Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR9G4 Gene

Aliases for OR9G4 Gene

  • Olfactory Receptor Family 9 Subfamily G Member 4 2 3 5
  • Olfactory Receptor OR11-216 3 4
  • Olfactory Receptor 9G4 3 4
  • Olfactory Receptor, Family 9, Subfamily G, Member 4 2
  • OR11-216 3
  • OR9G4 5

External Ids for OR9G4 Gene

Previous GeneCards Identifiers for OR9G4 Gene

  • GC11U990392
  • GC11M056286
  • GC11M056266
  • GC11M056510
  • GC11M056742
  • GC11M057231
  • GC11M057257
  • GC11M057157
  • GC11M059782
  • GC11M056928
  • GC11M061220
  • GC11M063685

Summaries for OR9G4 Gene

Entrez Gene Summary for OR9G4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR9G4 Gene

OR9G4 (Olfactory Receptor Family 9 Subfamily G Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR5B21.

UniProtKB/Swiss-Prot Summary for OR9G4 Gene

Gene Wiki entry for OR9G4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR9G4 Gene

Genomics for OR9G4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR9G4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J056841 Enhancer 0.7 Ensembl ENCODE 0.2 -92.8 -92797 0.6 ZNF654 REST TRIM22 CTCF MAFF RAD21 SMC3 MAFK ZNF143 EMSY piR-35564-022 OR5G3 HSALNG0084223-001 HSALNG0084223-002 OR9G4 OR5AK2
GH11J056884 Enhancer 0.7 Ensembl ENCODE 0.1 -137.0 -136980 1.8 CEBPA ZNF316 MAFG MAFF TFAP4 HDAC2 MAFK ZFP36 KDM1A OR5G5P FADS2B HSALNG0084223-001 HSALNG0084223-002 LINC02735 HSALNG0084226 OR5AK2 OR9G4
GH11J056886 Enhancer 0.6 Ensembl ENCODE 0.1 -138.2 -138186 0.6 CEBPA MAFF ZNF316 MAFK MAFG FADS2B HSALNG0084223-001 HSALNG0084223-002 LINC02735 HSALNG0084226 OR5AK2 OR9G4
GH11J056817 Enhancer 0.3 Ensembl 0.2 -69.3 -69304 0.4 ZFP64 lnc-OR9G4-1 piR-60794-004 OR5G5P HSALNG0084223-001 OR9G4 HSALNG0084223-002 OR5AK2
GH11J056932 Enhancer 0.6 ENCODE 0.1 -184.2 -184202 1.1 JUND CEBPB EP300 INSM2 ZNF24 ZNF362 SP7 ZNF366 ATF3 ZNF629 SLC43A3 HSALNG0084230 piR-44198-003 LOC105369310 OR5AK2 OR9G4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR9G4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR9G4

Top Transcription factor binding sites by QIAGEN in the OR9G4 gene promoter:
  • AML1a
  • COMP1
  • HOXA3
  • Pbx1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for OR9G4 Gene

Latest Assembly
chr11:56,741,223-56,748,697
(GRCh38/hg38)
Size:
7,475 bases
Orientation:
Minus strand

Previous Assembly
chr11:56,510,304-56,511,287
(GRCh37/hg19 by Entrez Gene)
Size:
984 bases
Orientation:
Minus strand

chr11:56,510,303-56,511,287
(GRCh37/hg19 by Ensembl)
Size:
985 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr11(ALT_REF_LOCI_1):59,065-66,539 (-)

Genomic View for OR9G4 Gene

Genes around OR9G4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR9G4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR9G4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR9G4 Gene

Proteins for OR9G4 Gene

  • Protein details for OR9G4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGQ1-OR9G4_HUMAN
    Recommended name:
    Olfactory receptor 9G4
    Protein Accession:
    Q8NGQ1
    Secondary Accessions:
    • Q6IF62
    • Q96RA9

    Protein attributes for OR9G4 Gene

    Size:
    327 amino acids
    Molecular mass:
    36344 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05959.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR9G4 Gene

Post-translational modifications for OR9G4 Gene

  • Glycosylation at Asn20

Other Protein References for OR9G4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR9G4 Gene

Domains & Families for OR9G4 Gene

Gene Families for OR9G4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR9G4 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR9G4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-216 (OR9G4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGQ1

UniProtKB/Swiss-Prot:

OR9G4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR9G4: view

Function for OR9G4 Gene

Molecular function for OR9G4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR9G4 Gene

Gene Ontology (GO) - Molecular Function for OR9G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA,IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR9G4: view
genes like me logo Genes that share phenotypes with OR9G4: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR9G4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR9G4 Gene

Localization for OR9G4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR9G4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR9G4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR9G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR9G4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR9G4 Gene

Pathways & Interactions for OR9G4 Gene

genes like me logo Genes that share pathways with OR9G4: view

Pathways by source for OR9G4 Gene

Interacting Proteins for OR9G4 Gene

Gene Ontology (GO) - Biological Process for OR9G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,IBA 21873635
GO:0007608 sensory perception of smell IEA,IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR9G4: view

No data available for SIGNOR curated interactions for OR9G4 Gene

Drugs & Compounds for OR9G4 Gene

No Compound Related Data Available

Transcripts for OR9G4 Gene

mRNA/cDNA for OR9G4 Gene

2 REFSEQ mRNAs :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR9G4

Alternative Splicing Database (ASD) splice patterns (SP) for OR9G4 Gene

No ASD Table

Relevant External Links for OR9G4 Gene

GeneLoc Exon Structure for
OR9G4

Expression for OR9G4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR9G4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR9G4

SOURCE GeneReport for Unigene cluster for OR9G4 Gene:

Hs.554521
genes like me logo Genes that share expression patterns with OR9G4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR9G4 Gene

Orthologs for OR9G4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR9G4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466578 29
  • 98.98 (n)
OR9G4 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR9G4 29 30
  • 88.21 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Or9g4 45 Olfr1006 29 16 30
  • 84.94 (n)
OneToOne
Or9g21-ps 45 Olfr1004-ps1
  • chr2:85,656,239-85,656,835
Or9g4b 45 Olfr1015
  • chr2:85,785,513-85,786,448
Cow
(Bos Taurus)
Mammalia LOC506891 29
  • 84.57 (n)
-- 30
  • 84 (a)
OneToMany
-- 30
  • 81 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Olr450 29
  • 84.08 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 83 (a)
OneToMany
-- 30
  • 80 (a)
OneToMany
-- 30
  • 79 (a)
OneToMany
Species where no ortholog for OR9G4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR9G4 Gene

ENSEMBL:
Gene Tree for OR9G4 (if available)
TreeFam:
Gene Tree for OR9G4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR9G4: view image
Alliance of Genome Resources:
Additional Orthologs for OR9G4

Paralogs for OR9G4 Gene

(439) SIMAP similar genes for OR9G4 Gene using alignment to 1 proteins:

  • OR9G4_HUMAN

Pseudogenes.org Pseudogenes for OR9G4 Gene

genes like me logo Genes that share paralogs with OR9G4: view

Variants for OR9G4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR9G4 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs11228763 -- p.Phe43Ser
rs513873 -- p.Val222Ala
rs577576 -- p.Asn206Asp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR9G4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR9G4 Gene

Variant ID Type Subtype PubMed ID
nsv468577 CNV gain 19166990
nsv555101 CNV gain 21841781

Variation tolerance for OR9G4 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.42; 85.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR9G4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR9G4
Leiden Open Variation Database (LOVD)
OR9G4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR9G4 Gene

Disorders for OR9G4 Gene

Additional Disease Information for OR9G4

No disorders were found for OR9G4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR9G4 Gene

Publications for OR9G4 Gene

  1. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q … O'Donnell CJ (BMC medical genetics 2007) 3 40
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4

Products for OR9G4 Gene

Sources for OR9G4 Gene