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Aliases for OR9A2 Gene

Aliases for OR9A2 Gene

  • Olfactory Receptor Family 9 Subfamily A Member 2 2 3 5
  • Olfactory Receptor OR7-2 3 4
  • Olfactory Receptor, Family 9, Subfamily A, Member 2 2
  • Olfactory Receptor 9A2 3

External Ids for OR9A2 Gene

Previous GeneCards Identifiers for OR9A2 Gene

  • GC07U990311
  • GC07M142196
  • GC07M142240
  • GC07M142433
  • GC07M142723

Summaries for OR9A2 Gene

Entrez Gene Summary for OR9A2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR9A2 Gene

OR9A2 (Olfactory Receptor Family 9 Subfamily A Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR9A4.

UniProtKB/Swiss-Prot for OR9A2 Gene

  • Odorant receptor.

Gene Wiki entry for OR9A2 Gene

Additional gene information for OR9A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR9A2 Gene

Genomics for OR9A2 Gene

GeneHancer (GH) Regulatory Elements for OR9A2 Gene

Promoters and enhancers for OR9A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J143003 Enhancer 0.9 Ensembl ENCODE 11.3 +23.8 23794 0.6 CTCF ARNT RAD21 YY1 CC2D1A PHF20 ARID2 VEZF1 SMC3 ZNF143 TAS2R40 OR9A2 OR9P1P OR6V1 KEL
GH07J143244 Enhancer 0.9 FANTOM5 Ensembl ENCODE 6.2 -218.0 -218012 1.3 MITF MCM7 PRDM6 ZNF266 FOSL2 GSTK1 CASP2 RN7SL535P FAM131B TMEM139 LOC105375545 LOC154761 LOC100507507 ZYX TCAF2
GH07J143004 Enhancer 0.4 ENCODE 11.3 +24.1 24140 0 CTCF ZNF512 IKZF1 TAS2R40 OR9A2 OR9P1P OR6V1 KEL
GH07J142803 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.9 +222.8 222797 1.6 HDGF TEAD4 TAL1 TSC22D4 TCF12 NCOR1 EGR1 NFATC1 EED CBFA2T2 TRBV30 OR9A2 CASP2 TAS2R39 EPHB6 TRBC2 GC07M142813 TRB
GH07J143351 Enhancer 0.7 FANTOM5 dbSUPER 3.2 -323.9 -323929 0.1 MITF SMARCE1 FOSL1 USF1 ZNF512 CBFA2T2 ZYX LOC100507507 CLCN1 HINT1P1 EPHA1-AS1 EPHA1 TAS2R41 FAM131B OR6V1 OR9A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR9A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR9A2 gene promoter:

Genomic Locations for OR9A2 Gene

Genomic Locations for OR9A2 Gene
chr7:142,997,851-143,027,284
(GRCh38/hg38)
Size:
29,434 bases
Orientation:
Minus strand
chr7:142,723,245-142,724,282
(GRCh37/hg19)

Genomic View for OR9A2 Gene

Genes around OR9A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR9A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR9A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR9A2 Gene

Proteins for OR9A2 Gene

  • Protein details for OR9A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGT5-OR9A2_HUMAN
    Recommended name:
    Olfactory receptor 9A2
    Protein Accession:
    Q8NGT5
    Secondary Accessions:
    • B9EH51
    • Q6IF71
    • Q8NGD9

    Protein attributes for OR9A2 Gene

    Size:
    310 amino acids
    Molecular mass:
    35330 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR9A2 Gene

Post-translational modifications for OR9A2 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR9A2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR9A2 Gene

Domains & Families for OR9A2 Gene

Gene Families for OR9A2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR9A2 Gene

Suggested Antigen Peptide Sequences for OR9A2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NGT5

UniProtKB/Swiss-Prot:

OR9A2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR9A2: view

Function for OR9A2 Gene

Molecular function for OR9A2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR9A2 Gene

Gene Ontology (GO) - Molecular Function for OR9A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR9A2: view
genes like me logo Genes that share phenotypes with OR9A2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR9A2 Gene

Localization for OR9A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR9A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR9A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR9A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR9A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR9A2 Gene

Pathways & Interactions for OR9A2 Gene

genes like me logo Genes that share pathways with OR9A2: view

Pathways by source for OR9A2 Gene

Gene Ontology (GO) - Biological Process for OR9A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR9A2: view

No data available for SIGNOR curated interactions for OR9A2 Gene

Drugs & Compounds for OR9A2 Gene

No Compound Related Data Available

Transcripts for OR9A2 Gene

mRNA/cDNA for OR9A2 Gene

(2) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR9A2 Gene

Olfactory receptor, family 9, subfamily A, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR9A2 Gene

No ASD Table

Relevant External Links for OR9A2 Gene

GeneLoc Exon Structure for
OR9A2
ECgene alternative splicing isoforms for
OR9A2

Expression for OR9A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR9A2 Gene

mRNA differential expression in normal tissues according to GTEx for OR9A2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x16.5), Brain - Substantia nigra (x5.6), and Brain - Hippocampus (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of OR9A2 Gene:

OR9A2

SOURCE GeneReport for Unigene cluster for OR9A2 Gene:

Hs.553594
genes like me logo Genes that share expression patterns with OR9A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR9A2 Gene

Orthologs for OR9A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR9A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC614298 33
  • 83.28 (n)
-- 34
  • 80 (a)
OneToMany
-- 34
  • 80 (a)
OneToMany
-- 34
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC100686794 33
  • 82.52 (n)
-- 34
  • 45 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Or9a2 51 Olfr459 16 34 33
  • 81.88 (n)
rat
(Rattus norvegicus)
Mammalia RGD1562066 33
  • 81.66 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii or101-1 34
  • 32 (a)
OneToMany
Species where no ortholog for OR9A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OR9A2 Gene

ENSEMBL:
Gene Tree for OR9A2 (if available)
TreeFam:
Gene Tree for OR9A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR9A2: view image

Paralogs for OR9A2 Gene

Paralogs for OR9A2 Gene

(425) SIMAP similar genes for OR9A2 Gene using alignment to 2 proteins:

  • OR9A2_HUMAN
  • A4D2H9_HUMAN

Pseudogenes.org Pseudogenes for OR9A2 Gene

genes like me logo Genes that share paralogs with OR9A2: view

Variants for OR9A2 Gene

Sequence variations from dbSNP and Humsavar for OR9A2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000047391 -- 143,028,576(-) T/C upstream_transcript_variant
rs1001219728 -- 143,028,996(-) C/T upstream_transcript_variant
rs1003134805 -- 143,028,120(-) G/T upstream_transcript_variant
rs1003187063 -- 143,028,457(-) T/A upstream_transcript_variant
rs1004513140 -- 143,025,860(-) T/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR9A2 Gene

Variant ID Type Subtype PubMed ID
esv2759569 CNV loss 17122850

Variation tolerance for OR9A2 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.01; 68.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR9A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR9A2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR9A2 Gene

Disorders for OR9A2 Gene

Additional Disease Information for OR9A2

No disorders were found for OR9A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR9A2 Gene

Publications for OR9A2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Natural selection on the olfactory receptor gene family in humans and chimpanzees. (PMID: 12908129) Gilad Y … Pääbo S (American journal of human genetics 2003) 3 58
  4. Novel human G-protein-coupled receptors. (PMID: 12732197) Vanti WB … O'Dowd BF (Biochemical and biophysical research communications 2003) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR9A2 Gene

Sources for OR9A2 Gene

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