Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR8I2 Gene

Aliases for OR8I2 Gene

  • Olfactory Receptor Family 8 Subfamily I Member 2 2 3 5
  • Olfactory Receptor OR11-170 3 4
  • Olfactory Receptor 8I2 3 4
  • Olfactory Receptor, Family 8, Subfamily I, Member 2 2
  • OR11-170 3
  • OR8I2 5

External Ids for OR8I2 Gene

Previous GeneCards Identifiers for OR8I2 Gene

  • GC11U990404
  • GC11P055617
  • GC11P055860

Summaries for OR8I2 Gene

Entrez Gene Summary for OR8I2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8I2 Gene

OR8I2 (Olfactory Receptor Family 8 Subfamily I Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR8H3.

UniProtKB/Swiss-Prot Summary for OR8I2 Gene

Gene Wiki entry for OR8I2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR8I2 Gene

Genomics for OR8I2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR8I2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J056058 Enhancer 0.4 Ensembl ENCODE 11.5 -35.4 -35356 1.4 NANOG piR-32559-069 OR5BN2P OR8H3 OR8I2 OR8I4P OR8H2 ENSG00000254547 FAM8A2P OR5AQ1P OR5AS1
GH11J056055 Enhancer 0.2 Ensembl 11.5 -36.7 -36676 0.8 OR5BN2P OR8H3 OR8I2 OR8I4P OR8H2 TRIM48 piR-32559-069 OR5AQ1P OR5AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8I2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR8I2

Top Transcription factor binding sites by QIAGEN in the OR8I2 gene promoter:
  • AML1a
  • CUTL1
  • HOXA3
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • PPAR-gamma2
  • Sox9

Genomic Locations for OR8I2 Gene

Latest Assembly
chr11:56,093,277-56,094,286
(GRCh38/hg38)
Size:
1,010 bases
Orientation:
Plus strand

Previous Assembly
chr11:55,860,784-55,861,716
(GRCh37/hg19 by Entrez Gene)
Size:
933 bases
Orientation:
Plus strand

chr11:55,860,753-55,861,762
(GRCh37/hg19 by Ensembl)
Size:
1,010 bases
Orientation:
Plus strand

Genomic View for OR8I2 Gene

Genes around OR8I2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8I2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8I2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8I2 Gene

Proteins for OR8I2 Gene

  • Protein details for OR8I2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Y5-OR8I2_HUMAN
    Recommended name:
    Olfactory receptor 8I2
    Protein Accession:
    Q8N0Y5
    Secondary Accessions:
    • B2RNN4
    • Q6IFC0
    • Q96RC5

    Protein attributes for OR8I2 Gene

    Size:
    310 amino acids
    Molecular mass:
    34661 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8I2 Gene

Post-translational modifications for OR8I2 Gene

  • Glycosylation at Asn5

Other Protein References for OR8I2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8I2 Gene

Domains & Families for OR8I2 Gene

Gene Families for OR8I2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8I2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR8I2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-170 (OR8I2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N0Y5

UniProtKB/Swiss-Prot:

OR8I2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8I2: view

Function for OR8I2 Gene

Molecular function for OR8I2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR8I2 Gene

Gene Ontology (GO) - Molecular Function for OR8I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR8I2: view

Phenotypes for OR8I2 Gene

genes like me logo Genes that share phenotypes with OR8I2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8I2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8I2 Gene

Localization for OR8I2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8I2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8I2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8I2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8I2 Gene

Pathways & Interactions for OR8I2 Gene

genes like me logo Genes that share pathways with OR8I2: view

Pathways by source for OR8I2 Gene

Interacting Proteins for OR8I2 Gene

Gene Ontology (GO) - Biological Process for OR8I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8I2: view

No data available for SIGNOR curated interactions for OR8I2 Gene

Drugs & Compounds for OR8I2 Gene

No Compound Related Data Available

Transcripts for OR8I2 Gene

mRNA/cDNA for OR8I2 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8I2

Alternative Splicing Database (ASD) splice patterns (SP) for OR8I2 Gene

No ASD Table

Relevant External Links for OR8I2 Gene

GeneLoc Exon Structure for
OR8I2

Expression for OR8I2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8I2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR8I2

SOURCE GeneReport for Unigene cluster for OR8I2 Gene:

Hs.554524
genes like me logo Genes that share expression patterns with OR8I2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8I2 Gene

Orthologs for OR8I2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8I2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466545 29
  • 98.82 (n)
OR8I2 30
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC100300545 29
  • 83.93 (n)
OR8I2 30
  • 82 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or8i2 45 Olfr1104 29 16 30
  • 83.6 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr536 29
  • 82.85 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 80 (a)
ManyToMany
-- 30
  • 76 (a)
ManyToMany
Species where no ortholog for OR8I2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR8I2 Gene

ENSEMBL:
Gene Tree for OR8I2 (if available)
TreeFam:
Gene Tree for OR8I2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR8I2: view image
Alliance of Genome Resources:
Additional Orthologs for OR8I2

Paralogs for OR8I2 Gene

(452) SIMAP similar genes for OR8I2 Gene using alignment to 1 proteins:

  • OR8I2_HUMAN

Pseudogenes.org Pseudogenes for OR8I2 Gene

genes like me logo Genes that share paralogs with OR8I2: view

Variants for OR8I2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR8I2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs17150021 -- p.Lys139Asn
rs17603011 -- p.Ile124Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR8I2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR8I2 Gene

Variant ID Type Subtype PubMed ID
dgv1205n100 CNV gain 25217958
dgv1905n54 CNV gain 21841781
dgv200e214 CNV gain 21293372
dgv389e212 CNV gain 25503493
esv2751030 CNV gain 17911159
esv3579715 CNV loss 25503493
esv3579782 CNV gain 25503493
esv3579805 CNV gain 25503493
esv3626466 CNV loss 21293372
esv3626467 CNV gain 21293372
esv3626473 CNV gain 21293372
esv3892014 CNV loss 25118596
nsv1036290 CNV loss 25217958
nsv1044174 CNV loss 25217958
nsv468575 CNV loss 19166990
nsv521440 CNV loss 19592680
nsv555095 CNV loss 21841781
nsv832160 CNV gain 17160897

Variation tolerance for OR8I2 Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.62; 78.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8I2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8I2
Leiden Open Variation Database (LOVD)
OR8I2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8I2 Gene

Disorders for OR8I2 Gene

Additional Disease Information for OR8I2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR8I2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8I2 Gene

Publications for OR8I2 Gene

  1. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A … EUROSPAN consortium (PLoS genetics 2012) 3 40
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR8I2 Gene

Sources for OR8I2 Gene