Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR8K5 Gene

Aliases for OR8K5 Gene

  • Olfactory Receptor Family 8 Subfamily K Member 5 2 3 5
  • Olfactory Receptor OR11-174 3 4
  • Olfactory Receptor 8K5 3 4
  • Olfactory Receptor, Family 8, Subfamily K, Member 5 2
  • OR11-174 3
  • OR8K5 5

External Ids for OR8K5 Gene

Previous GeneCards Identifiers for OR8K5 Gene

  • GC11U990399
  • GC11M055683
  • GC11M055926

Summaries for OR8K5 Gene

Entrez Gene Summary for OR8K5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8K5 Gene

OR8K5 (Olfactory Receptor Family 8 Subfamily K Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR8K3.

UniProtKB/Swiss-Prot Summary for OR8K5 Gene

Gene Wiki entry for OR8K5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR8K5 Gene

Genomics for OR8K5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR8K5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J056173 Enhancer 0.4 ENCODE 0.4 -12.4 -12443 0.2 MAFF ZNF316 MAFK HSALNG0084208 OR5J2 OR8K5
GH11J056172 Enhancer 0.3 ENCODE 0.4 -12.2 -12243 0.2 MAFF MAFK HSALNG0084208 OR5J2 OR8K5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8K5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR8K5

Top Transcription factor binding sites by QIAGEN in the OR8K5 gene promoter:
  • Cart-1
  • GR
  • GR-alpha
  • GR-beta
  • HOXA3
  • Pbx1a
  • POU2F1c
  • POU3F2
  • TBP
  • TFIID

Genomic Locations for OR8K5 Gene

Latest Assembly
chr11:56,159,394-56,160,317
(GRCh38/hg38)
Size:
924 bases
Orientation:
Minus strand

Previous Assembly
chr11:55,926,870-55,927,793
(GRCh37/hg19 by Entrez Gene)
Size:
924 bases
Orientation:
Minus strand

chr11:55,926,870-55,927,793
(GRCh37/hg19 by Ensembl)
Size:
924 bases
Orientation:
Minus strand

Genomic View for OR8K5 Gene

Genes around OR8K5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8K5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8K5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8K5 Gene

Proteins for OR8K5 Gene

  • Protein details for OR8K5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH50-OR8K5_HUMAN
    Recommended name:
    Olfactory receptor 8K5
    Protein Accession:
    Q8NH50
    Secondary Accessions:
    • Q6IFB5

    Protein attributes for OR8K5 Gene

    Size:
    307 amino acids
    Molecular mass:
    35190 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8K5 Gene

Post-translational modifications for OR8K5 Gene

  • Glycosylation at Asn5 and Asn263
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8K5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8K5 Gene

Domains & Families for OR8K5 Gene

Gene Families for OR8K5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8K5 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR8K5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-174 (OR8K5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH50

UniProtKB/Swiss-Prot:

OR8K5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8K5: view

Function for OR8K5 Gene

Molecular function for OR8K5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR8K5: view
genes like me logo Genes that share phenotypes with OR8K5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8K5

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8K5 Gene

Localization for OR8K5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8K5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8K5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8K5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8K5 Gene

Pathways & Interactions for OR8K5 Gene

genes like me logo Genes that share pathways with OR8K5: view

Pathways by source for OR8K5 Gene

Interacting Proteins for OR8K5 Gene

Gene Ontology (GO) - Biological Process for OR8K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8K5: view

No data available for SIGNOR curated interactions for OR8K5 Gene

Drugs & Compounds for OR8K5 Gene

No Compound Related Data Available

Transcripts for OR8K5 Gene

mRNA/cDNA for OR8K5 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8K5

Alternative Splicing Database (ASD) splice patterns (SP) for OR8K5 Gene

No ASD Table

Relevant External Links for OR8K5 Gene

GeneLoc Exon Structure for
OR8K5

Expression for OR8K5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8K5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR8K5

SOURCE GeneReport for Unigene cluster for OR8K5 Gene:

Hs.553626
genes like me logo Genes that share expression patterns with OR8K5: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8K5 Gene

Orthologs for OR8K5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8K5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466549 29
  • 99.11 (n)
Cow
(Bos Taurus)
Mammalia LOC790274 29
  • 84.58 (n)
-- 30
  • 81 (a)
OneToMany
-- 30
  • 81 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia LOC100684477 29
  • 82.84 (n)
Rat
(Rattus norvegicus)
Mammalia Olr490 29
  • 79.37 (n)
Mouse
(Mus musculus)
Mammalia Or8k21 45 Olfr1053 29 16 30
  • 79.15 (n)
OneToMany
Or8k18 45 Olfr1049 30
  • 75 (a)
OneToMany
Or8k20 45 Olfr1051 30
  • 75 (a)
OneToMany
Or8k16 45 Olfr1008 30
  • 74 (a)
OneToMany
Or8k17 45 Olfr1048 30
  • 72 (a)
OneToMany
Species where no ortholog for OR8K5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR8K5 Gene

ENSEMBL:
Gene Tree for OR8K5 (if available)
TreeFam:
Gene Tree for OR8K5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR8K5: view image
Alliance of Genome Resources:
Additional Orthologs for OR8K5

Paralogs for OR8K5 Gene

(440) SIMAP similar genes for OR8K5 Gene using alignment to 1 proteins:

  • OR8K5_HUMAN

Pseudogenes.org Pseudogenes for OR8K5 Gene

genes like me logo Genes that share paralogs with OR8K5: view

Variants for OR8K5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR8K5 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs2512938 -- p.Phe68Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR8K5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR8K5 Gene

Variant ID Type Subtype PubMed ID
dgv1205n100 CNV gain 25217958
dgv200e214 CNV gain 21293372
esv3579715 CNV loss 25503493
esv3579722 CNV loss 25503493
esv3579782 CNV gain 25503493
esv3626473 CNV gain 21293372
esv3892014 CNV loss 25118596
nsv1036290 CNV loss 25217958
nsv468575 CNV loss 19166990
nsv521440 CNV loss 19592680
nsv555095 CNV loss 21841781

Variation tolerance for OR8K5 Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.68; 72.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8K5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8K5
Leiden Open Variation Database (LOVD)
OR8K5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8K5 Gene

Disorders for OR8K5 Gene

Additional Disease Information for OR8K5

No disorders were found for OR8K5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8K5 Gene

Publications for OR8K5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR8K5 Gene

Sources for OR8K5 Gene