)
ManyToMany
Species where no ortholog for OR9Q2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR9Q2 Gene

ENSEMBL:
Gene Tree for OR9Q2 (if available)
TreeFam:
Gene Tree for OR9Q2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR9Q2: view image

Paralogs for OR9Q2 Gene

(456) SIMAP similar genes for OR9Q2 Gene using alignment to 2 proteins:

  • OR9Q2_HUMAN
  • B9EIK5_HUMAN

Pseudogenes.org Pseudogenes for OR9Q2 Gene

genes like me logo Genes that share paralogs with OR9Q2: view

Variants for OR9Q2 Gene

Sequence variations from dbSNP and Humsavar for OR9Q2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001125231 -- 58,191,424(+) A/G coding_sequence_variant, missense_variant
rs1002247973 -- 58,189,391(+) T/G upstream_transcript_variant
rs1004843255 -- 58,189,231(+) A/C upstream_transcript_variant
rs1005075664 -- 58,188,743(+) T/G upstream_transcript_variant
rs1005196205 -- 58,188,874(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR9Q2 Gene

Variant ID Type Subtype PubMed ID
nsv832165 CNV gain 17160897
nsv832166 CNV gain+loss 17160897

Variation tolerance for OR9Q2 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.22; 88.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR9Q2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR9Q2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR9Q2 Gene

Disorders for OR9Q2 Gene

Additional Disease Information for OR9Q2

No disorders were found for OR9Q2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR9Q2 Gene

Publications for OR9Q2 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  2. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PMID: 17903306) Newton-Cheh C … Larson MG (BMC medical genetics 2007) 43 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56

Products for OR9Q2 Gene

Sources for OR9Q2 Gene