Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR9I1 Gene

Aliases for OR9I1 Gene

  • Olfactory Receptor Family 9 Subfamily I Member 1 2 3 5
  • Olfactory Receptor OR11-228 3 4
  • Olfactory Receptor 9I1 3 4
  • Olfactory Receptor, Family 9, Subfamily I, Member 1 2
  • OR11-228 3

External Ids for OR9I1 Gene

Previous GeneCards Identifiers for OR9I1 Gene

  • GC11U990324
  • GC11M057662
  • GC11M057642
  • GC11M057887
  • GC11M058119
  • GC11M058337

Summaries for OR9I1 Gene

Entrez Gene Summary for OR9I1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR9I1 Gene

OR9I1 (Olfactory Receptor Family 9 Subfamily I Member 1) is a Protein Coding gene. Among its related pathways are Olfactory transduction and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR9Q2.

UniProtKB/Swiss-Prot Summary for OR9I1 Gene

Gene Wiki entry for OR9I1 Gene

Additional gene information for OR9I1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR9I1 Gene

Genomics for OR9I1 Gene

GeneHancer (GH) Regulatory Elements for OR9I1 Gene

Promoters and enhancers for OR9I1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J057637 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.3 +486.2 486177 4.8 CTCF MLX RBPJ NR2F1 NR2F6 MIXL1 MYC NFYC RAD21 POLR2A CLP1 ENSG00000254602 MIR130A TIMM10 ZDHHC5 ENSG00000269570 UBE2L6 RPS4XP13 SERPING1 MED19
GH11J058154 Enhancer 0.2 Ensembl 11.3 -28.9 -28871 0.4 OR9I1 OR9Q2 RNU6-899P OR9Q1 OR9I2P HSALNG0084335
GH11J057946 Enhancer 0.2 FANTOM5 5.5 +179.1 179096 0 OR5BD1P lnc-OR9I1-4 piR-38352-080 piR-50308-086 OR10W1 OR10Q1 OR9Q2 OR5B2 OR9Q1 OR5B12
GH11J058033 Enhancer 0.2 FANTOM5 1.4 +91.6 91568 0.3 OR6Q1 OR1S1 OR5B12 OR9I1 RF00994-182 OR9Q1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR9I1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR9I1 gene promoter:
  • Bach1
  • c-Rel
  • CUTL1
  • FOXC1
  • FOXI1
  • FOXO3
  • HFH-3
  • HNF-3beta
  • Pax-3
  • RelA

Genomic Locations for OR9I1 Gene

Genomic Locations for OR9I1 Gene
chr11:58,116,742-58,125,530
(GRCh38/hg38)
Size:
8,789 bases
Orientation:
Minus strand
chr11:57,885,972-57,886,916
(GRCh37/hg19)
Size:
945 bases
Orientation:
Minus strand

Genomic View for OR9I1 Gene

Genes around OR9I1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR9I1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR9I1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR9I1 Gene

Proteins for OR9I1 Gene

  • Protein details for OR9I1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGQ6-OR9I1_HUMAN
    Recommended name:
    Olfactory receptor 9I1
    Protein Accession:
    Q8NGQ6
    Secondary Accessions:
    • Q6IFH0
    • Q96RA8

    Protein attributes for OR9I1 Gene

    Size:
    314 amino acids
    Molecular mass:
    34908 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR9I1 Gene

Post-translational modifications for OR9I1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR9I1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR9I1 Gene

Domains & Families for OR9I1 Gene

Gene Families for OR9I1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR9I1 Gene

Suggested Antigen Peptide Sequences for OR9I1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-228 (OR9I1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGQ6

UniProtKB/Swiss-Prot:

OR9I1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR9I1: view

Function for OR9I1 Gene

Molecular function for OR9I1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR9I1 Gene

Gene Ontology (GO) - Molecular Function for OR9I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR9I1: view

Phenotypes for OR9I1 Gene

genes like me logo Genes that share phenotypes with OR9I1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR9I1 Gene

Localization for OR9I1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR9I1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR9I1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR9I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR9I1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR9I1 Gene

Pathways & Interactions for OR9I1 Gene

genes like me logo Genes that share pathways with OR9I1: view

Pathways by source for OR9I1 Gene

Interacting Proteins for OR9I1 Gene

Gene Ontology (GO) - Biological Process for OR9I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR9I1: view

No data available for SIGNOR curated interactions for OR9I1 Gene

Drugs & Compounds for OR9I1 Gene

No Compound Related Data Available

Transcripts for OR9I1 Gene

mRNA/cDNA for OR9I1 Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR9I1 Gene

No ASD Table

Relevant External Links for OR9I1 Gene

GeneLoc Exon Structure for
OR9I1
ECgene alternative splicing isoforms for
OR9I1

Expression for OR9I1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR9I1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR9I1 Gene:

OR9I1

SOURCE GeneReport for Unigene cluster for OR9I1 Gene:

Hs.632122
genes like me logo Genes that share expression patterns with OR9I1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR9I1 Gene

Orthologs for OR9I1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR9I1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466593 32
  • 99.26 (n)
OR9I1 33
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC483485 32
  • 86.94 (n)
OR9I1 33
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC524304 32
  • 83.01 (n)
OR9I1 33
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or9i1b 49 Olfr1505 17 33
  • 82 (a)
Or9i1 49 Olfr1502 33 32
  • 80.6 (n)
OneToMany
Or9i14 49 Olfr1499 33
  • 79 (a)
OneToMany
Or9i13-ps 49 Olfr1498-ps1
  • chr19:13,804,434-13,805,325
Or9i15-ps 49 Olfr1503-ps1
  • chr19:13,877,451-13,878,247
rat
(Rattus norvegicus)
Mammalia Olr384 32
  • 80.57 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 75 (a)
OneToMany
-- 33
  • 72 (a)
OneToMany
-- 33
  • 71 (a)
OneToMany
OPOR158 33
  • 68 (a)
OneToMany
Species where no ortholog for OR9I1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR9I1 Gene

ENSEMBL:
Gene Tree for OR9I1 (if available)
TreeFam:
Gene Tree for OR9I1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR9I1: view image

Paralogs for OR9I1 Gene

(441) SIMAP similar genes for OR9I1 Gene using alignment to 1 proteins:

  • OR9I1_HUMAN

Pseudogenes.org Pseudogenes for OR9I1 Gene

genes like me logo Genes that share paralogs with OR9I1: view

Variants for OR9I1 Gene

Sequence variations from dbSNP and Humsavar for OR9I1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs386352342 uncertain-significance, not provided 58,119,227(-) T/C coding_sequence_variant, missense_variant
rs1000869196 -- 58,119,402(-) T/C coding_sequence_variant, missense_variant
rs1003045726 -- 58,119,781(-) A/G upstream_transcript_variant
rs1003340949 -- 58,119,990(-) C/T upstream_transcript_variant
rs1005384984 -- 58,120,390(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR9I1 Gene

Variant ID Type Subtype PubMed ID
nsv832165 CNV gain 17160897
nsv832166 CNV gain+loss 17160897

Variation tolerance for OR9I1 Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 27.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR9I1 Gene

Human Gene Mutation Database (HGMD)
OR9I1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR9I1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR9I1 Gene

Disorders for OR9I1 Gene

Additional Disease Information for OR9I1

No disorders were found for OR9I1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR9I1 Gene

Publications for OR9I1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 56
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 56
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56

Products for OR9I1 Gene

Sources for OR9I1 Gene