Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR8U3 Gene

Aliases for OR8U3 Gene

  • Olfactory Receptor Family 8 Subfamily U Member 3 2 3 5
  • Olfactory Receptor Family 5 Subfamily R Member 1 2 3
  • Olfactory Receptor OR11-185 3 4
  • Olfactory Receptor 8U3 3 4
  • Olfactory Receptor 5R1 3 4
  • OR5R1P 3 4
  • OR5R1 3 4
  • Olfactory Receptor, Family 5, Subfamily R, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor Family 5 Subfamily R Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 5, Subfamily R, Member 1 Pseudogene 3
  • OR11-185 3
  • OR8U3 5

External Ids for OR8U3 Gene

Previous HGNC Symbols for OR8U3 Gene

  • OR5R1P
  • OR5R1

Previous GeneCards Identifiers for OR8U3 Gene

  • GC11M064469

Summaries for OR8U3 Gene

Entrez Gene Summary for OR8U3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR8U3 Gene

OR8U3 (Olfactory Receptor Family 8 Subfamily U Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. An important paralog of this gene is OR8U1.

UniProtKB/Swiss-Prot Summary for OR8U3 Gene

Gene Wiki entry for OR8U3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR8U3 Gene

Genomics for OR8U3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR8U3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J056895 Enhancer 0.2 FANTOM5 6.3 -477.6 -477584 0 OR5M10 OR5M9 OR5AP2 OR5M1 OR5M3 OR5AR1 OR5M8 OR8U3 OR5M11 FADS2B
GH11J056443 Enhancer 0.2 ENCODE 0.3 -25.3 -25328 0.2 piR-49097-019 OR5M4P OR5M9 OR8U3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8U3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR8U3

Genomic Locations for OR8U3 Gene

Latest Assembly
chr11:56,417,258-56,418,232
(GRCh38/hg38)
Size:
975 bases
Orientation:
Minus strand

Previous Assembly
chr11:56,184,734-56,185,708
(GRCh37/hg19 by Entrez Gene)
Size:
975 bases
Orientation:
Minus strand

Genomic View for OR8U3 Gene

Genes around OR8U3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8U3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8U3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8U3 Gene

Proteins for OR8U3 Gene

  • Protein details for OR8U3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH85-OR5R1_HUMAN
    Recommended name:
    Olfactory receptor 8U3
    Protein Accession:
    Q8NH85

    Protein attributes for OR8U3 Gene

    Size:
    324 amino acids
    Molecular mass:
    36708 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8U3 Gene

Post-translational modifications for OR8U3 Gene

  • Glycosylation at Asn265
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8U3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OR8U3 Gene

Domains & Families for OR8U3 Gene

Gene Families for OR8U3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8U3 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR8U3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-185 (OR5R1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH85

UniProtKB/Swiss-Prot:

OR5R1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8U3: view

Function for OR8U3 Gene

Molecular function for OR8U3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR8U3 Gene

Gene Ontology (GO) - Molecular Function for OR8U3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR8U3: view
genes like me logo Genes that share phenotypes with OR8U3: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8U3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8U3 Gene

Localization for OR8U3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8U3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8U3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8U3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8U3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8U3 Gene

Pathways & Interactions for OR8U3 Gene

genes like me logo Genes that share pathways with OR8U3: view

Pathways by source for OR8U3 Gene

Interacting Proteins for OR8U3 Gene

Gene Ontology (GO) - Biological Process for OR8U3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8U3: view

No data available for SIGNOR curated interactions for OR8U3 Gene

Drugs & Compounds for OR8U3 Gene

No Compound Related Data Available

Transcripts for OR8U3 Gene

mRNA/cDNA for OR8U3 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8U3

Alternative Splicing Database (ASD) splice patterns (SP) for OR8U3 Gene

No ASD Table

Relevant External Links for OR8U3 Gene

GeneLoc Exon Structure for
OR8U3

Expression for OR8U3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR8U3

SOURCE GeneReport for Unigene cluster for OR8U3 Gene:

Hs.553630
No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8U3 Gene

Orthologs for OR8U3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8U3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466563 29
  • 98.87 (n)
Dog
(Canis familiaris)
Mammalia LOC100684702 29
  • 89.86 (n)
Cow
(Bos Taurus)
Mammalia OR5R1 29
  • 86.62 (n)
Mouse
(Mus musculus)
Mammalia Olfr1038-ps 29 16
  • 84.01 (n)
Or5r1 45 Olfr1038
  • chr2:86,121,925-86,122,797
Or5r3-ps 45 Olfr1035-ps1
  • chr2:86,056,002-86,056,964
Rat
(Rattus norvegicus)
Mammalia Olr477 29
  • 83.8 (n)
Species where no ortholog for OR8U3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR8U3 Gene

ENSEMBL:
Gene Tree for OR8U3 (if available)
TreeFam:
Gene Tree for OR8U3 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR8U3

Paralogs for OR8U3 Gene

genes like me logo Genes that share paralogs with OR8U3: view

Variants for OR8U3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR8U3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs12785840 -- p.Ile162Thr
rs17150578 -- p.Tyr132His
rs6591324 -- p.Cys122Arg
rs7111634 -- p.Asp121Gly
rs7123108 -- p.Cys103Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR8U3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR8U3 Gene

Variant ID Type Subtype PubMed ID
dgv1948n54 CNV loss 21841781
esv3579724 CNV loss 25503493
nsv825905 CNV loss 20364138

Variation tolerance for OR8U3 Gene

Residual Variation Intolerance Score: 98.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.00; 98.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8U3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8U3
Leiden Open Variation Database (LOVD)
OR8U3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8U3 Gene

Disorders for OR8U3 Gene

Additional Disease Information for OR8U3

No disorders were found for OR8U3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8U3 Gene

Publications for OR8U3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3

Products for OR8U3 Gene

Sources for OR8U3 Gene