Aliases for OR8J3 Gene

Aliases for OR8J3 Gene

  • Olfactory Receptor Family 8 Subfamily J Member 3 2 3 5
  • Olfactory Receptor OR11-173 3 4
  • Olfactory Receptor 8J3 3 4
  • Olfactory Receptor, Family 8, Subfamily J, Member 3 2
  • OR11-173 3
  • OR8J3 5

External Ids for OR8J3 Gene

Previous GeneCards Identifiers for OR8J3 Gene

  • GC11U990402
  • GC11M055681
  • GC11M055660
  • GC11M055904
  • GC11M056137
  • GC11M056360
  • GC11M056375
  • GC11M056272
  • GC11M059773
  • GC11M056138
  • GC11M056356
  • GC11M061209
  • GC11M063675

Summaries for OR8J3 Gene

GeneCards Summary for OR8J3 Gene

OR8J3 (Olfactory Receptor Family 8 Subfamily J Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR8J1.

UniProtKB/Swiss-Prot Summary for OR8J3 Gene

Gene Wiki entry for OR8J3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR8J3 Gene

Genomics for OR8J3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR8J3

Top Transcription factor binding sites by QIAGEN in the OR8J3 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • Meis-1
  • Meis-1a
  • Meis-1b
  • NF-Y
  • POU2F1
  • POU2F1a

Genomic Locations for OR8J3 Gene

Latest Assembly
5,481 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
5,481 bases
Minus strand

(GRCh37/hg19 by Ensembl)
948 bases
Minus strand

Genomic View for OR8J3 Gene

Genes around OR8J3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8J3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8J3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8J3 Gene

Proteins for OR8J3 Gene

  • Protein details for OR8J3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 8J3
    Protein Accession:
    Secondary Accessions:
    • Q6IFB6
    • Q96RC2

    Protein attributes for OR8J3 Gene

    315 amino acids
    Molecular mass:
    35481 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8J3 Gene

Post-translational modifications for OR8J3 Gene

  • Glycosylation at Asn5 and Asn265
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8J3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8J3 Gene

Domains & Families for OR8J3 Gene

Gene Families for OR8J3 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8J3 Gene

  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR8J3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-173 (OR8J3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8J3: view

Function for OR8J3 Gene

Molecular function for OR8J3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR8J3: view
genes like me logo Genes that share phenotypes with OR8J3: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8J3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8J3 Gene

Localization for OR8J3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8J3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8J3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8J3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8J3 Gene

Pathways & Interactions for OR8J3 Gene

genes like me logo Genes that share pathways with OR8J3: view

Pathways by source for OR8J3 Gene

Interacting Proteins for OR8J3 Gene

Gene Ontology (GO) - Biological Process for OR8J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8J3: view

No data available for SIGNOR curated interactions for OR8J3 Gene

Drugs & Compounds for OR8J3 Gene

No Compound Related Data Available

Transcripts for OR8J3 Gene

mRNA/cDNA for OR8J3 Gene

3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8J3

Alternative Splicing Database (ASD) splice patterns (SP) for OR8J3 Gene

No ASD Table

Relevant External Links for OR8J3 Gene

GeneLoc Exon Structure for

Expression for OR8J3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8J3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR8J3

SOURCE GeneReport for Unigene cluster for OR8J3 Gene:

genes like me logo Genes that share expression patterns with OR8J3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8J3 Gene

Orthologs for OR8J3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8J3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100609139 29
  • 99.26 (n)
(Bos Taurus)
Mammalia LOC100300446 29
  • 83.17 (n)
-- 30
  • 83 (a)
-- 30
  • 81 (a)
-- 30
  • 79 (a)
-- 30
  • 78 (a)
-- 30
  • 78 (a)
(Rattus norvegicus)
Mammalia Olr484 29
  • 82.01 (n)
(Mus musculus)
Mammalia Or8j3 45 Olfr1045 29 16 30
  • 82.01 (n)
Or8j3b 45 Olfr1057
  • chr2:86,374,466-86,375,410
Or8j3c 45 Olfr1062
  • chr2:86,422,730-86,423,674
(Monodelphis domestica)
Mammalia -- 30
  • 75 (a)
-- 30
  • 71 (a)
-- 30
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 67 (a)
(Canis familiaris)
Mammalia OR10G10 30
  • 57 (a)
Species where no ortholog for OR8J3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR8J3 Gene

Gene Tree for OR8J3 (if available)
Gene Tree for OR8J3 (if available)
Evolutionary constrained regions (ECRs) for OR8J3: view image
Alliance of Genome Resources:
Additional Orthologs for OR8J3

Paralogs for OR8J3 Gene

(441) SIMAP similar genes for OR8J3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR8J3: view

Variants for OR8J3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR8J3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1384094 -- p.Val208Phe
rs17150102 -- p.Asp271Glu
rs1947924 -- p.Asn57Thr
rs7937461 -- p.Val87Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR8J3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR8J3 Gene

Variant ID Type Subtype PubMed ID
dgv1205n100 CNV gain 25217958
dgv200e214 CNV gain 21293372
esv3579715 CNV loss 25503493
esv3579782 CNV gain 25503493
esv3579805 CNV gain 25503493
esv3626473 CNV gain 21293372
esv3892014 CNV loss 25118596
nsv1036290 CNV loss 25217958
nsv468575 CNV loss 19166990
nsv521440 CNV loss 19592680
nsv555095 CNV loss 21841781
nsv832160 CNV gain 17160897
nsv972029 CNV duplication 23825009

Variation tolerance for OR8J3 Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.76; 86.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8J3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8J3 Gene

Disorders for OR8J3 Gene

Additional Disease Information for OR8J3

No disorders were found for OR8J3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8J3 Gene

Publications for OR8J3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PMID: 20235792) Uhl GR … Munafò MR (Pharmacogenomics 2010) 40

Products for OR8J3 Gene

Sources for OR8J3 Gene