Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR8S1 Gene

Aliases for OR8S1 Gene

  • Olfactory Receptor Family 8 Subfamily S Member 1 2 3 5
  • Olfactory Receptor 8S1 3 4
  • Olfactory Receptor, Family 8, Subfamily S, Member 1 2
  • OR8S1 5

External Ids for OR8S1 Gene

Previous GeneCards Identifiers for OR8S1 Gene

  • GC00U903088
  • GC12P047206
  • GC12P047208
  • GC12P048919
  • GC12P048507

Summaries for OR8S1 Gene

Entrez Gene Summary for OR8S1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8S1 Gene

OR8S1 (Olfactory Receptor Family 8 Subfamily S Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5BS1P.

UniProtKB/Swiss-Prot Summary for OR8S1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR8S1 Gene

Genomics for OR8S1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR8S1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8S1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR8S1

Top Transcription factor binding sites by QIAGEN in the OR8S1 gene promoter:
  • AML1a
  • Evi-1
  • ITF-2
  • MyoD
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Tal-1beta

Genomic Locations for OR8S1 Gene

Latest Assembly
chr12:48,525,632-48,528,103
(GRCh38/hg38)
Size:
2,472 bases
Orientation:
Plus strand

Previous Assembly
chr12:48,919,415-48,921,886
(GRCh37/hg19 by Entrez Gene)
Size:
2,472 bases
Orientation:
Plus strand

Genomic View for OR8S1 Gene

Genes around OR8S1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8S1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8S1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8S1 Gene

Proteins for OR8S1 Gene

  • Protein details for OR8S1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH09-OR8S1_HUMAN
    Recommended name:
    Olfactory receptor 8S1
    Protein Accession:
    Q8NH09

    Protein attributes for OR8S1 Gene

    Size:
    359 amino acids
    Molecular mass:
    39645 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8S1 Gene

Post-translational modifications for OR8S1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8S1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8S1 Gene

Domains & Families for OR8S1 Gene

Gene Families for OR8S1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8S1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR8S1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 8S1 (OR8S1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH09

UniProtKB/Swiss-Prot:

OR8S1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8S1: view

Function for OR8S1 Gene

Molecular function for OR8S1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR8S1 Gene

Gene Ontology (GO) - Molecular Function for OR8S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR8S1: view
genes like me logo Genes that share phenotypes with OR8S1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8S1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8S1 Gene

Localization for OR8S1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8S1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8S1 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OR8S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8S1: view

Pathways & Interactions for OR8S1 Gene

genes like me logo Genes that share pathways with OR8S1: view

Pathways by source for OR8S1 Gene

Interacting Proteins for OR8S1 Gene

Gene Ontology (GO) - Biological Process for OR8S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8S1: view

No data available for SIGNOR curated interactions for OR8S1 Gene

Drugs & Compounds for OR8S1 Gene

No Compound Related Data Available

Transcripts for OR8S1 Gene

mRNA/cDNA for OR8S1 Gene

2 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8S1

Alternative Splicing Database (ASD) splice patterns (SP) for OR8S1 Gene

No ASD Table

Relevant External Links for OR8S1 Gene

GeneLoc Exon Structure for
OR8S1

Expression for OR8S1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8S1 Gene

mRNA differential expression in normal tissues according to GTEx for OR8S1 Gene

This gene is overexpressed in Testis (x5.3) and Ovary (x4.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR8S1

SOURCE GeneReport for Unigene cluster for OR8S1 Gene:

Hs.524373
genes like me logo Genes that share expression patterns with OR8S1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8S1 Gene

Orthologs for OR8S1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8S1 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia OR8S1 29
  • 86.82 (n)
Dog
(Canis familiaris)
Mammalia OR8S1 29
  • 86.2 (n)
Mouse
(Mus musculus)
Mammalia Or8s10 45 Olfr282
  • chr15:98,437,471-98,438,394
Or8s8 45 Olfr281
  • chr15:98,456,258-98,457,244
Species where no ortholog for OR8S1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR8S1 Gene

ENSEMBL:
Gene Tree for OR8S1 (if available)
TreeFam:
Gene Tree for OR8S1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR8S1: view image
Alliance of Genome Resources:
Additional Orthologs for OR8S1

Paralogs for OR8S1 Gene

(408) SIMAP similar genes for OR8S1 Gene using alignment to 1 proteins:

  • OR8S1_HUMAN
genes like me logo Genes that share paralogs with OR8S1: view

Variants for OR8S1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR8S1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs12425460 -- p.Arg128Cys
rs2731073 -- p.Met48Val
rs4075258 -- p.Leu82Pro

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR8S1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR8S1 Gene

Variant ID Type Subtype PubMed ID
nsv697 CNV insertion 18451855

Variation tolerance for OR8S1 Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.12; 95.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8S1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8S1
Leiden Open Variation Database (LOVD)
OR8S1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8S1 Gene

Disorders for OR8S1 Gene

Additional Disease Information for OR8S1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR8S1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8S1 Gene

Publications for OR8S1 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 40
  2. A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2. (PMID: 24105470) Wu Y … Tai ES (Human molecular genetics 2014) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4

Products for OR8S1 Gene

Sources for OR8S1 Gene