Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR9A2 Gene

Aliases for OR9A2 Gene

  • Olfactory Receptor Family 9 Subfamily A Member 2 2 3 5
  • Olfactory Receptor OR7-2 3 4
  • Olfactory Receptor 9A2 3 4
  • Olfactory Receptor, Family 9, Subfamily A, Member 2 2
  • OR9A2 5

External Ids for OR9A2 Gene

Previous GeneCards Identifiers for OR9A2 Gene

  • GC07U990311
  • GC07M142196
  • GC07M142240
  • GC07M142433
  • GC07M142723

Summaries for OR9A2 Gene

Entrez Gene Summary for OR9A2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR9A2 Gene

OR9A2 (Olfactory Receptor Family 9 Subfamily A Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR9A4.

UniProtKB/Swiss-Prot Summary for OR9A2 Gene

Gene Wiki entry for OR9A2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR9A2 Gene

Genomics for OR9A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR9A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J143003 Enhancer 0.7 ENCODE 11.3 +23.6 23586 0.2 ZNF654 YY1 CTCF REST TRIM22 ARNT RAD21 SMC3 SKIL EHMT2 TAS2R40 OR9A2 OR9P1P OR6V1 HSALNG0061937 KEL
GH07J143244 Promoter/Enhancer 1 FANTOM5 Ensembl ENCODE 6.2 -218.1 -218101 1.3 MCM7 PRDM6 TOE1 ZNF266 FOS GSTK1 CASP2 RN7SL535P FAM131B TMEM139 TMEM139-AS1 LOC154761 ZYX ENSG00000232533 TCAF2
GH07J143004 Enhancer 0.4 ENCODE 11.3 +24.1 24051 0 IKZF1 ZNF512 CTCF TAS2R40 OR9A2 OR9P1P OR6V1 HSALNG0061937 KEL
GH07J142782 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.9 +228.5 228549 31.7 BCLAF1 SP1 ZNF654 NCOR1 JUND ZNF592 POLR2A BCL11A CTCF REST LT626065 TRBJ2-2P TRBJ2-3 TRBJ2-4 TRBJ2-5 TRBJ2-6 TRBJ2-7 TRBV30 TCAF2 CASP2
GH07J143005 Enhancer 0.3 Ensembl 11.3 +22.7 22694 0.2 FOXA2 TAS2R40 OR9A2 OR9P1P OR6V1 HSALNG0061937 KEL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR9A2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR9A2

Top Transcription factor binding sites by QIAGEN in the OR9A2 gene promoter:
  • Evi-1
  • HNF-1A
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • Nkx2-5
  • Nkx6-1
  • RORalpha1
  • Sox5

Genomic Locations for OR9A2 Gene

Latest Assembly
chr7:143,026,158-143,027,195
(GRCh38/hg38)
Size:
1,038 bases
Orientation:
Minus strand

Previous Assembly
chr7:142,723,287-142,724,219
(GRCh37/hg19 by Entrez Gene)
Size:
933 bases
Orientation:
Minus strand

chr7:142,723,245-142,724,282
(GRCh37/hg19 by Ensembl)
Size:
1,038 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr7(ALT_REF_LOCI_1):1,049,267-1,050,199 (-)

Genomic View for OR9A2 Gene

Genes around OR9A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR9A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR9A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR9A2 Gene

Proteins for OR9A2 Gene

  • Protein details for OR9A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGT5-OR9A2_HUMAN
    Recommended name:
    Olfactory receptor 9A2
    Protein Accession:
    Q8NGT5
    Secondary Accessions:
    • B9EH51
    • Q6IF71
    • Q8NGD9

    Protein attributes for OR9A2 Gene

    Size:
    310 amino acids
    Molecular mass:
    35330 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR9A2 Gene

Post-translational modifications for OR9A2 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR9A2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR9A2 Gene

Domains & Families for OR9A2 Gene

Gene Families for OR9A2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR9A2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR9A2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 9, subfamily A, member 2 (A4D2H9_HUMAN)
  • Olfactory receptor OR7-2 (OR9A2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGT5

UniProtKB/Swiss-Prot:

OR9A2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR9A2: view

Function for OR9A2 Gene

Molecular function for OR9A2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR9A2 Gene

Gene Ontology (GO) - Molecular Function for OR9A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR9A2: view
genes like me logo Genes that share phenotypes with OR9A2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR9A2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR9A2 Gene

Localization for OR9A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR9A2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR9A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR9A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR9A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR9A2 Gene

Pathways & Interactions for OR9A2 Gene

genes like me logo Genes that share pathways with OR9A2: view

Pathways by source for OR9A2 Gene

Interacting Proteins for OR9A2 Gene

Gene Ontology (GO) - Biological Process for OR9A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR9A2: view

No data available for SIGNOR curated interactions for OR9A2 Gene

Drugs & Compounds for OR9A2 Gene

No Compound Related Data Available

Transcripts for OR9A2 Gene

mRNA/cDNA for OR9A2 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR9A2

Alternative Splicing Database (ASD) splice patterns (SP) for OR9A2 Gene

No ASD Table

Relevant External Links for OR9A2 Gene

GeneLoc Exon Structure for
OR9A2

Expression for OR9A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR9A2 Gene

mRNA differential expression in normal tissues according to GTEx for OR9A2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x16.5), Brain - Substantia nigra (x5.6), and Brain - Hippocampus (x4.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR9A2

SOURCE GeneReport for Unigene cluster for OR9A2 Gene:

Hs.553594
genes like me logo Genes that share expression patterns with OR9A2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR9A2 Gene

Orthologs for OR9A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR9A2 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia LOC614298 29
  • 83.28 (n)
-- 30
  • 80 (a)
OneToMany
-- 30
  • 80 (a)
OneToMany
-- 30
  • 79 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia LOC100686794 29
  • 82.52 (n)
-- 30
  • 45 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Or9a2 45 Olfr459 29 16 30
  • 81.88 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1562066 29
  • 81.66 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 67 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii or101-1 30
  • 32 (a)
OneToMany
Species where no ortholog for OR9A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for OR9A2 Gene

ENSEMBL:
Gene Tree for OR9A2 (if available)
TreeFam:
Gene Tree for OR9A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR9A2: view image
Alliance of Genome Resources:
Additional Orthologs for OR9A2

Paralogs for OR9A2 Gene

(425) SIMAP similar genes for OR9A2 Gene using alignment to 2 proteins:

  • OR9A2_HUMAN
  • A4D2H9_HUMAN

Pseudogenes.org Pseudogenes for OR9A2 Gene

genes like me logo Genes that share paralogs with OR9A2: view

Variants for OR9A2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR9A2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs9885986 -- p.Arg53His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR9A2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR9A2 Gene

Variant ID Type Subtype PubMed ID
esv2759569 CNV loss 17122850

Variation tolerance for OR9A2 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.01; 68.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR9A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR9A2
Leiden Open Variation Database (LOVD)
OR9A2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR9A2 Gene

Disorders for OR9A2 Gene

Additional Disease Information for OR9A2

No disorders were found for OR9A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR9A2 Gene

Publications for OR9A2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  3. Novel human G-protein-coupled receptors. (PMID: 12732197) Vanti WB … O'Dowd BF (Biochemical and biophysical research communications 2003) 3
  4. Natural selection on the olfactory receptor gene family in humans and chimpanzees. (PMID: 12908129) Gilad Y … Pääbo S (American journal of human genetics 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR9A2 Gene

Sources for OR9A2 Gene