Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR8H1 Gene

Aliases for OR8H1 Gene

  • Olfactory Receptor Family 8 Subfamily H Member 1 2 3 5
  • Olfactory Receptor OR11-180 3 4
  • Olfactory Receptor 8H1 3 4
  • Olfactory Receptor, Family 8, Subfamily H, Member 1 2
  • OR11-180 3
  • OR8H1 5

External Ids for OR8H1 Gene

Previous GeneCards Identifiers for OR8H1 Gene

  • GC11U990352
  • GC11M055833
  • GC11M055814
  • GC11M056057
  • GC11M056290
  • GC11M057079
  • GC11M057092
  • GC11M056406
  • GC11M059776
  • GC11M056482
  • GC11M061213
  • GC11M063679

Summaries for OR8H1 Gene

Entrez Gene Summary for OR8H1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8H1 Gene

OR8H1 (Olfactory Receptor Family 8 Subfamily H Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR8H3.

UniProtKB/Swiss-Prot Summary for OR8H1 Gene

Gene Wiki entry for OR8H1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR8H1 Gene

Genomics for OR8H1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR8H1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J056289 Enhancer 0.2 Ensembl 0.7 +2.3 2253 0.4 OR8K3 ENSG00000254547 OR8H1 OR5T1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8H1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR8H1

Top Transcription factor binding sites by QIAGEN in the OR8H1 gene promoter:
  • AML1a
  • HOXA3
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Nkx2-2
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for OR8H1 Gene

Latest Assembly
chr11:56,288,462-56,292,254
(GRCh38/hg38)
Size:
3,793 bases
Orientation:
Minus strand

Previous Assembly
chr11:56,055,938-56,059,730
(GRCh37/hg19 by Entrez Gene)
Size:
3,793 bases
Orientation:
Minus strand

chr11:56,057,529-56,058,566
(GRCh37/hg19 by Ensembl)
Size:
1,038 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr11(ALT_REF_LOCI_1):99,211-103,003 (-)

Genomic View for OR8H1 Gene

Genes around OR8H1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8H1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8H1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8H1 Gene

Proteins for OR8H1 Gene

  • Protein details for OR8H1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGG4-OR8H1_HUMAN
    Recommended name:
    Olfactory receptor 8H1
    Protein Accession:
    Q8NGG4
    Secondary Accessions:
    • B2RNI7
    • Q6IFC5

    Protein attributes for OR8H1 Gene

    Size:
    311 amino acids
    Molecular mass:
    35228 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8H1 Gene

Post-translational modifications for OR8H1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8H1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8H1 Gene

Domains & Families for OR8H1 Gene

Gene Families for OR8H1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8H1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR8H1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-180 (OR8H1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGG4

UniProtKB/Swiss-Prot:

OR8H1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8H1: view

Function for OR8H1 Gene

Molecular function for OR8H1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR8H1 Gene

Gene Ontology (GO) - Molecular Function for OR8H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA,IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR8H1: view

Phenotypes for OR8H1 Gene

GenomeRNAi human phenotypes for OR8H1:
genes like me logo Genes that share phenotypes with OR8H1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8H1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8H1 Gene

Localization for OR8H1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8H1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8H1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8H1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8H1 Gene

Pathways & Interactions for OR8H1 Gene

genes like me logo Genes that share pathways with OR8H1: view

Pathways by source for OR8H1 Gene

Interacting Proteins for OR8H1 Gene

Gene Ontology (GO) - Biological Process for OR8H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,IBA 21873635
GO:0007608 sensory perception of smell IEA,IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8H1: view

No data available for SIGNOR curated interactions for OR8H1 Gene

Drugs & Compounds for OR8H1 Gene

No Compound Related Data Available

Transcripts for OR8H1 Gene

mRNA/cDNA for OR8H1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8H1

Alternative Splicing Database (ASD) splice patterns (SP) for OR8H1 Gene

No ASD Table

Relevant External Links for OR8H1 Gene

GeneLoc Exon Structure for
OR8H1

Expression for OR8H1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8H1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR8H1

SOURCE GeneReport for Unigene cluster for OR8H1 Gene:

Hs.553628
genes like me logo Genes that share expression patterns with OR8H1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8H1 Gene

Orthologs for OR8H1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8H1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OR8H1 30
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC100685331 29
  • 84.8 (n)
-- 30
  • 80 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia OR8H3 29
  • 79.98 (n)
-- 30
  • 74 (a)
ManyToMany
-- 30
  • 73 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Or8h9 45 Olfr1099 29 16 30
  • 78.79 (n)
ManyToMany
Or8h8 45 Olfr1098 30
  • 71 (a)
ManyToMany
Or8h7 45 Olfr1097 30
  • 71 (a)
ManyToMany
Or8h10 45 Olfr1100 30
  • 70 (a)
ManyToMany
Or8h11-ps 45 Olfr1103-ps1
  • chr2:87,009,941-87,010,874
Or8h6 45 Olfr1096
  • chr2:86,872,777-86,873,721
Rat
(Rattus norvegicus)
Mammalia Olr529 29
  • 77.16 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 59 (a)
ManyToMany
-- 30
  • 57 (a)
ManyToMany
Species where no ortholog for OR8H1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR8H1 Gene

ENSEMBL:
Gene Tree for OR8H1 (if available)
TreeFam:
Gene Tree for OR8H1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR8H1: view image
Alliance of Genome Resources:
Additional Orthologs for OR8H1

Paralogs for OR8H1 Gene

(452) SIMAP similar genes for OR8H1 Gene using alignment to 1 proteins:

  • OR8H1_HUMAN
genes like me logo Genes that share paralogs with OR8H1: view

Variants for OR8H1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR8H1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs11600896 -- p.Gly2Ser
rs17540861 -- p.Glu22Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR8H1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR8H1 Gene

Variant ID Type Subtype PubMed ID
esv3579722 CNV loss 25503493
esv3892014 CNV loss 25118596
nsv832161 CNV gain 17160897

Variation tolerance for OR8H1 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.56; 55.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8H1 Gene

Human Gene Mutation Database (HGMD)
OR8H1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8H1
Leiden Open Variation Database (LOVD)
OR8H1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8H1 Gene

Disorders for OR8H1 Gene

Additional Disease Information for OR8H1

No disorders were found for OR8H1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8H1 Gene

Publications for OR8H1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR8H1 Gene

Sources for OR8H1 Gene