Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR9A4 Gene

Aliases for OR9A4 Gene

  • Olfactory Receptor Family 9 Subfamily A Member 4 2 3 5
  • Olfactory Receptor OR7-1 3 4
  • Olfactory Receptor 9A4 3 4
  • Olfactory Receptor, Family 9, Subfamily A, Member 4 2
  • OR9A4 5

External Ids for OR9A4 Gene

Previous GeneCards Identifiers for OR9A4 Gene

  • GC07U990309
  • GC07P141026
  • GC07P141071
  • GC07P141265
  • GC07P141619
  • GC07P141622
  • GC07P142619
  • GC07P142928
  • GC07P144261
  • GC07P144402
  • GC07P144586
  • GC07P144826
  • GC07P143072
  • GC07P143221
  • GC07P143416
  • GC07P143567
  • GC07P143717
  • GC07P143844
  • GC07P143984
  • GC07P144117
  • GC07P145076
  • GC07P145364

Summaries for OR9A4 Gene

Entrez Gene Summary for OR9A4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR9A4 Gene

OR9A4 (Olfactory Receptor Family 9 Subfamily A Member 4) is a Protein Coding gene. Diseases associated with OR9A4 include Lung Carcinoma In Situ. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR9A2.

UniProtKB/Swiss-Prot Summary for OR9A4 Gene

Gene Wiki entry for OR9A4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR9A4 Gene

Genomics for OR9A4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR9A4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J141915 Enhancer 0.7 Ensembl ENCODE 265.6 -0.6 -576 1.2 NFE2 SPI1 PKNOX1 POLR2A BACH1 MNT FOS OR9A4 WEE2-AS1 CLEC5A lnc-OR9A4-1-002 MGAM
GH07J141917 Enhancer 0.2 Ensembl 250.7 +1.3 1302 0.2 OR9A4 MGAM piR-57394-210 CLEC5A
GH07J141884 Enhancer 0.9 FANTOM5 Ensembl 22.9 -30.9 -30898 2.6 BCL11A TARDBP IRF4 EBF1 CBFB BATF NFATC1 TCF7 MTA3 ATF2 OR9A1P piR-41195-076 OR9A4 WEE2-AS1 CLEC5A MGAM OR9N1P TAS2R38 PRSS37
GH07J141874 Enhancer 0.8 FANTOM5 Ensembl ENCODE 15 -40.8 -40799 2.4 ATF4 ATF2 ATF3 WEE2-AS1 OR9A4 CLEC5A TAS2R38 piR-41195-076 lnc-MGAM-2 PRSS37 MGAM
GH07J141945 Promoter/Enhancer 0.8 Ensembl ENCODE 14 +29.3 29295 1.3 CTCF SPI1 MYC MAX POLR2A CLEC5A lnc-TAS2R38-1 OR9A4 WEE2-AS1 MG828668-114 MGAM
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR9A4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR9A4

Top Transcription factor binding sites by QIAGEN in the OR9A4 gene promoter:
  • aMEF-2
  • AML1a
  • En-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • HSF2
  • LCR-F1
  • MEF-2A
  • PPAR-gamma2
  • S8

Genomic Locations for OR9A4 Gene

Latest Assembly
chr7:141,916,399-141,920,625
(GRCh38/hg38)
Size:
4,227 bases
Orientation:
Plus strand

Previous Assembly
chr7:141,616,199-141,620,425
(GRCh37/hg19 by Entrez Gene)
Size:
4,227 bases
Orientation:
Plus strand

chr7:141,618,617-141,619,709
(GRCh37/hg19 by Ensembl)
Size:
1,093 bases
Orientation:
Plus strand

Genomic View for OR9A4 Gene

Genes around OR9A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR9A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR9A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR9A4 Gene

Proteins for OR9A4 Gene

  • Protein details for OR9A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGU2-OR9A4_HUMAN
    Recommended name:
    Olfactory receptor 9A4
    Protein Accession:
    Q8NGU2
    Secondary Accessions:
    • B9EGV6
    • Q6IFI4

    Protein attributes for OR9A4 Gene

    Size:
    314 amino acids
    Molecular mass:
    35758 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR9A4 Gene

Post-translational modifications for OR9A4 Gene

  • Glycosylation at Asn4 and Asn190
  • Modification sites at PhosphoSitePlus

Other Protein References for OR9A4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR9A4 Gene

Domains & Families for OR9A4 Gene

Gene Families for OR9A4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR9A4 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR9A4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR7-1 (OR9A4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGU2

UniProtKB/Swiss-Prot:

OR9A4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR9A4: view

Function for OR9A4 Gene

Molecular function for OR9A4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR9A4 Gene

Gene Ontology (GO) - Molecular Function for OR9A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR9A4: view
genes like me logo Genes that share phenotypes with OR9A4: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR9A4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR9A4 Gene

Localization for OR9A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR9A4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR9A4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR9A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR9A4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR9A4 Gene

Pathways & Interactions for OR9A4 Gene

genes like me logo Genes that share pathways with OR9A4: view

Pathways by source for OR9A4 Gene

Interacting Proteins for OR9A4 Gene

Gene Ontology (GO) - Biological Process for OR9A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR9A4: view

No data available for SIGNOR curated interactions for OR9A4 Gene

Drugs & Compounds for OR9A4 Gene

No Compound Related Data Available

Transcripts for OR9A4 Gene

mRNA/cDNA for OR9A4 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR9A4

Alternative Splicing Database (ASD) splice patterns (SP) for OR9A4 Gene

No ASD Table

Relevant External Links for OR9A4 Gene

GeneLoc Exon Structure for
OR9A4

Expression for OR9A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR9A4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR9A4

SOURCE GeneReport for Unigene cluster for OR9A4 Gene:

Hs.690171
genes like me logo Genes that share expression patterns with OR9A4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR9A4 Gene

Orthologs for OR9A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR9A4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC472536 29
  • 99.15 (n)
OR9A4 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 89 (a)
OneToMany
-- 30
  • 89 (a)
OneToMany
LOC100855949 29
  • 86.62 (n)
-- 30
  • 85 (a)
OneToMany
-- 30
  • 85 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia OR9A4 29 30
  • 86.84 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Or9a4 45 Olfr460 29 16 30
  • 84.39 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr799 29
  • 84.18 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 69 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii or101-1 30
  • 35 (a)
OneToMany
Species where no ortholog for OR9A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for OR9A4 Gene

ENSEMBL:
Gene Tree for OR9A4 (if available)
TreeFam:
Gene Tree for OR9A4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR9A4: view image
Alliance of Genome Resources:
Additional Orthologs for OR9A4

Paralogs for OR9A4 Gene

(440) SIMAP similar genes for OR9A4 Gene using alignment to 1 proteins:

  • OR9A4_HUMAN

Pseudogenes.org Pseudogenes for OR9A4 Gene

genes like me logo Genes that share paralogs with OR9A4: view

Variants for OR9A4 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR9A4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR9A4 Gene

Variant ID Type Subtype PubMed ID
nsv5974 CNV deletion 18451855
nsv831161 CNV loss 17160897

Variation tolerance for OR9A4 Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR9A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR9A4
Leiden Open Variation Database (LOVD)
OR9A4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR9A4 Gene

Disorders for OR9A4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR9A4 Gene - From: COP

Disorder Aliases PubMed IDs
lung carcinoma in situ
- elite association - COSMIC cancer census association via MalaCards
Search OR9A4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR9A4

genes like me logo Genes that share disorders with OR9A4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR9A4 Gene

Publications for OR9A4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4
  3. Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing. (PMID: 30890647) Viita T … Vartiainen MK (Journal of cell science 2019) 3
  4. Genetic variants associated with disordered eating. (PMID: 23568457) Wade TD … Martin NG (The International journal of eating disorders 2013) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR9A4 Gene

Sources for OR9A4 Gene