Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR9G1 Gene

Aliases for OR9G1 Gene

  • Olfactory Receptor Family 9 Subfamily G Member 1 2 3 5
  • Olfactory Receptor OR11-114 3 4
  • Olfactory Receptor 9G1 3 4
  • Olfactory Receptor 9G5 3 4
  • OR9G5 3 4
  • Olfactory Receptor, Family 9, Subfamily G, Member 1 2
  • Olfactory Receptor, Family 9, Subfamily G, Member 5 3
  • Olfactory Receptor OR11-210 3
  • OR9G1 5

External Ids for OR9G1 Gene

Previous HGNC Symbols for OR9G1 Gene

  • OR9G5

Previous GeneCards Identifiers for OR9G1 Gene

  • GC11U990395
  • GC11P056244
  • GC11P056224
  • GC11P056469

Summaries for OR9G1 Gene

Entrez Gene Summary for OR9G1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR9G1 Gene

OR9G1 (Olfactory Receptor Family 9 Subfamily G Member 1) is a Protein Coding gene. Diseases associated with OR9G1 include Extratemporal Epilepsy. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11H12.

UniProtKB/Swiss-Prot Summary for OR9G1 Gene

Gene Wiki entry for OR9G1 Gene

Additional gene information for OR9G1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR9G1 Gene

Genomics for OR9G1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR9G1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J056700 Enhancer 0.2 Ensembl 600.7 +1.4 1406 0.6 OR9G1 CLP1 FAM8A2P ENSG00000254953 OR9G4
GH11J056706 Enhancer 0.2 Ensembl 0.4 +7.3 7306 0.4 OR9G1 ENSG00000254953 OR9G4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR9G1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR9G1

Top Transcription factor binding sites by QIAGEN in the OR9G1 gene promoter:
  • CBF(2)
  • FOXC1
  • GR
  • GR-alpha
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • RFX1

Genomic Locations for OR9G1 Gene

Genomic Locations for OR9G1 Gene
chr11:56,699,095-56,703,884
(GRCh38/hg38)
Size:
4,790 bases
Orientation:
Plus strand
chr11:56,467,864-56,468,781
(GRCh37/hg19)
Size:
918 bases
Orientation:
Plus strand

Genomic View for OR9G1 Gene

Genes around OR9G1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR9G1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR9G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR9G1 Gene

Proteins for OR9G1 Gene

  • Protein details for OR9G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH87-OR9G1_HUMAN
    Recommended name:
    Olfactory receptor 9G1
    Protein Accession:
    Q8NH87
    Secondary Accessions:
    • Q6IEU9
    • Q8NGQ0

    Protein attributes for OR9G1 Gene

    Size:
    305 amino acids
    Molecular mass:
    34071 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR9G1 Gene

Post-translational modifications for OR9G1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR9G1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR9G1 Gene

Domains & Families for OR9G1 Gene

Gene Families for OR9G1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR9G1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR9G1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-114 (OR9G1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH87

UniProtKB/Swiss-Prot:

OR9G1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR9G1: view

Function for OR9G1 Gene

Molecular function for OR9G1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR9G1 Gene

Gene Ontology (GO) - Molecular Function for OR9G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR9G1: view
genes like me logo Genes that share phenotypes with OR9G1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR9G1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR9G1 Gene

Localization for OR9G1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR9G1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR9G1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR9G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR9G1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR9G1 Gene

Pathways & Interactions for OR9G1 Gene

genes like me logo Genes that share pathways with OR9G1: view

Pathways by source for OR9G1 Gene

Interacting Proteins for OR9G1 Gene

Gene Ontology (GO) - Biological Process for OR9G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR9G1: view

No data available for SIGNOR curated interactions for OR9G1 Gene

Drugs & Compounds for OR9G1 Gene

No Compound Related Data Available

Transcripts for OR9G1 Gene

mRNA/cDNA for OR9G1 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR9G1

Alternative Splicing Database (ASD) splice patterns (SP) for OR9G1 Gene

No ASD Table

Relevant External Links for OR9G1 Gene

GeneLoc Exon Structure for
OR9G1

Expression for OR9G1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR9G1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR9G1

SOURCE GeneReport for Unigene cluster for OR9G1 Gene:

Hs.553752
genes like me logo Genes that share expression patterns with OR9G1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR9G1 Gene

Orthologs for OR9G1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR9G1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466576 30
  • 97.38 (n)
OR9G1 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR9G1 30
  • 84.76 (n)
-- 31
  • 83 (a)
OneToMany
-- 31
  • 83 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia OR9G1 30 31
  • 81.85 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Olfr1014 30 17 31
  • 79.21 (n)
OneToMany
Olfr1016 31
  • 75 (a)
OneToMany
Or9g19 46 Olfr1013 31
  • 75 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia OR9G1 31
  • 79 (a)
OneToOne
Species where no ortholog for OR9G1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR9G1 Gene

ENSEMBL:
Gene Tree for OR9G1 (if available)
TreeFam:
Gene Tree for OR9G1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR9G1: view image

Paralogs for OR9G1 Gene

(435) SIMAP similar genes for OR9G1 Gene using alignment to 1 proteins:

  • OR9G1_HUMAN

Pseudogenes.org Pseudogenes for OR9G1 Gene

genes like me logo Genes that share paralogs with OR9G1: view

Variants for OR9G1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR9G1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10896516 - p.Tyr233His
rs10896517 - p.Tyr233Cys
rs11228732 - p.Cys98Gly
rs11228733 - p.Arg169Cys
rs11228735 - p.Glu185Lys

Additional dbSNP identifiers (rs#s) for OR9G1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR9G1 Gene

Variant ID Type Subtype PubMed ID
esv1004082 CNV insertion 20482838
esv2744543 CNV deletion 23290073
esv7703 CNV loss 19470904
nsv1076377 CNV duplication 25765185
nsv1110197 CNV duplication 24896259
nsv1115410 CNV duplication 24896259
nsv1149747 CNV duplication 26484159
nsv325 CNV insertion 18451855
nsv509410 CNV insertion 20534489
nsv952453 CNV duplication 24416366
nsv975930 CNV duplication 23825009

Variation tolerance for OR9G1 Gene

Residual Variation Intolerance Score: 99.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.18; 84.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR9G1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR9G1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR9G1 Gene

Disorders for OR9G1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR9G1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
extratemporal epilepsy
- elite association - COSMIC cancer census association via MalaCards
Search OR9G1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR9G1

genes like me logo Genes that share disorders with OR9G1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR9G1 Gene

Publications for OR9G1 Gene

  1. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q … O'Donnell CJ (BMC medical genetics 2007) 3 41
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4

Products for OR9G1 Gene

Sources for OR9G1 Gene