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Aliases for OR8K5 Gene

Aliases for OR8K5 Gene

  • Olfactory Receptor Family 8 Subfamily K Member 5 2 3 5
  • Olfactory Receptor OR11-174 3 4
  • Olfactory Receptor, Family 8, Subfamily K, Member 5 2
  • Olfactory Receptor 8K5 3
  • OR11-174 3

External Ids for OR8K5 Gene

Previous GeneCards Identifiers for OR8K5 Gene

  • GC11U990399
  • GC11M055683
  • GC11M055926

Summaries for OR8K5 Gene

Entrez Gene Summary for OR8K5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8K5 Gene

OR8K5 (Olfactory Receptor Family 8 Subfamily K Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR8K3.

UniProtKB/Swiss-Prot for OR8K5 Gene

  • Odorant receptor.

Gene Wiki entry for OR8K5 Gene

Additional gene information for OR8K5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8K5 Gene

Genomics for OR8K5 Gene

GeneHancer (GH) Regulatory Elements for OR8K5 Gene

Top Transcription factor binding sites by QIAGEN in the OR8K5 gene promoter:
  • Pbx1a
  • TBP
  • HOXA3
  • POU3F2
  • GR
  • GR-alpha
  • GR-beta
  • Cart-1
  • POU2F1c

Genomic Locations for OR8K5 Gene

Genomic Locations for OR8K5 Gene
924 bases
Minus strand
924 bases
Minus strand

Genomic View for OR8K5 Gene

Genes around OR8K5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8K5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8K5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8K5 Gene

Proteins for OR8K5 Gene

  • Protein details for OR8K5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 8K5
    Protein Accession:
    Secondary Accessions:
    • Q6IFB5

    Protein attributes for OR8K5 Gene

    307 amino acids
    Molecular mass:
    35190 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8K5 Gene

Post-translational modifications for OR8K5 Gene

  • Glycosylation at isoforms=263 and isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8K5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8K5 Gene

Domains & Families for OR8K5 Gene

Gene Families for OR8K5 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8K5 Gene

Suggested Antigen Peptide Sequences for OR8K5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8K5: view

Function for OR8K5 Gene

Molecular function for OR8K5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8K5: view
genes like me logo Genes that share phenotypes with OR8K5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8K5 Gene

Localization for OR8K5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8K5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8K5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8K5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8K5 Gene

Pathways & Interactions for OR8K5 Gene

genes like me logo Genes that share pathways with OR8K5: view

Pathways by source for OR8K5 Gene

Interacting Proteins for OR8K5 Gene

Gene Ontology (GO) - Biological Process for OR8K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA,IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8K5: view

No data available for SIGNOR curated interactions for OR8K5 Gene

Drugs & Compounds for OR8K5 Gene

No Compound Related Data Available

Transcripts for OR8K5 Gene

mRNA/cDNA for OR8K5 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR8K5 Gene

Olfactory receptor, family 8, subfamily K, member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8K5 Gene

No ASD Table

Relevant External Links for OR8K5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR8K5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR8K5 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR8K5 Gene:


SOURCE GeneReport for Unigene cluster for OR8K5 Gene:

genes like me logo Genes that share expression patterns with OR8K5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8K5 Gene

Orthologs for OR8K5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8K5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466549 33
  • 99.11 (n)
(Bos Taurus)
Mammalia LOC790274 33
  • 84.58 (n)
-- 34
  • 81 (a)
-- 34
  • 81 (a)
(Canis familiaris)
Mammalia LOC100684477 33
  • 82.84 (n)
(Rattus norvegicus)
Mammalia Olr490 33
  • 79.37 (n)
(Mus musculus)
Mammalia Or8k21 51 Olfr1053 16 34 33
  • 79.15 (n)
Or8k18 51 Olfr1049 34
  • 75 (a)
Or8k20 51 Olfr1051 34
  • 75 (a)
Or8k16 51 Olfr1008 34
  • 74 (a)
Or8k17 51 Olfr1048 34
  • 72 (a)
Species where no ortholog for OR8K5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8K5 Gene

Gene Tree for OR8K5 (if available)
Gene Tree for OR8K5 (if available)
Evolutionary constrained regions (ECRs) for OR8K5: view image

Paralogs for OR8K5 Gene

Paralogs for OR8K5 Gene

(440) SIMAP similar genes for OR8K5 Gene using alignment to 1 proteins:

  • OR8K5_HUMAN Pseudogenes for OR8K5 Gene

genes like me logo Genes that share paralogs with OR8K5: view

Variants for OR8K5 Gene

Sequence variations from dbSNP and Humsavar for OR8K5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000356154 -- 56,161,851(-) C/T upstream_transcript_variant
rs1001254018 -- 56,159,207(-) C/A downstream_transcript_variant
rs1002660606 -- 56,160,441(-) C/T upstream_transcript_variant
rs1002868369 -- 56,160,501(-) A/G upstream_transcript_variant
rs1003188515 -- 56,159,249(-) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR8K5 Gene

Variant ID Type Subtype PubMed ID
dgv1205n100 CNV gain 25217958
dgv200e214 CNV gain 21293372
esv3579715 CNV loss 25503493
esv3579722 CNV loss 25503493
esv3579782 CNV gain 25503493
esv3626473 CNV gain 21293372
esv3892014 CNV loss 25118596
nsv1036290 CNV loss 25217958
nsv468575 CNV loss 19166990
nsv521440 CNV loss 19592680
nsv555095 CNV loss 21841781

Variation tolerance for OR8K5 Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.68; 72.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8K5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8K5 Gene

Disorders for OR8K5 Gene

Additional Disease Information for OR8K5

No disorders were found for OR8K5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8K5 Gene

Publications for OR8K5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR8K5 Gene

Sources for OR8K5 Gene

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