Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR9K2 Gene

Aliases for OR9K2 Gene

  • Olfactory Receptor Family 9 Subfamily K Member 2 2 3 5
  • Olfactory Receptor OR12-2 3 4
  • Olfactory Receptor 9K2 3 4
  • Olfactory Receptor, Family 9, Subfamily K, Member 2 2
  • OR12-2 3
  • OR9K2 5

External Ids for OR9K2 Gene

Previous GeneCards Identifiers for OR9K2 Gene

  • GC12U990185
  • GC12P053812
  • GC12P055523

Summaries for OR9K2 Gene

Entrez Gene Summary for OR9K2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR9K2 Gene

OR9K2 (Olfactory Receptor Family 9 Subfamily K Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR9H1P.

UniProtKB/Swiss-Prot Summary for OR9K2 Gene

Gene Wiki entry for OR9K2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR9K2 Gene

Genomics for OR9K2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR9K2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J055020 Enhancer 0.3 FANTOM5 dbSUPER 7.2 -105.6 -105556 0 NEUROD4 OR6C3 OR6C65 OR9K2 OR6C75 OR6C6 OR6C2 OR10A7 OR6C74 OR6C76
GH12J055629 Enhancer 0.3 FANTOM5 dbSUPER 2.4 +502.9 502876 0 MMP19 OR6C4 OR10P1 OR6C65 ZC3H10 OR6C74 OR9K2 OR6C3 OR6C2 OR6C6
GH12J055068 Enhancer 1 Ensembl ENCODE dbSUPER 0.2 -58.2 -58203 1.4 ZNF654 CTCF REST ZNF341 RAD21 SMC3 YY1 SPI1 GLIS1 ZNF660 NEUROD4 TESPA1 piR-32662 piR-37026-125 OR9K2
GH12J055019 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 0.1 -106.4 -106405 0.8 POLR2A REST SIN3A MNT ZNF217 NKRF IRF9 ZBTB40 EHMT2 SMARCE1 NEUROD4 LOC101927484 OR9K2
GH12J055072 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.2 -54.1 -54130 0.6 CTCF REST RAD21 SMC3 YY1 NFIB ZNF143 TRIM22 NEUROD4 TESPA1 piR-32662 piR-37026-125 OR9K2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR9K2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR9K2

Top Transcription factor binding sites by QIAGEN in the OR9K2 gene promoter:
  • C/EBPalpha
  • COMP1
  • CUTL1
  • GR
  • GR-alpha
  • HNF-3beta
  • ITF-2
  • POU3F1
  • POU6F1 (c2)
  • Tal-1beta

Genomic Locations for OR9K2 Gene

Latest Assembly
chr12:55,126,406-55,132,750
(GRCh38/hg38)
Size:
6,345 bases
Orientation:
Plus strand

Previous Assembly
chr12:55,520,190-55,526,534
(GRCh37/hg19 by Entrez Gene)
Size:
6,345 bases
Orientation:
Plus strand

chr12:55,523,465-55,524,586
(GRCh37/hg19 by Ensembl)
Size:
1,122 bases
Orientation:
Plus strand

Genomic View for OR9K2 Gene

Genes around OR9K2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR9K2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR9K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR9K2 Gene

Proteins for OR9K2 Gene

  • Protein details for OR9K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGE7-OR9K2_HUMAN
    Recommended name:
    Olfactory receptor 9K2
    Protein Accession:
    Q8NGE7
    Secondary Accessions:
    • B9EH19
    • Q6IFD6

    Protein attributes for OR9K2 Gene

    Size:
    335 amino acids
    Molecular mass:
    37746 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC06080.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR9K2 Gene

Post-translational modifications for OR9K2 Gene

  • Glycosylation at Asn30 and Asn114
  • Modification sites at PhosphoSitePlus

Other Protein References for OR9K2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR9K2 Gene

Domains & Families for OR9K2 Gene

Gene Families for OR9K2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR9K2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR9K2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR12-2 (OR9K2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGE7

UniProtKB/Swiss-Prot:

OR9K2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR9K2: view

Function for OR9K2 Gene

Molecular function for OR9K2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR9K2 Gene

Gene Ontology (GO) - Molecular Function for OR9K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR9K2: view

Phenotypes for OR9K2 Gene

genes like me logo Genes that share phenotypes with OR9K2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR9K2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR9K2 Gene

Localization for OR9K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR9K2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR9K2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR9K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR9K2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR9K2 Gene

Pathways & Interactions for OR9K2 Gene

genes like me logo Genes that share pathways with OR9K2: view

Pathways by source for OR9K2 Gene

Interacting Proteins for OR9K2 Gene

Gene Ontology (GO) - Biological Process for OR9K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR9K2: view

No data available for SIGNOR curated interactions for OR9K2 Gene

Drugs & Compounds for OR9K2 Gene

No Compound Related Data Available

Transcripts for OR9K2 Gene

mRNA/cDNA for OR9K2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR9K2

Alternative Splicing Database (ASD) splice patterns (SP) for OR9K2 Gene

No ASD Table

Relevant External Links for OR9K2 Gene

GeneLoc Exon Structure for
OR9K2

Expression for OR9K2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR9K2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR9K2

SOURCE GeneReport for Unigene cluster for OR9K2 Gene:

Hs.553827
genes like me logo Genes that share expression patterns with OR9K2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR9K2 Gene

Orthologs for OR9K2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR9K2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC467017 29
  • 99.4 (n)
OR9K2 30
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC511753 29
  • 88.39 (n)
-- 30
  • 85 (a)
OneToMany
-- 30
  • 85 (a)
OneToMany
-- 30
  • 84 (a)
OneToMany
-- 30
  • 83 (a)
OneToMany
-- 30
  • 82 (a)
OneToMany
-- 30
  • 82 (a)
OneToMany
-- 30
  • 81 (a)
OneToMany
-- 30
  • 49 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Or9k2b 45 Olfr826 16 30
  • 88 (a)
OneToMany
Or9k2 45 Olfr825 29 16 30
  • 85.27 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia LOC100687255 29
  • 87.43 (n)
-- 30
  • 86 (a)
OneToMany
-- 30
  • 80 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Olr1070 29
  • 84.99 (n)
Oppossum
(Monodelphis domestica)
Mammalia OR9K2 30
  • 69 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia OR9K2 30
  • 63 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 52 (a)
OneToMany
-- 30
  • 43 (a)
OneToMany
Species where no ortholog for OR9K2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR9K2 Gene

ENSEMBL:
Gene Tree for OR9K2 (if available)
TreeFam:
Gene Tree for OR9K2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR9K2: view image
Alliance of Genome Resources:
Additional Orthologs for OR9K2

Paralogs for OR9K2 Gene

(455) SIMAP similar genes for OR9K2 Gene using alignment to 1 proteins:

  • OR9K2_HUMAN

Pseudogenes.org Pseudogenes for OR9K2 Gene

genes like me logo Genes that share paralogs with OR9K2: view

Variants for OR9K2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR9K2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs12303066 -- p.Arg45Cys
rs7305779 -- p.Glu103Ala
rs7306491 -- p.Arg207His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR9K2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR9K2 Gene

Variant ID Type Subtype PubMed ID
nsv1048657 CNV gain 25217958
nsv1054634 CNV gain 25217958
nsv559001 CNV loss 21841781

Variation tolerance for OR9K2 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.51; 98.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR9K2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR9K2
Leiden Open Variation Database (LOVD)
OR9K2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR9K2 Gene

Disorders for OR9K2 Gene

Additional Disease Information for OR9K2

No disorders were found for OR9K2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR9K2 Gene

Publications for OR9K2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn PT … Mollon JD (Genes, brain, and behavior 2014) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR9K2 Gene

Sources for OR9K2 Gene