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Aliases for OR8K3 Gene

Aliases for OR8K3 Gene

  • Olfactory Receptor Family 8 Subfamily K Member 3 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor OR11-181 3 4
  • Olfactory Receptor, Family 8, Subfamily K, Member 3 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 8, Subfamily K, Member 3 3
  • Olfactory Receptor 8K3 3
  • OR11-181 3

External Ids for OR8K3 Gene

Previous GeneCards Identifiers for OR8K3 Gene

  • GC11U990401
  • GC11P055862
  • GC11P055842
  • GC11P056085

Summaries for OR8K3 Gene

Entrez Gene Summary for OR8K3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR8K3 Gene

OR8K3 (Olfactory Receptor Family 8 Subfamily K Member 3 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR8K5.

UniProtKB/Swiss-Prot for OR8K3 Gene

  • Odorant receptor.

Gene Wiki entry for OR8K3 Gene

Additional gene information for OR8K3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8K3 Gene

Genomics for OR8K3 Gene

GeneHancer (GH) Regulatory Elements for OR8K3 Gene

Top Transcription factor binding sites by QIAGEN in the OR8K3 gene promoter:
  • FOXO3b
  • FOXO3a
  • FOXO3
  • C/EBPbeta
  • Tal-1beta
  • E47
  • PPAR-gamma2
  • PPAR-gamma1
  • POU2F1
  • POU2F1a

Genomic Locations for OR8K3 Gene

Genomic Locations for OR8K3 Gene
5,496 bases
Plus strand
939 bases
Plus strand

Genomic View for OR8K3 Gene

Genes around OR8K3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8K3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8K3 Gene

Proteins for OR8K3 Gene

  • Protein details for OR8K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 8K3
    Protein Accession:
    Secondary Accessions:
    • Q6IFC4

    Protein attributes for OR8K3 Gene

    312 amino acids
    Molecular mass:
    35463 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8K3 Gene

Post-translational modifications for OR8K3 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8K3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8K3 Gene

Domains & Families for OR8K3 Gene

Gene Families for OR8K3 Gene

Protein Domains for OR8K3 Gene

Suggested Antigen Peptide Sequences for OR8K3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8K3: view

Function for OR8K3 Gene

Molecular function for OR8K3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8K3: view

Phenotypes for OR8K3 Gene

genes like me logo Genes that share phenotypes with OR8K3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8K3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8K3 Gene

Localization for OR8K3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8K3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8K3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8K3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8K3 Gene

Pathways & Interactions for OR8K3 Gene

genes like me logo Genes that share pathways with OR8K3: view

Pathways by source for OR8K3 Gene

Interacting Proteins for OR8K3 Gene

Gene Ontology (GO) - Biological Process for OR8K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA,IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8K3: view

No data available for SIGNOR curated interactions for OR8K3 Gene

Drugs & Compounds for OR8K3 Gene

No Compound Related Data Available

Transcripts for OR8K3 Gene

mRNA/cDNA for OR8K3 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR8K3 Gene

Olfactory receptor, family 8, subfamily K, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8K3

Alternative Splicing Database (ASD) splice patterns (SP) for OR8K3 Gene

No ASD Table

Relevant External Links for OR8K3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR8K3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR8K3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR8K3 Gene:


SOURCE GeneReport for Unigene cluster for OR8K3 Gene:

genes like me logo Genes that share expression patterns with OR8K3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8K3 Gene

Orthologs for OR8K3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8K3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466557 33
  • 99.57 (n)
(Canis familiaris)
Mammalia LOC100688585 33
  • 83.88 (n)
(Bos Taurus)
Mammalia LOC514057 33
  • 83.17 (n)
(Mus musculus)
Mammalia Or8k22 51 Olfr1054 16 33
  • 80.43 (n)
Or8k23 51 Olfr1056
  • chr2:86,355,442-86,356,380
Or8k24 51 Olfr1058
  • chr2:86,385,469-86,386,416
Or8k25 51 Olfr1061
  • chr2:86,413,112-86,414,050
Or8k26-ps 51 Olfr1063-ps1
  • chr2:86,434,314-86,435,231
Or8k27 51 Olfr1065
  • chr2:86,445,042-86,445,980
Or8k28 51 Olfr1066
  • chr2:86,455,331-86,456,269
Or8k29-ps 51 Olfr1069-ps1
  • chr2:86,463,824-86,464,596
Or8k3 51 Olfr1047
  • chr2:86,228,013-86,228,969
Or8k30 51 Olfr1076
  • chr2:86,508,461-86,509,399
Or8k31-ps 51 Olfr1077-ps1
  • chr2:86,525,237-86,526,175
Or8k32 51 Olfr1079
  • chr2:86,537,969-86,538,913
Or8k33 51 Olfr1080
  • chr2:86,553,184-86,554,122
Or8k34-ps 51 Olfr1081-ps1
  • chr2:86,567,123-86,568,064
Or8k35 51 Olfr1082
  • chr2:86,593,888-86,594,826
Or8k36-ps 51 Olfr1083-ps1
  • chr2:86,606,630-86,607,569
Or8k37 51 Olfr1084
  • chr2:86,638,768-86,639,706
Or8k38 51 Olfr1085
  • chr2:86,657,518-86,658,456
Or8k39 51 Olfr1089
  • chr2:86,732,678-86,733,610
Or8k3b 51 Olfr1087
  • chr2:86,690,035-86,690,973
Or8k40 51 Olfr1090
  • chr2:86,753,798-86,754,736
Or8k41 51 Olfr228_Olfr1072
  • chr2:86,482,802-86,483,740
Or8k42-ps 51 Olfr1073-ps1
  • chr2:86,488,414-86,488,787
Or8y1-ps 51 Olfr1059-ps1
  • chr2:86,389,093-86,389,604
Species where no ortholog for OR8K3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8K3 Gene

Gene Tree for OR8K3 (if available)
Gene Tree for OR8K3 (if available)

Paralogs for OR8K3 Gene

Paralogs for OR8K3 Gene

(446) SIMAP similar genes for OR8K3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR8K3: view

Variants for OR8K3 Gene

Sequence variations from dbSNP and Humsavar for OR8K3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs193920753 uncertain-significance, Malignant tumor of prostate 56,319,006(+) C/A coding_sequence_variant, missense_variant
rs1001562053 -- 56,319,449(+) T/G downstream_transcript_variant
rs1001643716 -- 56,317,405(+) A/G upstream_transcript_variant
rs1002096267 -- 56,317,120(+) AAAGAA/AA upstream_transcript_variant
rs1002182958 -- 56,319,612(+) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR8K3 Gene

Variant ID Type Subtype PubMed ID
dgv1948n54 CNV loss 21841781
esv3579724 CNV loss 25503493
esv3579827 CNV gain 25503493
esv3892014 CNV loss 25118596
nsv832161 CNV gain 17160897

Variation tolerance for OR8K3 Gene

Residual Variation Intolerance Score: 59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8K3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8K3 Gene

Disorders for OR8K3 Gene

Additional Disease Information for OR8K3

No disorders were found for OR8K3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8K3 Gene

Publications for OR8K3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3 58
  3. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR8K3 Gene

Sources for OR8K3 Gene

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